| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cholinergic receptor, nicotinic, alpha 2 (neuronal)|Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009] (NCBI Entrez Gene Database, 1135) |
| External Link | https://ncbi.nlm.nih.gov/gene/1135 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the CHRNA2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0149434 |
| ATF3 | activating transcription factor 3 | 0.0116383 |
| HOPX | HOP homeobox | 0.0116282 |
| TSPAN8 | tetraspanin 8 | 0.011552 |
| GNAS | GNAS complex locus | 0.0113102 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0106836 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.0105753 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.0105275 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00999936 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | 0.00990736 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00959157 |
| GPC3 | glypican 3 | 0.00938597 |
| SST | somatostatin | 0.00936359 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.00921786 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00916521 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.0089654 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.00886635 |
| INHBB | inhibin, beta B | 0.00869828 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.00860677 |
| TMEM14B | transmembrane protein 14B | 0.00845987 |
| KRT10 | keratin 10, type I | 0.00840611 |
| CNPY3 | canopy FGF signaling regulator 3 | 0.00833413 |
| CA2 | carbonic anhydrase II | 0.00791619 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0079007 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.00788611 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00772175 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.00758653 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.00750727 |
| CLEC2B | C-type lectin domain family 2, member B | 0.00747309 |
| CPE | carboxypeptidase E | 0.00746614 |
| NMU | neuromedin U | 0.00738028 |
| HBB | hemoglobin, beta | 0.00736802 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00733532 |
| S100A10 | S100 calcium binding protein A10 | 0.00732869 |
| KRT17 | keratin 17, type I | 0.00730878 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00727667 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.00725939 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | 0.00724828 |
| HNMT | histamine N-methyltransferase | 0.00720887 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00702939 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.00690327 |
| HAL | histidine ammonia-lyase | 0.00685514 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | 0.00683383 |
| TGFB3 | transforming growth factor, beta 3 | 0.00679362 |
| CP | ceruloplasmin (ferroxidase) | 0.00677135 |
| PLK1 | polo-like kinase 1 | 0.00675075 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.00674888 |
| KRT1 | keratin 1, type II | 0.00674098 |
| CHPT1 | choline phosphotransferase 1 | 0.00672943 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.00670685 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00666 |
| LUM | lumican | 0.00664112 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.00660117 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.0066009 |
| GTF3A | general transcription factor IIIA | 0.00656468 |
| ATP5F1C | ATP synthase F1 subunit gamma | 0.00653802 |
| GMFG | glia maturation factor, gamma | 0.0065377 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00652784 |
| ASS1 | argininosuccinate synthase 1 | 0.00652666 |
| GUK1 | guanylate kinase 1 | 0.0065218 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | 0.00651446 |
| CD52 | CD52 molecule | 0.00648024 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.00645375 |
| DSP | desmoplakin | 0.00644506 |
| THBD | thrombomodulin | 0.00643836 |
| HINT1 | histidine triad nucleotide binding protein 1 | 0.00642573 |
| C6ORF48 | chromosome 6 open reading frame 48 | 0.00638896 |
| EVI2A | ecotropic viral integration site 2A | 0.00638376 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.00637546 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.0063244 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 0.00630863 |
| RGCC | regulator of cell cycle | 0.00630042 |
| GLO1 | glyoxalase I | 0.00627588 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00627321 |
| ANOS1 | anosmin 1 | 0.00625626 |
| TMSB15A | thymosin beta 15a | 0.00623655 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.00623096 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00621932 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | 0.00619303 |
| VAMP5 | vesicle-associated membrane protein 5 | 0.00617676 |
| MMD | monocyte to macrophage differentiation-associated | 0.00615998 |
