CIT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description citron rho-interacting serine/threonine kinase|This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 11113)
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Genes

349 genes differentially expressed following the CIT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CCDC152 coiled-coil domain containing 152 4.09977
SFTPD surfactant protein D 4.09977
FAM135B family with sequence similarity 135, member B 4.09977
NIM1K NIM1 serine/threonine protein kinase 4.09977
MYOT myotilin 4.09977
PHOSPHO1 phosphatase, orphan 1 4.09977
TDRD10 tudor domain containing 10 4.09977
PDCD1 programmed cell death 1 4.09977
AMBP alpha-1-microglobulin/bikunin precursor 4.09977
TEX101 testis expressed 101 4.09977
BTNL8 butyrophilin-like 8 4.09977
KLHL1 kelch-like family member 1 4.09977
GPR12 G protein-coupled receptor 12 4.09977
FBXL8 F-box and leucine-rich repeat protein 8 4.09977
GRXCR1 glutaredoxin, cysteine rich 1 4.09977
ERAS ES cell expressed Ras 4.09977
TMEM217 transmembrane protein 217 4.09977
KLLN killin, p53-regulated DNA replication inhibitor 4.09977
PHF24 PHD finger protein 24 4.09977
SP5 Sp5 transcription factor 4.09977
LGALS9 lectin, galactoside-binding, soluble, 9 4.09977
PLPP4 phospholipid phosphatase 4 4.09977
SMIM31 small integral membrane protein 31 4.09977
EVI2A ecotropic viral integration site 2A 4.09977
CELA3B chymotrypsin-like elastase family, member 3B 4.09977
SLC38A8 solute carrier family 38, member 8 4.09977
HIC1 hypermethylated in cancer 1 4.03749
AKR1C2 aldo-keto reductase family 1, member C2 4.03749
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 4.03749
ANKRD22 ankyrin repeat domain 22 4.03749
CBLN2 cerebellin 2 precursor 4.03749
IGFL3 IGF-like family member 3 4.03749
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 4.03749
SLC26A1 solute carrier family 26 (anion exchanger), member 1 4.03749
PRDM1 PR domain containing 1, with ZNF domain 4.03749
ADGRE3 adhesion G protein-coupled receptor E3 4.03749
OIT3 oncoprotein induced transcript 3 4.03749
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 4.03749
MYBPHL myosin binding protein H-like 4.03749
TKTL2 transketolase-like 2 4.03749
RFX6 regulatory factor X, 6 4.03749
SLC23A3 solute carrier family 23, member 3 4.03749
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 4.03749
SPRR1B small proline-rich protein 1B 4.03749
ADGB androglobin 4.03749
PTGFR prostaglandin F receptor (FP) 4.03749
S100A5 S100 calcium binding protein A5 4.03749
C3ORF22 chromosome 3 open reading frame 22 4.03749
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 4.03749
ASB12 ankyrin repeat and SOCS box containing 12 4.03749
MAGEA2 melanoma antigen family A2 4.03749
RAX retina and anterior neural fold homeobox 4.03749
CNTNAP4 contactin associated protein-like 4 4.03749
OR10A4 olfactory receptor, family 10, subfamily A, member 4 4.03749
BMP3 bone morphogenetic protein 3 4.03749
FFAR4 free fatty acid receptor 4 4.03749
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 4.03749
DIO3 deiodinase, iodothyronine, type III 4.03749
OR51L1 olfactory receptor, family 51, subfamily L, member 1 4.03749
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 4.03749
LY6S-AS1 LY6S antisense RNA 1 4.03749
MGAT4D MGAT4 family, member D 4.03749
SPRR2E small proline-rich protein 2E 4.03749
FMO1 flavin containing monooxygenase 1 4.03749
C20ORF202 chromosome 20 open reading frame 202 4.03749
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 4.03749
SPATA31H1 SPATA31 subfamily H member 1 4.03749
ZNF705D zinc finger protein 705D 4.03749
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 4.03749
CXCL13 chemokine (C-X-C motif) ligand 13 4.03749
ALX4 ALX homeobox 4 4.03749
LOC124906010 uncharacterized LOC124906010 4.03749
SPAAR small regulatory polypeptide of amino acid response 4.03749
STPG3 sperm-tail PG-rich repeat containing 3 4.03749
CCN5 cellular communication network factor 5 4.03749
HAO2 hydroxyacid oxidase 2 (long chain) 4.03749
UNC93A unc-93 homolog A (C. elegans) 4.03749
FAM240A family with sequence similarity 240 member A 4.03749
OPRM1 opioid receptor, mu 1 4.03749
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 4.03749
TMEM119 transmembrane protein 119 4.03749
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 4.03749
CLIP4 CAP-GLY domain containing linker protein family, member 4 4.03749
