CHEK1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description checkpoint kinase 1|The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 1111)
Similar Terms
Downloads & Tools

Genes

295 genes differentially expressed following the CHEK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MAGIX MAGI family member, X-linked 3.18123
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 3.18123
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 3.18123
TMEM217 transmembrane protein 217 3.18123
PSCA prostate stem cell antigen 3.18123
OCSTAMP osteoclast stimulatory transmembrane protein 3.18123
LRRC66 leucine rich repeat containing 66 3.18123
HBZ hemoglobin, zeta 3.18123
MUC22 mucin 22 3.18123
MYOM3 myomesin 3 3.18123
SHCBP1L SHC SH2-domain binding protein 1-like 3.18123
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.18123
FOXR1 forkhead box R1 3.18123
PTH2 parathyroid hormone 2 3.18123
PAX5 paired box 5 3.18123
SLC15A5 solute carrier family 15, member 5 3.18123
PLCH2 phospholipase C, eta 2 3.18123
MANSC4 MANSC domain containing 4 3.18123
FMO1 flavin containing monooxygenase 1 3.18123
HBD hemoglobin, delta 3.18123
TREML2 triggering receptor expressed on myeloid cells-like 2 3.18123
STX11 syntaxin 11 3.18123
GPX6 glutathione peroxidase 6 3.18123
TSHR thyroid stimulating hormone receptor 3.18123
HRG histidine-rich glycoprotein 3.18123
GALP galanin-like peptide 3.18123
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.18123
LKAAEAR1 LKAAEAR motif containing 1 3.18123
TCF12 transcription factor 12 3.18123
GPR171 G protein-coupled receptor 171 3.18123
IL23R interleukin 23 receptor 3.18123
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 3.18123
PRDM12 PR domain containing 12 3.18123
LGALS2 lectin, galactoside-binding, soluble, 2 3.18123
TMC3 transmembrane channel-like 3 3.18123
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.18123
THSD1 thrombospondin, type I, domain containing 1 3.18123
CD300LF CD300 molecule-like family member f 3.18123
ZNF804A zinc finger protein 804A 3.18123
LOC102724877 uncharacterized LOC102724877 3.18123
GPR179 G protein-coupled receptor 179 3.18123
SLC25A41 solute carrier family 25, member 41 3.18123
STARD6 StAR-related lipid transfer (START) domain containing 6 3.18123
C5ORF52 chromosome 5 open reading frame 52 3.18123
DTHD1 death domain containing 1 3.18123
CCIN calicin 3.18123
FOXD1 forkhead box D1 3.18123
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.18123
FPR3 formyl peptide receptor 3 3.18123
HBA2 hemoglobin, alpha 2 3.18123
MCEMP1 mast cell-expressed membrane protein 1 3.18123
ZSWIM2 zinc finger, SWIM-type containing 2 3.18123
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.18123
VCX3B variable charge, X-linked 3B 3.18123
RBM41 RNA binding motif protein 41 3.18123
C1QL4 complement component 1, q subcomponent-like 4 3.18123
RNF113B ring finger protein 113B 3.18123
REC114 REC114 meiotic recombination protein 3.18123
TLR1 toll-like receptor 1 3.18123
COX8C cytochrome c oxidase subunit VIIIC 3.18123
TOX3 TOX high mobility group box family member 3 3.18123
LOC124906892 uncharacterized LOC124906892 3.18123
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.18123
IL16 interleukin 16 3.18123
CELF1 CUGBP, Elav-like family member 1 3.18123
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.18123
HES7 hes family bHLH transcription factor 7 3.18123
GLYAT glycine-N-acyltransferase 3.18123
RRAD Ras-related associated with diabetes 3.18123
FMR1NB fragile X mental retardation 1 neighbor 3.18123
CLEC19A C-type lectin domain family 19, member A 3.18123
OR10A4 olfactory receptor, family 10, subfamily A, member 4 3.18123
IGFL2 IGF-like family member 2 3.18123
