| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | checkpoint kinase 2|In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 11200) |
| External Link | https://ncbi.nlm.nih.gov/gene/11200 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the CHEK2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | 0.0166219 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.0153023 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.0151502 |
| GPER1 | G protein-coupled estrogen receptor 1 | 0.0132651 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0131651 |
| TSPAN4 | tetraspanin 4 | 0.013118 |
| STAG3 | stromal antigen 3 | 0.0130496 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.0122388 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0120875 |
| TSPYL5 | TSPY-like 5 | 0.0115285 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0113663 |
| STK10 | serine/threonine kinase 10 | 0.0111002 |
| DMXL2 | Dmx-like 2 | 0.0110999 |
| CANT1 | calcium activated nucleotidase 1 | 0.0108863 |
| PPP1R7 | protein phosphatase 1, regulatory subunit 7 | 0.0108369 |
| HMGA1 | high mobility group AT-hook 1 | 0.0107958 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.0107938 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0107273 |
| C1ORF115 | chromosome 1 open reading frame 115 | 0.0106629 |
| CTSH | cathepsin H | 0.0105659 |
| ZWINT | ZW10 interacting kinetochore protein | 0.0105243 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0104199 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0103402 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.0103135 |
| PCNA | proliferating cell nuclear antigen | 0.0102636 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0102398 |
| PCP4 | Purkinje cell protein 4 | 0.0102073 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.0101766 |
| TMSB15A | thymosin beta 15a | 0.00973531 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00966737 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.00956832 |
| IDE | insulin-degrading enzyme | 0.0095266 |
| ACADM | acyl-CoA dehydrogenase, C-4 to C-12 straight chain | 0.00947244 |
| EPCAM | epithelial cell adhesion molecule | 0.00945878 |
| MXRA5 | matrix-remodelling associated 5 | 0.0093976 |
| C2CD5 | C2 calcium-dependent domain containing 5 | 0.00933523 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00933033 |
| PCGF2 | polycomb group ring finger 2 | 0.00924721 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.00917074 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | 0.00916747 |
| WBP1L | WW domain binding protein 1-like | 0.00914933 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00913374 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | 0.00904667 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 0.00899989 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.00898991 |
| INHBB | inhibin, beta B | 0.00897865 |
| NVL | nuclear VCP-like | 0.00897574 |
| CHN2 | chimerin 2 | 0.00897387 |
| KRT7 | keratin 7, type II | 0.00896526 |
| POSTN | periostin, osteoblast specific factor | 0.00894751 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00894545 |
| MYL6B | myosin, light chain 6B, alkali, smooth muscle and non-muscle | 0.0089066 |
| PDGFC | platelet derived growth factor C | 0.00884162 |
| HSPA12A | heat shock 70kDa protein 12A | 0.00880579 |
| EGR2 | early growth response 2 | 0.00873894 |
| EGF | epidermal growth factor | 0.00872182 |
| TRIM8 | tripartite motif containing 8 | 0.00869384 |
| ASS1 | argininosuccinate synthase 1 | 0.00867879 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | 0.00862154 |
| OBSL1 | obscurin-like 1 | 0.00859581 |
| PAK6 | p21 protein (Cdc42/Rac)-activated kinase 6 | 0.00856802 |
| AQP9 | aquaporin 9 | 0.00852357 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit | 0.00851121 |
| KIF20A | kinesin family member 20A | 0.00845837 |
| ACVR2A | activin A receptor, type IIA | 0.00844628 |
| GRB14 | growth factor receptor-bound protein 14 | 0.00844137 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00842705 |
| CHMP4A | charged multivesicular body protein 4A | 0.00842283 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 0.00839397 |
| MT1F | metallothionein 1F | 0.00830806 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.0082951 |
| MAMLD1 | mastermind-like domain containing 1 | 0.0082839 |
| IPO13 | importin 13 | 0.00823355 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 0.00822368 |
| MT2A | metallothionein 2A | 0.00822013 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.00818426 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.00816541 |
| CHODL | chondrolectin | 0.00814797 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00812265 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.00810238 |
