CIITA Gene Set

Dataset ChEA Transcription Factor Targets
Category genomics
Type transcription factor
Description class II, major histocompatibility complex, transactivator|This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] (NCBI Entrez Gene Database, 4261)
External Link http://www.ncbi.nlm.nih.gov/gene/4261
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Genes

52 target genes of the CIITA transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Symbol Name
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BTN2A2 butyrophilin, subfamily 2, member A2
C4A complement component 4A (Rodgers blood group)
CACYBP calcyclin binding protein
CALML3 calmodulin-like 3
CEP63 centrosomal protein 63kDa
CNOT7 CCR4-NOT transcription complex, subunit 7
COG5 component of oligomeric golgi complex 5
DLX6 distal-less homeobox 6
DVL2 dishevelled segment polarity protein 2
ECSIT ECSIT signalling integrator
ENO1 enolase 1, (alpha)
FAM72D family with sequence similarity 72, member D
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOS FBJ murine osteosarcoma viral oncogene homolog
GORASP1 golgi reassembly stacking protein 1, 65kDa
GTPBP3 GTP binding protein 3 (mitochondrial)
IGHA1 immunoglobulin heavy constant alpha 1
IQCH IQ motif containing H
KDM3A lysine (K)-specific demethylase 3A
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KMT2E lysine (K)-specific methyltransferase 2E
KRT14 keratin 14, type I
KRTAP5-9 keratin associated protein 5-9
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing
MARCO macrophage receptor with collagenous structure
MAT2A methionine adenosyltransferase II, alpha
MRPL47 mitochondrial ribosomal protein L47
MSH3 mutS homolog 3
MYLK myosin light chain kinase
NBPF11 neuroblastoma breakpoint family, member 11
NBPF14 neuroblastoma breakpoint family, member 14
NIN ninein (GSK3B interacting protein)
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
OR14K1 olfactory receptor, family 14, subfamily K, member 1
PARVG parvin, gamma
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
RBM12B RNA binding motif protein 12B
RNASE7 ribonuclease, RNase A family, 7
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A5P2 solute carrier family 7 (amino acid transporter light chain, L system), member 5 pseudogene 2
SRSF2 serine/arginine-rich splicing factor 2
TLR4 toll-like receptor 4
TMED1 transmembrane emp24 protein transport domain containing 1
TMEM14C transmembrane protein 14C
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRAF2 TNF receptor-associated factor 2
ZFAND3 zinc finger, AN1-type domain 3