| DEFB1 | defensin, beta 1 | 0.00615839 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.0061293 |
| AFP | alpha-fetoprotein | 0.00611852 |
| RPA3 | replication protein A3, 14kDa | 0.00611539 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.00610027 |
| MAT2B | methionine adenosyltransferase II, beta | 0.00609622 |
| C4BPB | complement component 4 binding protein, beta | 0.00609065 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.00607707 |
| LAGE3 | L antigen family, member 3 | 0.00603202 |
| SLC38A2 | solute carrier family 38, member 2 | 0.00601498 |
| AHSG | alpha-2-HS-glycoprotein | 0.00600182 |
| ODC1 | ornithine decarboxylase 1 | 0.00599985 |
| SAR1B | secretion associated, Ras related GTPase 1B | 0.00599479 |
| C4BPA | complement component 4 binding protein, alpha | 0.00597638 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.00597566 |
| SKP1 | S-phase kinase-associated protein 1 | 0.00592903 |
| CHMP5 | charged multivesicular body protein 5 | 0.00592558 |
| PRDX6 | peroxiredoxin 6 | 0.00591125 |
| CFI | complement factor I | 0.00590028 |
| FABP7 | fatty acid binding protein 7, brain | 0.0058811 |
| CCK | cholecystokinin | 0.00584932 |
| YME1L1 | YME1-like 1 ATPase | 0.00584734 |
| YIF1A | Yip1 interacting factor homolog A (S. cerevisiae) | 0.00582325 |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 | 0.00580393 |
| IL1RN | interleukin 1 receptor antagonist | 0.00580005 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00579537 |
| PAM16 | presequence translocase-associated motor 16 homolog (S. cerevisiae) | 0.00578462 |
| CDK1 | cyclin-dependent kinase 1 | 0.00578036 |
| PPA1 | pyrophosphatase (inorganic) 1 | 0.00578034 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.00577629 |
| GRP | gastrin-releasing peptide | 0.00576767 |
| TFRC | transferrin receptor | 0.00574934 |
| RPN2 | ribophorin II | 0.00573112 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.00573031 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.00572067 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.0057141 |
| EMP2 | epithelial membrane protein 2 | 0.00570622 |
| SLC25A15 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | 0.00569836 |
| CCNI | cyclin I | 0.00569207 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00569175 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.00568098 |
| TTC1 | tetratricopeptide repeat domain 1 | 0.00566163 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.00565654 |
| SKIV2L | superkiller viralicidic activity 2-like (S. cerevisiae) | 0.00565632 |
| CD53 | CD53 molecule | 0.00565373 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | 0.00564459 |
| RPL26L1 | ribosomal protein L26-like 1 | 0.00563077 |
| S100A2 | S100 calcium binding protein A2 | 0.00562899 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00562294 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.00560779 |
| ORMDL2 | ORMDL sphingolipid biosynthesis regulator 2 | 0.00558672 |
| MREG | melanoregulin | 0.00558415 |
| MED28 | mediator complex subunit 28 | 0.00557037 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00556798 |
| KLK7 | kallikrein-related peptidase 7 | 0.00556273 |
| METTL5 | methyltransferase like 5 | 0.00556003 |
| PEX2 | peroxisomal biogenesis factor 2 | 0.00555632 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00554966 |
| AK4 | adenylate kinase 4 | 0.00554262 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.00553074 |
| NDUFB6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | 0.00552639 |
| SCEL | sciellin | 0.00552543 |
| LYRM4 | LYR motif containing 4 | 0.00551844 |
| KLK11 | kallikrein-related peptidase 11 | 0.0055107 |
| ERGIC2 | ERGIC and golgi 2 | 0.0055105 |
| NELFE | negative elongation factor complex member E | 0.00550896 |
| APOA1 | apolipoprotein A-I | 0.00550103 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00549725 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 0.00548986 |
| COMMD3 | COMM domain containing 3 | 0.00548342 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00548145 |
| MRPL19 | mitochondrial ribosomal protein L19 | 0.00547351 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00547245 |
| POLR2G | polymerase (RNA) II (DNA directed) polypeptide G | 0.00547185 |
| MRPS16 | mitochondrial ribosomal protein S16 | 0.00546164 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 0.00546111 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00545735 |
| GDI2 | GDP dissociation inhibitor 2 | 0.00544519 |
| MRPS18B | mitochondrial ribosomal protein S18B | 0.00544294 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.005414 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.00539487 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | 0.00538515 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | 0.00537812 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.00537708 |
