CFTR Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)|This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1080)
External Link http://www.ncbi.nlm.nih.gov/gene/1080
Similar Terms
Downloads & Tools

Genes

237 interacting proteins for CFTR from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTB actin, beta
ADCY8 adenylate cyclase 8 (brain)
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP6 A kinase (PRKA) anchor protein 6
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANO1 anoctamin 1, calcium activated chloride channel
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APC adenomatous polyposis coli
APOA2 apolipoprotein A-II
ATAD3A ATPase family, AAA domain containing 3A
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATXN2L ataxin 2-like
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
BAG1 BCL2-associated athanogene
BAG2 BCL2-associated athanogene 2
BCAP31 B-cell receptor-associated protein 31
BCR breakpoint cluster region
C6ORF48 chromosome 6 open reading frame 48
CALU calumenin
CAND1 cullin-associated and neddylation-dissociated 1
CANX calnexin
CAPNS1 calpain, small subunit 1
CAPRIN1 cell cycle associated protein 1
CASP14 caspase 14, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC51 coiled-coil domain containing 51
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEP170 centrosomal protein 170kDa
CFL1 cofilin 1 (non-muscle)
CLCA1 chloride channel accessory 1
CLCN3 chloride channel, voltage-sensitive 3
CLINT1 clathrin interactor 1
CLTA clathrin, light chain A
CLTCL1 clathrin, heavy chain-like 1
COMMD1 copper metabolism (Murr1) domain containing 1
COPB1 coatomer protein complex, subunit beta 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSTB cystatin B (stefin B)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCLK1 doublecortin-like kinase 1
DERL1 derlin 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DSG1 desmoglein 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEA1 early endosome antigen 1
EMC2 ER membrane protein complex subunit 2
EMD emerin
EPCAM epithelial cell adhesion molecule
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2IP erbb2 interacting protein
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
ESYT1 extended synaptotagmin-like protein 1
EXO1 exonuclease 1
EZR ezrin
FAM120A family with sequence similarity 120A
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FAT1 FAT atypical cadherin 1
FLOT2 flotillin 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GOPC golgi-associated PDZ and coiled-coil motif containing
GORASP2 golgi reassembly stacking protein 2, 55kDa
GRN granulin
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAX1 HCLS1 associated protein X-1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDAC6 histone deacetylase 6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
IPO11 importin 11
IPO5 importin 5
IPO7 importin 7
IPO9 importin 9
JKAMP JNK1/MAPK8-associated membrane protein
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIF3A kinesin family member 3A
KIF5B kinesin family member 5B
KIF5C kinesin family member 5C
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT8 keratin 8, type II
KRT9 keratin 9, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LIMA1 LIM domain and actin binding 1
LIN7C lin-7 homolog C (C. elegans)
LMNA lamin A/C
LMO7 LIM domain 7
LMTK2 lemur tyrosine kinase 2
LPAR2 lysophosphatidic acid receptor 2
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MARCKSL1 MARCKS-like 1
MED12 mediator complex subunit 12
MS4A5 membrane-spanning 4-domains, subfamily A, member 5
MUC13 mucin 13, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MYH9 myosin, heavy chain 9, non-muscle
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NPEPPS aminopeptidase puromycin sensitive
NRIP3 nuclear receptor interacting protein 3
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCDHB8 protocadherin beta 8
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDCD6 programmed cell death 6
PDZD3 PDZ domain containing 3
PDZK1 PDZ domain containing 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLD2 phospholipase D2
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRKG1 protein kinase, cGMP-dependent, type I
PSAP prosaposin
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PTGES3 prostaglandin E synthase 3 (cytosolic)
RAB11A RAB11A, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REPS1 RALBP1 associated Eps domain containing 1
RHOT1 ras homolog family member T1
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RYK receptor-like tyrosine kinase
RYR2 ryanodine receptor 2 (cardiac)
RYR3 ryanodine receptor 3
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEPT11 septin 11
SEPT6 septin 6
SEPT9 septin 9
SFXN3 sideroflexin 3
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNAP23 synaptosomal-associated protein, 23kDa
SNX4 sorting nexin 4
SNX9 sorting nexin 9
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
STIP1 stress-induced phosphoprotein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX1A syntaxin 1A (brain)
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
SVIL supervillin
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCP1 t-complex 1
TFG TRK-fused gene
THEM6 thioesterase superfamily member 6
TIAM1 T-cell lymphoma invasion and metastasis 1
TJP1 tight junction protein 1
TJP3 tight junction protein 3
TMEM43 transmembrane protein 43
TMOD3 tropomodulin 3 (ubiquitous)
TNPO3 transportin 3
TPM3 tropomyosin 3
TRIP12 thyroid hormone receptor interactor 12
UBB ubiquitin B
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE3A ubiquitin protein ligase E3A
USP10 ubiquitin specific peptidase 10
USP19 ubiquitin specific peptidase 19
USP9X ubiquitin specific peptidase 9, X-linked
VCP valosin containing protein
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WFS1 Wolfram syndrome 1 (wolframin)
WSB1 WD repeat and SOCS box containing 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XPO1 exportin 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6