CHEK2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description checkpoint kinase 2|In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 11200)
External Link http://www.ncbi.nlm.nih.gov/gene/11200
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81 interacting proteins for CHEK2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
APP amyloid beta (A4) precursor protein
ARHGAP1 Rho GTPase activating protein 1
ASF1A anti-silencing function 1A histone chaperone
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CHEK1 checkpoint kinase 1
CSNK2B casein kinase 2, beta polypeptide
CUL1 cullin 1
CUL4A cullin 4A
DAPK3 death-associated protein kinase 3
DBF4 DBF4 zinc finger
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
ELAVL1 ELAV like RNA binding protein 1
ERCC6 excision repair cross-complementation group 6
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HIST1H1C histone cluster 1, H1c
HNF4A hepatocyte nuclear factor 4, alpha
JPH1 junctophilin 1
KAT2B K(lysine) acetyltransferase 2B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LATS2 large tumor suppressor kinase 2
MAPT microtubule-associated protein tau
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MRC1 mannose receptor, C type 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MUS81 MUS81 structure-specific endonuclease subunit
NBN nibrin
NR4A1 nuclear receptor subfamily 4, group A, member 1
PER3 period circadian clock 3
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PML promyelocytic leukemia
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RAD50 RAD50 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RB1 retinoblastoma 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPS27A ribosomal protein S27a
SRPK1 SRSF protein kinase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38 serine/threonine kinase 38
STRAP serine/threonine kinase receptor associated protein
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TSSK1B testis-specific serine kinase 1B
TTK TTK protein kinase
UBC ubiquitin C
UBR5 ubiquitin protein ligase E3 component n-recognin 5
VCP valosin containing protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1