| DNM3 | dynamin 3 | 0.00810165 |
| NCF2 | neutrophil cytosolic factor 2 | 0.00806988 |
| SMYD2 | SET and MYND domain containing 2 | 0.00798777 |
| CPB1 | carboxypeptidase B1 (tissue) | 0.00796428 |
| HAL | histidine ammonia-lyase | 0.00791207 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.00789849 |
| ARG2 | arginase 2 | 0.00789145 |
| SHTN1 | shootin 1 | 0.00784623 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.00783624 |
| LPXN | leupaxin | 0.00783489 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.00774557 |
| CDC25B | cell division cycle 25B | 0.00774223 |
| ZNF331 | zinc finger protein 331 | 0.00773831 |
| SLC35E2B | solute carrier family 35, member E2B | 0.00771074 |
| ABHD6 | abhydrolase domain containing 6 | 0.00771033 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00770826 |
| TMPRSS4 | transmembrane protease, serine 4 | 0.00769576 |
| ICAM2 | intercellular adhesion molecule 2 | 0.00765083 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | 0.00762245 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.0076103 |
| TMEM176B | transmembrane protein 176B | 0.00757945 |
| HPCAL1 | hippocalcin-like 1 | 0.00756885 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00753473 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.0074997 |
| NAXD | NAD(P)HX dehydratase | 0.00749452 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.00749 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | 0.00747731 |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.00746806 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00746197 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.00742194 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.00741952 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00741105 |
| TFEB | transcription factor EB | 0.00740622 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.00736709 |
| COG2 | component of oligomeric golgi complex 2 | 0.00735478 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00733567 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.00733179 |
| TBC1D16 | TBC1 domain family, member 16 | 0.00730603 |
| NSL1 | NSL1, MIS12 kinetochore complex component | 0.00730499 |
| THY1 | Thy-1 cell surface antigen | 0.00730152 |
| SCG5 | secretogranin V | 0.00729535 |
| GTF2E1 | general transcription factor IIE, polypeptide 1, alpha 56kDa | 0.00729436 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.00729047 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.00728081 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | 0.00728002 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 0.00727046 |
| APMAP | adipocyte plasma membrane associated protein | 0.00723761 |
| MX2 | MX dynamin-like GTPase 2 | 0.00721497 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.00719663 |
| SLC23A2 | solute carrier family 23 (ascorbic acid transporter), member 2 | 0.00719612 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.00718934 |
| ISYNA1 | inositol-3-phosphate synthase 1 | 0.00713774 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00712919 |
| RAB13 | RAB13, member RAS oncogene family | 0.007084 |
| FOXM1 | forkhead box M1 | 0.00706785 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.00705867 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.00704894 |
| NEDD8 | neural precursor cell expressed, developmentally down-regulated 8 | 0.0070362 |
| S100A4 | S100 calcium binding protein A4 | 0.00702269 |
| CD52 | CD52 molecule | 0.00701885 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.00701869 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.00695333 |
| TARBP2 | TAR (HIV-1) RNA binding protein 2 | 0.00693929 |
| DTX4 | deltex 4, E3 ubiquitin ligase | 0.00691175 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00689504 |
| VPS51 | vacuolar protein sorting 51 homolog (S. cerevisiae) | 0.00689102 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00687656 |
| PHTF2 | putative homeodomain transcription factor 2 | 0.00687134 |
| L1CAM | L1 cell adhesion molecule | 0.00686889 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 0.00685099 |
| WT1 | Wilms tumor 1 | 0.00684836 |
| AGO3 | argonaute RISC catalytic component 3 | 0.00684616 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.00683745 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | 0.00681096 |
| EVI2A | ecotropic viral integration site 2A | 0.0067904 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.0067812 |
| HOMER3 | homer scaffolding protein 3 | 0.00674418 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.00674332 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.00666523 |
