CEP250 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description centrosomal protein 250kDa|This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. [provided by RefSeq, Jun 2009] (NCBI Entrez Gene Database, 11190)
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Genes

353 genes differentially expressed following the CEP250 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KCNIP2 Kv channel interacting protein 2 2.86183
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.86183
ZNF436 zinc finger protein 436 2.86183
HRH4 histamine receptor H4 2.86183
SHC4 SHC (Src homology 2 domain containing) family, member 4 2.86183
PLET1 placenta expressed transcript 1 2.86183
FCRL5 Fc receptor-like 5 2.86183
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.86183
CATSPER4 cation channel, sperm associated 4 2.86183
F11 coagulation factor XI 2.86183
IL1A interleukin 1, alpha 2.85578
ZCCHC12 zinc finger, CCHC domain containing 12 2.85578
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.85578
TOR4A torsin family 4, member A 2.85578
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.85578
BHLHE41 basic helix-loop-helix family, member e41 2.85578
PRDM6 PR domain containing 6 2.85578
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.85578
UNC93A unc-93 homolog A (C. elegans) 2.85578
IL4I1 interleukin 4 induced 1 2.85578
RIPOR1 RHO family interacting cell polarization regulator 1 2.85578
CDCP2 CUB domain containing protein 2 2.85578
PENK proenkephalin 2.85578
HRH1 histamine receptor H1 2.85578
EPOP elongin BC and polycomb repressive complex 2 associated protein 2.85578
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.85578
ABLIM3 actin binding LIM protein family, member 3 2.85578
CPLX1 complexin 1 2.85578
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.81971
AKAP3 A kinase (PRKA) anchor protein 3 2.80918
TMPRSS11A transmembrane protease, serine 11A 2.80918
GJA4 gap junction protein, alpha 4, 37kDa 2.80918
ADHFE1 alcohol dehydrogenase, iron containing, 1 2.80918
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.80918
TMPRSS11D transmembrane protease, serine 11D 2.80918
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 2.80918
PLIN4 perilipin 4 2.80918
DUXA double homeobox A 2.80918
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.80918
GPR162 G protein-coupled receptor 162 2.80918
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.80918
CST11 cystatin 11 2.80918
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 2.80918
GNLY granulysin 2.80918
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.80918
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.80918
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.80918
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 2.80918
ARSI arylsulfatase family, member I 2.80918
GADL1 glutamate decarboxylase-like 1 2.80918
SFTPB surfactant protein B 2.80918
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.80918
RPL3L ribosomal protein L3-like 2.80918
NLRP10 NLR family, pyrin domain containing 10 2.80918
TMEM71 transmembrane protein 71 2.80918
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.80918
ASPA aspartoacylase 2.80918
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.80918
PKD1L1 polycystic kidney disease 1 like 1 2.80918
IL5RA interleukin 5 receptor, alpha 2.80918
DRICH1 aspartate-rich 1 2.80918
UMOD uromodulin 2.80918
C8ORF48 chromosome 8 open reading frame 48 2.80918
PROB1 proline-rich basic protein 1 2.80918
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.80918
LRRC56 leucine rich repeat containing 56 2.80918
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.80918
LCN15 lipocalin 15 2.80918
GRXCR1 glutaredoxin, cysteine rich 1 2.80918
LOC124901449 uncharacterized LOC124901449 2.80918
ROPN1L rhophilin associated tail protein 1-like 2.80918
ADGRG3 adhesion G protein-coupled receptor G3 2.80918
CXCL13 chemokine (C-X-C motif) ligand 13 2.80918
KRT80 keratin 80, type II 2.80918
FOXN4 forkhead box N4 2.80918
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.80918
IQUB IQ motif and ubiquitin domain containing 2.80918
TMPRSS6 transmembrane protease, serine 6 2.80918
ACSL5 acyl-CoA synthetase long-chain family member 5 2.80918
ASB4 ankyrin repeat and SOCS box containing 4 2.80918
YIPF7 Yip1 domain family, member 7 2.80918
RAG2 recombination activating gene 2 2.80918
CIMAP2 ciliary microtubule associated protein 2 2.80918
