CHEK1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description checkpoint kinase 1|The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 1111)
External Link http://www.ncbi.nlm.nih.gov/gene/1111
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Genes

142 substrates of the kinase CHEK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ADD1 adducin 1 (alpha)
ADD2 adducin 2 (beta)
ADD3 adducin 3 (gamma)
ANKRD12 ankyrin repeat domain 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLM Bloom syndrome, RecQ helicase-like
BUD13 BUD13 homolog (S. cerevisiae)
C17ORF85 chromosome 17 open reading frame 85
CAAP1 caspase activity and apoptosis inhibitor 1
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCDC6 coiled-coil domain containing 6
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK13 cyclin-dependent kinase 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP170B centrosomal protein 170B
CHD7 chromodomain helicase DNA binding protein 7
CHEK1 checkpoint kinase 1
CHTOP chromatin target of PRMT1
CLK3 CDC-like kinase 3
CLSPN claspin
CSNK2B casein kinase 2, beta polypeptide
CTR9 CTR9, Paf1/RNA polymerase II complex component
CTTN cortactin
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DRG2 developmentally regulated GTP binding protein 2
E2F3 E2F transcription factor 3
E2F6 E2F transcription factor 6
EBNA1BP2 EBNA1 binding protein 2
EML3 echinoderm microtubule associated protein like 3
EPRS glutamyl-prolyl-tRNA synthetase
ERRFI1 ERBB receptor feedback inhibitor 1
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FEN1 flap structure-specific endonuclease 1
FYTTD1 forty-two-three domain containing 1
GOLGA4 golgin A4
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
H3F3A H3 histone, family 3A
HDLBP high density lipoprotein binding protein
HIST1H3A histone cluster 1, H3a
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPM heterogeneous nuclear ribonucleoprotein M
IDI1 isopentenyl-diphosphate delta isomerase 1
INF2 inverted formin, FH2 and WH2 domain containing
ING1 inhibitor of growth family, member 1
KIFC1 kinesin family member C1
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMC1 laminin, gamma 1 (formerly LAMB2)
LATS2 large tumor suppressor kinase 2
LIG1 ligase I, DNA, ATP-dependent
LMNA lamin A/C
LMO7 LIM domain 7
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP4 microtubule-associated protein 4
MAPT microtubule-associated protein tau
MATR3 matrin 3
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MDC1 mediator of DNA-damage checkpoint 1
MDM4 MDM4, p53 regulator
MED1 mediator complex subunit 1
MINK1 misshapen-like kinase 1
MKI67 marker of proliferation Ki-67
MYBBP1A MYB binding protein (P160) 1a
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NEK11 NIMA-related kinase 11
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NUP153 nucleoporin 153kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSBPL11 oxysterol binding protein-like 11
PHF2 PHD finger protein 2
PHF8 PHD finger protein 8
PLRG1 pleiotropic regulator 1
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPME1 protein phosphatase methylesterase 1
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PROSER2 proline and serine rich 2
PRPF3 pre-mRNA processing factor 3
PRR5 proline rich 5 (renal)
PRRC2B proline-rich coiled-coil 2B
PRRC2C proline-rich coiled-coil 2C
RACGAP1 Rac GTPase activating protein 1
RALY RALY heterogeneous nuclear ribonucleoprotein
RANBP2 RAN binding protein 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RAVER1 ribonucleoprotein, PTB-binding 1
RB1 retinoblastoma 1
RBM14 RNA binding motif protein 14
RBM26 RNA binding motif protein 26
RBM42 RNA binding motif protein 42
RIF1 replication timing regulatory factor 1
RPL13 ribosomal protein L13
RPL19 ribosomal protein L19
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SCAF11 SR-related CTD-associated factor 11
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SEPT7 septin 7
SETMAR SET domain and mariner transposase fusion gene
SIN3A SIN3 transcription regulator family member A
SLTM SAFB-like, transcription modulator
SNCB synuclein, beta
SPEN spen family transcriptional repressor
SRRM2 serine/arginine repetitive matrix 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STK4 serine/threonine kinase 4
SYK spleen tyrosine kinase
TBC1D4 TBC1 domain family, member 4
TFDP1 transcription factor Dp-1
TICRR TOPBP1-interacting checkpoint and replication regulator
TLK1 tousled-like kinase 1
TLK2 tousled-like kinase 2
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TRIP12 thyroid hormone receptor interactor 12
UIMC1 ubiquitin interaction motif containing 1
WIZ widely interspaced zinc finger motifs
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YBX2 Y box binding protein 2
YBX3 Y box binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZC3HC1 zinc finger, C3HC-type containing 1
ZNF395 zinc finger protein 395
ZNF638 zinc finger protein 638