SLC46A3 solute carrier family 46, member 3 3.18123
RNF183 ring finger protein 183 3.18123
LY86 lymphocyte antigen 86 3.18123
ZNF705D zinc finger protein 705D 3.18123
LRRD1 leucine-rich repeats and death domain containing 1 3.18123
CARD18 caspase recruitment domain family, member 18 3.18123
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.18123
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 3.18123
SCGN secretagogin, EF-hand calcium binding protein 3.18123
C8ORF48 chromosome 8 open reading frame 48 3.18123
CDCP2 CUB domain containing protein 2 3.18123
VWA3A von Willebrand factor A domain containing 3A 3.18123
SMIM35 small integral membrane protein 35 3.18123
CTSW cathepsin W 3.18123
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.18123
TUBA8 tubulin, alpha 8 3.18123
CLIC5 chloride intracellular channel 5 3.18123
CH25H cholesterol 25-hydroxylase 3.18123
AKR1B15 aldo-keto reductase family 1, member B15 3.18123
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.18123
MORC1 MORC family CW-type zinc finger 1 3.18123
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.18123
LRRC36 leucine rich repeat containing 36 3.18123
RTL5 retrotransposon Gag like 5 3.18123
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.18123
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 3.18123
PNMA6F PNMA family member 6F 3.18123
C11ORF91 chromosome 11 open reading frame 91 3.18123
RESP18 regulated endocrine-specific protein 18 3.18123
C22ORF42 chromosome 22 open reading frame 42 3.18123
GPR83 G protein-coupled receptor 83 3.18123
C11ORF16 chromosome 11 open reading frame 16 3.18123
TPSB2 tryptase beta 2 (gene/pseudogene) 3.18123
TDRD10 tudor domain containing 10 3.18123
C17ORF113 chromosome 17 open reading frame 113 3.18123
INSYN1 inhibitory synaptic factor 1 3.18123
KIF1C-AS1 KIF1C antisense RNA 1 3.18123
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.18123
CYSLTR1 cysteinyl leukotriene receptor 1 3.18123
ANKRD63 ankyrin repeat domain 63 3.18123
ANKRD61 ankyrin repeat domain 61 3.18123
ARR3 arrestin 3, retinal (X-arrestin) 3.18123
AQP3 aquaporin 3 (Gill blood group) 3.18123
AMH anti-Mullerian hormone 3.18123
MMP19 matrix metallopeptidase 19 3.18123
APOL6 apolipoprotein L, 6 3.18123
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.18123
APOL3 apolipoprotein L, 3 3.18123
CCN6 cellular communication network factor 6 3.18123
RHAG Rh-associated glycoprotein 3.18123
GFY golgi-associated, olfactory signaling regulator 3.18123
C20ORF204 chromosome 20 open reading frame 204 3.18123
BCAS1 breast carcinoma amplified sequence 1 3.18123
CGA glycoprotein hormones, alpha polypeptide 3.18123
OR2H2 olfactory receptor, family 2, subfamily H, member 2 3.18123
SFTA2 surfactant associated 2 3.18123
EOMES eomesodermin 3.18123
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.18123
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.18123
ART1 ADP-ribosyltransferase 1 3.18123
OXNAD1 oxidoreductase NAD-binding domain containing 1 3.18123
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 3.18123
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.18123
PRH2 proline-rich protein HaeIII subfamily 2 3.18123
ZMYND15 zinc finger, MYND-type containing 15 3.18123
ACSM1 acyl-CoA synthetase medium-chain family member 1 3.18123
GPR62 G protein-coupled receptor 62 3.18123
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 3.18123
C1ORF105 chromosome 1 open reading frame 105 3.18123
C9ORF50 chromosome 9 open reading frame 50 3.18123
NUTM2F NUT family member 2F 3.18123
ANGPTL6 angiopoietin-like 6 3.18123
ROM1 retinal outer segment membrane protein 1 3.18123
CHRM4 cholinergic receptor, muscarinic 4 3.18123