| HIST2H2BE | histone cluster 2, H2be | 0.00666166 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00664877 |
| MEPCE | methylphosphate capping enzyme | 0.00661012 |
| FAM234B | family with sequence similarity 234 member B | 0.00659196 |
| EHD1 | EH-domain containing 1 | 0.0065864 |
| DMXL1 | Dmx-like 1 | 0.0065824 |
| MT1G | metallothionein 1G | 0.0065776 |
| BSCL2 | Berardinelli-Seip congenital lipodystrophy 2 (seipin) | 0.00655928 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00654693 |
| IRS1 | insulin receptor substrate 1 | 0.00654427 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00652956 |
| C3AR1 | complement component 3a receptor 1 | 0.00652409 |
| C11ORF71 | chromosome 11 open reading frame 71 | 0.00651625 |
| FKBP3 | FK506 binding protein 3, 25kDa | 0.00651289 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.00651201 |
| INTS6 | integrator complex subunit 6 | 0.00650824 |
| CRNKL1 | crooked neck pre-mRNA splicing factor 1 | 0.00650253 |
| COL3A1 | collagen, type III, alpha 1 | 0.00649571 |
| PTEN | phosphatase and tensin homolog | 0.00648718 |
| ATF3 | activating transcription factor 3 | 0.00648512 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.00647738 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.00646875 |
| LUM | lumican | 0.00646337 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0064546 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | 0.00645244 |
| RGS1 | regulator of G-protein signaling 1 | 0.00644857 |
| ADRA2A | adrenoceptor alpha 2A | 0.00644458 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.00642644 |
| PPM1H | protein phosphatase, Mg2+/Mn2+ dependent, 1H | 0.00642296 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00641622 |
| FHOD1 | formin homology 2 domain containing 1 | 0.00641396 |
| COASY | CoA synthase | 0.00640628 |
| CALB1 | calbindin 1, 28kDa | 0.00640524 |
| HMGB2 | high mobility group box 2 | 0.00639027 |
| CPE | carboxypeptidase E | 0.00638432 |
| KCNS3 | potassium voltage-gated channel, modifier subfamily S, member 3 | 0.00638109 |
| SMUG1 | single-strand-selective monofunctional uracil-DNA glycosylase 1 | 0.00637234 |
| PER3 | period circadian clock 3 | 0.00635533 |
| ZDHHC4 | zinc finger, DHHC-type containing 4 | 0.00635046 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00634843 |
| ASRGL1 | asparaginase like 1 | 0.00633451 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | 0.00633245 |
| PLEK | pleckstrin | 0.00632784 |
| COL7A1 | collagen, type VII, alpha 1 | 0.00631359 |
| PHYH | phytanoyl-CoA 2-hydroxylase | 0.00628293 |
| S100B | S100 calcium binding protein B | 0.00628054 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00627556 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.00625743 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | 0.00624 |
| FGR | FGR proto-oncogene, Src family tyrosine kinase | 0.00623411 |
| RAPSN | receptor-associated protein of the synapse | 0.00622863 |
| PLA2G12A | phospholipase A2, group XIIA | 0.00622322 |
| BCL2A1 | BCL2-related protein A1 | 0.00621914 |
| MARCKSL1 | MARCKS-like 1 | 0.00620789 |
| ATP1A1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 0.00619842 |
| MSLN | mesothelin | 0.00619388 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00618153 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.00618083 |
| KIAA0513 | KIAA0513 | 0.00617533 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | 0.00616572 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00615404 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.00613371 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | 0.00612754 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.00612469 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | 0.0061246 |
| CMTR1 | cap methyltransferase 1 | 0.00611217 |
| DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding) | 0.00611086 |
| PLXNC1 | plexin C1 | 0.00610938 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00610224 |
| FEN1 | flap structure-specific endonuclease 1 | 0.00609545 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00609397 |
| HOMER2 | homer scaffolding protein 2 | 0.00609189 |
| MCM6 | minichromosome maintenance complex component 6 | 0.00608398 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00608171 |
| COBL | cordon-bleu WH2 repeat protein | 0.00608133 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 | 0.00606409 |
| CBS | cystathionine-beta-synthase | 0.00606094 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00605268 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0060459 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.0060343 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.00602343 |
| TMEM223 | transmembrane protein 223 | 0.00599905 |
