CEP57 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description centrosomal protein 57kDa|This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 9702)
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Genes

343 genes differentially expressed following the CEP57 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FPR2 formyl peptide receptor 2 3.12064
PRELP proline/arginine-rich end leucine-rich repeat protein 3.12064
CNTNAP4 contactin associated protein-like 4 3.12064
PCDHGB3 protocadherin gamma subfamily B, 3 3.12064
SPDYE4 speedy/RINGO cell cycle regulator family member E4 3.12064
DUSP16 dual specificity phosphatase 16 3.12064
FOXR1 forkhead box R1 3.12064
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 3.12064
FETUB fetuin B 3.12064
LRG1 leucine-rich alpha-2-glycoprotein 1 3.12064
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.12064
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.12064
FAM153A family with sequence similarity 153, member A 3.12064
COL19A1 collagen, type XIX, alpha 1 3.12064
CST11 cystatin 11 3.12064
ZACN zinc activated ligand-gated ion channel 3.12064
MYBPHL myosin binding protein H-like 3.12064
ZNF503 zinc finger protein 503 3.12064
PROKR1 prokineticin receptor 1 3.12064
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.12064
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.12064
OPRL1 opiate receptor-like 1 3.12064
DOCK6 dedicator of cytokinesis 6 3.12064
SSTR3 somatostatin receptor 3 3.12064
ADH6 alcohol dehydrogenase 6 (class V) 3.12064
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.12064
SPACA3 sperm acrosome associated 3 3.12064
NWD1 NACHT and WD repeat domain containing 1 3.12064
ZNF804B zinc finger protein 804B 3.12064
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.12064
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 3.12064
LHX6 LIM homeobox 6 3.12064
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.12064
BHMT2 betaine--homocysteine S-methyltransferase 2 3.12064
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.12064
GPR21 G protein-coupled receptor 21 3.12064
CA1 carbonic anhydrase I 3.12064
RFPL2 ret finger protein-like 2 3.12064
ADAMTSL5 ADAMTS-like 5 3.12064
DEFB124 defensin, beta 124 3.12064
C1QB complement component 1, q subcomponent, B chain 3.12064
CD68 CD68 molecule 3.12064
OC90 otoconin 90 3.12064
GFRA4 GDNF family receptor alpha 4 3.12064
NRGN neurogranin (protein kinase C substrate, RC3) 3.12064
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.12064
GBP3 guanylate binding protein 3 3.12064
LTB4R2 leukotriene B4 receptor 2 3.12064
MYH4 myosin, heavy chain 4, skeletal muscle 3.12064
VN1R2 vomeronasal 1 receptor 2 3.12064
STMN4 stathmin-like 4 3.12064
PKD2L1 polycystic kidney disease 2-like 1 3.12064
SMLR1 small leucine-rich protein 1 3.12064
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 3.12064
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.12064
TMOD4 tropomodulin 4 (muscle) 3.12064
CLXN calaxin 3.12064
REELD1 reeler domain containing 1 3.12064
CIMAP1B ciliary microtubule associated protein 1B 3.12064
LOC124902436 talanin 3.12064
GNG5B G protein subunit gamma 5B 3.12064
H4C14 H4 clustered histone 14 3.12064
AKAIN1 A-kinase anchor inhibitor 1 3.12064
H2BW2 H2B.W histone 2 3.12064
RNF227 ring finger protein 227 3.12064
CABCOCO1 ciliary associated calcium binding coiled-coil 1 3.12064
RASD1 RAS, dexamethasone-induced 1 3.12064
TSPAN8 tetraspanin 8 3.12064
GPR37L1 G protein-coupled receptor 37 like 1 3.12064
TFEB transcription factor EB 3.12064
GOLGA7B golgin A7 family, member B 3.12064
SLC22A25 solute carrier family 22, member 25 3.12064
THPO thrombopoietin 3.12064
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 3.12064
VIT vitrin 3.12064
RHOXF2 Rhox homeobox family, member 2 3.12064
GDA guanine deaminase 3.12064
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.12064
BHLHA9 basic helix-loop-helix family, member a9 3.12064
CFAP45 cilia and flagella associated protein 45 3.12064
CSAG3 CSAG family, member 3 3.12064
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.12064
DLK2 delta-like 2 homolog (Drosophila) 3.12064
PNPLA1 patatin-like phospholipase domain containing 1 3.12064
