CHUK Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description conserved helix-loop-helix ubiquitous kinase|This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1147)
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Genes

321 genes differentially expressed following the CHUK gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MC4R melanocortin 4 receptor 3.93533
IRX4 iroquois homeobox 4 3.93533
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.93533
PRDM7 PR domain containing 7 3.93533
STARD6 StAR-related lipid transfer (START) domain containing 6 3.93533
KLK6 kallikrein-related peptidase 6 3.93533
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.93533
CCDC38 coiled-coil domain containing 38 3.93533
PITX2 paired-like homeodomain 2 3.93533
RORC RAR-related orphan receptor C 3.93533
HKDC1 hexokinase domain containing 1 3.93533
PCDHB6 protocadherin beta 6 3.93533
CD28 CD28 molecule 3.93533
FMO2 flavin containing monooxygenase 2 (non-functional) 3.93533
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.93533
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 3.93533
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 3.93533
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.93533
TWIST1 twist family bHLH transcription factor 1 3.93533
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.93528
TAS2R1 taste receptor, type 2, member 1 3.93528
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 3.93528
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.93528
SPAG8 sperm associated antigen 8 3.93528
PKP1 plakophilin 1 3.93528
PCDHB8 protocadherin beta 8 3.93528
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 3.93528
DNASE1L3 deoxyribonuclease I-like 3 3.93528
MAGEB2 melanoma antigen family B2 3.93528
PRELP proline/arginine-rich end leucine-rich repeat protein 3.93528
DUXB double homeobox B 3.93528
LIPN lipase, family member N 3.93528
C11ORF87 chromosome 11 open reading frame 87 3.93528
THRSP thyroid hormone responsive 3.93528
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.93528
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 3.93528
TAS2R10 taste receptor, type 2, member 10 3.93528
CPLX4 complexin 4 3.93528
C2ORF78 chromosome 2 open reading frame 78 3.93528
SPACA5 sperm acrosome associated 5 3.93528
TAS2R13 taste receptor, type 2, member 13 3.93528
RFX6 regulatory factor X, 6 3.93528
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.93528
EVPL envoplakin 3.93528
GNRH2 gonadotropin-releasing hormone 2 3.93528
IL18R1 interleukin 18 receptor 1 3.93528
ANKK1 ankyrin repeat and kinase domain containing 1 3.93528
SMIM5 small integral membrane protein 5 3.93528
LCN12 lipocalin 12 3.93528
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.93528
SIGLECL1 SIGLEC family like 1 3.93528
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.93528
ENAM enamelin 3.93528
C10ORF53 chromosome 10 open reading frame 53 3.93528
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.93528
CLEC6A C-type lectin domain family 6, member A 3.93528
PXDC1 PX domain containing 1 3.93528
GDF6 growth differentiation factor 6 3.93528
FGFBP2 fibroblast growth factor binding protein 2 3.93528
S100G S100 calcium binding protein G 3.93528
TCF23 transcription factor 23 3.93528
H1-6 H1.6 linker histone, cluster member 3.93528
ALPG alkaline phosphatase, germ cell 3.93528
CIMIP2B ciliary microtubule inner protein 2B 3.93528
EPCIP exosomal polycystin 1 interacting protein 3.93528
H2AC19 H2A clustered histone 19 3.93528
PEAK3 PEAK family member 3 3.93528
ACP4 acid phosphatase 4 3.93528
MEIOSIN meiosis initiator 3.93528
DIPK2B divergent protein kinase domain 2B 3.93528
GK3 glycerol kinase 3 3.93528
TBX3 T-box 3 3.93528
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 3.93528
MEP1B meprin A, beta 3.93528
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.93528
CCDC116 coiled-coil domain containing 116 3.93528
