CISAPRIDE Gene Set

Dataset DGIdb Drug Targets 2026
Category physical interactions
Type drug
Description The amide resulting from formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with cis-1-[3-(4-fluorophenoxy)propyl]-3-methoxypiperidin-4-amine. It has been used (as its monohydrate or as its tartrate) for the treatment of gastro-oesophageal reflux disease and for non-ulcer dyspepsia, but its propensity to cause cardiac arrhythmias resulted in its complete withdrawal from many countries, including the U.K., and restrictions on its use elsewhere. (Chemical Entities of Biological Interest Ontology, CHEBI_3720)
External Link https://dgidb.org/results?searchType=drug&searchTerms=CISAPRIDE
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Genes

4 interacting proteins for the CISAPRIDE drug from theDGIdb Drug Targets 2026 dataset.

Symbol Name Standardized Value
PPY pancreatic polypeptide 8.822
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.24288
SCN5A sodium channel, voltage gated, type V alpha subunit 0.249679
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 0.108172