PHLDB3 pleckstrin homology-like domain, family B, member 3 3.12064
CELA2A chymotrypsin-like elastase family, member 2A 3.12064
GSC goosecoid homeobox 3.12064
MYOT myotilin 3.12064
PRR18 proline rich 18 3.12064
NKX2-4 NK2 homeobox 4 3.12064
MAB21L3 mab-21-like 3 (C. elegans) 3.12064
EDN2 endothelin 2 3.12064
PLA1A phospholipase A1 member A 3.12064
RGS13 regulator of G-protein signaling 13 3.12064
C8ORF89 chromosome 8 open reading frame 89 3.12064
MRLN myoregulin 3.12064
FSHR follicle stimulating hormone receptor 3.12064
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.12064
FGR FGR proto-oncogene, Src family tyrosine kinase 3.12064
ZC3H12D zinc finger CCCH-type containing 12D 3.12064
MORN5 MORN repeat containing 5 3.12064
APOB apolipoprotein B 3.12064
FBXO39 F-box protein 39 3.12064
DMRT1 doublesex and mab-3 related transcription factor 1 3.12064
MPZL2 myelin protein zero-like 2 3.12064
TMEM150B transmembrane protein 150B 3.12064
CIDEA cell death-inducing DFFA-like effector a 3.12064
C11ORF97 chromosome 11 open reading frame 97 3.12064
CRYBB2 crystallin, beta B2 3.12064
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.12064
TREH trehalase (brush-border membrane glycoprotein) 3.12064
CGB7 chorionic gonadotropin, beta polypeptide 7 3.12064
CPA4 carboxypeptidase A4 3.12064
PCDHGA2 protocadherin gamma subfamily A, 2 3.12064
AGXT2 alanine--glyoxylate aminotransferase 2 3.12064
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.12064
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.12064
CD52 CD52 molecule 3.12064
CHI3L2 chitinase 3-like 2 3.12064
HPX hemopexin 3.12064
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 3.12064
IL21R interleukin 21 receptor 3.12064
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.12064
NANOGNB NANOG neighbor homeobox 3.12064
CXCR6 chemokine (C-X-C motif) receptor 6 3.12064
MAGEB17 melanoma antigen family B17 3.12064
LPO lactoperoxidase 3.12064
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.12064
ARGFX arginine-fifty homeobox 3.12064
OR4D1 olfactory receptor, family 4, subfamily D, member 1 3.12064
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.12064
DRC7 dynein regulatory complex subunit 7 3.12064
FRMPD2 FERM and PDZ domain containing 2 3.12064
SSX3 synovial sarcoma, X breakpoint 3 3.12064
PGM5 phosphoglucomutase 5 3.12064
MMP12 matrix metallopeptidase 12 3.12064
IL32 interleukin 32 3.12064
DNAH8 dynein, axonemal, heavy chain 8 3.12064
GPR17 G protein-coupled receptor 17 3.12064
BHLHA15 basic helix-loop-helix family, member a15 3.12064
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.12064
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.12064
POPDC2 popeye domain containing 2 3.12064
ART1 ADP-ribosyltransferase 1 3.12064
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.12064
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 3.12064
SLC7A4 solute carrier family 7, member 4 3.12064
SP100 SP100 nuclear antigen 3.12064
TULP2 tubby like protein 2 3.12064
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.12064
SH2D1B SH2 domain containing 1B 3.12064
SYNGR4 synaptogyrin 4 3.12064
NKX6-2 NK6 homeobox 2 3.12064
SIGLEC15 sialic acid binding Ig-like lectin 15 3.12064
CHRM4 cholinergic receptor, muscarinic 4 3.12064
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 3.12064
PATE2 prostate and testis expressed 2 3.12064
APOL3 apolipoprotein L, 3 3.12064
SCN3A sodium channel, voltage gated, type III alpha subunit 3.12064
C16ORF54 chromosome 16 open reading frame 54 3.05918
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 3.03914
SEC23B Sec23 homolog B (S. cerevisiae) 2.95326
FMO3 flavin containing monooxygenase 3 2.93697
PSD3 pleckstrin and Sec7 domain containing 3 2.78546
ACTN1 actinin, alpha 1 2.78546
VWCE von Willebrand factor C and EGF domains 2.74343
BNIPL BCL2/adenovirus E1B 19kD interacting protein like 2.70613
MCAM melanoma cell adhesion molecule 2.69447
CHD1 chromodomain helicase DNA binding protein 1 2.6378
MYO19 myosin XIX 2.63194
SAT1 spermidine/spermine N1-acetyltransferase 1 2.62074
GRB2 growth factor receptor-bound protein 2 2.61924
TCEAL8 transcription elongation factor A (SII)-like 8 2.55363
EBF3 early B-cell factor 3 2.53044
MAP9 microtubule-associated protein 9 2.52864