TMPRSS11F transmembrane protease, serine 11F 3.93528
TMPRSS11B transmembrane protease, serine 11B 3.93528
MYO7B myosin VIIB 3.93528
FGF21 fibroblast growth factor 21 3.93528
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.93528
TBX21 T-box 21 3.93528
LOC390937 Ets2 repressor factor-like 3.93528
TLR4 toll-like receptor 4 3.93528
TLR7 toll-like receptor 7 3.93528
MSX1 msh homeobox 1 3.93528
ANXA10 annexin A10 3.93528
TRIM60 tripartite motif containing 60 3.93528
CLDN2 claudin 2 3.93528
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.93528
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.93528
DRC11L dynein regulatory complex subunit 11 like 3.93528
WFDC6 WAP four-disulfide core domain 6 3.93528
NPPA natriuretic peptide A 3.93528
EPGN epithelial mitogen 3.93528
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 3.93528
SMIM22 small integral membrane protein 22 3.93528
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 3.93528
TG thyroglobulin 3.93528
NPBWR1 neuropeptides B/W receptor 1 3.93528
NUTM2A NUT family member 2A 3.93528
SCN3A sodium channel, voltage gated, type III alpha subunit 3.93528
CALML6 calmodulin-like 6 3.93528
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.93528
RHAG Rh-associated glycoprotein 3.93528
IL10RA interleukin 10 receptor, alpha 3.93528
ENDOU endonuclease, polyU-specific 3.93528
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.93528
TRIM50 tripartite motif containing 50 3.93528
KCTD21 potassium channel tetramerization domain containing 21 3.93528
CXCR6 chemokine (C-X-C motif) receptor 6 3.93528
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.93528
CST4 cystatin S 3.93528
RGSL1 regulator of G-protein signaling like 1 3.93528
PCDHGA3 protocadherin gamma subfamily A, 3 3.93528
MUC17 mucin 17, cell surface associated 3.93528
CHI3L2 chitinase 3-like 2 3.93528
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.93528
AKR1B15 aldo-keto reductase family 1, member B15 3.93528
TMEM132D transmembrane protein 132D 3.93528
FNDC8 fibronectin type III domain containing 8 3.93528
PRTN3 proteinase 3 3.93528
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 3.93528
CNGB1 cyclic nucleotide gated channel beta 1 3.93528
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.93528
RBP4 retinol binding protein 4, plasma 3.93528
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.93528
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 3.93528
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.93528
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.93528
CD3E CD3e molecule, epsilon (CD3-TCR complex) 3.93528
CD226 CD226 molecule 3.93528
AREG amphiregulin 3.93528
ZNF831 zinc finger protein 831 3.93528
GOLGA8K golgin A8 family, member K 3.93528
MMRN1 multimerin 1 3.93528
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.93528
EPHB3 EPH receptor B3 3.93528
IGLL1 immunoglobulin lambda-like polypeptide 1 3.93528
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.93528
TSPAN19 tetraspanin 19 3.93528
MMP12 matrix metallopeptidase 12 3.93528
FAIM2 Fas apoptotic inhibitory molecule 2 3.93528
ADAM18 ADAM metallopeptidase domain 18 3.93528
GOLGA8R golgin A8 family, member R 3.93528
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.93528
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.93528
GOLGA8N golgin A8 family, member N 3.93528
BMP8B bone morphogenetic protein 8b 3.87265
NRSN1 neurensin 1 3.87265
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 3.87265
TMEM151B transmembrane protein 151B 3.62663
FABP5 fatty acid binding protein 5 (psoriasis-associated) 3.23277
ZBTB7B zinc finger and BTB domain containing 7B 2.88981
ZNF670 zinc finger protein 670 2.82848
SYNPO synaptopodin 2.81245
TF transferrin 2.81245
TMEM213 transmembrane protein 213 2.81245
SOX15 SRY (sex determining region Y)-box 15 2.73562
FDX2 ferredoxin 2 2.69078
AK9 adenylate kinase 9 2.66865
GPN2 GPN-loop GTPase 2 2.60751
