CFB Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description complement factor B|This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 629)
External Link http://www.ncbi.nlm.nih.gov/gene/629
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Genes

177 interacting proteins for CFB from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
A2M alpha-2-macroglobulin
ADRA1B adrenoceptor alpha 1B
AGA aspartylglucosaminidase
AHSG alpha-2-HS-glycoprotein
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
AMPD3 adenosine monophosphate deaminase 3
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOM apolipoprotein M
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATM ATM serine/threonine kinase
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4BPA complement component 4 binding protein, alpha
C4BPB complement component 4 binding protein, beta
C5 complement component 5
C6 complement component 6
C9 complement component 9
CABLES1 Cdk5 and Abl enzyme substrate 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMTA1 calmodulin binding transcription activator 1
CD5L CD5 molecule-like
CDC45 cell division cycle 45
CDCP1 CUB domain containing protein 1
CEP44 centrosomal protein 44kDa
CFD complement factor D (adipsin)
CFH complement factor H
CFP complement factor properdin
CHKB choline kinase beta
CLCA2 chloride channel accessory 2
CLU clusterin
CNOT1 CCR4-NOT transcription complex, subunit 1
COL6A6 collagen, type VI, alpha 6
CP ceruloplasmin (ferroxidase)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CROT carnitine O-octanoyltransferase
CST3 cystatin C
CTAGE5 CTAGE family, member 5
DCD dermcidin
DDB1 damage-specific DNA binding protein 1, 127kDa
DERL1 derlin 1
DGKG diacylglycerol kinase, gamma 90kDa
DICER1 dicer 1, ribonuclease type III
DMD dystrophin
EPYC epiphycan
ETF1 eukaryotic translation termination factor 1
EXOC6 exocyst complex component 6
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM71E2 family with sequence similarity 71, member E2
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GC group-specific component (vitamin D binding protein)
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GFAP glial fibrillary acidic protein
GJC2 gap junction protein, gamma 2, 47kDa
GRAP2 GRB2-related adaptor protein 2
GSN gelsolin
GZMM granzyme M (lymphocyte met-ase 1)
HBA2 hemoglobin, alpha 2
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HPX hemopexin
HRG histidine-rich glycoprotein
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGKC immunoglobulin kappa constant
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB5 integrin, beta 5
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JARID2 jumonji, AT rich interactive domain 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0232 KIAA0232
KIAA0753 KIAA0753
KIAA1551 KIAA1551
KIRREL kin of IRRE like (Drosophila)
KLK3 kallikrein-related peptidase 3
KNG1 kininogen 1
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT9 keratin 9, type I
LAMC3 laminin, gamma 3
LAT linker for activation of T cells
LBP lipopolysaccharide binding protein
LDB3 LIM domain binding 3
LUM lumican
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK3 myosin light chain kinase 3
NCOA3 nuclear receptor coactivator 3
NLRC4 NLR family, CARD domain containing 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
OBSL1 obscurin-like 1
ONECUT1 one cut homeobox 1
OPTN optineurin
OR2T6 olfactory receptor, family 2, subfamily T, member 6
OR3A2 olfactory receptor, family 3, subfamily A, member 2
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene)
PALB2 partner and localizer of BRCA2
PCDH1 protocadherin 1
PCED1B PC-esterase domain containing 1B
PDE4B phosphodiesterase 4B, cAMP-specific
PDZRN4 PDZ domain containing ring finger 4
PEG3 paternally expressed 3
PF4V1 platelet factor 4 variant 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PLA2G4F phospholipase A2, group IVF
PLAG1 pleiomorphic adenoma gene 1
PLG plasminogen
PON1 paraoxonase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PROS1 protein S (alpha)
PRSS3 protease, serine, 3
PRSS3P2 protease, serine, 3 pseudogene 2
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RANBP2 RAN binding protein 2
RANBP3 RAN binding protein 3
RLF rearranged L-myc fusion
RPA2 replication protein A2, 32kDa
RYR2 ryanodine receptor 2 (cardiac)
SAA2 serum amyloid A2
SAA4 serum amyloid A4, constitutive
SACS sacsin molecular chaperone
SCAF1 SR-related CTD-associated factor 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SETX senataxin
SGOL2 shugoshin-like 2 (S. pombe)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SHBG sex hormone-binding globulin
SLA2 Src-like-adaptor 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SORBS3 sorbin and SH3 domain containing 3
SPAST spastin
SPATA31A7 SPATA31 subfamily A, member 7
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
THRAP3 thyroid hormone receptor associated protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN2 talin 2
TRAPPC11 trafficking protein particle complex 11
TRIM33 tripartite motif containing 33
TSC22D1 TSC22 domain family, member 1
TTN titin
TTPAL tocopherol (alpha) transfer protein-like
TTR transthyretin
VTN vitronectin
ZNF232 zinc finger protein 232
ZNF292 zinc finger protein 292