CHLOROTHIAZIDE Gene Set

Dataset	DGIdb Drug Targets 2026
Category	physical interactions
Type	drug
Description	4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. (Chemical Entities of Biological Interest Ontology, CHEBI_3640)
External Link	https://dgidb.org/results?searchType=drug&searchTerms=CHLOROTHIAZIDE
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Genes

6 interacting proteins for the CHLOROTHIAZIDE drug from theDGIdb Drug Targets 2026 dataset.

Symbol	Name	Standardized Value
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	8.822
SLC12A3	solute carrier family 12 (sodium/chloride transporter), member 3	1.96044
CA4	carbonic anhydrase IV	1.26029
CA2	carbonic anhydrase II	0.802
CA1	carbonic anhydrase I	0.490111
KCNMA1	potassium channel, calcium activated large conductance subfamily M alpha, member 1	0.215171