CHK1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description checkpoint kinase 1|The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011] (NCBI Entrez Gene Database, 1111)
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100 substrates of the kinase CHK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
LCK LCK proto-oncogene, Src family tyrosine kinase
MFF mitochondrial fission factor
ZNF462 zinc finger protein 462
HOMER3 homer scaffolding protein 3
TRIM33 tripartite motif containing 33
E2F7 E2F transcription factor 7
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
ZFYVE9 zinc finger, FYVE domain containing 9
AKAP12 A kinase (PRKA) anchor protein 12
AKAP10 A kinase (PRKA) anchor protein 10
PARP8 poly (ADP-ribose) polymerase family, member 8
SBNO1 strawberry notch homolog 1 (Drosophila)
C19ORF26 chromosome 19 open reading frame 26
MACF1 microtubule-actin crosslinking factor 1
PRDM2 PR domain containing 2, with ZNF domain
KDM5C lysine (K)-specific demethylase 5C
TTC4 tetratricopeptide repeat domain 4
ACOT12 acyl-CoA thioesterase 12
TLK1 tousled-like kinase 1
ANKRD34A ankyrin repeat domain 34A
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
RPL27A ribosomal protein L27a
PLEC plectin
RBBP6 retinoblastoma binding protein 6
IQGAP3 IQ motif containing GTPase activating protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
SHROOM3 shroom family member 3
PROX1 prospero homeobox 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
UBE4B ubiquitination factor E4B
SCEL sciellin
NADK NAD kinase
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
NIN ninein (GSK3B interacting protein)
MSH2 mutS homolog 2
SASH3 SAM and SH3 domain containing 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
DOT1L DOT1-like histone H3K79 methyltransferase
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
CLIP1 CAP-GLY domain containing linker protein 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
MSX2 msh homeobox 2
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
RABEP1 rabaptin, RAB GTPase binding effector protein 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
NAV1 neuron navigator 1
PDE4A phosphodiesterase 4A, cAMP-specific
NSRP1 nuclear speckle splicing regulatory protein 1
DRD3 dopamine receptor D3
BUD13 BUD13 homolog (S. cerevisiae)
JAKMIP2 janus kinase and microtubule interacting protein 2
JAKMIP1 janus kinase and microtubule interacting protein 1
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
SNTA1 syntrophin, alpha 1
TESPA1 thymocyte expressed, positive selection associated 1
TRAPPC10 trafficking protein particle complex 10
LOC285556 uncharacterized LOC285556
RSBN1 round spermatid basic protein 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
TIPE2 TNF alpha induced protein 8 like 2
ZNF84 zinc finger protein 84
SORBS2 sorbin and SH3 domain containing 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
DPH7 diphthamide biosynthesis 7
NCOA7 nuclear receptor coactivator 7
XIRP1 xin actin binding repeat containing 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
CEP112 centrosomal protein 112kDa
DST dystonin
ARHGAP23 Rho GTPase activating protein 23
ZBTB35 zinc finger and BTB domain containing 35
PARD3B par-3 family cell polarity regulator beta
DMWD dystrophia myotonica, WD repeat containing
PXK PX domain containing serine/threonine kinase
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
MED1 mediator complex subunit 1
R3HDM1 R3H domain containing 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
PPP4R4 protein phosphatase 4, regulatory subunit 4
PFAS phosphoribosylformylglycinamidine synthase
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
AGO2 argonaute RISC catalytic component 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
CTNND2 catenin (cadherin-associated protein), delta 2
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTPN7 protein tyrosine phosphatase, non-receptor type 7
UBR4 ubiquitin protein ligase E3 component n-recognin 4
MAP3K3 mitogen-activated protein kinase kinase kinase 3