| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | checkpoint kinase 1|The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 1111) |
| External Link | https://ncbi.nlm.nih.gov/gene/1111 |
| Similar Terms | |
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499 genes differentially expressed following the CHEK1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0184923 |
| CA2 | carbonic anhydrase II | 0.0171384 |
| ATF3 | activating transcription factor 3 | 0.0158069 |
| S100A9 | S100 calcium binding protein A9 | 0.0122324 |
| SIK1 | salt-inducible kinase 1 | 0.0117521 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.0114703 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.011269 |
| LTF | lactotransferrin | 0.0107265 |
| S100A12 | S100 calcium binding protein A12 | 0.0104239 |
| NCF2 | neutrophil cytosolic factor 2 | 0.010295 |
| KRT17 | keratin 17, type I | 0.0102844 |
| HBD | hemoglobin, delta | 0.00992622 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00987902 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00965426 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0094772 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00941174 |
| HOPX | HOP homeobox | 0.00940283 |
| JUNB | jun B proto-oncogene | 0.00936756 |
| S100A8 | S100 calcium binding protein A8 | 0.0093599 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00920402 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.00920261 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.00908579 |
| ANXA3 | annexin A3 | 0.00904936 |
| MMP9 | matrix metallopeptidase 9 | 0.00904818 |
| EGR1 | early growth response 1 | 0.0090364 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00892988 |
| WDR7 | WD repeat domain 7 | 0.00884141 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00879257 |
| ARG1 | arginase 1 | 0.00858999 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00837336 |
| KRT14 | keratin 14, type I | 0.00836075 |
| RGS1 | regulator of G-protein signaling 1 | 0.00835872 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00834851 |
| RHOB | ras homolog family member B | 0.00824399 |
| SRGN | serglycin | 0.008217 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00816393 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00815923 |
| ARMCX3 | armadillo repeat containing, X-linked 3 | 0.00813189 |
| HTRA1 | HtrA serine peptidase 1 | 0.00805725 |
| H1-2 | H1.2 linker histone, cluster member | 0.00786602 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0078453 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00783984 |
| KLK10 | kallikrein-related peptidase 10 | 0.00783508 |
| HIST1H2BD | histone cluster 1, H2bd | 0.0078328 |
| FSCN1 | fascin actin-bundling protein 1 | 0.00782794 |
| H1-0 | H1.0 linker histone | 0.00769051 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00766287 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00764175 |
| TUBA4A | tubulin, alpha 4a | 0.00763997 |
| EGR3 | early growth response 3 | 0.00760038 |
| MICALL1 | MICAL-like 1 | 0.00757872 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00757741 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00752632 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00742201 |
| C5AR1 | complement component 5a receptor 1 | 0.0073962 |
| SOCS1 | suppressor of cytokine signaling 1 | 0.00733877 |
| RNF167 | ring finger protein 167 | 0.00733355 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.00728373 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00727145 |
| SELL | selectin L | 0.0072683 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00723216 |
| ZYX | zyxin | 0.00720428 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00709525 |
| CLC | Charcot-Leyden crystal galectin | 0.00708942 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00708205 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | 0.00707497 |
| CD69 | CD69 molecule | 0.00705772 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.00701845 |
| ACTN1 | actinin, alpha 1 | 0.00701525 |
| IRS2 | insulin receptor substrate 2 | 0.00701277 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.00700984 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00700361 |
| BTG2 | BTG family, member 2 | 0.00699832 |
| PIP5K1B | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 0.00699296 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00698251 |
| SESN1 | sestrin 1 | 0.00697421 |
| IL32 | interleukin 32 | 0.00697334 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00695665 |
| MAGEA3 | melanoma antigen family A3 | 0.00695529 |
| PLEK | pleckstrin | 0.00685316 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00672909 |
