CHEK2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description checkpoint kinase 2|In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 11200)
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23 substrates of the kinase CHEK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
BDNF brain-derived neurotrophic factor
BRCA1 breast cancer 1, early onset
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDK11B cyclin-dependent kinase 11B
CHEK2 checkpoint kinase 2
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
ELAVL1 ELAV like RNA binding protein 1
FOXM1 forkhead box M1
HIST1H1C histone cluster 1, H1c
LATS2 large tumor suppressor kinase 2
MAPT microtubule-associated protein tau
MDM4 MDM4, p53 regulator
PML promyelocytic leukemia
RB1 retinoblastoma 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
TP53 tumor protein p53
TRIM28 tripartite motif containing 28
TTK TTK protein kinase
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1