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.18123
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 3.11056
MED7 mediator complex subunit 7 2.93259
TAS2R31 taste receptor, type 2, member 31 2.93015
VAC14 Vac14 homolog (S. cerevisiae) 2.85433
NEK9 NIMA-related kinase 9 2.84758
SCP2 sterol carrier protein 2 2.76253
IL1RAP interleukin 1 receptor accessory protein 2.74462
TUFM Tu translation elongation factor, mitochondrial 2.70831
HMGN4 high mobility group nucleosomal binding domain 4 2.68364
ZNF805 zinc finger protein 805 2.65683
BAX BCL2-associated X protein 2.61346
NAF1 nuclear assembly factor 1 ribonucleoprotein 2.5681
MPHOSPH9 M-phase phosphoprotein 9 2.55672
FLNC filamin C, gamma 2.53588
ZBTB47 zinc finger and BTB domain containing 47 2.53588
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.45781
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 2.45518
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 2.45473
KLHL34 kelch-like family member 34 2.45154
KLF5 Kruppel-like factor 5 (intestinal) 2.44976
ADRB2 adrenoceptor beta 2, surface 2.44976
CIRSR corepressor of RBPJ and splicing regulator 2.43251
MIGA1 mitoguardin 1 2.40807
TFDP1 transcription factor Dp-1 2.40649
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 2.40475
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.38308
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.38308
HDX highly divergent homeobox 2.35331
TRIM25 tripartite motif containing 25 2.32391
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.3159
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.30966
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 2.30065
FXR1 fragile X mental retardation, autosomal homolog 1 2.29577
GYPE glycophorin E (MNS blood group) 2.29504
DOC2B double C2-like domains, beta 2.29504
MSL3 male-specific lethal 3 homolog (Drosophila) 2.28872
PARP4 poly (ADP-ribose) polymerase family, member 4 2.28703
ADAM23 ADAM metallopeptidase domain 23 2.27567
NCK1 NCK adaptor protein 1 2.21799
STXBP1 syntaxin binding protein 1 2.21767
SLC22A23 solute carrier family 22, member 23 2.21234
SPEN spen family transcriptional repressor 2.20708
ZNF576 zinc finger protein 576 2.19473
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 2.19285
UBE2E3 ubiquitin-conjugating enzyme E2E 3 2.16925
UBL5 ubiquitin-like 5 2.16925
PACRG PARK2 co-regulated 2.16286
STON1 stonin 1 2.1577
MUC4 mucin 4, cell surface associated 2.14505
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 2.12066
USP10 ubiquitin specific peptidase 10 2.10087
TARS1 threonyl-tRNA synthetase 1 2.08038
FOXL2 forkhead box L2 2.08038
NRIP3 nuclear receptor interacting protein 3 2.07879
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.06602
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 2.04639
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 2.03815
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.02909
KIF21A kinesin family member 21A 2.02909
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 2.02909
VWC2 von Willebrand factor C domain containing 2 2.02387
ZNF649 zinc finger protein 649 2.01154
ELF2 E74-like factor 2 (ets domain transcription factor) 2.01114
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 2.00012

decreased expression

Symbol Name Standardized Value
CIMAP3 ciliary microtubule associated protein 3 -3.18123
MRO maestro -3.18123
C1QTNF12 C1q and TNF related 12 -3.18123
DHCR24 24-dehydrocholesterol reductase -3.18123
DDTL D-dopachrome tautomerase-like -3.18123
HAPLN4 hyaluronan and proteoglycan link protein 4 -2.98526
C10ORF143 chromosome 10 open reading frame 143 -2.93259
CHPF2 chondroitin polymerizing factor 2 -2.93259
