CEP57 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description centrosomal protein 57kDa|This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 9702)
External Link http://www.ncbi.nlm.nih.gov/gene/9702
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164 interacting proteins for CEP57 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABR active BCR-related
ACIN1 apoptotic chromatin condensation inducer 1
ACTA1 actin, alpha 1, skeletal muscle
AJUBA ajuba LIM protein
APP amyloid beta (A4) precursor protein
ATAD3A ATPase family, AAA domain containing 3A
ATAD3B ATPase family, AAA domain containing 3B
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
ATXN10 ataxin 10
AURKA aurora kinase A
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CCDC33 coiled-coil domain containing 33
CCDC8 coiled-coil domain containing 8
CDK11A cyclin-dependent kinase 11A
CDK11B cyclin-dependent kinase 11B
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP170 centrosomal protein 170kDa
CEP290 centrosomal protein 290kDa
CERS2 ceramide synthase 2
CHP1 calcineurin-like EF-hand protein 1
CLTCL1 clathrin, heavy chain-like 1
CPNE7 copine VII
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CPVL carboxypeptidase, vitellogenic-like
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSTA cystatin A (stefin A)
CUL1 cullin 1
CYB5R1 cytochrome b5 reductase 1
DCAF7 DDB1 and CUL4 associated factor 7
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DSC1 desmocollin 1
EDC4 enhancer of mRNA decapping 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELAVL1 ELAV like RNA binding protein 1
ETV6 ets variant 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM96B family with sequence similarity 96, member B
FBLN5 fibulin 5
FBXW11 F-box and WD repeat domain containing 11
FGF2 fibroblast growth factor 2 (basic)
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
GCC1 GRIP and coiled-coil domain containing 1
GIGYF2 GRB10 interacting GYF protein 2
GIMAP5 GTPase, IMAP family member 5
GRWD1 glutamate-rich WD repeat containing 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HDAC6 histone deacetylase 6
HINT3 histidine triad nucleotide binding protein 3
HIST1H4F histone cluster 1, H4f
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
ICAM2 intercellular adhesion molecule 2
IPO9 importin 9
IQCB1 IQ motif containing B1
IQGAP1 IQ motif containing GTPase activating protein 1
IRS4 insulin receptor substrate 4
KDM1A lysine (K)-specific demethylase 1A
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRPPRC leucine-rich pentatricopeptide repeat containing
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6G5B lymphocyte antigen 6 complex, locus G5B
LYZ lysozyme
MARK2 MAP/microtubule affinity-regulating kinase 2
MCM7 minichromosome maintenance complex component 7
MEGF10 multiple EGF-like-domains 10
MMRN1 multimerin 1
MOGS mannosyl-oligosaccharide glucosidase
MRPL40 mitochondrial ribosomal protein L40
MRPL49 mitochondrial ribosomal protein L49
MRPS11 mitochondrial ribosomal protein S11
MRPS23 mitochondrial ribosomal protein S23
MRPS7 mitochondrial ribosomal protein S7
MSN moesin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NCAPD3 non-SMC condensin II complex, subunit D3
NUP50 nucleoporin 50kDa
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHKA2 phosphorylase kinase, alpha 2 (liver)
PLAA phospholipase A2-activating protein
PML promyelocytic leukemia
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF19 pre-mRNA processing factor 19
PRRC2C proline-rich coiled-coil 2C
PTGES3 prostaglandin E synthase 3 (cytosolic)
PUF60 poly-U binding splicing factor 60KDa
RALBP1 ralA binding protein 1
RNF213 ring finger protein 213
RPL11 ribosomal protein L11
RPL22 ribosomal protein L22
RPL23 ribosomal protein L23
RPL30 ribosomal protein L30
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS14 ribosomal protein S14
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS17 ribosomal protein S17
RPS18 ribosomal protein S18
RPS23 ribosomal protein S23
RPS25 ribosomal protein S25
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS7 ribosomal protein S7
RTN3 reticulon 3
RTN4 reticulon 4
S100A13 S100 calcium binding protein A13
SCAMP3 secretory carrier membrane protein 3
SEC16A SEC16 homolog A (S. cerevisiae)
SF3A1 splicing factor 3a, subunit 1, 120kDa
SKP1 S-phase kinase-associated protein 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLIRP SRA stem-loop interacting RNA binding protein
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRRM2 serine/arginine repetitive matrix 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TBC1D15 TBC1 domain family, member 15
TBC1D4 TBC1 domain family, member 4
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM55B transmembrane protein 55B
TRIM27 tripartite motif containing 27
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae)
TTN titin
TUBA4A tubulin, alpha 4a
UBB ubiquitin B
UBC ubiquitin C
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UIMC1 ubiquitin interaction motif containing 1
USP47 ubiquitin specific peptidase 47
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMYM3 zinc finger, MYM-type 3
ZNF385A zinc finger protein 385A