ERVFRD-1 endogenous retrovirus group FRD, member 1 4.03749
VIT vitrin 4.03749
MTNR1B melatonin receptor 1B 4.03749
ATP13A4 ATPase type 13A4 4.03749
ZNF98 zinc finger protein 98 4.03749
LAPTM5 lysosomal protein transmembrane 5 4.03749
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 4.03749
CD79A CD79a molecule, immunoglobulin-associated alpha 4.03749
CBLN3 cerebellin 3 precursor 4.03749
STARD6 StAR-related lipid transfer (START) domain containing 6 4.03749
OPN5 opsin 5 4.03749
CELA2A chymotrypsin-like elastase family, member 2A 4.03749
GJD4 gap junction protein, delta 4, 40.1kDa 4.03749
TBX3 T-box 3 4.03749
RUNX3 runt-related transcription factor 3 4.03749
PDZK1IP1 PDZK1 interacting protein 1 4.03749
TMCO2 transmembrane and coiled-coil domains 2 4.03749
CD5 CD5 molecule 4.03749
HSPB9 heat shock protein, alpha-crystallin-related, B9 4.03749
PRM1 protamine 1 4.03749
WFDC8 WAP four-disulfide core domain 8 4.03749
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 4.03749
CPA3 carboxypeptidase A3 (mast cell) 4.03749
MAB21L2 mab-21-like 2 (C. elegans) 4.03749
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 4.03749
BAHCC1 BAH domain and coiled-coil containing 1 4.03749
LMOD2 leiomodin 2 (cardiac) 4.03749
KLHL41 kelch-like family member 41 4.03749
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 4.03749
CNTF ciliary neurotrophic factor 4.03749
MAGEB17 melanoma antigen family B17 4.03749
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 4.03749
OR6C75 olfactory receptor, family 6, subfamily C, member 75 4.03749
TMEM132E transmembrane protein 132E 4.03749
KCNK4 potassium channel, two pore domain subfamily K, member 4 4.03749
F2RL2 coagulation factor II (thrombin) receptor-like 2 4.03749
ZNF132 zinc finger protein 132 4.03749
RSAD2 radical S-adenosyl methionine domain containing 2 4.03749
ALOXE3 arachidonate lipoxygenase 3 4.03749
PCDHGB5 protocadherin gamma subfamily B, 5 4.03749
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 4.03749
SLC25A34 solute carrier family 25, member 34 4.03749
NKX6-2 NK6 homeobox 2 4.03749
LMAN1L lectin, mannose-binding, 1 like 4.03749
POU4F1 POU class 4 homeobox 1 4.03749
C11ORF42 chromosome 11 open reading frame 42 4.03749
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 4.03749
OR52N1 olfactory receptor, family 52, subfamily N, member 1 4.03749
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 4.03749
MYLK2 myosin light chain kinase 2 4.03749
DLX3 distal-less homeobox 3 4.03749
RBM24 RNA binding motif protein 24 4.03749
EPGN epithelial mitogen 4.03749
KLK7 kallikrein-related peptidase 7 4.03749
LRRC15 leucine rich repeat containing 15 4.03749
SAMD7 sterile alpha motif domain containing 7 4.03749
UTS2R urotensin 2 receptor 4.03749
OCM oncomodulin 4.03749
ITGB7 integrin, beta 7 4.03749
TH tyrosine hydroxylase 4.03749
NLRP14 NLR family, pyrin domain containing 14 4.03749
WFDC10A WAP four-disulfide core domain 10A 4.03749
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 4.03749
FITM1 fat storage-inducing transmembrane protein 1 4.03749
SLC7A4 solute carrier family 7, member 4 4.03749
ANGPTL6 angiopoietin-like 6 4.03749
CSF3R colony stimulating factor 3 receptor (granulocyte) 4.03749
ALOX5AP arachidonate 5-lipoxygenase-activating protein 4.03749
GREM1 gremlin 1, DAN family BMP antagonist 4.03749
PPP1R3G protein phosphatase 1, regulatory subunit 3G 4.03749
OXER1 oxoeicosanoid (OXE) receptor 1 4.03749
THEM5 thioesterase superfamily member 5 4.03749
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 4.03749
FGF10 fibroblast growth factor 10 4.03749
ITPKA inositol-trisphosphate 3-kinase A 4.03749
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 4.03749
CHAT choline O-acetyltransferase 4.03749
CHRDL2 chordin-like 2 4.03749
RNF224 ring finger protein 224 4.03749
GREM2 gremlin 2, DAN family BMP antagonist 3.97956
DEGS2 delta(4)-desaturase, sphingolipid 2 3.48841
SYNPO2L synaptopodin 2-like 3.48841
GNPAT glyceronephosphate O-acyltransferase 3.28589
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 3.22064
ALS2CL ALS2 C-terminal like 3.14408
RPL23 ribosomal protein L23 2.97044
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.92267
PNPLA1 patatin-like phospholipase domain containing 1 2.92267
CCR6 chemokine (C-C motif) receptor 6 2.92267
KRT222 keratin 222, type II 2.92267
