CIC Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description capicua transcriptional repressor|The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] (NCBI Entrez Gene Database, 23152)
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Genes

334 genes differentially expressed following the CIC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
WEE2 WEE1 homolog 2 (S. pombe) 2.75025
PDZD9 PDZ domain containing 9 2.75025
SLC25A45 solute carrier family 25, member 45 2.75025
CXORF65 chromosome X open reading frame 65 2.75025
CLSTN2 calsyntenin 2 2.75025
LMO1 LIM domain only 1 (rhombotin 1) 2.75025
AADACL4 arylacetamide deacetylase-like 4 2.75025
LRRC55 leucine rich repeat containing 55 2.75025
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.75025
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.75025
BMP8B bone morphogenetic protein 8b 2.75025
UNC13C unc-13 homolog C (C. elegans) 2.75025
PCDHB6 protocadherin beta 6 2.75025
SRL sarcalumenin 2.75025
TSSK4 testis-specific serine kinase 4 2.75025
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.75025
NOTO notochord homeobox 2.75025
CLEC12A C-type lectin domain family 12, member A 2.75025
FGD2 FYVE, RhoGEF and PH domain containing 2 2.75025
IZUMO3 IZUMO family member 3 2.75025
ALOX15 arachidonate 15-lipoxygenase 2.75025
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.75025
BTC betacellulin 2.75025
GFAP glial fibrillary acidic protein 2.75025
SIGLEC7 sialic acid binding Ig-like lectin 7 2.75025
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.75025
LRRC63 leucine rich repeat containing 63 2.75025
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.75025
TAS2R10 taste receptor, type 2, member 10 2.75025
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.75025
MPL MPL proto-oncogene, thrombopoietin receptor 2.75025
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.75025
CPLX1 complexin 1 2.75025
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.75025
C2ORF78 chromosome 2 open reading frame 78 2.75025
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.75025
TMEM71 transmembrane protein 71 2.75025
OPRL1 opiate receptor-like 1 2.75025
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.75025
SSTR5 somatostatin receptor 5 2.75025
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.75025
MFAP5 microfibrillar associated protein 5 2.75025
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 2.75025
LYNX1 Ly6/neurotoxin 1 2.75025
BIRC3 baculoviral IAP repeat containing 3 2.75025
NCKAP1L NCK-associated protein 1-like 2.75025
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.75025
CHPT1 choline phosphotransferase 1 2.75025
CIMIP4 ciliary microtubule inner protein 4 2.75025
VN1R1 vomeronasal 1 receptor 1 2.75025
CXCL13 chemokine (C-X-C motif) ligand 13 2.75025
SPEM1 spermatid maturation 1 2.75025
FOXN4 forkhead box N4 2.75025
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.75025
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 2.75025
ANO3 anoctamin 3 2.75025
IQCF1 IQ motif containing F1 2.75025
IGSF22 immunoglobulin superfamily, member 22 2.75025
SRPK3 SRSF protein kinase 3 2.75025
CCER2 coiled-coil glutamate-rich protein 2 2.75025
CLDN14 claudin 14 2.75025
SPEGNB SPEG neighbor 2.75025
SMIM32 small integral membrane protein 32 2.75025
THSD8 thrombospondin type 1 domain containing 8 2.75025
H3-7 H3.7 histone (putative) 2.75025
TMEM225B transmembrane protein 225B 2.75025
CFAP107 cilia and flagella associated protein 107 2.75025
H3-5 H3.5 histone 2.75025
STING1 stimulator of interferon response cGAMP interactor 1 2.75025
OTOF otoferlin 2.75025
GBP4 guanylate binding protein 4 2.75025
TOP1 topoisomerase (DNA) I 2.75025
SPATA22 spermatogenesis associated 22 2.75025
OVOL1 ovo-like zinc finger 1 2.75025
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.75025
ZAN zonadhesin (gene/pseudogene) 2.75025
SLC45A2 solute carrier family 45, member 2 2.75025
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 2.75025
ZIC4 Zic family member 4 2.75025
NPIPB9 nuclear pore complex interacting protein family, member B9 2.75025
