CJM Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
Description Melanoma cell line (Cancer Dependency Map)
External Link https://depmap.org/portal/cell_line/ACH-000458
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Genes

292 gene knockdowns changing fitness of CJM relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
DLX4 distal-less homeobox 4 10.8415
FAM162B family with sequence similarity 162, member B 7.99723
HRAS Harvey rat sarcoma viral oncogene homolog 6.77737
DUOX2 dual oxidase 2 6.59818
RNASEH1 ribonuclease H1 6.38184
USP54 ubiquitin specific peptidase 54 5.67494
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 5.47801
CILP2 cartilage intermediate layer protein 2 5.37455
SLC25A45 solute carrier family 25, member 45 5.30287
SVIL supervillin 5.23896
PEX14 peroxisomal biogenesis factor 14 4.96233
TRNP1 TMF1-regulated nuclear protein 1 4.84806
EEF2K eukaryotic elongation factor 2 kinase 4.83002
TRPV1 transient receptor potential cation channel, subfamily V, member 1 4.78657
KANSL1L KAT8 regulatory NSL complex subunit 1-like 4.73209
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 4.72757
TP53BP1 tumor protein p53 binding protein 1 4.64927
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 4.62949
LBX1 ladybird homeobox 1 4.58201
MS4A10 membrane-spanning 4-domains, subfamily A, member 10 4.57439
NR1I2 nuclear receptor subfamily 1, group I, member 2 4.52775
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 4.50132
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 4.48646
QTRT1 queuine tRNA-ribosyltransferase 1 4.47295
DOCK6 dedicator of cytokinesis 6 4.44262
DGCR6 DiGeorge syndrome critical region gene 6 4.36656
RPL22L1 ribosomal protein L22-like 1 4.31776
NFIB nuclear factor I/B 4.29851
RERG RAS-like, estrogen-regulated, growth inhibitor 4.2818
IL36A interleukin 36, alpha 4.27343
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 4.26671
FBXO46 F-box protein 46 4.2626
LPPR5 lipid phosphate phosphatase-related protein type 5 4.23601
ZNF706 zinc finger protein 706 4.14665
PCDH20 protocadherin 20 4.09994
PID1 phosphotyrosine interaction domain containing 1 4.08964
C3ORF18 chromosome 3 open reading frame 18 4.0344
CKAP2L cytoskeleton associated protein 2-like 3.98864
SUCO SUN domain containing ossification factor 3.98162
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.96632
AVPR1B arginine vasopressin receptor 1B 3.95308
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.94517
SAMD4A sterile alpha motif domain containing 4A 3.93268
DMKN dermokine 3.92857
ZBTB8B zinc finger and BTB domain containing 8B 3.91821
ARRDC2 arrestin domain containing 2 3.91502
FAM159A family with sequence similarity 159, member A 3.85565
SPOP speckle-type POZ protein 3.83164
IL1R2 interleukin 1 receptor, type II 3.83159
FZD5 frizzled class receptor 5 3.8139
NIBAN3 niban apoptosis regulator 3 3.76236
BARHL1 BarH-like homeobox 1 3.75348
TP63 tumor protein p63 3.73715
KLF17 Kruppel-like factor 17 3.73249
MYD88 myeloid differentiation primary response 88 3.69415
NOD1 nucleotide-binding oligomerization domain containing 1 3.64575
GAL3ST3 galactose-3-O-sulfotransferase 3 3.60943
MPST mercaptopyruvate sulfurtransferase 3.57815
ANKRD33B ankyrin repeat domain 33B 3.55668
NME6 NME/NM23 nucleoside diphosphate kinase 6 3.55352
HIST1H3B histone cluster 1, H3b 3.54629
GOLM2 golgi membrane protein 2 3.54157
ZNF879 zinc finger protein 879 3.49264
R3HCC1 R3H domain and coiled-coil containing 1 3.47373
MRGPRX4 MAS-related GPR, member X4 3.46532
MEOX2 mesenchyme homeobox 2 3.44327
SYNGR1 synaptogyrin 1 3.43354
FAM167A family with sequence similarity 167, member A 3.43003
INPP5F inositol polyphosphate-5-phosphatase F 3.37826
TMEM158 transmembrane protein 158 (gene/pseudogene) 3.36602
FBXO42 F-box protein 42 3.36453