| EPHB2 | EPH receptor B2 | 0.0059987 |
| NLRP2 | NLR family, pyrin domain containing 2 | 0.00599681 |
| ETV1 | ets variant 1 | 0.00598334 |
| RRBP1 | ribosome binding protein 1 | 0.00596435 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00596211 |
| PTGES | prostaglandin E synthase | 0.00595926 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00595529 |
| TESC | tescalcin | 0.00595516 |
| CBX5 | chromobox homolog 5 | 0.00595419 |
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | -0.0563037 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.0176836 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0162599 |
| IL1B | interleukin 1, beta | -0.0159228 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.0151618 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.0147454 |
| CNN3 | calponin 3, acidic | -0.0143165 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.0142929 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.0129125 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.012582 |
| S100A7 | S100 calcium binding protein A7 | -0.0122627 |
| ANXA1 | annexin A1 | -0.0121456 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -0.012065 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.0119837 |
| XIC | X chromosome inactivation center | -0.0119499 |
| KRT13 | keratin 13, type I | -0.0117559 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0117368 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0115965 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0114777 |
| KRT20 | keratin 20, type I | -0.0113927 |
| PRDX2 | peroxiredoxin 2 | -0.011312 |
| SPINK1 | serine peptidase inhibitor, Kazal type 1 | -0.0112517 |
| PERP | PERP, TP53 apoptosis effector | -0.0111609 |
| SPRR3 | small proline-rich protein 3 | -0.0110939 |
| ADM | adrenomedullin | -0.0110623 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0110526 |
| ELANE | elastase, neutrophil expressed | -0.010908 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.0106984 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.0106885 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0106334 |
| DSG3 | desmoglein 3 | -0.0106183 |
| NDRG1 | N-myc downstream regulated 1 | -0.0105809 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0104171 |
| TMPRSS11E | transmembrane protease, serine 11E | -0.0103567 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0102897 |
| TUBB6 | tubulin, beta 6 class V | -0.0102735 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.0102121 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0102045 |
| IL1A | interleukin 1, alpha | -0.0101147 |
| PRTN3 | proteinase 3 | -0.0100076 |
| RBM34 | RNA binding motif protein 34 | -0.00988005 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00985734 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00981098 |
| MAP7 | microtubule-associated protein 7 | -0.00980408 |
| FSTL1 | follistatin-like 1 | -0.00979726 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.00965861 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00963965 |
| KRT5 | keratin 5, type II | -0.00960762 |
| ACTB | actin, beta | -0.00960296 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00945052 |
| CCNG1 | cyclin G1 | -0.00943076 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00942845 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.00936957 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.00933117 |
| FABP1 | fatty acid binding protein 1, liver | -0.00930235 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -0.00919017 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.00918286 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00916704 |
| BPGM | 2,3-bisphosphoglycerate mutase | -0.00913321 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00907094 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00903072 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.00897 |
| MYBPC1 | myosin binding protein C, slow type | -0.00896062 |
| HEPH | hephaestin | -0.00889507 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00874189 |
| HMOX1 | heme oxygenase 1 | -0.00873186 |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) | -0.00871519 |
| CSF2 | colony stimulating factor 2 (granulocyte-macrophage) | -0.0086929 |
| GPC3 | glypican 3 | -0.00868643 |
| IFNGR1 | interferon gamma receptor 1 | -0.00864112 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | -0.00862811 |
| NPTX2 | neuronal pentraxin II | -0.00861451 |
| MPO | myeloperoxidase | -0.00857448 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.00851199 |
| PITX3 | paired-like homeodomain 3 | -0.00851174 |
| RIOK3 | RIO kinase 3 | -0.008502 |