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.75025
IL31RA interleukin 31 receptor A 2.75025
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.75025
GSC goosecoid homeobox 2.75025
ABHD15 abhydrolase domain containing 15 2.75025
VSIG8 V-set and immunoglobulin domain containing 8 2.75025
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.75025
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.75025
CNTN6 contactin 6 2.75025
PCDHGC4 protocadherin gamma subfamily C, 4 2.75025
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.75025
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.75025
LGSN lengsin, lens protein with glutamine synthetase domain 2.75025
WNT9B wingless-type MMTV integration site family, member 9B 2.75025
GPR85 G protein-coupled receptor 85 2.75025
FPR3 formyl peptide receptor 3 2.75025
LVRN laeverin 2.75025
DMTN dematin actin binding protein 2.75025
C11ORF96 chromosome 11 open reading frame 96 2.75025
CLRN1 clarin 1 2.75025
CXCR6 chemokine (C-X-C motif) receptor 6 2.75025
SMIM24 small integral membrane protein 24 2.75025
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.75025
CGB7 chorionic gonadotropin, beta polypeptide 7 2.75025
TBXA2R thromboxane A2 receptor 2.75025
COX7B2 cytochrome c oxidase subunit VIIb2 2.75025
IL1A interleukin 1, alpha 2.75025
TEKT5 tektin 5 2.75025
BTNL2 butyrophilin-like 2 2.75025
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.75025
FATE1 fetal and adult testis expressed 1 2.75025
PDCD1 programmed cell death 1 2.75025
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.75025
APOD apolipoprotein D 2.75025
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.75025
TMEM132E transmembrane protein 132E 2.75025
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.75025
ZSCAN2 zinc finger and SCAN domain containing 2 2.75025
OPRK1 opioid receptor, kappa 1 2.75025
EXTL1 exostosin-like glycosyltransferase 1 2.75025
EFCAB9 EF-hand calcium binding domain 9 2.75025
PCDH12 protocadherin 12 2.75025
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.75025
ABLIM3 actin binding LIM protein family, member 3 2.75025
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.75025
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.75025
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.75025
PCDH20 protocadherin 20 2.75025
LRRN4 leucine rich repeat neuronal 4 2.75025
MACROD1 MACRO domain containing 1 2.75025
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.75025
UPK1B uroplakin 1B 2.75025
SIDT1 SID1 transmembrane family, member 1 2.75025
MYLK2 myosin light chain kinase 2 2.75025
LRRC25 leucine rich repeat containing 25 2.75025
SLC38A3 solute carrier family 38, member 3 2.75025
KLK7 kallikrein-related peptidase 7 2.75025
UTS2B urotensin 2B 2.75025
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.75025
RBM24 RNA binding motif protein 24 2.75025
ANKRD55 ankyrin repeat domain 55 2.75025
TPPP3 tubulin polymerization-promoting protein family member 3 2.75025
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.75025
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 2.75025
PRH2 proline-rich protein HaeIII subfamily 2 2.75025
IDI2 isopentenyl-diphosphate delta isomerase 2 2.75025
HSPB2 heat shock 27kDa protein 2 2.75025
IL18R1 interleukin 18 receptor 1 2.75025
TGM6 transglutaminase 6 2.75025
A1CF APOBEC1 complementation factor 2.75025
NMUR2 neuromedin U receptor 2 2.75025
AGBL4 ATP/GTP binding protein-like 4 2.75025
CLCNKB chloride channel, voltage-sensitive Kb 2.75025
DUOXA1 dual oxidase maturation factor 1 2.75025
TSKS testis-specific serine kinase substrate 2.75025
TMPRSS13 transmembrane protease, serine 13 2.75025
SLC51B solute carrier family 51, beta subunit 2.75025
SDSL serine dehydratase-like 2.75025
AMDHD1 amidohydrolase domain containing 1 2.75025
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.75025
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.75025
SETD6 SET domain containing 6 2.75025
ANXA2R annexin A2 receptor 2.75025
RBP4 retinol binding protein 4, plasma 2.75025
SGK2 serum/glucocorticoid regulated kinase 2 2.75025
ICAM2 intercellular adhesion molecule 2 2.75025