RASGEF1A RasGEF domain family, member 1A -2.93081
PMP22 peripheral myelin protein 22 -2.89674
TP53TG5 TP53 target 5 -2.89674
FAM181B family with sequence similarity 181, member B -2.89674
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -2.89674
ZNF804B zinc finger protein 804B -2.89674
CD22 CD22 molecule -2.89674
TRAM1L1 translocation associated membrane protein 1-like 1 -2.89674
CD86 CD86 molecule -2.89674
HEPHL1 hephaestin-like 1 -2.89674
FOXJ1 forkhead box J1 -2.89674
MYZAP myocardial zonula adherens protein -2.89674
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -2.89674
ACTA2 actin, alpha 2, smooth muscle, aorta -2.89674
GPR162 G protein-coupled receptor 162 -2.89674
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.89674
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.89674
TMOD4 tropomodulin 4 (muscle) -2.89674
PDZD9 PDZ domain containing 9 -2.89674
CSTL1 cystatin-like 1 -2.89674
SGPP2 sphingosine-1-phosphate phosphatase 2 -2.89674
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -2.89674
QRFP pyroglutamylated RFamide peptide -2.89674
FNDC5 fibronectin type III domain containing 5 -2.89674
PLSCR2 phospholipid scramblase 2 -2.89674
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -2.89674
CCDC183 coiled-coil domain containing 183 -2.89674
FIBIN fin bud initiation factor homolog (zebrafish) -2.89674
MC5R melanocortin 5 receptor -2.89674
F2RL2 coagulation factor II (thrombin) receptor-like 2 -2.89674
LRRC26 leucine rich repeat containing 26 -2.89674
FNDC3A fibronectin type III domain containing 3A -2.86909
WDR36 WD repeat domain 36 -2.86039
APAF1 apoptotic peptidase activating factor 1 -2.73468
MANSC1 MANSC domain containing 1 -2.718
POU2AF3 POU class 2 homeobox associating factor 3 -2.718
HARBI1 harbinger transposase derived 1 -2.61941
H3C4 H3 clustered histone 4 -2.54996
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.54996
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -2.54996
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.5406
KDM2B lysine (K)-specific demethylase 2B -2.53922
WDR12 WD repeat domain 12 -2.47773
WDR6 WD repeat domain 6 -2.44563
DYNLT3 dynein, light chain, Tctex-type 3 -2.4216
XPO5 exportin 5 -2.41599
CNOT12 CCR4-NOT transcription complex subunit 12 -2.41412
HDIP1 HDAC and MIER1 interacting protein 1 -2.40807
MAP6 microtubule-associated protein 6 -2.39428
LINC02560 long intergenic non-protein coding RNA 2560 -2.39428
C1R complement component 1, r subcomponent -2.39428
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.36128
GEN1 GEN1 Holliday junction 5' flap endonuclease -2.34454
QTRT1 queuine tRNA-ribosyltransferase 1 -2.34377
NME2 NME/NM23 nucleoside diphosphate kinase 2 -2.32336
PDLIM2 PDZ and LIM domain 2 (mystique) -2.31429
MEPCE methylphosphate capping enzyme -2.30802
DENND4B DENN/MADD domain containing 4B -2.29018
RRM2B ribonucleotide reductase M2 B (TP53 inducible) -2.28269
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -2.2682
CNTD1 cyclin N-terminal domain containing 1 -2.25886
OR1F1 olfactory receptor, family 1, subfamily F, member 1 -2.25886
ASL argininosuccinate lyase -2.25629
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 -2.25176
DKK3 dickkopf WNT signaling pathway inhibitor 3 -2.19447
EFL1 elongation factor like GTPase 1 -2.18487
CSMD1 CUB and Sushi multiple domains 1 -2.14505
TMEM9 transmembrane protein 9 -2.13096
LRRC17 leucine rich repeat containing 17 -2.12066
RASA2 RAS p21 protein activator 2 -2.11412
TBC1D17 TBC1 domain family, member 17 -2.08845
MARVELD1 MARVEL domain containing 1 -2.04019
SETD1B SET domain containing 1B -2.02639
LIN28A lin-28 homolog A (C. elegans) -2.02062
C3ORF18 chromosome 3 open reading frame 18 -2.02062