CHD1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description chromodomain helicase DNA binding protein 1|The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1105)
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Genes

350 genes differentially expressed following the CHD1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ALB albumin 3.43074
SLC25A45 solute carrier family 25, member 45 3.43074
SH2D6 SH2 domain containing 6 3.43074
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 3.43074
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.43074
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 3.43074
OLIG1 oligodendrocyte transcription factor 1 3.43074
OPRL1 opiate receptor-like 1 3.43074
NEU4 sialidase 4 3.43074
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.43074
UPB1 ureidopropionase, beta 3.43074
NCF1 neutrophil cytosolic factor 1 3.43074
TM4SF4 transmembrane 4 L six family member 4 3.43074
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.43074
ASB15 ankyrin repeat and SOCS box containing 15 3.43074
UCN urocortin 3.43074
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.43074
ZNF492 zinc finger protein 492 3.43074
CD1C CD1c molecule 3.43074
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.43074
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.43074
PON1 paraoxonase 1 3.43074
ASPA aspartoacylase 3.43074
C11ORF86 chromosome 11 open reading frame 86 3.43074
NRROS negative regulator of reactive oxygen species 3.43074
CPLX4 complexin 4 3.43074
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.43074
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.43074
TDO2 tryptophan 2,3-dioxygenase 3.43074
STEAP4 STEAP family member 4 3.43074
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.43074
RNASE6 ribonuclease, RNase A family, k6 3.43074
BTBD16 BTB (POZ) domain containing 16 3.43074
HRC histidine rich calcium binding protein 3.43074
MPL MPL proto-oncogene, thrombopoietin receptor 3.43074
AVP arginine vasopressin 3.43074
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.43074
ZNF558 zinc finger protein 558 3.43074
MROH2B maestro heat-like repeat family member 2B 3.43074
TTLL2 tubulin tyrosine ligase-like family member 2 3.43074
SPDYE11 speedy/RINGO cell cycle regulator family member E11 3.43074
RIMBP3C RIMS binding protein 3C 3.43074
GNG13 guanine nucleotide binding protein (G protein), gamma 13 3.43074
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.43074
HBZ hemoglobin, zeta 3.43074
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 3.43074
NPR3 natriuretic peptide receptor 3 3.43074
UPK3A uroplakin 3A 3.43074
TEX53 testis expressed 53 3.43074
LOC122539214 Zinc finger protein LOC122539214 3.43074
VSIR V-set immunoregulatory receptor 3.43074
H2BC1 H2B clustered histone 1 3.43074
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.43074
CES4A carboxylesterase 4A 3.43074
OTOF otoferlin 3.43074
GPR35 G protein-coupled receptor 35 3.43074
STMN4 stathmin-like 4 3.43074
SPRR2F small proline-rich protein 2F 3.43074
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.43074
VEGFD vascular endothelial growth factor D 3.43074
DNAI7 dynein axonemal intermediate chain 7 3.43074
PNMA6F PNMA family member 6F 3.43074
TBC1D3I TBC1 domain family member 3I 3.43074
DRC3 dynein regulatory complex subunit 3 3.43074
TMEM238L transmembrane protein 238 like 3.43074
CCDC197 coiled-coil domain containing 197 3.43074
CFAP107 cilia and flagella associated protein 107 3.43074
DEFB131B defensin beta 131B 3.43074
CCDC187 coiled-coil domain containing 187 3.43074
MSANTD5 Myb/SANT DNA binding domain containing 5 3.43074
COL3A1 collagen, type III, alpha 1 3.43074
SRPK3 SRSF protein kinase 3 3.43074
RAB36 RAB36, member RAS oncogene family 3.43074
SBSN suprabasin 3.43074
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.43074
BHLHA9 basic helix-loop-helix family, member a9 3.43074
ZBTB16 zinc finger and BTB domain containing 16 3.43074
ZBTB12 zinc finger and BTB domain containing 12 3.43074
CFAP99 cilia and flagella associated protein 99 3.43074
ISM2 isthmin 2 3.43074
NDRG1 N-myc downstream regulated 1 3.43074
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.43074
IL1R1 interleukin 1 receptor, type I 3.43074
PTH parathyroid hormone 3.43074
