CHEK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description checkpoint kinase 2|In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 11200)
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Genes

263 genes differentially expressed following the CHEK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TSPAN32 tetraspanin 32 2.95385
PXT1 peroxisomal, testis specific 1 2.95385
ELOVL3 ELOVL fatty acid elongase 3 2.95385
FGF16 fibroblast growth factor 16 2.95385
CD300LF CD300 molecule-like family member f 2.95385
OXER1 oxoeicosanoid (OXE) receptor 1 2.95385
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.95385
SH2D7 SH2 domain containing 7 2.95385
KLK14 kallikrein-related peptidase 14 2.95385
ASB4 ankyrin repeat and SOCS box containing 4 2.95385
TTC9B tetratricopeptide repeat domain 9B 2.95385
LRRC32 leucine rich repeat containing 32 2.95385
TGM4 transglutaminase 4 2.95385
F2 coagulation factor II (thrombin) 2.95385
TPBGL trophoblast glycoprotein-like 2.95385
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.95385
CFAP119 cilia and flagella associated protein 119 2.95385
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.95385
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.95385
SPMIP11 sperm microtubule inner protein 11 2.95385
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.88769
ADGRE3 adhesion G protein-coupled receptor E3 2.88769
MAP3K7CL MAP3K7 C-terminal like 2.88769
TRIM15 tripartite motif containing 15 2.88769
MYO7B myosin VIIB 2.88769
SOX1 SRY (sex determining region Y)-box 1 2.88769
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.88769
FAM90A26 family with sequence similarity 90, member A26, pseudogene 2.88769
CD274 CD274 molecule 2.88769
AGTR1 angiotensin II receptor, type 1 2.88769
DNASE1L2 deoxyribonuclease I-like 2 2.88769
C3ORF22 chromosome 3 open reading frame 22 2.88769
SPRR1B small proline-rich protein 1B 2.88769
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.88769
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.88769
ESX1 ESX homeobox 1 2.88769
FAM90A1 family with sequence similarity 90, member A1 2.88769
PAX6 paired box 6 2.88769
PAX3 paired box 3 2.88769
PDE7B phosphodiesterase 7B 2.88769
GJB1 gap junction protein, beta 1, 32kDa 2.88769
NCF1 neutrophil cytosolic factor 1 2.88769
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.88769
SOX14 SRY (sex determining region Y)-box 14 2.88769
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2.88769
SOX18 SRY (sex determining region Y)-box 18 2.88769
GPHB5 glycoprotein hormone beta 5 2.88769
KLF14 Kruppel-like factor 14 2.88769
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.88769
PDC phosducin 2.88769
POM121L2 POM121 transmembrane nucleoporin-like 2 2.88769
FGFBP1 fibroblast growth factor binding protein 1 2.88769
TAS2R60 taste receptor, type 2, member 60 2.88769
ROPN1B rhophilin associated tail protein 1B 2.88769
C3AR1 complement component 3a receptor 1 2.88769
OTOS otospiralin 2.88769
STING1 stimulator of interferon response cGAMP interactor 1 2.88769
ANGPTL8 angiopoietin like 8 2.88769
TMEM275 transmembrane protein 275 2.88769
LOC112694756 uncharaterized LOC112694756 2.88769
PLAAT2 phospholipase A and acyltransferase 2 2.88769
H2AC1 H2A clustered histone 1 2.88769
THSD8 thrombospondin type 1 domain containing 8 2.88769
CIMIP4 ciliary microtubule inner protein 4 2.88769
TMPRSS3 transmembrane protease, serine 3 2.88769
OR1C1 olfactory receptor, family 1, subfamily C, member 1 2.88769
RDH8 retinol dehydrogenase 8 (all-trans) 2.88769
C5ORF52 chromosome 5 open reading frame 52 2.88769
CFAP99 cilia and flagella associated protein 99 2.88769
IL31RA interleukin 31 receptor A 2.88769
MYH13 myosin, heavy chain 13, skeletal muscle 2.88769
SBSN suprabasin 2.88769
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.88769
ACE2 angiotensin I converting enzyme 2 2.88769
PRG4 proteoglycan 4 2.88769
SOAT2 sterol O-acyltransferase 2 2.88769
LTB lymphotoxin beta (TNF superfamily, member 3) 2.88769
ZG16B zymogen granule protein 16B 2.88769
RNF183 ring finger protein 183 2.88769
GATA5 GATA binding protein 5 2.88769
ZNF705A zinc finger protein 705A 2.88769
TSPAN1 tetraspanin 1 2.88769
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.88769
LOC122455340 uncharacterized LOC122455340 2.88769
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.88769
GOLGA8N golgin A8 family, member N 2.88769