| RGCC | regulator of cell cycle | 0.00671655 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | 0.00662811 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.00661357 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.00660482 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00659995 |
| BCL2A1 | BCL2-related protein A1 | 0.00658669 |
| CYBB | cytochrome b-245, beta polypeptide | 0.00658474 |
| P2RY13 | purinergic receptor P2Y, G-protein coupled, 13 | 0.006526 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.00646744 |
| RUNX3 | runt-related transcription factor 3 | 0.00646366 |
| MCL1 | myeloid cell leukemia 1 | 0.00642991 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.0064221 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00641657 |
| SNAI2 | snail family zinc finger 2 | 0.00636808 |
| INHBB | inhibin, beta B | 0.00635768 |
| AQP9 | aquaporin 9 | 0.00635643 |
| MCOLN1 | mucolipin 1 | 0.00633111 |
| LCN2 | lipocalin 2 | 0.00632338 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.00629585 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00623922 |
| IER5 | immediate early response 5 | 0.0062383 |
| CYTIP | cytohesin 1 interacting protein | 0.00623721 |
| S100P | S100 calcium binding protein P | 0.00622268 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00621125 |
| DEFA4 | defensin, alpha 4, corticostatin | 0.00618453 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.00617211 |
| MPO | myeloperoxidase | 0.00612351 |
| AHSP | alpha hemoglobin stabilizing protein | 0.00607614 |
| RGS2 | regulator of G-protein signaling 2 | 0.00607454 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00607049 |
| IER2 | immediate early response 2 | 0.00606963 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00606461 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.00604232 |
| WBP5 | WW domain binding protein 5 | 0.00600052 |
| BIN2 | bridging integrator 2 | 0.00599938 |
| IL1RN | interleukin 1 receptor antagonist | 0.00599551 |
| CENPE | centromere protein E, 312kDa | 0.00597634 |
| CST7 | cystatin F (leukocystatin) | 0.0059701 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.005926 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00591908 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0059184 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.00591334 |
| CPE | carboxypeptidase E | 0.00591289 |
| SLAMF7 | SLAM family member 7 | 0.00589718 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00588604 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00588182 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.005848 |
| GSTZ1 | glutathione S-transferase zeta 1 | 0.00584302 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | 0.0058427 |
| RPS27L | ribosomal protein S27-like | 0.00583897 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.00582513 |
| SERHL2 | serine hydrolase-like 2 | 0.00581304 |
| PLXNC1 | plexin C1 | 0.00576877 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00575248 |
| KRT1 | keratin 1, type II | 0.00574013 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00573912 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.00573291 |
| HBB | hemoglobin, beta | 0.00573067 |
| VNN2 | vanin 2 | 0.00572135 |
| GDF15 | growth differentiation factor 15 | 0.00571894 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00571413 |
| BTG3 | BTG family, member 3 | 0.00570641 |
| MOSPD1 | motile sperm domain containing 1 | 0.00570333 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.00567074 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.005667 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0056042 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.00559457 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.00558546 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 0.00558524 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.00557945 |
| KLK8 | kallikrein-related peptidase 8 | 0.00557195 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00555959 |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.0055544 |
| FGGY | FGGY carbohydrate kinase domain containing | 0.00555326 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00554995 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.00554344 |
| GCH1 | GTP cyclohydrolase 1 | 0.00553782 |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 0.00552835 |
| IQCG | IQ motif containing G | 0.00550477 |
| CD86 | CD86 molecule | 0.00550367 |
| SIRPA | signal-regulatory protein alpha | 0.00547545 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.00545403 |
| LY96 | lymphocyte antigen 96 | 0.00543633 |