VMAC vimentin-type intermediate filament associated coiled-coil protein 2.85339
VWC2L von Willebrand factor C domain containing protein 2-like 2.84733
RTL8B retrotransposon Gag like 8B 2.84414
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.74083
CHDH choline dehydrogenase 2.73989
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.67831
SIRT6 sirtuin 6 2.67831
KIFC3 kinesin family member C3 2.67831
CDKL3 cyclin-dependent kinase-like 3 2.67444
PCYOX1 prenylcysteine oxidase 1 2.51404
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 2.513
MIB1 mindbomb E3 ubiquitin protein ligase 1 2.50577
SYT16 synaptotagmin XVI 2.4968
TMEM178A transmembrane protein 178A 2.4849
FOXP2 forkhead box P2 2.42768
ECEL1 endothelin converting enzyme-like 1 2.42768
CD58 CD58 molecule 2.42458
PYGB phosphorylase, glycogen; brain 2.3829
SLC39A6 solute carrier family 39 (zinc transporter), member 6 2.38105
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.33604
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.3272
TCEAL8 transcription elongation factor A (SII)-like 8 2.32657
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 2.30656
RPL32 ribosomal protein L32 2.30656
AOX1 aldehyde oxidase 1 2.30656
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 2.30406
CPNE1 copine I 2.29541
MYH9 myosin, heavy chain 9, non-muscle 2.29183
LRRTM2 leucine rich repeat transmembrane neuronal 2 2.27267
LNPEP leucyl/cystinyl aminopeptidase 2.27267
CBX3 chromobox homolog 3 2.27265
TMEM154 transmembrane protein 154 2.26073
SOBP sine oculis binding protein homolog (Drosophila) 2.25871
VCAN versican 2.25072
SPN sialophorin 2.22626
SP140 SP140 nuclear body protein 2.22626
RPL38 ribosomal protein L38 2.22216
ARL3 ADP-ribosylation factor-like 3 2.22181
SPATS2L spermatogenesis associated, serine-rich 2-like 2.20981
KANSL1 KAT8 regulatory NSL complex subunit 1 2.20721
GGCX gamma-glutamyl carboxylase 2.18328
ZBTB2 zinc finger and BTB domain containing 2 2.1768
CDKN3 cyclin-dependent kinase inhibitor 3 2.17232
PTPRS protein tyrosine phosphatase, receptor type, S 2.16881
HYKK hydroxylysine kinase 2.16881
ALG9 ALG9, alpha-1,2-mannosyltransferase 2.14917
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.14061
MNMIP1 manchette microtubule inner protein 1 2.11385
TMEM101 transmembrane protein 101 2.09949
ARMC6 armadillo repeat containing 6 2.09949
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.08374
DNAAF5 dynein, axonemal, assembly factor 5 2.08157
ZRANB3 zinc finger, RAN-binding domain containing 3 2.06482
RUFY1 RUN and FYVE domain containing 1 2.06246
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.06246
TBC1D14 TBC1 domain family, member 14 2.06246
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 2.05574
BDNF brain-derived neurotrophic factor 2.03344
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 2.0319
GPR156 G protein-coupled receptor 156 2.02364
CEP43 centrosomal protein 43 2.02354
TPST1 tyrosylprotein sulfotransferase 1 2.00163
BTBD9 BTB (POZ) domain containing 9 2.0003

decreased expression

Symbol Name Standardized Value
CCDC172 coiled-coil domain containing 172 -4.09977
GCKR glucokinase (hexokinase 4) regulator -4.09977
NLRC3 NLR family, CARD domain containing 3 -4.09977
WSCD2 WSC domain containing 2 -4.09977
CH25H cholesterol 25-hydroxylase -4.03749
PSPN persephin -4.03749
YPEL4 yippee-like 4 (Drosophila) -4.03749
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -4.03749
CCDC160 coiled-coil domain containing 160 -4.03749
SHISA7 shisa family member 7 -4.03749
CMKLR1 chemerin chemokine-like receptor 1 -4.03749
TMEM121 transmembrane protein 121 -4.03749
PCP4L1 Purkinje cell protein 4 like 1 -4.03749
TMIGD3 transmembrane and immunoglobulin domain containing 3 -4.03749
CD80 CD80 molecule -4.03749
LTF lactotransferrin -4.03749
TTC36 tetratricopeptide repeat domain 36 -4.03749
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 -4.03749
MAB21L1 mab-21-like 1 (C. elegans) -4.03749
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -4.03749
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B -4.03749
ZNF283 zinc finger protein 283 -4.03749
GFRA3 GDNF family receptor alpha 3 -4.03749
NOTCH4 notch 4 -4.03749
UNC13C unc-13 homolog C (C. elegans) -4.03749
RDH16 retinol dehydrogenase 16 (all-trans) -4.03749
JAML junction adhesion molecule like -4.03749