| GTF2H5 | general transcription factor IIH, polypeptide 5 | 0.00536553 |
| MRPL57 | mitochondrial ribosomal protein L57 | 0.00536508 |
| COMMD10 | COMM domain containing 10 | 0.00534899 |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.00534274 |
| CSNK2B | casein kinase 2, beta polypeptide | 0.00534063 |
| ADGRG2 | adhesion G protein-coupled receptor G2 | 0.00533046 |
| MRPS33 | mitochondrial ribosomal protein S33 | 0.00532868 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 0.00532734 |
| LDHA | lactate dehydrogenase A | 0.00532081 |
| CDCA4 | cell division cycle associated 4 | 0.00532071 |
| THYN1 | thymocyte nuclear protein 1 | 0.00531528 |
| RER1 | retention in endoplasmic reticulum sorting receptor 1 | 0.00530682 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | 0.00529124 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00529056 |
| NIBAN1 | niban apoptosis regulator 1 | 0.00528981 |
| LY96 | lymphocyte antigen 96 | 0.00528891 |
| MAL | mal, T-cell differentiation protein | 0.00528353 |
| NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | 0.00527715 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00527058 |
| TYRP1 | tyrosinase-related protein 1 | 0.00526941 |
| ERGIC3 | ERGIC and golgi 3 | 0.00525496 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00523533 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | 0.00523475 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.00522862 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 0.00521906 |
| PLIN2 | perilipin 2 | 0.00521367 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 0.00521016 |
| MECOM | MDS1 and EVI1 complex locus | 0.00520888 |
| H2AFV | H2A histone family, member V | 0.00519468 |
| PSMD8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 0.00519436 |
| BTG3 | BTG family, member 3 | 0.00519278 |
| RANBP9 | RAN binding protein 9 | 0.005192 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.00518288 |
| NIF3L1 | NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) | 0.00516 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.00514701 |
| GPX3 | glutathione peroxidase 3 | 0.00514357 |
| WDR61 | WD repeat domain 61 | 0.00514263 |
| MARCHF5 | membrane associated ring-CH-type finger 5 | 0.00514214 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0051393 |
| VNN2 | vanin 2 | 0.00512359 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00512243 |
| MGMT | O-6-methylguanine-DNA methyltransferase | 0.0050931 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00508352 |
| TMEM126B | transmembrane protein 126B | 0.00508351 |
| PRDX2 | peroxiredoxin 2 | 0.00508232 |
| FAM162A | family with sequence similarity 162, member A | 0.00507709 |
| ASPH | aspartate beta-hydroxylase | 0.00507575 |
| APOA2 | apolipoprotein A-II | 0.00507448 |
| ADI1 | acireductone dioxygenase 1 | 0.00507116 |
| RPP30 | ribonuclease P/MRP 30kDa subunit | 0.00506735 |
| CDC123 | cell division cycle 123 | 0.00504463 |
| SRM | spermidine synthase | 0.00502818 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0050201 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.00501675 |
| HOMER2 | homer scaffolding protein 2 | 0.00500555 |
| DUSP22 | dual specificity phosphatase 22 | 0.00499783 |
| KRT16 | keratin 16, type I | 0.0049922 |
| RPP40 | ribonuclease P/MRP 40kDa subunit | 0.0049903 |
| SSR1 | signal sequence receptor, alpha | 0.0049886 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.00498809 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 0.00498663 |
| RBBP4 | retinoblastoma binding protein 4 | 0.00498503 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.00498127 |
| IFI44L | interferon-induced protein 44-like | 0.00498092 |
| NEK7 | NIMA-related kinase 7 | 0.0049777 |
| ZNF395 | zinc finger protein 395 | 0.00497748 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 0.00497208 |
| ATRAID | all-trans retinoic acid-induced differentiation factor | 0.00496516 |
| DSG1 | desmoglein 1 | 0.00496507 |
| NRN1 | neuritin 1 | 0.00496279 |
| TMEM33 | transmembrane protein 33 | 0.00495373 |
| LMBRD1 | LMBR1 domain containing 1 | 0.00495235 |
| NDUFB3 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | 0.00495061 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | 0.00493324 |
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | 0.00493089 |
| MOCOS | molybdenum cofactor sulfurase | 0.00491114 |
| PKP1 | plakophilin 1 | 0.00488667 |
| MCTS1 | malignant T cell amplified sequence 1 | 0.00488457 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A | 0.00487763 |
| LYRM2 | LYR motif containing 2 | 0.00487681 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.00487477 |
| CPB2 | carboxypeptidase B2 (plasma) | 0.00487045 |
| RAB5IF | RAB5 interacting factor | 0.00486124 |