| GALC | galactosylceramidase | 0.00543152 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | 0.00539337 |
| KLF9 | Kruppel-like factor 9 | 0.0053872 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00538415 |
| DCTN6 | dynactin 6 | 0.00537309 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | 0.0053682 |
| ITK | IL2-inducible T-cell kinase | 0.00536515 |
| DUSP5 | dual specificity phosphatase 5 | 0.00533184 |
| GATA2 | GATA binding protein 2 | 0.0053289 |
| CSTA | cystatin A (stefin A) | 0.00532737 |
| LY75 | lymphocyte antigen 75 | 0.00528621 |
| ACO2 | aconitase 2, mitochondrial | 0.00527896 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.00527295 |
| CTSS | cathepsin S | 0.00526268 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.00525895 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00525527 |
| CLGN | calmegin | 0.00522818 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00522233 |
| SLC27A2 | solute carrier family 27 (fatty acid transporter), member 2 | 0.00521241 |
| IL1B | interleukin 1, beta | 0.00519528 |
| DUSP2 | dual specificity phosphatase 2 | 0.00518838 |
| GRAMD2B | GRAM domain containing 2B | 0.00517834 |
| NCF4 | neutrophil cytosolic factor 4, 40kDa | 0.00517749 |
| MRPL40 | mitochondrial ribosomal protein L40 | 0.00517281 |
| BPI | bactericidal/permeability-increasing protein | 0.00517202 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | 0.00514763 |
| CLEC4A | C-type lectin domain family 4, member A | 0.00514008 |
| DENND3 | DENN/MADD domain containing 3 | 0.00512803 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.00512407 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.00511658 |
| PKP1 | plakophilin 1 | 0.0050942 |
| VAMP7 | vesicle-associated membrane protein 7 | 0.00508374 |
| IL2RG | interleukin 2 receptor, gamma | 0.00507996 |
| CDC37 | cell division cycle 37 | 0.00507011 |
| EGR2 | early growth response 2 | 0.00503841 |
| FGF13 | fibroblast growth factor 13 | 0.00503403 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | 0.00501824 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | 0.00501691 |
| FDXR | ferredoxin reductase | 0.00501415 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00500162 |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.00499856 |
| MARCKSL1 | MARCKS-like 1 | 0.00499564 |
| GPI | glucose-6-phosphate isomerase | 0.00499472 |
| MMP8 | matrix metallopeptidase 8 | 0.0049942 |
| KIAA0355 | KIAA0355 | 0.0049928 |
| KLK11 | kallikrein-related peptidase 11 | 0.00497931 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.00496656 |
| ABHD4 | abhydrolase domain containing 4 | 0.00495745 |
| VEGFA | vascular endothelial growth factor A | 0.00493669 |
| LST1 | leukocyte specific transcript 1 | 0.00493119 |
| ZFP36 | ZFP36 ring finger protein | 0.00493034 |
| UROD | uroporphyrinogen decarboxylase | 0.00492878 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00492754 |
| FOXO1 | forkhead box O1 | 0.00491897 |
| KLK5 | kallikrein-related peptidase 5 | 0.00489706 |
| ZNF395 | zinc finger protein 395 | 0.00489341 |
| IL15 | interleukin 15 | 0.00488116 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00487184 |
| KRT10 | keratin 10, type I | 0.00485544 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00484922 |
| S100A2 | S100 calcium binding protein A2 | 0.00484212 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0048378 |
| CDK14 | cyclin-dependent kinase 14 | 0.00483197 |
| KIF20A | kinesin family member 20A | 0.00482113 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.00481474 |
| INHBA | inhibin, beta A | 0.00481238 |
| KLK7 | kallikrein-related peptidase 7 | 0.00478747 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.00476994 |
| ABLIM1 | actin binding LIM protein 1 | 0.0047699 |
| GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | 0.00476741 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00476536 |
| FPR1 | formyl peptide receptor 1 | 0.00476275 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.00475269 |
| GPSM3 | G-protein signaling modulator 3 | 0.00474791 |
| HECA | headcase homolog (Drosophila) | 0.00474697 |
| DEFB4A | defensin, beta 4A | 0.00474362 |
| MGAM | maltase-glucoamylase | 0.00473571 |
| KRT16 | keratin 16, type I | 0.00472885 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.00472192 |
| CD83 | CD83 molecule | 0.0047166 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00468934 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.00467522 |
| PALMD | palmdelphin | 0.00465286 |
| SLC25A46 | solute carrier family 25, member 46 | 0.00464183 |
| OLFML2A | olfactomedin-like 2A | 0.00464141 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MGP | matrix Gla protein | -0.0175866 |