C5ORF46 chromosome 5 open reading frame 46 2.75025
ZNF396 zinc finger protein 396 2.75025
RAB7B RAB7B, member RAS oncogene family 2.75025
ZBED8 zinc finger, BED-type containing 8 2.75025
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.75025
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.75025
ZNF534 zinc finger protein 534 2.75025
CHRM4 cholinergic receptor, muscarinic 4 2.75025
CARNS1 carnosine synthase 1 2.75025
AOC3 amine oxidase, copper containing 3 2.75025
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.75025
ECM1 extracellular matrix protein 1 2.75025
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.75025
CHAD chondroadherin 2.75025
EIF2A eukaryotic translation initiation factor 2A, 65kDa 2.6934
RASD2 RASD family, member 2 2.69293
GOLGA8H golgin A8 family, member H 2.65277
SLX4IP SLX4 interacting protein 2.62655
RPS19 ribosomal protein S19 2.62305
TCEAL9 transcription elongation factor A like 9 2.5889
NRBF2 nuclear receptor binding factor 2 2.57161
LOC124902436 talanin 2.55608
C10ORF143 chromosome 10 open reading frame 143 2.53455
FRMPD1 FERM and PDZ domain containing 1 2.44956
ODAD1 outer dynein arm docking complex subunit 1 2.44956
TMEM86A transmembrane protein 86A 2.44956
F10 coagulation factor X 2.44956
ZNF687 zinc finger protein 687 2.44866
ZNF615 zinc finger protein 615 2.44308
CNOT6L CCR4-NOT transcription complex, subunit 6-like 2.41714
CHGB chromogranin B 2.41096
GALR3 galanin receptor 3 2.40827
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.34713
ZNF215 zinc finger protein 215 2.32785
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.3232
DGCR6L DiGeorge syndrome critical region gene 6-like 2.31693
RAG2 recombination activating gene 2 2.31693
LDOC1 leucine zipper, down-regulated in cancer 1 2.31507
CHD6 chromodomain helicase DNA binding protein 6 2.29695
PTMA prothymosin, alpha 2.25712
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 2.25712
CCDC15 coiled-coil domain containing 15 2.25562
MPHOSPH6 M-phase phosphoprotein 6 2.2248
STEAP1B STEAP family member 1B 2.19625
NANOS1 nanos homolog 1 (Drosophila) 2.18814
NOL7 nucleolar protein 7, 27kDa 2.16916
MTIF3 mitochondrial translational initiation factor 3 2.16264
RLF rearranged L-myc fusion 2.14752
ZNF773 zinc finger protein 773 2.12631
COA5 cytochrome c oxidase assembly factor 5 2.10437
POFUT1 protein O-fucosyltransferase 1 2.10375
OCIAD1 OCIA domain containing 1 2.08538
VSIG10 V-set and immunoglobulin domain containing 10 2.07763
MED10 mediator complex subunit 10 2.07148
GPAT4 glycerol-3-phosphate acyltransferase 4 2.02203
RHBDD1 rhomboid domain containing 1 2.01805
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.01725
FN1 fibronectin 1 2.00071

decreased expression

Symbol Name Standardized Value
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -2.75025
KCTD4 potassium channel tetramerization domain containing 4 -2.75025
ZNF467 zinc finger protein 467 -2.75025
PF4V1 platelet factor 4 variant 1 -2.75025
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 -2.75025
C10ORF90 chromosome 10 open reading frame 90 -2.75025
VWC2 von Willebrand factor C domain containing 2 -2.75025
ZNF492 zinc finger protein 492 -2.75025
NOS2 nitric oxide synthase 2, inducible -2.75025
NKX3-1 NK3 homeobox 1 -2.75025
ATP13A3 ATPase type 13A3 -2.75025
PCDHA5 protocadherin alpha 5 -2.75025
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.75025
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.75025
UPK3A uroplakin 3A -2.75025
S100A2 S100 calcium binding protein A2 -2.75025
IDUA iduronidase, alpha-L- -2.75025
HEPHL1 hephaestin-like 1 -2.75025
MEF2C myocyte enhancer factor 2C -2.75025
ARHGAP30 Rho GTPase activating protein 30 -2.75025
ATG4A autophagy related 4A, cysteine peptidase -2.75025
SPTB spectrin, beta, erythrocytic -2.75025
PRDM1 PR domain containing 1, with ZNF domain -2.75025
CFAP54 cilia and flagella associated 54 -2.75025
ZNF804A zinc finger protein 804A -2.75025
VSTM2B V-set and transmembrane domain containing 2B -2.75025
BTBD18 BTB (POZ) domain containing 18 -2.75025
CD48 CD48 molecule -2.75025
C6ORF118 chromosome 6 open reading frame 118 -2.75025