| CAVIN1 | caveolae associated protein 1 | -0.00849876 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.00849001 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00847929 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.00846454 |
| EDNRB | endothelin receptor type B | -0.00844907 |
| CD34 | CD34 molecule | -0.00841828 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0084174 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00841228 |
| KRT14 | keratin 14, type I | -0.0084079 |
| COG5 | component of oligomeric golgi complex 5 | -0.00839645 |
| SI | sucrase-isomaltase (alpha-glucosidase) | -0.00838029 |
| RASA4 | RAS p21 protein activator 4 | -0.00835218 |
| TXNIP | thioredoxin interacting protein | -0.00832266 |
| CRYAB | crystallin, alpha B | -0.00830579 |
| GATA6 | GATA binding protein 6 | -0.00828769 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00828548 |
| LTF | lactotransferrin | -0.00821697 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00816663 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -0.00816245 |
| STAP2 | signal transducing adaptor family member 2 | -0.00813233 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00813008 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00812525 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00810029 |
| CTSB | cathepsin B | -0.00798532 |
| CAVIN2 | caveolae associated protein 2 | -0.00797596 |
| MYLK | myosin light chain kinase | -0.00791562 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00786152 |
| CD99 | CD99 molecule | -0.0078392 |
| MN1 | meningioma (disrupted in balanced translocation) 1 | -0.00780357 |
| CSRP2 | cysteine and glycine-rich protein 2 | -0.00779734 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.00778596 |
| EDN3 | endothelin 3 | -0.00778453 |
| PIGR | polymeric immunoglobulin receptor | -0.00774739 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00773451 |
| AZU1 | azurocidin 1 | -0.00773021 |
| IL20RA | interleukin 20 receptor, alpha | -0.00771488 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00769954 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.00768336 |
| IL6R | interleukin 6 receptor | -0.00766726 |
| TAL1 | T-cell acute lymphocytic leukemia 1 | -0.00765142 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00764022 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00760493 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.00760032 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.00759183 |
| FOXF2 | forkhead box F2 | -0.00753925 |
| ITGA8 | integrin, alpha 8 | -0.00748604 |
| MFAP4 | microfibrillar-associated protein 4 | -0.0074689 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.00744936 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.00740021 |
| ECM1 | extracellular matrix protein 1 | -0.00737996 |
| UPK1A | uroplakin 1A | -0.00731987 |
| GYPC | glycophorin C (Gerbich blood group) | -0.00731163 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00731039 |
| ITGA6 | integrin, alpha 6 | -0.00730304 |
| NPC2 | Niemann-Pick disease, type C2 | -0.00729292 |
| MCAM | melanoma cell adhesion molecule | -0.00728463 |
| IL18 | interleukin 18 | -0.00726084 |
| TRIM16 | tripartite motif containing 16 | -0.00724319 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.00724196 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00724033 |
| GPX1 | glutathione peroxidase 1 | -0.00722555 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.00721656 |
| MRPS2 | mitochondrial ribosomal protein S2 | -0.00718997 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.00717915 |
| SCP2 | sterol carrier protein 2 | -0.00717799 |
| SLC14A1 | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | -0.00716312 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00715264 |
| HLA-B | major histocompatibility complex, class I, B | -0.00712921 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.00712899 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | -0.0071231 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00709758 |
| CAPNS1 | calpain, small subunit 1 | -0.0070952 |
| RNASET2 | ribonuclease T2 | -0.00707014 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | -0.00701432 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.00700884 |
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | -0.00700139 |
| SPP1 | secreted phosphoprotein 1 | -0.00699598 |
| B2M | beta-2-microglobulin | -0.00698039 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 | -0.00694995 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 | -0.00694667 |
| STOM | stomatin | -0.00694041 |
| APOC3 | apolipoprotein C-III | -0.00693688 |
| UBB | ubiquitin B | -0.00692894 |
| PLTP | phospholipid transfer protein | -0.00692326 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00691703 |