| REEP5 | receptor accessory protein 5 | 0.00484892 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.00484853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SFRP1 | secreted frizzled-related protein 1 | -0.0103882 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00996853 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.00996051 |
| METRN | meteorin, glial cell differentiation regulator | -0.0096022 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | -0.0092293 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00915613 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -0.00885881 |
| GOLGA8H | golgin A8 family, member H | -0.00882245 |
| XYLT1 | xylosyltransferase I | -0.00881944 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0087576 |
| SIRPA | signal-regulatory protein alpha | -0.00843808 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.00830414 |
| XIC | X chromosome inactivation center | -0.0082565 |
| PTK2B | protein tyrosine kinase 2 beta | -0.0082361 |
| ANKRD10 | ankyrin repeat domain 10 | -0.00822964 |
| JMJD6 | jumonji domain containing 6 | -0.00814803 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0081469 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0080325 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.00795903 |
| CTBP2 | C-terminal binding protein 2 | -0.00793503 |
| HIP1 | huntingtin interacting protein 1 | -0.00785667 |
| GOLGA8A | golgin A8 family, member A | -0.00770502 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0076947 |
| OLFM4 | olfactomedin 4 | -0.00768959 |
| CD9 | CD9 molecule | -0.00757214 |
| OAT | ornithine aminotransferase | -0.00747574 |
| APOD | apolipoprotein D | -0.00747201 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00742732 |
| SMAD7 | SMAD family member 7 | -0.00738319 |
| PLAU | plasminogen activator, urokinase | -0.00735155 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00733502 |
| DGKZ | diacylglycerol kinase, zeta | -0.00733149 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.00724386 |
| AZU1 | azurocidin 1 | -0.00722444 |
| MXRA7 | matrix-remodelling associated 7 | -0.00719857 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00711406 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00708437 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00704948 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.00693789 |
| CALB1 | calbindin 1, 28kDa | -0.00693548 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00687072 |
| KIAA0930 | KIAA0930 | -0.00682537 |
| SPATA20 | spermatogenesis associated 20 | -0.00671056 |
| TLE4 | transducin-like enhancer of split 4 | -0.00670238 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.00664945 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00664623 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00649552 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00647633 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00647039 |
| EOGT | EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase | -0.00646448 |
| CD44 | CD44 molecule (Indian blood group) | -0.0063477 |
| ELANE | elastase, neutrophil expressed | -0.00631389 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | -0.00631112 |
| FBN2 | fibrillin 2 | -0.00630079 |
| HOXC6 | homeobox C6 | -0.00629787 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.00629289 |
| ISYNA1 | inositol-3-phosphate synthase 1 | -0.00628775 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.00628231 |
| MEIS2 | Meis homeobox 2 | -0.00625673 |
| RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | -0.00623975 |
| NKG7 | natural killer cell granule protein 7 | -0.00622896 |
| HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | -0.00620923 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00619188 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.00613413 |
| TFF1 | trefoil factor 1 | -0.00611575 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.00610262 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.00607403 |
| IPO13 | importin 13 | -0.00605966 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.00605473 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.00603342 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00602495 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00602352 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -0.00598101 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0059443 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.00592629 |
| SMTN | smoothelin | -0.00591579 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | -0.00590701 |
| GALC | galactosylceramidase | -0.00588333 |
| EHD3 | EH-domain containing 3 | -0.0058671 |
| DOCK10 | dedicator of cytokinesis 10 | -0.00586598 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.00584984 |