ABHD15 abhydrolase domain containing 15 3.43074
PCP4L1 Purkinje cell protein 4 like 1 3.43074
ZNF705D zinc finger protein 705D 3.43074
F5 coagulation factor V (proaccelerin, labile factor) 3.43074
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.43074
CLEC6A C-type lectin domain family 6, member A 3.43074
CCDC42 coiled-coil domain containing 42 3.43074
ACE2 angiotensin I converting enzyme 2 3.43074
LRRC70 leucine rich repeat containing 70 3.43074
TIMD4 T-cell immunoglobulin and mucin domain containing 4 3.43074
HLX H2.0-like homeobox 3.43074
CLUL1 clusterin-like 1 (retinal) 3.43074
ONECUT3 one cut homeobox 3 3.43074
SMYD1 SET and MYND domain containing 1 3.43074
COL11A2 collagen, type XI, alpha 2 3.43074
KRT17 keratin 17, type I 3.43074
BCL2L15 BCL2-like 15 3.43074
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 3.43074
LYZ lysozyme 3.43074
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.43074
ZMYND10 zinc finger, MYND-type containing 10 3.43074
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.43074
LIMS2 LIM and senescent cell antigen-like domains 2 3.43074
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.43074
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.43074
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.43074
CDH22 cadherin 22, type 2 3.43074
MAPK11 mitogen-activated protein kinase 11 3.43074
ECM1 extracellular matrix protein 1 3.43074
BARHL2 BarH-like homeobox 2 3.43074
APOD apolipoprotein D 3.43074
IL17REL interleukin 17 receptor E-like 3.43074
FNDC9 fibronectin type III domain containing 9 3.43074
NIPAL4 NIPA-like domain containing 4 3.43074
SPATA3 spermatogenesis associated 3 3.43074
SH2D4B SH2 domain containing 4B 3.43074
CLEC4C C-type lectin domain family 4, member C 3.43074
CYS1 cystin 1 3.43074
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.43074
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 3.43074
ITGB7 integrin, beta 7 3.43074
HSPA1L heat shock 70kDa protein 1-like 3.43074
CTAGE9 CTAGE family, member 9 3.43074
MYF6 myogenic factor 6 (herculin) 3.43074
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3.43074
RSAD2 radical S-adenosyl methionine domain containing 2 3.43074
C7ORF33 chromosome 7 open reading frame 33 3.43074
APLNR apelin receptor 3.43074
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.43074
EDN3 endothelin 3 3.43074
CD27 CD27 molecule 3.43074
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.43074
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.43074
TGM1 transglutaminase 1 3.43074
SYT5 synaptotagmin V 3.43074
BPIFC BPI fold containing family C 3.43074
SPNS3 spinster homolog 3 (Drosophila) 3.43074
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.43074
AGBL4 ATP/GTP binding protein-like 4 3.43074
TTC22 tetratricopeptide repeat domain 22 3.43074
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.43074
SDSL serine dehydratase-like 3.43074
ISX intestine-specific homeobox 3.43074
PADI4 peptidyl arginine deiminase, type IV 3.43074
CD226 CD226 molecule 3.43074
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.43074
C5ORF46 chromosome 5 open reading frame 46 3.43074
SLC36A3 solute carrier family 36, member 3 3.43074
MMP10 matrix metallopeptidase 10 3.43074
SSX1 synovial sarcoma, X breakpoint 1 3.43074
PADI6 peptidyl arginine deiminase, type VI 3.43074
WNT4 wingless-type MMTV integration site family, member 4 3.43074
CASQ2 calsequestrin 2 (cardiac muscle) 3.43074
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.43074
OR8J1 olfactory receptor, family 8, subfamily J, member 1 3.43074
RERGL RERG/RAS-like 3.43074
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 3.43074
DEFB134 defensin, beta 134 3.43074
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 3.43074
ZNF534 zinc finger protein 534 3.43074
SLC51B solute carrier family 51, beta subunit 3.43074
AQP10 aquaporin 10 3.43074
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 3.43074
SNTN sentan, cilia apical structure protein 3.43074
ACVR1C activin A receptor, type IC 3.31857
PABPC4L poly(A) binding protein, cytoplasmic 4-like 3.31857
PM20D1 peptidase M20 domain containing 1 3.31857
HMMR hyaluronan-mediated motility receptor (RHAMM) 3.26896
SAMD15 sterile alpha motif domain containing 15 2.82584
XTBD1 XRN2 binding domain containing 1 2.79891