| KRT19 | keratin 19, type I | -0.0168654 |
| CHEK1 | checkpoint kinase 1 | -0.0165111 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0161035 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0133035 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -0.0122394 |
| SRPX | sushi-repeat containing protein, X-linked | -0.011877 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.0117584 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0117173 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.011696 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0115637 |
| CFD | complement factor D (adipsin) | -0.011461 |
| PEG10 | paternally expressed 10 | -0.0113115 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | -0.0111923 |
| EPCAM | epithelial cell adhesion molecule | -0.0106157 |
| CTSZ | cathepsin Z | -0.0105568 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0103729 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0102292 |
| FBLN1 | fibulin 1 | -0.0100033 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.00987937 |
| TUBB6 | tubulin, beta 6 class V | -0.00942693 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00940045 |
| SYNM | synemin, intermediate filament protein | -0.00936642 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.00934182 |
| GPX3 | glutathione peroxidase 3 | -0.00930353 |
| GPC3 | glypican 3 | -0.00927914 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00924039 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.00913316 |
| FHL1 | four and a half LIM domains 1 | -0.00910081 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00908529 |
| CES1 | carboxylesterase 1 | -0.00881432 |
| BEX1 | brain expressed, X-linked 1 | -0.00874512 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.00863945 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00862277 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.00843957 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.00834109 |
| STK39 | serine threonine kinase 39 | -0.00813932 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00797513 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00797164 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00786305 |
| CFH | complement factor H | -0.00778614 |
| OLFM1 | olfactomedin 1 | -0.00771543 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | -0.00769151 |
| COMP | cartilage oligomeric matrix protein | -0.00764844 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.00758158 |
| THBS2 | thrombospondin 2 | -0.00757051 |
| IRX5 | iroquois homeobox 5 | -0.00745593 |
| AGR2 | anterior gradient 2 | -0.00743865 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00736153 |
| GNAS | GNAS complex locus | -0.00733922 |
| TUBB2B | tubulin, beta 2B class IIb | -0.00725532 |
| PTN | pleiotrophin | -0.00720326 |
| A2M | alpha-2-macroglobulin | -0.00716194 |
| TXNIP | thioredoxin interacting protein | -0.00714479 |
| TMEM255A | transmembrane protein 255A | -0.00709643 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00708303 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.00707423 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00701421 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00690855 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0068886 |
| CRYBG1 | crystallin beta-gamma domain containing 1 | -0.00688549 |
| MAOA | monoamine oxidase A | -0.00679214 |
| S100A10 | S100 calcium binding protein A10 | -0.00678622 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00678146 |
| ATP9A | ATPase, class II, type 9A | -0.00675305 |
| ALB | albumin | -0.00673114 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.00670976 |
| HIP1 | huntingtin interacting protein 1 | -0.00670383 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | -0.00669931 |
| THBS4 | thrombospondin 4 | -0.00668951 |
| GLS | glutaminase | -0.00665958 |
| METTL7A | methyltransferase like 7A | -0.00661482 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00658003 |
| COL9A3 | collagen, type IX, alpha 3 | -0.00656727 |
| LAMB1 | laminin, beta 1 | -0.00655007 |
| SCRG1 | stimulator of chondrogenesis 1 | -0.00653597 |
| PNMA8A | PNMA family member 8A | -0.00653069 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00647249 |
| SIK3 | SIK family kinase 3 | -0.00647106 |
| IL17RB | interleukin 17 receptor B | -0.00646519 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.00645156 |
| TMEM243 | transmembrane protein 243, mitochondrial | -0.00642867 |
| MATN2 | matrilin 2 | -0.00642163 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00641771 |
| SNX7 | sorting nexin 7 | -0.00640297 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0063927 |
| STC1 | stanniocalcin 1 | -0.00639038 |
