CIMETIDINE Gene Set

Dataset	DGIdb Drug Targets 2026
Category	physical interactions
Type	drug
Description	A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. (Chemical Entities of Biological Interest Ontology, CHEBI_3699)
External Link	https://dgidb.org/results?searchType=drug&searchTerms=CIMETIDINE
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Genes

12 interacting proteins for the CIMETIDINE drug from theDGIdb Drug Targets 2026 dataset.

Symbol	Name	Standardized Value
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	1.7644
SLC47A2	solute carrier family 47 (multidrug and toxin extrusion), member 2	1.47033
SLC47A1	solute carrier family 47 (multidrug and toxin extrusion), member 1	0.8822
HRH2	histamine receptor H2	0.648676
SLC29A4	solute carrier family 29 (equilibrative nucleoside transporter), member 4	0.401
FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	0.169654
NOS1	nitric oxide synthase 1 (neuronal)	0.126029
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.0288772
POLK	polymerase (DNA directed) kappa	0.0167083
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.0151062
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.00995711
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.00924738