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.66867
PCDHB2 protocadherin beta 2 2.66141
CCNB1 cyclin B1 2.58404
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 2.58404
KRABD5 KRAB domain containing 5 2.5201
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.51561
LINGO1 leucine rich repeat and Ig domain containing 1 2.50175
LCN15 lipocalin 15 2.48798
CCL25 chemokine (C-C motif) ligand 25 2.48798
FAM43B family with sequence similarity 43, member B 2.48798
SRSF10 serine/arginine-rich splicing factor 10 2.46057
BORCS5 BLOC-1 related complex subunit 5 2.43041
CTPS1 CTP synthase 1 2.39868
EHD1 EH-domain containing 1 2.3817
PPP1R3F protein phosphatase 1, regulatory subunit 3F 2.3817
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.35031
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.33754
C17ORF49 chromosome 17 open reading frame 49 2.33495
KCTD18 potassium channel tetramerization domain containing 18 2.33495
PRORP protein only RNase P catalytic subunit 2.31588
PKD1L1 polycystic kidney disease 1 like 1 2.31588
MRPL36 mitochondrial ribosomal protein L36 2.31588
MT2A metallothionein 2A 2.31588
ADGRG1 adhesion G protein-coupled receptor G1 2.31588
C19ORF25 chromosome 19 open reading frame 25 2.29626
PABIR2 PABIR family member 2 2.29122
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.29122
SFMBT2 Scm-like with four mbt domains 2 2.27929
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 2.25864
TTLL6 tubulin tyrosine ligase-like family member 6 2.25126
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 2.25084
ANKRD36B ankyrin repeat domain 36B 2.24768
TMEM143 transmembrane protein 143 2.24147
UNC79 unc-79 homolog (C. elegans) 2.20679
GIPR gastric inhibitory polypeptide receptor 2.20679
SECISBP2L SECIS binding protein 2-like 2.19367
MRPL44 mitochondrial ribosomal protein L44 2.19282
C2ORF42 chromosome 2 open reading frame 42 2.15891
ZFTA zinc finger translocation associated 2.15875
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 2.15718
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.14102
TRMT5 tRNA methyltransferase 5 2.13579
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.12935
ZC3H7B zinc finger CCCH-type containing 7B 2.12508
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 2.11021
TMF1 TATA element modulatory factor 1 2.10847
RPE ribulose-5-phosphate-3-epimerase 2.10623
RFK riboflavin kinase 2.09749
ANKRD44 ankyrin repeat domain 44 2.09542
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.09151
PARVA parvin, alpha 2.08499
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.07063
AURKA aurora kinase A 2.06953
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.03666
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.03237
LPAR2 lysophosphatidic acid receptor 2 2.00856

decreased expression

Symbol Name Standardized Value
MINAR1 membrane integral NOTCH2 associated receptor 1 -3.43074
GLRA3 glycine receptor, alpha 3 -3.43074
PDZK1 PDZ domain containing 1 -3.43074
CORO6 coronin 6 -3.43074
ADH6 alcohol dehydrogenase 6 (class V) -3.43074
CHD1 chromodomain helicase DNA binding protein 1 -3.43074
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -3.43074
WDR5B WD repeat domain 5B -3.43074
NKD2 naked cuticle homolog 2 (Drosophila) -3.43074
BTBD18 BTB (POZ) domain containing 18 -3.43074
ZNF396 zinc finger protein 396 -3.43074
ROM1 retinal outer segment membrane protein 1 -3.43074
RORC RAR-related orphan receptor C -3.43074
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -3.43074
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -3.43074
VWA5B1 von Willebrand factor A domain containing 5B1 -3.43074
ACTA2 actin, alpha 2, smooth muscle, aorta -3.43074
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -3.43074
CNTN5 contactin 5 -3.43074
COX8C cytochrome c oxidase subunit VIIIC -3.43074
ZAR1L zygote arrest 1-like -3.43074
C1QTNF2 C1q and tumor necrosis factor related protein 2 -3.43074
PRRT1 proline-rich transmembrane protein 1 -3.43074
LEF1 lymphoid enhancer-binding factor 1 -3.43074
ERVFRD-1 endogenous retrovirus group FRD, member 1 -3.43074
ZAN zonadhesin (gene/pseudogene) -3.43074
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.43074
FAM167A family with sequence similarity 167, member A -3.43074
PLA2G4E phospholipase A2, group IVE -3.43074