| APOA1 | apolipoprotein A-I | -0.00690365 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.00690219 |
| PITX1 | paired-like homeodomain 1 | -0.00690082 |
| PSAP | prosaposin | -0.00689598 |
| ACLY | ATP citrate lyase | -0.0068928 |
| IL6 | interleukin 6 | -0.00688731 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00688128 |
| RGS5 | regulator of G-protein signaling 5 | -0.00688089 |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase | -0.00686063 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | -0.00685943 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.00685681 |
| CRCT1 | cysteine-rich C-terminal 1 | -0.00685499 |
| TFF1 | trefoil factor 1 | -0.0068517 |
| PRKD3 | protein kinase D3 | -0.00681398 |
| BMP2 | bone morphogenetic protein 2 | -0.00679979 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00678704 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -0.00675079 |
| GAS6 | growth arrest-specific 6 | -0.006739 |
| CCND2 | cyclin D2 | -0.00671249 |
| COL4A2 | collagen, type IV, alpha 2 | -0.00670863 |
| RBBP5 | retinoblastoma binding protein 5 | -0.0067071 |
| MALL | mal, T-cell differentiation protein-like | -0.00669541 |
| DIO2 | deiodinase, iodothyronine, type II | -0.00667485 |
| COL21A1 | collagen, type XXI, alpha 1 | -0.00666821 |
| RND3 | Rho family GTPase 3 | -0.00666335 |
| GSN | gelsolin | -0.00665672 |
| VPREB1 | pre-B lymphocyte 1 | -0.00665535 |
| TBX3 | T-box 3 | -0.00665502 |
| AQP4 | aquaporin 4 | -0.00665186 |
| KRT15 | keratin 15, type I | -0.00663324 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.00663078 |
| IL13RA2 | interleukin 13 receptor, alpha 2 | -0.00662506 |
| SELE | selectin E | -0.00662175 |
| ZNF586 | zinc finger protein 586 | -0.00661861 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00658565 |
| RTN4 | reticulon 4 | -0.00653471 |
| SSR4 | signal sequence receptor, delta | -0.0065298 |
| CLIP3 | CAP-GLY domain containing linker protein 3 | -0.00652431 |
| KIF5B | kinesin family member 5B | -0.00651914 |
| IRF1 | interferon regulatory factor 1 | -0.00651852 |
| GLTP | glycolipid transfer protein | -0.0065097 |
| APOB | apolipoprotein B | -0.00648941 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.00647056 |
| UBE2M | ubiquitin-conjugating enzyme E2M | -0.00645673 |
| CAV2 | caveolin 2 | -0.00645174 |
| PLAU | plasminogen activator, urokinase | -0.00644907 |
| PLPP3 | phospholipid phosphatase 3 | -0.00643802 |
| EFNA1 | ephrin-A1 | -0.00643289 |
| PLS1 | plastin 1 | -0.00642585 |
| AGR2 | anterior gradient 2 | -0.00642346 |
| AREG | amphiregulin | -0.00641104 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.00638767 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00637749 |
| CTTN | cortactin | -0.00637731 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0063728 |
| POLR2J2 | polymerase (RNA) II (DNA directed) polypeptide J2 | -0.00636956 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00635781 |
| DLX5 | distal-less homeobox 5 | -0.00635291 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00635122 |
| LAMB1 | laminin, beta 1 | -0.00634936 |
| RBM38 | RNA binding motif protein 38 | -0.00634916 |
| CANX | calnexin | -0.00634783 |
| YIPF5 | Yip1 domain family, member 5 | -0.00633972 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.0063381 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00633758 |
| ZYX | zyxin | -0.00633302 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00633248 |
| ELOB | elongin B | -0.00633054 |
| SLC6A15 | solute carrier family 6 (neutral amino acid transporter), member 15 | -0.00632634 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.00630942 |
| CLCA4 | chloride channel accessory 4 | -0.00630494 |
| HBE1 | hemoglobin, epsilon 1 | -0.00630182 |
| AKIRIN1 | akirin 1 | -0.00630165 |
| KRT17 | keratin 17, type I | -0.00629343 |
| EPHA3 | EPH receptor A3 | -0.00627739 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | -0.00626326 |
| NDNF | neuron-derived neurotrophic factor | -0.00626288 |
| REEP5 | receptor accessory protein 5 | -0.00623285 |
| CLDN15 | claudin 15 | -0.00622784 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | -0.00620662 |
| TGM3 | transglutaminase 3 | -0.00618903 |
| FAXDC2 | fatty acid hydroxylase domain containing 2 | -0.00618569 |
| RPS5 | ribosomal protein S5 | -0.00618431 |
| OAZ1 | ornithine decarboxylase antizyme 1 | -0.00618309 |
| RNF11 | ring finger protein 11 | -0.00617902 |
| CLCA2 | chloride channel accessory 2 | -0.00616942 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | -0.00616769 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00616414 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00615542 |