COL17A1 collagen, type XVII, alpha 1 -2.75025
CNGB3 cyclic nucleotide gated channel beta 3 -2.75025
SLC49A3 solute carrier family 49 member 3 -2.75025
TERB1 telomere repeat binding bouquet formation protein 1 -2.75025
SPEF2 sperm flagellar 2 -2.75025
SMIM10 small integral membrane protein 10 -2.75025
CFAP299 cilia and flagella associated protein 299 -2.75025
IGSF10 immunoglobulin superfamily, member 10 -2.75025
H4C6 H4 clustered histone 6 -2.75025
FBXO15 F-box protein 15 -2.75025
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.75025
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.75025
OR6A2 olfactory receptor, family 6, subfamily A, member 2 -2.75025
LMOD1 leiomodin 1 (smooth muscle) -2.75025
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -2.75025
OR3A2 olfactory receptor, family 3, subfamily A, member 2 -2.75025
CNTN5 contactin 5 -2.75025
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.75025
TNN tenascin N -2.75025
AANAT aralkylamine N-acetyltransferase -2.75025
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 -2.75025
SMIM41 small integral membrane protein 41 -2.75025
SMIM38 small integral membrane protein 38 -2.75025
PCDHGA6 protocadherin gamma subfamily A, 6 -2.75025
XK X-linked Kx blood group -2.75025
DHH desert hedgehog -2.75025
MPZL3 myelin protein zero-like 3 -2.65489
TMEM200B transmembrane protein 200B -2.5889
TMEM187 transmembrane protein 187 -2.5889
HPS1 Hermansky-Pudlak syndrome 1 -2.55948
MARCHF4 membrane associated ring-CH-type finger 4 -2.5469
MYO18B myosin XVIIIB -2.5469
INSYN2B inhibitory synaptic factor family member 2B -2.5469
ZFP3 ZFP3 zinc finger protein -2.5469
CAPN12 calpain 12 -2.53762
TULP4 tubby like protein 4 -2.45671
KLK8 kallikrein-related peptidase 8 -2.45321
SPATC1 spermatogenesis and centriole associated 1 -2.45321
MISO1 mitochondrial inner membrane subdomain organizer 1 -2.44148
TTC1 tetratricopeptide repeat domain 1 -2.43048
CEP19 centrosomal protein 19kDa -2.4083
TGIF2 TGFB-induced factor homeobox 2 -2.38798
METAP1 methionyl aminopeptidase 1 -2.38103
ZNF721 zinc finger protein 721 -2.37
EGR1 early growth response 1 -2.35049
SPDYE21 speedy/RINGO cell cycle regulator family member E21 -2.35049
TMEM209 transmembrane protein 209 -2.3124
FBLIM1 filamin binding LIM protein 1 -2.3124
MASP2 mannan-binding lectin serine peptidase 2 -2.28434
CTNND2 catenin (cadherin-associated protein), delta 2 -2.26074
PTPDC1 protein tyrosine phosphatase domain containing 1 -2.24767
NANP N-acetylneuraminic acid phosphatase -2.23385
CKAP2 cytoskeleton associated protein 2 -2.16636
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -2.14103
MT1G metallothionein 1G -2.14103
COPE coatomer protein complex, subunit epsilon -2.13482
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 -2.13432
LEAP2 liver expressed antimicrobial peptide 2 -2.13228
CPTP ceramide-1-phosphate transfer protein -2.13228
H2BC13 H2B clustered histone 13 -2.13228
METTL26 methyltransferase like 26 -2.13228
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.13228
DUSP5 dual specificity phosphatase 5 -2.13044
BBS9 Bardet-Biedl syndrome 9 -2.12753
GNPDA1 glucosamine-6-phosphate deaminase 1 -2.10998
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.10437
BTN3A1 butyrophilin, subfamily 3, member A1 -2.09493
FAM149B1 family with sequence similarity 149, member B1 -2.08829
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.08363
LIPA lipase A, lysosomal acid, cholesterol esterase -2.07977
FBXL5 F-box and leucine-rich repeat protein 5 -2.07254
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -2.07148
PRELID1 PRELI domain containing 1 -2.07148
COPRS coordinator of PRMT5, differentiation stimulator -2.06919
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) -2.05184
TANGO6 transport and golgi organization 6 homolog (Drosophila) -2.04874
BLTP1 bridge-like lipid transfer protein family member 1 -2.0449
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -2.04094
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -2.02203
MAP1S microtubule-associated protein 1S -2.01412
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -2.01218