SPATA31H1 SPATA31 subfamily H member 1 2.80918
LITAFD LITAF domain containing 2.80918
LOC122526780 uncharacterized LOC122526780 2.80918
ZNF593OS ZNF593 opposite strand 2.80918
GREP1 glycine rich extracellular protein 1 2.80918
CLEC20A C-type lectin domain containing 20A 2.80918
SLURP2 secreted LY6/PLAUR domain containing 2 2.80918
TMEM275 transmembrane protein 275 2.80918
DERPC DERPC proline and glycine rich nuclear protein 2.80918
MYL10 myosin, light chain 10, regulatory 2.80918
RTL1 retrotransposon-like 1 2.80918
TACSTD2 tumor-associated calcium signal transducer 2 2.80918
MEOX2 mesenchyme homeobox 2 2.80918
OR51B6 olfactory receptor, family 51, subfamily B, member 6 2.80918
GOLGA6L4 golgin A6 family-like 4 2.80918
IL31RA interleukin 31 receptor A 2.80918
AMBN ameloblastin (enamel matrix protein) 2.80918
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.80918
TLE6 transducin-like enhancer of split 6 2.80918
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.80918
CDX1 caudal type homeobox 1 2.80918
TOP3B topoisomerase (DNA) III beta 2.80918
IL5 interleukin 5 2.80918
DLK1 delta-like 1 homolog (Drosophila) 2.80918
WNT9B wingless-type MMTV integration site family, member 9B 2.80918
NPIPB7 nuclear pore complex interacting protein family, member B7 2.80918
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.80918
C7ORF57 chromosome 7 open reading frame 57 2.80918
S100B S100 calcium binding protein B 2.80918
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 2.80918
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.80918
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 2.80918
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.80918
PCDHA7 protocadherin alpha 7 2.80918
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.80918
LRRC46 leucine rich repeat containing 46 2.80918
TMEM132D transmembrane protein 132D 2.80918
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.80918
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.80918
MRGPRE MAS-related GPR, member E 2.80918
SMKR1 small lysine-rich protein 1 2.80918
LCNL1 lipocalin-like 1 2.80918
CLDN34 claudin 34 2.80918
KLHL6 kelch-like family member 6 2.80918
S100A14 S100 calcium binding protein A14 2.80918
KRT3 keratin 3, type II 2.80918
PHOSPHO1 phosphatase, orphan 1 2.80918
MPZL2 myelin protein zero-like 2 2.80918
ADGRF5 adhesion G protein-coupled receptor F5 2.80918
FADS6 fatty acid desaturase 6 2.80918
POU3F2 POU class 3 homeobox 2 2.80918
LPAR5 lysophosphatidic acid receptor 5 2.80918
PRAM1 PML-RARA regulated adaptor molecule 1 2.80918
WDFY4 WDFY family member 4 2.80918
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.80918
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.80918
ZMYND15 zinc finger, MYND-type containing 15 2.80918
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.80918
AQP5 aquaporin 5 2.80918
ARR3 arrestin 3, retinal (X-arrestin) 2.80918
DPRX divergent-paired related homeobox 2.80918
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.80918
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.80918
PLCD4 phospholipase C, delta 4 2.80918
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.80918
MYADML2 myeloid-associated differentiation marker-like 2 2.80918
IL26 interleukin 26 2.80918
CASQ2 calsequestrin 2 (cardiac muscle) 2.80918
GOLGA8R golgin A8 family, member R 2.80918
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.80918
FOXS1 forkhead box S1 2.80918
FAHD2B fumarylacetoacetate hydrolase domain containing 2B 2.80918
KLK14 kallikrein-related peptidase 14 2.80918
CCDC73 coiled-coil domain containing 73 2.80918
CALHM3 calcium homeostasis modulator 3 2.80918
CPA3 carboxypeptidase A3 (mast cell) 2.80918
CPA2 carboxypeptidase A2 (pancreatic) 2.80918
PAGE4 P antigen family, member 4 (prostate associated) 2.80918
FAM209A family with sequence similarity 209, member A 2.80918
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.80918
PCDHGA7 protocadherin gamma subfamily A, 7 2.80918
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 2.80918
ISL2 ISL LIM homeobox 2 2.80918
PCDH12 protocadherin 12 2.80918
MZB1 marginal zone B and B1 cell-specific protein 2.80918
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.80918
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.80918
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.80918
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.80918