| PILRB | paired immunoglobin-like type 2 receptor beta | -0.00584647 |
| COL9A2 | collagen, type IX, alpha 2 | -0.00584135 |
| PDZD8 | PDZ domain containing 8 | -0.00582351 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | -0.00582096 |
| AOC1 | amine oxidase, copper containing 1 | -0.00580611 |
| EPS8L2 | EPS8-like 2 | -0.00579902 |
| NOTCH1 | notch 1 | -0.0057857 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | -0.00574976 |
| SCPEP1 | serine carboxypeptidase 1 | -0.00573999 |
| TGM2 | transglutaminase 2 | -0.00573849 |
| RAB40B | RAB40B, member RAS oncogene family | -0.00572942 |
| TSPAN1 | tetraspanin 1 | -0.00572935 |
| MYO5C | myosin VC | -0.00572426 |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | -0.00570882 |
| HIP1R | huntingtin interacting protein 1 related | -0.00570637 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.00565457 |
| PENK | proenkephalin | -0.00563076 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00561083 |
| ELAPOR1 | endosome-lysosome associated apoptosis and autophagy regulator 1 | -0.00558719 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.00558393 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | -0.00557838 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.00557766 |
| MSN | moesin | -0.00557161 |
| RALGDS | ral guanine nucleotide dissociation stimulator | -0.00557113 |
| EFHD2 | EF-hand domain family, member D2 | -0.0055591 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.00554094 |
| CA12 | carbonic anhydrase XII | -0.00553839 |
| MMP1 | matrix metallopeptidase 1 | -0.00552851 |
| RNASE3 | ribonuclease, RNase A family, 3 | -0.00552703 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | -0.00551831 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | -0.00550092 |
| HCLS1 | hematopoietic cell-specific Lyn substrate 1 | -0.00548842 |
| CHD8 | chromodomain helicase DNA binding protein 8 | -0.0054675 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.00546242 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00545171 |
| P2RX5 | purinergic receptor P2X, ligand gated ion channel, 5 | -0.00545026 |
| HOMER3 | homer scaffolding protein 3 | -0.00543394 |
| MLEC | malectin | -0.00542748 |
| AGR2 | anterior gradient 2 | -0.00542743 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00542396 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | -0.00541168 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.00539607 |
| NFASC | neurofascin | -0.0053919 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.00538888 |
| PLXNB1 | plexin B1 | -0.0053543 |
| MID1 | midline 1 | -0.00530271 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00529503 |
| DPEP1 | dipeptidase 1 (renal) | -0.00529108 |
| ROGDI | rogdi homolog (Drosophila) | -0.00528008 |
| MT1X | metallothionein 1X | -0.00527917 |
| SPAG1 | sperm associated antigen 1 | -0.00527816 |
| PLCB4 | phospholipase C, beta 4 | -0.00526818 |
| RRBP1 | ribosome binding protein 1 | -0.0052678 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.00526605 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00526271 |
| TSPYL4 | TSPY-like 4 | -0.00522186 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.00521671 |
| PLPP3 | phospholipid phosphatase 3 | -0.00521566 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | -0.005214 |
| DMPK | dystrophia myotonica-protein kinase | -0.00520799 |
| RHOB | ras homolog family member B | -0.00519876 |
| NDRG1 | N-myc downstream regulated 1 | -0.00518257 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | -0.00517462 |
| SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | -0.00517365 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00515983 |
| CTSZ | cathepsin Z | -0.00514418 |
| SNX7 | sorting nexin 7 | -0.00514124 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00513757 |
| USP47 | ubiquitin specific peptidase 47 | -0.00513214 |
| HIRA | histone cell cycle regulator | -0.00512935 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | -0.00510979 |
| CTSW | cathepsin W | -0.00503075 |
| BCR | breakpoint cluster region | -0.00501923 |
| MAP7 | microtubule-associated protein 7 | -0.0050158 |
| PIGB | phosphatidylinositol glycan anchor biosynthesis, class B | -0.00500521 |
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | -0.00499487 |
| DMXL2 | Dmx-like 2 | -0.00497966 |
| LAMB1 | laminin, beta 1 | -0.00497596 |
| CD81 | CD81 molecule | -0.00496489 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.004954 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.00492895 |
| ZNF12 | zinc finger protein 12 | -0.00491709 |
| GATAD2A | GATA zinc finger domain containing 2A | -0.0049166 |
| CTSD | cathepsin D | -0.0049143 |
| BMP4 | bone morphogenetic protein 4 | -0.0048865 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00488276 |