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -3.43074
UTS2R urotensin 2 receptor -3.43074
SIGLEC15 sialic acid binding Ig-like lectin 15 -3.43074
ADGRD1 adhesion G protein-coupled receptor D1 -3.43074
KLF9 Kruppel-like factor 9 -3.43074
C11ORF96 chromosome 11 open reading frame 96 -3.43074
C16ORF46 chromosome 16 open reading frame 46 -3.43074
ZBTB41 zinc finger and BTB domain containing 41 -3.05652
STX6 syntaxin 6 -3.03241
CCNH cyclin H -2.95269
ZNF175 zinc finger protein 175 -2.94488
ZNF768 zinc finger protein 768 -2.85343
LYPLA1 lysophospholipase I -2.82167
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 -2.82167
RBM11 RNA binding motif protein 11 -2.82167
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.81671
STXBP5L syntaxin binding protein 5-like -2.71703
RPL10 ribosomal protein L10 -2.69409
NRXN1 neurexin 1 -2.69409
ULK1 unc-51 like autophagy activating kinase 1 -2.68595
INTS5 integrator complex subunit 5 -2.60785
SNW1 SNW domain containing 1 -2.58483
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.52865
FMNL2 formin-like 2 -2.52165
PREB prolactin regulatory element binding -2.49454
TRIM61 tripartite motif containing 61 -2.48763
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.39916
C3ORF49 chromosome 3 open reading frame 49 -2.39916
CFAP54 cilia and flagella associated 54 -2.39916
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.39916
MAPK15 mitogen-activated protein kinase 15 -2.39916
UFSP1 UFM1-specific peptidase 1 (non-functional) -2.3817
GLIS1 GLIS family zinc finger 1 -2.3817
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.3748
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -2.37369
EIF1B eukaryotic translation initiation factor 1B -2.33495
ZNF750 zinc finger protein 750 -2.31588
MBD5 methyl-CpG binding domain protein 5 -2.31588
ALK anaplastic lymphoma receptor tyrosine kinase -2.31588
HMCN2 hemicentin 2 -2.31588
TAC1 tachykinin, precursor 1 -2.31588
CD82 CD82 molecule -2.31588
LRRC39 leucine rich repeat containing 39 -2.31588
ZNF723 zinc finger protein 723 -2.31588
GPR18 G protein-coupled receptor 18 -2.31588
MMD2 monocyte to macrophage differentiation-associated 2 -2.31588
CD79B CD79b molecule, immunoglobulin-associated beta -2.31588
ATP9B ATPase, class II, type 9B -2.3005
WDR11 WD repeat domain 11 -2.27502
FAM76A family with sequence similarity 76, member A -2.2667
LEMD2 LEM domain containing 2 -2.26203
WDR24 WD repeat domain 24 -2.26175
TBCD tubulin folding cofactor D -2.26175
ZFAND2A zinc finger, AN1-type domain 2A -2.26065
SUOX sulfite oxidase -2.22805
AHCY adenosylhomocysteinase -2.22805
SLC6A16 solute carrier family 6, member 16 -2.20679
UNC5A unc-5 homolog A (C. elegans) -2.20679
MTMR10 myotubularin related protein 10 -2.19433
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase -2.19367
FLII flightless I homolog (Drosophila) -2.19285
CCNYL1 cyclin Y-like 1 -2.16619
GON4L gon-4-like (C. elegans) -2.15088
SHROOM2 shroom family member 2 -2.13604
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.13604
HMGB2 high mobility group box 2 -2.12963
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -2.12218
PSTK phosphoseryl-tRNA kinase -2.10623
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) -2.10623
MAGT1 magnesium transporter 1 -2.10007
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.09814
TLE3 transducin-like enhancer of split 3 -2.09405
FBXO16 F-box protein 16 -2.09141
PEPD peptidase D -2.07191
WDR62 WD repeat domain 62 -2.07027
PLEKHA6 pleckstrin homology domain containing, family A member 6 -2.07004
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) -2.06953
STEAP1 six transmembrane epithelial antigen of the prostate 1 -2.06484
TTC13 tetratricopeptide repeat domain 13 -2.05791
HIPK3 homeodomain interacting protein kinase 3 -2.05673
PRR5L proline rich 5 like -2.03925
RHOT2 ras homolog family member T2 -2.03925
DEPTOR DEP domain containing MTOR-interacting protein -2.03666
STAG2 stromal antigen 2 -2.0336
HVCN1 hydrogen voltage gated channel 1 -2.03237
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) -2.02598
PLAC1 placenta-specific 1 -2.01702
CLDN1 claudin 1 -2.01702
ANAPC2 anaphase promoting complex subunit 2 -2.01702
CEP78 centrosomal protein 78kDa -2.00847
ADAT1 adenosine deaminase, tRNA-specific 1 -2.00506