AHSG alpha-2-HS-glycoprotein 2.80918
LPO lactoperoxidase 2.80918
THSD1 thrombospondin, type I, domain containing 1 2.80918
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.80918
RTP4 receptor (chemosensory) transporter protein 4 2.80918
IRX2 iroquois homeobox 2 2.80918
BTBD19 BTB (POZ) domain containing 19 2.80918
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.80918
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.80918
FXYD2 FXYD domain containing ion transport regulator 2 2.80918
GRM6 glutamate receptor, metabotropic 6 2.80918
BMP3 bone morphogenetic protein 3 2.80918
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.80918
ANKK1 ankyrin repeat and kinase domain containing 1 2.80918
SMCO3 single-pass membrane protein with coiled-coil domains 3 2.80918
GREM1 gremlin 1, DAN family BMP antagonist 2.80918
CLCNKA chloride channel, voltage-sensitive Ka 2.80918
ALLC allantoicase 2.80918
LRRC66 leucine rich repeat containing 66 2.80918
TAS2R19 taste receptor, type 2, member 19 2.80918
PPY pancreatic polypeptide 2.80918
CD80 CD80 molecule 2.80918
CCNO cyclin O 2.80918
USP33 ubiquitin specific peptidase 33 2.80918
SHD Src homology 2 domain containing transforming protein D 2.80918
ZDHHC6 zinc finger, DHHC-type containing 6 2.78566
TALDO1 transaldolase 1 2.71997
OPTC opticin 2.70776
SPATA18 spermatogenesis associated 18 2.70776
IRS1 insulin receptor substrate 1 2.64139
ERGIC2 ERGIC and golgi 2 2.62727
MKX mohawk homeobox 2.62727
RAB28 RAB28, member RAS oncogene family 2.61106
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.56013
SORT1 sortilin 1 2.54115
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 2.54115
TMEM132B transmembrane protein 132B 2.54115
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 2.54115
PLAC8 placenta-specific 8 2.49717
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.48186
CORIN corin, serine peptidase 2.46839
TADA3 transcriptional adaptor 3 2.44504
SCARA5 scavenger receptor class A, member 5 2.44504
DKC1 dyskeratosis congenita 1, dyskerin 2.4169
ZRANB1 zinc finger, RAN-binding domain containing 1 2.40347
PTPRG protein tyrosine phosphatase, receptor type, G 2.39182
BTBD8 BTB (POZ) domain containing 8 2.38692
TMEM39A transmembrane protein 39A 2.35674
CNN1 calponin 1, basic, smooth muscle 2.33834
UNC13A unc-13 homolog A (C. elegans) 2.33079
UBR1 ubiquitin protein ligase E3 component n-recognin 1 2.3305
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.30019
RLIM ring finger protein, LIM domain interacting 2.29923
CNOT3 CCR4-NOT transcription complex, subunit 3 2.24086
TRPS1 trichorhinophalangeal syndrome I 2.2246
DRC8 dynein regulatory complex subunit 8 2.20914
GFRA2 GDNF family receptor alpha 2 2.2038
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.2038
CEP112 centrosomal protein 112kDa 2.19605
RFK riboflavin kinase 2.17899
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.16446
HAUS6 HAUS augmin-like complex, subunit 6 2.14689
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2.14297
USF1 upstream transcription factor 1 2.11357
AP3B1 adaptor-related protein complex 3, beta 1 subunit 2.10598
TRIP11 thyroid hormone receptor interactor 11 2.09782
TEX22 testis expressed 22 2.09509
CCDC6 coiled-coil domain containing 6 2.06592
HMGXB3 HMG box domain containing 3 2.05678
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.0331
NKTR natural killer cell triggering receptor 2.02185
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D 2.02185
ZNF275 zinc finger protein 275 2.0122
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2.0107
ZNF684 zinc finger protein 684 2.01027
ZNF544 zinc finger protein 544 2.01008
KIAA2012 KIAA2012 2.00506
STK26 serine/threonine protein kinase 26 2.00091

decreased expression

Symbol Name Standardized Value
NBPF26 neuroblastoma breakpoint family, member 26 -2.85578
TBX19 T-box 19 -2.85578
ATXN2 ataxin 2 -2.80918
TMF1 TATA element modulatory factor 1 -2.80918
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.80918
CHD8 chromodomain helicase DNA binding protein 8 -2.80918
TCF25 transcription factor 25 (basic helix-loop-helix) -2.80918
ZNF799 zinc finger protein 799 -2.80918
PIKFYVE phosphoinositide kinase, FYVE finger containing -2.80918
GDAP2 ganglioside induced differentiation associated protein 2 -2.80918
CEP250 centrosomal protein 250kDa -2.80408
PLA2G15 phospholipase A2, group XV -2.77309
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -2.65667