NT5DC2 5'-nucleotidase domain containing 2 2.60054
BEST4 bestrophin 4 2.55204
COA6 cytochrome c oxidase assembly factor 6 2.54576
ARMC1 armadillo repeat containing 1 2.49331
MVP major vault protein 2.48232
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.41694
ERG28 ergosterol biosynthesis 28 homolog 2.40984
MFN1 mitofusin 1 2.40753
TMEM238 transmembrane protein 238 2.38098
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 2.37457
CKB creatine kinase, brain 2.35759
SOCS7 suppressor of cytokine signaling 7 2.33048
BEX4 brain expressed, X-linked 4 2.32684
LDHB lactate dehydrogenase B 2.31035
RAD23B RAD23 homolog B (S. cerevisiae) 2.28943
GTF2A2 general transcription factor IIA, 2, 12kDa 2.2884
TRIM17 tripartite motif containing 17 2.28055
PGBD4 piggyBac transposable element derived 4 2.28055
PLSCR2 phospholipid scramblase 2 2.28055
ARRDC2 arrestin domain containing 2 2.28055
PCDHA1 protocadherin alpha 1 2.26999
LGI1 leucine-rich, glioma inactivated 1 2.26999
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.26999
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.26999
APLN apelin 2.26999
LCT lactase 2.26999
ADARB1 adenosine deaminase, RNA-specific, B1 2.26351
BEX1 brain expressed, X-linked 1 2.25649
PRODH proline dehydrogenase (oxidase) 1 2.24844
DRAM1 DNA-damage regulated autophagy modulator 1 2.24308
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 2.24252
H3-3B H3.3 histone B 2.2389
SHPK sedoheptulokinase 2.21758
LNX2 ligand of numb-protein X 2 2.17796
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 2.17796
OPLAH 5-oxoprolinase (ATP-hydrolysing) 2.16508
CCDC87 coiled-coil domain containing 87 2.15929
FAM9B family with sequence similarity 9, member B 2.15929
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.14789
ATP5F1E ATP synthase F1 subunit epsilon 2.13528
MORC3 MORC family CW-type zinc finger 3 2.1205
ECD ecdysoneless homolog (Drosophila) 2.10513
PGAM5 phosphoglycerate mutase family member 5 2.10168
RPL36 ribosomal protein L36 2.09983
BMP2K BMP2 inducible kinase 2.09764
DIRAS1 DIRAS family, GTP-binding RAS-like 1 2.09764
HOOK3 hook microtubule-tethering protein 3 2.07609
ZFP36L2 ZFP36 ring finger protein-like 2 2.07179
COX7B cytochrome c oxidase subunit VIIb 2.05706
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.02911
ZNF785 zinc finger protein 785 2.02839
BBC3 BCL2 binding component 3 2.01517
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 2.01462
C1ORF94 chromosome 1 open reading frame 94 2.01193
ATP5MF ATP synthase membrane subunit f 2.01073

decreased expression

Symbol Name Standardized Value
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -3.93533
MEIKIN meiotic kinetochore factor -3.93533
PRRT1 proline-rich transmembrane protein 1 -3.93533
ULBP3 UL16 binding protein 3 -3.93533
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -3.93533
SHOX short stature homeobox -3.93528
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -3.93528
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -3.93528
TRIP4 thyroid hormone receptor interactor 4 -3.93528
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled -3.93528
PSORS1C1 psoriasis susceptibility 1 candidate 1 -3.93528
BPIFC BPI fold containing family C -3.93528
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -3.93528
PPP1R3A protein phosphatase 1, regulatory subunit 3A -3.93528
CX3CR1 chemokine (C-X3-C motif) receptor 1 -3.93528
CAPS calcyphosine -3.93528
NRGN neurogranin (protein kinase C substrate, RC3) -3.93528
HIGD1C HIG1 hypoxia inducible domain family, member 1C -3.93528
ETV2 ets variant 2 -3.93528
KCNK9 potassium channel, two pore domain subfamily K, member 9 -3.93528
RNF17 ring finger protein 17 -3.93528
LYG2 lysozyme G-like 2 -3.93528
VEGFD vascular endothelial growth factor D -3.93528
WNT16 wingless-type MMTV integration site family, member 16 -3.93528
FGF7 fibroblast growth factor 7 -3.93528