ATAD2 ATPase family, AAA domain containing 2 2.49435
PELI1 pellino E3 ubiquitin protein ligase 1 2.48222
CBLN1 cerebellin 1 precursor 2.45671
RUSC2 RUN and SH3 domain containing 2 2.41228
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 2.39481
PTPRM protein tyrosine phosphatase, receptor type, M 2.39003
PTGFR prostaglandin F receptor (FP) 2.37875
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 2.34407
MED4 mediator complex subunit 4 2.32953
PCDHB2 protocadherin beta 2 2.31741
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.31474
NUDCD2 NudC domain containing 2 2.29325
PRMT6 protein arginine methyltransferase 6 2.25971
ZSWIM7 zinc finger, SWIM-type containing 7 2.2589
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.2589
ADAM8 ADAM metallopeptidase domain 8 2.2523
PFN2 profilin 2 2.2523
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.2523
EFHD1 EF-hand domain family, member D1 2.2523
SARS1 seryl-tRNA synthetase 1 2.2523
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 2.2523
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 2.2523
TENT4B terminal nucleotidyltransferase 4B 2.2523
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.2523
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.2523
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.2523
ABHD3 abhydrolase domain containing 3 2.23411
RPL36 ribosomal protein L36 2.22375
TRPC4 transient receptor potential cation channel, subfamily C, member 4 2.22375
LOXL1 lysyl oxidase-like 1 2.22046
GDI2 GDP dissociation inhibitor 2 2.20457
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.19664
CNTRL centriolin 2.18282
RRAGB Ras-related GTP binding B 2.18282
IPO7 importin 7 2.18282
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 2.14697
RUFY2 RUN and FYVE domain containing 2 2.14697
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.14412
FBXO22 F-box protein 22 2.12072
SRP72 signal recognition particle 72kDa 2.0896
IGSF5 immunoglobulin superfamily, member 5 2.08338
BAG3 BCL2-associated athanogene 3 2.06126
MXRA7 matrix-remodelling associated 7 2.04593
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 2.0294
IRX2 iroquois homeobox 2 2.02768
ZNF707 zinc finger protein 707 2.02534

decreased expression

Symbol Name Standardized Value
TUSC2 tumor suppressor candidate 2 -3.12064
RAP1GAP RAP1 GTPase activating protein -3.12064
C20ORF203 chromosome 20 open reading frame 203 -3.12064
L3MBTL3 l(3)mbt-like 3 (Drosophila) -3.12064
FOXO6 forkhead box O6 -3.12064
SYCE3 synaptonemal complex central element protein 3 -3.12064
LGALS14 lectin, galactoside-binding, soluble, 14 -3.12064
LIMS2 LIM and senescent cell antigen-like domains 2 -3.12064
CEP57 centrosomal protein 57kDa -3.10563
NCOA1 nuclear receptor coactivator 1 -3.05867
ZBED6 zinc finger, BED-type containing 6 -2.84921
PRB3 proline-rich protein BstNI subfamily 3 -2.84921
DRICH1 aspartate-rich 1 -2.84921
TMPRSS11D transmembrane protease, serine 11D -2.84921
PURB purine-rich element binding protein B -2.84921
TMPRSS11F transmembrane protease, serine 11F -2.84921
ZNF324 zinc finger protein 324 -2.84921
OCA2 oculocutaneous albinism II -2.84921
IFI16 interferon, gamma-inducible protein 16 -2.84921
SH2D7 SH2 domain containing 7 -2.84921
PTH2 parathyroid hormone 2 -2.84921
BHLHE40 basic helix-loop-helix family, member e40 -2.84921
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.84921
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.84921
SPON2 spondin 2, extracellular matrix protein -2.84921
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -2.84921
MIXL1 Mix paired-like homeobox -2.84921
C6ORF58 chromosome 6 open reading frame 58 -2.84921
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.84921
PITX3 paired-like homeodomain 3 -2.84921
EPHX4 epoxide hydrolase 4 -2.84921
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.84921
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -2.84921
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.84921
HCFC2 host cell factor C2 -2.84921
CDK20 cyclin-dependent kinase 20 -2.84921
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.84921
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -2.84921