RFT1 RFT1 homolog (S. cerevisiae) -2.63746
ARSJ arylsulfatase family, member J -2.62727
NQO2 NAD(P)H dehydrogenase, quinone 2 -2.60652
NR1H3 nuclear receptor subfamily 1, group H, member 3 -2.59243
WARS1 tryptophanyl-tRNA synthetase 1 -2.56013
GPR34 G protein-coupled receptor 34 -2.56013
TRIB3 tribbles pseudokinase 3 -2.56013
ARPIN actin-related protein 2/3 complex inhibitor -2.55959
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -2.54115
MT1M metallothionein 1M -2.54115
UPB1 ureidopropionase, beta -2.54115
ADIRF adipogenesis regulatory factor -2.54115
HCST hematopoietic cell signal transducer -2.54115
SYTL5 synaptotagmin-like 5 -2.54115
NKPD1 NTPase, KAP family P-loop domain containing 1 -2.54115
HRC histidine rich calcium binding protein -2.54115
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.54115
SVOP SV2 related protein homolog (rat) -2.54115
DIO1 deiodinase, iodothyronine, type I -2.54115
DPPA3 developmental pluripotency associated 3 -2.54115
HAS1 hyaluronan synthase 1 -2.54115
ZEB2 zinc finger E-box binding homeobox 2 -2.54115
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.54115
COL9A2 collagen, type IX, alpha 2 -2.54115
SIM1 single-minded family bHLH transcription factor 1 -2.54115
TACR2 tachykinin receptor 2 -2.54115
CXCR4 chemokine (C-X-C motif) receptor 4 -2.54115
KLF5 Kruppel-like factor 5 (intestinal) -2.54115
MAB21L2 mab-21-like 2 (C. elegans) -2.54115
PLEKHN1 pleckstrin homology domain containing, family N member 1 -2.54115
OVOL1 ovo-like zinc finger 1 -2.54115
DPH1 diphthamide biosynthesis 1 -2.54115
CLUL1 clusterin-like 1 (retinal) -2.54115
CELA2B chymotrypsin-like elastase family, member 2B -2.54115
IL12A interleukin 12A -2.54115
FGF22 fibroblast growth factor 22 -2.54115
HSPB8 heat shock 22kDa protein 8 -2.54115
EGFLAM EGF-like, fibronectin type III and laminin G domains -2.54115
RAD21L1 RAD21-like 1 (S. pombe) -2.54115
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.54115
NOXA1 NADPH oxidase activator 1 -2.54115
KRT10 keratin 10, type I -2.53272
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -2.51217
MPPE1 metallophosphoesterase 1 -2.50658
GLRX3 glutaredoxin 3 -2.44504
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.44055
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -2.43943
TRIM56 tripartite motif containing 56 -2.38453
HBQ1 hemoglobin, theta 1 -2.38412
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -2.38412
RAB40B RAB40B, member RAS oncogene family -2.38412
SCAF11 SR-related CTD-associated factor 11 -2.38412
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -2.38412
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 -2.37948
CHMP6 charged multivesicular body protein 6 -2.378
GLG1 golgi glycoprotein 1 -2.378
RTL4 retrotransposon Gag like 4 -2.3546
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.3546
DLL1 delta-like 1 (Drosophila) -2.35093
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 -2.35093
NBPF15 neuroblastoma breakpoint family, member 15 -2.33834
CCDC51 coiled-coil domain containing 51 -2.29466
TMEM218 transmembrane protein 218 -2.29466
NBN nibrin -2.28362
NUP42 nucleoporin 42 -2.27413
SRP72 signal recognition particle 72kDa -2.2566
ZFYVE9 zinc finger, FYVE domain containing 9 -2.23863
BAG6 BCL2-associated athanogene 6 -2.2117
MPZL3 myelin protein zero-like 3 -2.20712
ZNF414 zinc finger protein 414 -2.20305
ZNF585B zinc finger protein 585B -2.20305
ZBED3 zinc finger, BED-type containing 3 -2.20165
GPX3 glutathione peroxidase 3 -2.19845
PRNP prion protein -2.18348
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.17864
TEP1 telomerase-associated protein 1 -2.17324
SPIN1 spindlin 1 -2.16386
OTUD5 OTU deubiquitinase 5 -2.14689
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -2.13676
FABP6 fatty acid binding protein 6, ileal -2.12441
AHDC1 AT hook, DNA binding motif, containing 1 -2.12384
EIF3K eukaryotic translation initiation factor 3, subunit K -2.12108
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -2.11578
GNPAT glyceronephosphate O-acyltransferase -2.10764
ABRAXAS2 abraxas 2, BRISC complex subunit -2.08544
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -2.08342
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -2.07607
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 -2.03881
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -2.02459
ATP2A3 ATPase, Ca++ transporting, ubiquitous -2.01273