SCNN1B sodium channel, non voltage gated 1 beta subunit -4.03749
TPPP2 tubulin polymerization-promoting protein family member 2 -4.03749
ASB14 ankyrin repeat and SOCS box containing 14 -4.03749
SPEF1 sperm flagellar 1 -4.03749
CHIC1 cysteine-rich hydrophobic domain 1 -4.00571
ZNF879 zinc finger protein 879 -3.96577
NECAB2 N-terminal EF-hand calcium binding protein 2 -3.96577
YEATS2 YEATS domain containing 2 -3.52894
LDHB lactate dehydrogenase B -3.34229
RPL18 ribosomal protein L18 -3.25069
GPATCH1 G patch domain containing 1 -3.17253
THAP12 THAP domain containing 12 -3.09941
FAM110D family with sequence similarity 110, member D -2.91282
BMP8A bone morphogenetic protein 8a -2.91175
LAMA4 laminin, alpha 4 -2.91175
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.91175
ZNF184 zinc finger protein 184 -2.91175
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.91175
CSF1 colony stimulating factor 1 (macrophage) -2.91175
BAZ1B bromodomain adjacent to zinc finger domain, 1B -2.87683
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.79018
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -2.75006
LZTS1 leucine zipper, putative tumor suppressor 1 -2.73421
EML6 echinoderm microtubule associated protein like 6 -2.62412
TTC23 tetratricopeptide repeat domain 23 -2.61841
GRB2 growth factor receptor-bound protein 2 -2.60735
EVI2B ecotropic viral integration site 2B -2.55814
TMEM208 transmembrane protein 208 -2.54523
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -2.4968
YTHDC1 YTH domain containing 1 -2.4849
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -2.41677
FAM219A family with sequence similarity 219, member A -2.40166
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.38721
MMP21 matrix metallopeptidase 21 -2.38721
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.38721
DENND2B DENN domain containing 2B -2.38105
TOR4A torsin family 4, member A -2.34584
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -2.33916
LRR1 leucine rich repeat protein 1 -2.3272
SEPTIN8 septin 8 -2.32021
RPS3 ribosomal protein S3 -2.31832
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -2.30858
PNMA8C PNMA family member 8C -2.30858
HSBP1L1 heat shock factor binding protein 1-like 1 -2.30858
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.30656
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -2.30656
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.30406
CLEC11A C-type lectin domain family 11, member A -2.29765
UBFD1 ubiquitin family domain containing 1 -2.28277
ODC1 ornithine decarboxylase 1 -2.27581
TXNL1 thioredoxin-like 1 -2.27362
TOP3A topoisomerase (DNA) III alpha -2.27362
ACVR1C activin A receptor, type IC -2.27265
CAPN3 calpain 3, (p94) -2.27187
RSAD1 radical S-adenosyl methionine domain containing 1 -2.25474
PDPN podoplanin -2.22181
PPP1R13B protein phosphatase 1, regulatory subunit 13B -2.21694
ACBD7 acyl-CoA binding domain containing 7 -2.20981
AKAP8L A kinase (PRKA) anchor protein 8-like -2.20119
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -2.19941
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.1977
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 -2.1977
MALRD1 MAM and LDL receptor class A domain containing 1 -2.19515
MRPL2 mitochondrial ribosomal protein L2 -2.17671
ELAVL1 ELAV like RNA binding protein 1 -2.11385
SOX4 SRY (sex determining region Y)-box 4 -2.11385
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -2.11018
NCS1 neuronal calcium sensor 1 -2.10531
EXT2 exostosin glycosyltransferase 2 -2.09831
FMNL3 formin-like 3 -2.08715
PTPRU protein tyrosine phosphatase, receptor type, U -2.08374
PPP1R36 protein phosphatase 1, regulatory subunit 36 -2.08157
RNF43 ring finger protein 43 -2.07419
LSM10 LSM10, U7 small nuclear RNA associated -2.06482
UBAP1 ubiquitin associated protein 1 -2.06482
C9ORF72 chromosome 9 open reading frame 72 -2.06482
FTH1 ferritin, heavy polypeptide 1 -2.06246
SNAP47 synaptosomal-associated protein, 47kDa -2.06246
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -2.06246
ZBTB22 zinc finger and BTB domain containing 22 -2.06246
CHD8 chromodomain helicase DNA binding protein 8 -2.0594
FANCF Fanconi anemia, complementation group F -2.05906
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.05775
UTP4 UTP4 small subunit processome component -2.03769
KRT19 keratin 19, type I -2.01739
FZD8 frizzled class receptor 8 -2.01108