| Dataset | KEA Substrates of Kinases |
| Category | physical interactions |
| Type | kinase |
| Description | checkpoint kinase 2|In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 11200) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/11200 |
| Similar Terms | |
| Downloads & Tools |
32 substrates of the kinase CHEK2 from the curated KEA Substrates of Kinases dataset.
| Symbol | Name |
|---|---|
| AATF | apoptosis antagonizing transcription factor |
| BDNF | brain-derived neurotrophic factor |
| BRCA1 | breast cancer 1, early onset |
| CDC25A | cell division cycle 25A |
| CDC25C | cell division cycle 25C |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 |
| CHEK2 | checkpoint kinase 2 |
| E2F1 | E2F transcription factor 1 |
| E2F3 | E2F transcription factor 3 |
| ELAVL1 | ELAV like RNA binding protein 1 |
| FOXM1 | forkhead box M1 |
| HIST1H1C | histone cluster 1, H1c |
| LATS2 | large tumor suppressor kinase 2 |
| MAPT | microtubule-associated protein tau |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
| MDM4 | MDM4, p53 regulator |
| PLK1 | polo-like kinase 1 |
| PLK3 | polo-like kinase 3 |
| PML | promyelocytic leukemia |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha |
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma |
| PPP2R5D | protein phosphatase 2, regulatory subunit B', delta |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform |
| RB1 | retinoblastoma 1 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit |
| TP53 | tumor protein p53 |
| TRIM28 | tripartite motif containing 28 |
| TTK | TTK protein kinase |
| VHL | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
| XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 |