| MXRA5 | matrix-remodelling associated 5 | -0.00637886 |
| COLEC12 | collectin sub-family member 12 | -0.00635761 |
| HOXC6 | homeobox C6 | -0.0063467 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.00625406 |
| PCOLCE | procollagen C-endopeptidase enhancer | -0.00624801 |
| BAMBI | BMP and activin membrane-bound inhibitor | -0.0062465 |
| MELK | maternal embryonic leucine zipper kinase | -0.00622071 |
| AEBP1 | AE binding protein 1 | -0.00616364 |
| APOD | apolipoprotein D | -0.00616348 |
| SPC25 | SPC25, NDC80 kinetochore complex component | -0.00615829 |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | -0.00615409 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.00614016 |
| MFAP4 | microfibrillar-associated protein 4 | -0.0061352 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0061107 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -0.00610443 |
| NPTX2 | neuronal pentraxin II | -0.00607391 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | -0.00603971 |
| HOXC10 | homeobox C10 | -0.00601671 |
| JAM3 | junctional adhesion molecule 3 | -0.00599834 |
| AFP | alpha-fetoprotein | -0.00599404 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00595771 |
| CYB5R2 | cytochrome b5 reductase 2 | -0.0059562 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00592348 |
| GLOD4 | glyoxalase domain containing 4 | -0.00591482 |
| MPPED2 | metallophosphoesterase domain containing 2 | -0.00589992 |
| SSPN | sarcospan | -0.00587476 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00584493 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | -0.00582238 |
| BAG2 | BCL2-associated athanogene 2 | -0.00580483 |
| CHRDL1 | chordin-like 1 | -0.00580113 |
| ANXA10 | annexin A10 | -0.0057836 |
| CRABP1 | cellular retinoic acid binding protein 1 | -0.00576679 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.00576618 |
| AUTS2 | autism susceptibility candidate 2 | -0.00575897 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.00575506 |
| STMN2 | stathmin 2 | -0.00574278 |
| THYN1 | thymocyte nuclear protein 1 | -0.0057333 |
| CHGB | chromogranin B | -0.00572241 |
| RGS5 | regulator of G-protein signaling 5 | -0.00570247 |
| DPT | dermatopontin | -0.00570239 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -0.00569564 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00565364 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.00565155 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.00564163 |
| RAG1 | recombination activating gene 1 | -0.00563772 |
| PLLP | plasmolipin | -0.00562744 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.00559831 |
| RECQL | RecQ helicase-like | -0.00556543 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.00555305 |
| INAVA | innate immunity activator | -0.00553893 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00552986 |
| PLCB4 | phospholipase C, beta 4 | -0.00550854 |
| BRINP1 | bone morphogenetic protein/retinoic acid inducible neural-specific 1 | -0.00549892 |
| COL6A1 | collagen, type VI, alpha 1 | -0.00548425 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00548374 |
| KRT18 | keratin 18, type I | -0.00545511 |
| INA | internexin neuronal intermediate filament protein, alpha | -0.00542828 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | -0.00541926 |
| IL1R1 | interleukin 1 receptor, type I | -0.00541433 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.00541293 |
| NFASC | neurofascin | -0.00541225 |
| HDAC1 | histone deacetylase 1 | -0.00540265 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00538553 |
| SLIT1 | slit homolog 1 (Drosophila) | -0.00538469 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00536428 |
| ATP1A2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | -0.00532718 |
| GOLGA8A | golgin A8 family, member A | -0.00532615 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00531576 |
| EFHD1 | EF-hand domain family, member D1 | -0.00531539 |
| CNN1 | calponin 1, basic, smooth muscle | -0.00530551 |
| APOA2 | apolipoprotein A-II | -0.00528726 |
| LMOD1 | leiomodin 1 (smooth muscle) | -0.00527904 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | -0.00525377 |
| KRT20 | keratin 20, type I | -0.0052283 |
| DCPS | decapping enzyme, scavenger | -0.00521963 |
| HEBP2 | heme binding protein 2 | -0.00521787 |
| YEATS4 | YEATS domain containing 4 | -0.00520724 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.00520714 |
| APOB | apolipoprotein B | -0.00520373 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00520088 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.00519932 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.00519603 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.00519164 |
