CHK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description checkpoint kinase 2|In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 11200)
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100 substrates of the kinase CHK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
CDK13 cyclin-dependent kinase 13
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
NCOR1 nuclear receptor corepressor 1
OSBPL5 oxysterol binding protein-like 5
FAM65B family with sequence similarity 65, member B
CABLES1 Cdk5 and Abl enzyme substrate 1
CASP9 caspase 9, apoptosis-related cysteine peptidase
RUNDC3A RUN domain containing 3A
TNNI3 troponin I type 3 (cardiac)
SON SON DNA binding protein
PVRL4 poliovirus receptor-related 4
MYD88 myeloid differentiation primary response 88
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRA2A transformer 2 alpha homolog (Drosophila)
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
TBC1D4 TBC1 domain family, member 4
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
SPEG SPEG complex locus
UBE2O ubiquitin-conjugating enzyme E2O
LEMD2 LEM domain containing 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
GANAB glucosidase, alpha; neutral AB
ATF1 activating transcription factor 1
EPS8L1 EPS8-like 1
PRICKLE3 prickle homolog 3 (Drosophila)
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
RPL15 ribosomal protein L15
MYOF myoferlin
RASAL3 RAS protein activator like 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
DLC1 DLC1 Rho GTPase activating protein
MTMR10 myotubularin related protein 10
IQGAP3 IQ motif containing GTPase activating protein 3
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
S1PR1 sphingosine-1-phosphate receptor 1
DEPDC5 DEP domain containing 5
MEX3C mex-3 RNA binding family member C
C11ORF30 chromosome 11 open reading frame 30
EGFR epidermal growth factor receptor
WDR81 WD repeat domain 81
BAHD1 bromo adjacent homology domain containing 1
GCLM glutamate-cysteine ligase, modifier subunit
SOX9 SRY (sex determining region Y)-box 9
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
SRSF2 serine/arginine-rich splicing factor 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
AKAP5 A kinase (PRKA) anchor protein 5
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
PHACTR4 phosphatase and actin regulator 4
RARA retinoic acid receptor, alpha
CASC5 cancer susceptibility candidate 5
GRK7 G protein-coupled receptor kinase 7
DAPK3 death-associated protein kinase 3
MAP3K11 mitogen-activated protein kinase kinase kinase 11
RARG retinoic acid receptor, gamma
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
CDR2L cerebellar degeneration-related protein 2-like
SRRM2 serine/arginine repetitive matrix 2
ARHGAP23 Rho GTPase activating protein 23
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
ANKRD33B ankyrin repeat domain 33B
CHERP calcium homeostasis endoplasmic reticulum protein
PHACTR2 phosphatase and actin regulator 2
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN14 protein tyrosine phosphatase, non-receptor type 14
LPAR1 lysophosphatidic acid receptor 1
KIAA1522 KIAA1522
CEP128 centrosomal protein 128kDa
NUMBL numb homolog (Drosophila)-like
PDE7A phosphodiesterase 7A
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
CDCA2 cell division cycle associated 2
KCNK9 potassium channel, two pore domain subfamily K, member 9
MORC3 MORC family CW-type zinc finger 3
WNK4 WNK lysine deficient protein kinase 4
SUCO SUN domain containing ossification factor
FXYD1 FXYD domain containing ion transport regulator 1
TWIST1 twist family bHLH transcription factor 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
DCLRE1C DNA cross-link repair 1C
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
CREB1 cAMP responsive element binding protein 1
LARP4B La ribonucleoprotein domain family, member 4B
NUMB numb homolog (Drosophila)
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
PPP1R3D protein phosphatase 1, regulatory subunit 3D
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
CLK2 CDC-like kinase 2
INCENP inner centromere protein antigens 135/155kDa
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NCAPH non-SMC condensin I complex, subunit H
TRPM2 transient receptor potential cation channel, subfamily M, member 2
LIMK2 LIM domain kinase 2
DGAT1 diacylglycerol O-acyltransferase 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
PPP1R3G protein phosphatase 1, regulatory subunit 3G
RASSF1 Ras association (RalGDS/AF-6) domain family member 1