| TRRAP | transformation/transcription domain-associated protein | -0.00486946 |
| RNF19B | ring finger protein 19B | -0.00486492 |
| ITGA8 | integrin, alpha 8 | -0.00486485 |
| REG1A | regenerating islet-derived 1 alpha | -0.00485618 |
| HGSNAT | heparan-alpha-glucosaminide N-acetyltransferase | -0.00485257 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -0.00485191 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0048468 |
| ZZEF1 | zinc finger, ZZ-type with EF-hand domain 1 | -0.00484495 |
| PRTN3 | proteinase 3 | -0.0048419 |
| ADAM22 | ADAM metallopeptidase domain 22 | -0.00483141 |
| FZD2 | frizzled class receptor 2 | -0.0048169 |
| PNMA8A | PNMA family member 8A | -0.00481181 |
| MED22 | mediator complex subunit 22 | -0.0048007 |
| FHOD3 | formin homology 2 domain containing 3 | -0.00479654 |
| TOB2 | transducer of ERBB2, 2 | -0.00479196 |
| LOC283683 | uncharacterized LOC283683 | -0.00479175 |
| CCDC81 | coiled-coil domain containing 81 | -0.00479063 |
| CALML4 | calmodulin-like 4 | -0.00478736 |
| POSTN | periostin, osteoblast specific factor | -0.00478478 |
| POU2AF1 | POU class 2 associating factor 1 | -0.00477979 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.00477188 |
| ZNF264 | zinc finger protein 264 | -0.00476529 |
| TGFA | transforming growth factor, alpha | -0.00476337 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | -0.00476287 |
| PKD2 | polycystic kidney disease 2 (autosomal dominant) | -0.00476135 |
| MAMLD1 | mastermind-like domain containing 1 | -0.00475877 |
| MLPH | melanophilin | -0.00475801 |
| PDZK1 | PDZ domain containing 1 | -0.00475156 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.00473974 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.00473111 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.00473096 |
| S100A11 | S100 calcium binding protein A11 | -0.00472725 |
| GSDME | gasdermin E | -0.00472231 |
| STK38 | serine/threonine kinase 38 | -0.0047208 |
| JAG1 | jagged 1 | -0.00471643 |
| PHYH | phytanoyl-CoA 2-hydroxylase | -0.00470623 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.00470497 |
| MICALL2 | MICAL-like 2 | -0.00470308 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00469079 |
| PDE4DIP | phosphodiesterase 4D interacting protein | -0.00468995 |
| SACS | sacsin molecular chaperone | -0.00468324 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.00468102 |
| TTC37 | tetratricopeptide repeat domain 37 | -0.00467567 |
| MTCL1 | microtubule crosslinking factor 1 | -0.00467488 |
| CAVIN1 | caveolae associated protein 1 | -0.00467218 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00466944 |
| FRY | furry homolog (Drosophila) | -0.00466825 |
| KIAA1109 | KIAA1109 | -0.00466277 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00465925 |
| EXOC7 | exocyst complex component 7 | -0.00465608 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.00465269 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00465057 |
| SLC35D1 | solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 | -0.00465048 |
| MBTPS1 | membrane-bound transcription factor peptidase, site 1 | -0.00464224 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.00463257 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00463112 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.00462962 |
| DLD | dihydrolipoamide dehydrogenase | -0.0046278 |
| DSE | dermatan sulfate epimerase | -0.0046216 |
| RPIA | ribose 5-phosphate isomerase A | -0.00462096 |
| AKAP8L | A kinase (PRKA) anchor protein 8-like | -0.00461978 |
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | -0.00461619 |
| SCG5 | secretogranin V | -0.00460296 |
| NCOR1 | nuclear receptor corepressor 1 | -0.00458936 |
| TPM2 | tropomyosin 2 (beta) | -0.00458683 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.00458215 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.00456582 |
| RAB8A | RAB8A, member RAS oncogene family | -0.00456461 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | -0.00456283 |
| CUX1 | cut-like homeobox 1 | -0.00456072 |
| ZNF331 | zinc finger protein 331 | -0.00455853 |
| S100A4 | S100 calcium binding protein A4 | -0.00454668 |
| MAGED1 | melanoma antigen family D1 | -0.00454402 |
| HOXC10 | homeobox C10 | -0.00454201 |
| PCP4 | Purkinje cell protein 4 | -0.00453265 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00451763 |
| INHBA | inhibin, beta A | -0.00451757 |
| JAK1 | Janus kinase 1 | -0.00451443 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0045129 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | -0.0045109 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.00450954 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0045075 |
| USP24 | ubiquitin specific peptidase 24 | -0.00450417 |