| OLFML3 | olfactomedin-like 3 | -0.00518269 |
| ELN | elastin | -0.005155 |
| SGCE | sarcoglycan, epsilon | -0.00514858 |
| B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | -0.00514332 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00512711 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.00509913 |
| MYOC | myocilin, trabecular meshwork inducible glucocorticoid response | -0.00508572 |
| PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | -0.00508373 |
| CLTA | clathrin, light chain A | -0.00507648 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | -0.00507462 |
| ANXA5 | annexin A5 | -0.0050648 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00506261 |
| MAP1A | microtubule-associated protein 1A | -0.00505754 |
| RAB25 | RAB25, member RAS oncogene family | -0.00505468 |
| MB | myoglobin | -0.00504785 |
| DSTN | destrin (actin depolymerizing factor) | -0.0050104 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | -0.00496942 |
| APOA1 | apolipoprotein A-I | -0.00496792 |
| KLHL7 | kelch-like family member 7 | -0.00496156 |
| CD1B | CD1b molecule | -0.00495799 |
| AHNAK | AHNAK nucleoprotein | -0.00495252 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00493535 |
| PSPH | phosphoserine phosphatase | -0.00491582 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | -0.00491008 |
| HOXA5 | homeobox A5 | -0.00490965 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00489955 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0048976 |
| LPPR1 | lipid phosphate phosphatase-related protein type 1 | -0.00486618 |
| WASF1 | WAS protein family, member 1 | -0.00483859 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | -0.00483533 |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 | -0.00482759 |
| UNG | uracil-DNA glycosylase | -0.00480737 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0048024 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.00479713 |
| CD1E | CD1e molecule | -0.00479713 |
| DES | desmin | -0.00479667 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00477599 |
| MCM10 | minichromosome maintenance complex component 10 | -0.00477512 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.00477006 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.00476608 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.00476347 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00474539 |
| LPIN1 | lipin 1 | -0.00473816 |
| S100B | S100 calcium binding protein B | -0.00473402 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.00473353 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00472896 |
| PGC | progastricsin (pepsinogen C) | -0.00472881 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.00471532 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00471515 |
| SLC25A13 | solute carrier family 25 (aspartate/glutamate carrier), member 13 | -0.00470975 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.00468778 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.00468551 |
| CHEK2 | checkpoint kinase 2 | -0.00468537 |
| TRIP13 | thyroid hormone receptor interactor 13 | -0.00468434 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.00467631 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.00467111 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.00466386 |
| DLAT | dihydrolipoamide S-acetyltransferase | -0.00465827 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00464985 |
| CLSTN1 | calsyntenin 1 | -0.0046417 |
| ANK2 | ankyrin 2, neuronal | -0.00463917 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00463543 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | -0.0046307 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.00461447 |
| MAB21L1 | mab-21-like 1 (C. elegans) | -0.00460002 |
| SOBP | sine oculis binding protein homolog (Drosophila) | -0.00459628 |
| PTCH1 | patched 1 | -0.00459252 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0045895 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.00458669 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.0045631 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00456209 |
| LOC283683 | uncharacterized LOC283683 | -0.00455601 |
| COL11A1 | collagen, type XI, alpha 1 | -0.00455265 |
| C1S | complement component 1, s subcomponent | -0.00454261 |
| ARG2 | arginase 2 | -0.00453636 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | -0.00453421 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00453353 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00453258 |
| IMPDH1 | IMP (inosine 5'-monophosphate) dehydrogenase 1 | -0.004532 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00452122 |