SLC25A34 solute carrier family 25, member 34 -2.84921
SLC38A3 solute carrier family 38, member 3 -2.84921
MLANA melan-A -2.84921
TMEM225B transmembrane protein 225B -2.84921
PF4 platelet factor 4 -2.84921
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -2.84921
PCDHB13 protocadherin beta 13 -2.84921
OR2A5 olfactory receptor, family 2, subfamily A, member 5 -2.84921
POF1B premature ovarian failure, 1B -2.84921
PCDHA5 protocadherin alpha 5 -2.84921
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.84851
ZNF175 zinc finger protein 175 -2.78546
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 -2.77532
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -2.73876
CXCL5 chemokine (C-X-C motif) ligand 5 -2.72889
PNO1 partner of NOB1 homolog (S. cerevisiae) -2.70017
BRPF3 bromodomain and PHD finger containing, 3 -2.66308
LYSMD4 LysM, putative peptidoglycan-binding, domain containing 4 -2.65874
ZWINT ZW10 interacting kinetochore protein -2.63637
ADRA1A adrenoceptor alpha 1A -2.63194
LRRC19 leucine rich repeat containing 19 -2.63194
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.63194
ZNF232 zinc finger protein 232 -2.63074
IFT57 intraflagellar transport 57 -2.49286
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -2.48222
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.47588
IRF3 interferon regulatory factor 3 -2.45549
TAC4 tachykinin 4 (hemokinin) -2.45346
ARL11 ADP-ribosylation factor-like 11 -2.44189
FAM43A family with sequence similarity 43, member A -2.44189
TMEM167A transmembrane protein 167A -2.44189
FRMD1 FERM domain containing 1 -2.44189
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -2.39635
THEM4 thioesterase superfamily member 4 -2.39635
CCDC85B coiled-coil domain containing 85B -2.39635
TOM1 target of myb1 (chicken) -2.38761
CAMKV CaM kinase-like vesicle-associated -2.37875
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.3613
SPON1 spondin 1, extracellular matrix protein -2.2914
SNAP91 synaptosomal-associated protein, 91kDa -2.28783
PNMA6A paraneoplastic Ma antigen family member 6A -2.28783
TM7SF3 transmembrane 7 superfamily member 3 -2.28458
TOB2 transducer of ERBB2, 2 -2.27976
SPMIP8 sperm microtubule inner protein 8 -2.25918
TMEM213 transmembrane protein 213 -2.25918
SPATC1 spermatogenesis and centriole associated 1 -2.25918
CFDP1 craniofacial development protein 1 -2.2548
LZTS3 leucine zipper, putative tumor suppressor family member 3 -2.25244
GAR1 GAR1 ribonucleoprotein -2.2523
DPY19L4 dpy-19-like 4 (C. elegans) -2.2312
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.23015
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -2.22532
TNRC6A trinucleotide repeat containing 6A -2.22496
BLVRB biliverdin reductase B -2.22375
CNOT7 CCR4-NOT transcription complex, subunit 7 -2.22185
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.22046
SH2D2A SH2 domain containing 2A -2.21284
SET SET nuclear proto-oncogene -2.1975
GALR1 galanin receptor 1 -2.18709
ISCU iron-sulfur cluster assembly enzyme -2.18282
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B -2.18282
PXK PX domain containing serine/threonine kinase -2.17988
PCDH20 protocadherin 20 -2.17142
TRMO tRNA methyltransferase O -2.17142
MROH6 maestro heat-like repeat family member 6 -2.17142
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.17142
ACP5 acid phosphatase 5, tartrate resistant -2.14412
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -2.11519
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) -2.11458
NENF neudesin neurotrophic factor -2.09657
KCTD11 potassium channel tetramerization domain containing 11 -2.07026
GSR glutathione reductase -2.05398
RTBDN retbindin -2.05332
SLF2 SMC5-SMC6 complex localization factor 2 -2.04865
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -2.04865
NSFL1C NSFL1 (p97) cofactor (p47) -2.04593
RNF208 ring finger protein 208 -2.04052
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -2.03933
TRNP1 TMF1-regulated nuclear protein 1 -2.02973
MATN2 matrilin 2 -2.0294
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.02768
TMCO4 transmembrane and coiled-coil domains 4 -2.02768
BCAS4 breast carcinoma amplified sequence 4 -2.0146
FHIP1A FHF complex subunit HOOK interacting protein 1A -2.0059