GZMM granzyme M (lymphocyte met-ase 1) -3.93528
CIMAP2 ciliary microtubule associated protein 2 -3.93528
CD48 CD48 molecule -3.93528
ARFRP1 ADP-ribosylation factor related protein 1 -3.93528
PCDHA3 protocadherin alpha 3 -3.93528
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z -3.93528
OVGP1 oviductal glycoprotein 1, 120kDa -3.93528
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -3.92907
PLAC8 placenta-specific 8 -3.92907
INTU inturned planar cell polarity protein -3.66593
JARID2 jumonji, AT rich interactive domain 2 -3.55549
AP3D1 adaptor-related protein complex 3, delta 1 subunit -3.5355
ALKBH5 AlkB family member 5, RNA demethylase -3.46398
TBK1 TANK-binding kinase 1 -3.33595
FRMPD4 FERM and PDZ domain containing 4 -3.22057
OSBPL7 oxysterol binding protein-like 7 -3.11682
MIS18A MIS18 kinetochore protein A -2.97377
CD164L2 CD164 sialomucin-like 2 -2.9027
AHRR aryl-hydrocarbon receptor repressor -2.9027
BGN biglycan -2.88981
MAP3K4-AS1 MAP3K4 antisense RNA 1 -2.88981
LSMEM1 leucine-rich single-pass membrane protein 1 -2.88981
AKR1C1 aldo-keto reductase family 1, member C1 -2.88981
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.88981
NTN4 netrin 4 -2.85444
EBF1 early B-cell factor 1 -2.68699
PDGFC platelet derived growth factor C -2.68274
GATD1 glutamine amidotransferase class 1 domain containing 1 -2.67855
ENO4 enolase family member 4 -2.65659
RNF121 ring finger protein 121 -2.65414
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.65252
DUSP28 dual specificity phosphatase 28 -2.5898
ZNG1A Zn regulated GTPase metalloprotein activator 1A -2.54291
TNIP2 TNFAIP3 interacting protein 2 -2.53852
CCDC97 coiled-coil domain containing 97 -2.51506
FAAP100 FA core complex associated protein 100 -2.49776
RPUSD4 RNA pseudouridylate synthase domain containing 4 -2.49178
ANKRD31 ankyrin repeat domain 31 -2.47574
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -2.43863
NCAPD2 non-SMC condensin I complex, subunit D2 -2.43319
ITGA6 integrin, alpha 6 -2.42973
NPC2 Niemann-Pick disease, type C2 -2.41694
UBE2H ubiquitin-conjugating enzyme E2H -2.34457
GPR171 G protein-coupled receptor 171 -2.33176
CHUK conserved helix-loop-helix ubiquitous kinase -2.32718
CRIPT cysteine-rich PDZ-binding protein -2.31035
GLYCTK glycerate kinase -2.2961
SF3B3 splicing factor 3b, subunit 3, 130kDa -2.29444
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 -2.28245
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.28245
NTNG2 netrin G2 -2.27832
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -2.27832
CRIP1 cysteine-rich protein 1 (intestinal) -2.26999
MEIOB meiosis specific with OB domains -2.26999
RGS7 regulator of G-protein signaling 7 -2.25182
WDR62 WD repeat domain 62 -2.23942
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.21448
ADAM12 ADAM metallopeptidase domain 12 -2.21448
MOG myelin oligodendrocyte glycoprotein -2.21448
TMEM184A transmembrane protein 184A -2.21448
STRN striatin, calmodulin binding protein -2.20156
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.19771
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 -2.19681
EIF1AD eukaryotic translation initiation factor 1A domain containing -2.18068
KIAA0408 KIAA0408 -2.13762
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) -2.12191
TMEM259 transmembrane protein 259 -2.12181
GID4 GID complex subunit 4 -2.1205
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.11899
EED embryonic ectoderm development -2.10513
FBXL2 F-box and leucine-rich repeat protein 2 -2.10289
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -2.09886
SATB1 SATB homeobox 1 -2.09764
CACYBP calcyclin binding protein -2.09245
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 -2.08337
USP45 ubiquitin specific peptidase 45 -2.05636
NOXO1 NADPH oxidase organizer 1 -2.0418
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.02911
FRAS1 Fraser extracellular matrix complex subunit 1 -2.00916