SCGB1D4 secretoglobin, family 1D, member 4 2.88769
CBX8 chromobox homolog 8 2.88769
OAZ3 ornithine decarboxylase antizyme 3 2.88769
DEFB107B defensin, beta 107B 2.88769
KLHL6 kelch-like family member 6 2.88769
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.88769
CLDN34 claudin 34 2.88769
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 2.88769
KRT3 keratin 3, type II 2.88769
CLEC7A C-type lectin domain family 7, member A 2.88769
ERMN ermin, ERM-like protein 2.88769
KRT15 keratin 15, type I 2.88769
BCL2A1 BCL2-related protein A1 2.88769
TCF21 transcription factor 21 2.88769
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.88769
PRR23A proline rich 23A 2.88769
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 2.88769
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.88769
ZNF831 zinc finger protein 831 2.88769
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.88769
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 2.88769
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.88769
SLA Src-like-adaptor 2.88769
RBBP8NL RBBP8 N-terminal like 2.88769
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 2.88769
PRSS33 protease, serine, 33 2.88769
DLX3 distal-less homeobox 3 2.88769
GFRAL GDNF family receptor alpha like 2.88769
TF transferrin 2.88769
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.88769
AICDA activation-induced cytidine deaminase 2.88769
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.88769
ZC3H11D zinc finger CCCH-type containing 11D 2.88769
PRSS57 protease, serine, 57 2.88769
C11ORF16 chromosome 11 open reading frame 16 2.88769
ZPLD1 zona pellucida-like domain containing 1 2.88769
KIAA1755 KIAA1755 2.88769
TMEM45B transmembrane protein 45B 2.88769
TMPRSS15 transmembrane protease, serine 15 2.88769
DLL4 delta-like 4 (Drosophila) 2.88769
IL37 interleukin 37 2.88769
NMUR2 neuromedin U receptor 2 2.88769
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.88769
ANGPTL5 angiopoietin-like 5 2.88769
MMP13 matrix metallopeptidase 13 2.88769
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.88769
IL33 interleukin 33 2.88769
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.88769
TTC36 tetratricopeptide repeat domain 36 2.88769
PITX2 paired-like homeodomain 2 2.88769
MAPK11 mitogen-activated protein kinase 11 2.88769
STMND1 stathmin domain containing 1 2.88769
PMCH pro-melanin-concentrating hormone 2.88769
ASCL5 achaete-scute family bHLH transcription factor 5 2.88769
ASCL1 achaete-scute family bHLH transcription factor 1 2.88769
CLCA4 chloride channel accessory 4 2.88769
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.88257
PANO1 proapoptotic nucleolar protein 1 2.88257
WFDC10A WAP four-disulfide core domain 10A 2.88257
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.88257
SNPH syntaphilin 2.88257
FANCA Fanconi anemia, complementation group A 2.79642
ASB8 ankyrin repeat and SOCS box containing 8 2.69312
NAAA N-acylethanolamine acid amidase 2.68993
FADS2 fatty acid desaturase 2 2.62839
MARCHF6 membrane associated ring-CH-type finger 6 2.54795
ZDHHC11 zinc finger, DHHC-type containing 11 2.51015
TBC1D15 TBC1 domain family, member 15 2.51015
C1ORF202 chromosome 1 open reading frame 202 2.51015
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.43165
SAXO2 stabilizer of axonemal microtubules 2 2.40507
MYOCOS myocilin opposite strand 2.35356
IHO1 interactor of HORMAD1 1 2.35356
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.32968
FOSL1 FOS-like antigen 1 2.30688
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.29475
TP53BP2 tumor protein p53 binding protein 2 2.26431
TTC22 tetratricopeptide repeat domain 22 2.22133
ANGPT4 angiopoietin 4 2.21077
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 2.18102
GTF2IRD2 GTF2I repeat domain containing 2 2.16048
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.15302
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.12662
WDR55 WD repeat domain 55 2.12119
BCAR3 breast cancer anti-estrogen resistance 3 2.10842
LRP1 low density lipoprotein receptor-related protein 1 2.09887
ZBTB43 zinc finger and BTB domain containing 43 2.08162
CNR1 cannabinoid receptor 1 (brain) 2.07944
SNX12 sorting nexin 12 2.05978
STEEP1 STING1 ER exit protein 1 2.05092
ZNF385C zinc finger protein 385C 2.03138
FER fer (fps/fes related) tyrosine kinase 2.0202

decreased expression

Symbol Name Standardized Value
TMED6 transmembrane emp24 protein transport domain containing 6 -2.95385
TIMCC TIM double twin CX3C motif chaperone -2.88769
CHEK2 checkpoint kinase 2 -2.88769
EDNRB endothelin receptor type B -2.88769
SEPTIN9 septin 9 -2.88769
CRB1 crumbs family member 1, photoreceptor morphogenesis associated -2.88257
TBX15 T-box 15 -2.88257
KIF19 kinesin family member 19 -2.88257
PRSS21 protease, serine, 21 (testisin) -2.88257
ZNF467 zinc finger protein 467 -2.88257
PITX3 paired-like homeodomain 3 -2.88257
CPB2 carboxypeptidase B2 (plasma) -2.88257
NPIPA7 nuclear pore complex interacting protein family, member A7 -2.88257
HAS1 hyaluronan synthase 1 -2.88257
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E -2.88257
ZNF98 zinc finger protein 98 -2.88257
DNAAF8 dynein axonemal assembly factor 8 -2.88257
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -2.88257
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -2.88257
PKD2L1 polycystic kidney disease 2-like 1 -2.88257
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -2.88257
CNTN6 contactin 6 -2.88257
STARD6 StAR-related lipid transfer (START) domain containing 6 -2.88257
NXPE1 neurexophilin and PC-esterase domain family, member 1 -2.88257
ACOT1 acyl-CoA thioesterase 1 -2.88257
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -2.88257
VSTM1 V-set and transmembrane domain containing 1 -2.88257
DGCR6 DiGeorge syndrome critical region gene 6 -2.88257
TMEM132D transmembrane protein 132D -2.88257
VMO1 vitelline membrane outer layer 1 homolog (chicken) -2.88257
TMEM255A transmembrane protein 255A -2.88257
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -2.88257
ZNF843 zinc finger protein 843 -2.88257
PCDHGB1 protocadherin gamma subfamily B, 1 -2.88257
ARHGAP8 Rho GTPase activating protein 8 -2.83052
SYNM synemin, intermediate filament protein -2.82795
ZDBF2 zinc finger, DBF-type containing 2 -2.71251
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.71251
TMEM278 transmembrane protein 278 -2.57668
NPIPB2 nuclear pore complex interacting protein family member B2 -2.56491
CNBD2 cyclic nucleotide binding domain containing 2 -2.56491
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.54795
TNS1-AS1 TNS1 antisense RNA 1 -2.54795
MEGF6 multiple EGF-like-domains 6 -2.54457
EXOSC2 exosome component 2 -2.51015
FUBP3 far upstream element (FUSE) binding protein 3 -2.48701
GEMIN2 gem (nuclear organelle) associated protein 2 -2.4854
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -2.4289
MYT1 myelin transcription factor 1 -2.40069
GMNN geminin, DNA replication inhibitor -2.39994
ZC3H11C zinc finger CCCH-type containing 11C -2.39399
SNX7 sorting nexin 7 -2.36196
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -2.35611
USP31 ubiquitin specific peptidase 31 -2.35512
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled -2.3551
DPY30 dpy-30 homolog (C. elegans) -2.33401
ZSCAN20 zinc finger and SCAN domain containing 20 -2.31258
CTPS1 CTP synthase 1 -2.30049
CORO1B coronin, actin binding protein, 1B -2.29475
TMEM191C transmembrane protein 191C -2.29181
ANKRD50 ankyrin repeat domain 50 -2.28092
NOCT nocturnin -2.26882
KLHL13 kelch-like family member 13 -2.26175
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -2.24625
TIAM1 T-cell lymphoma invasion and metastasis 1 -2.20941
FAM89B family with sequence similarity 89, member B -2.18117
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 -2.18102
RTTN rotatin -2.15602
MINAR1 membrane integral NOTCH2 associated receptor 1 -2.12298
ORC2 origin recognition complex, subunit 2 -2.12186
LMO1 LIM domain only 1 (rhombotin 1) -2.12119
SPATA16 spermatogenesis associated 16 -2.12119
MRPL47 mitochondrial ribosomal protein L47 -2.11958
RNH1 ribonuclease/angiogenin inhibitor 1 -2.11193
EPB41 erythrocyte membrane protein band 4.1 -2.10185
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -2.08527
MRPL19 mitochondrial ribosomal protein L19 -2.07096
LENG8 leukocyte receptor cluster (LRC) member 8 -2.04451
NF1 neurofibromin 1 -2.03315
MACF1 microtubule-actin crosslinking factor 1 -2.03138
TTC3 tetratricopeptide repeat domain 3 -2.0082
TXNDC15 thioredoxin domain containing 15 -2.0082
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.00199
IGFBPL1 insulin-like growth factor binding protein-like 1 -2.00132
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -2.00132