ATF7 activating transcription factor 7 3.33865
GLRX glutaredoxin (thioltransferase) 3.32074
IL12RB2 interleukin 12 receptor, beta 2 3.29928
ABHD15 abhydrolase domain containing 15 3.26114
SLC22A10 solute carrier family 22, member 10 3.251
PTH2 parathyroid hormone 2 3.24949
OLIG2 oligodendrocyte lineage transcription factor 2 3.24433
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 3.24039
MTMR12 myotubularin related protein 12 3.22619
TBX21 T-box 21 3.22045
WNT9B wingless-type MMTV integration site family, member 9B 3.2179
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 3.20736
ZNF181 zinc finger protein 181 3.19235
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.18766
JTB jumping translocation breakpoint 3.17359
GPALPP1 GPALPP motifs containing 1 3.16534
CEP152 centrosomal protein 152kDa 3.15231
WDR59 WD repeat domain 59 3.13739
KRT6B keratin 6B, type II 3.13625
INHBB inhibin, beta B 3.12465
FAM181B family with sequence similarity 181, member B 3.12268
CCDC142 coiled-coil domain containing 142 3.12187
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.11674
GJD3 gap junction protein, delta 3, 31.9kDa 3.10821
PARN poly(A)-specific ribonuclease 3.10543
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 3.09317
SLF1 SMC5-SMC6 complex localization factor 1 3.09026
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 3.05743
FBXL12 F-box and leucine-rich repeat protein 12 3.0481
PRRT1 proline-rich transmembrane protein 1 3.01521
FTL ferritin, light polypeptide 2.99283
WDR4 WD repeat domain 4 2.98152
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 2.9655
TGM4 transglutaminase 4 2.96219
CCDC6 coiled-coil domain containing 6 2.95451
OR2K2 olfactory receptor, family 2, subfamily K, member 2 2.95444
ZNF462 zinc finger protein 462 2.94978
CELA1 chymotrypsin-like elastase family, member 1 2.94029
CROCC ciliary rootlet coiled-coil, rootletin 2.93565
AKAP8L A kinase (PRKA) anchor protein 8-like 2.93052
ADGRF5 adhesion G protein-coupled receptor F5 2.92081
LYZL6 lysozyme-like 6 2.89688
ZNF224 zinc finger protein 224 2.87928
CCDC51 coiled-coil domain containing 51 2.87581
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.85929
SGSM2 small G protein signaling modulator 2 2.85461
FAR1 fatty acyl CoA reductase 1 2.85118
LHB luteinizing hormone beta polypeptide 2.84986
SIGLEC10 sialic acid binding Ig-like lectin 10 2.84902
SSR4 signal sequence receptor, delta 2.84484
PAQR5 progestin and adipoQ receptor family member V 2.82865
TGFB3 transforming growth factor, beta 3 2.82311
VIT vitrin 2.81597
MEOX1 mesenchyme homeobox 1 2.80076
RASL10A RAS-like, family 10, member A 2.79598
MTFR1 mitochondrial fission regulator 1 2.79366
OR10A4 olfactory receptor, family 10, subfamily A, member 4 2.78029
RHOC ras homolog family member C 2.74813
TMEM151A transmembrane protein 151A 2.74784
TMEM139 transmembrane protein 139 2.74549
ZNF428 zinc finger protein 428 2.74354
OR2B2 olfactory receptor, family 2, subfamily B, member 2 2.74226
FKBP11 FK506 binding protein 11, 19 kDa 2.74101
CREB3L1 cAMP responsive element binding protein 3-like 1 2.736
MYL1 myosin, light chain 1, alkali; skeletal, fast 2.73208
OXT oxytocin/neurophysin I prepropeptide 2.72631
EHBP1L1 EH domain binding protein 1-like 1 2.71623
CTRB2 chymotrypsinogen B2 2.70693
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.68671
CLNK cytokine-dependent hematopoietic cell linker 2.68054
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.67437
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.66758
SLMAP sarcolemma associated protein 2.66407
FAM171A2 family with sequence similarity 171, member A2 2.6579
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 2.64618
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.64252
KRTAP9-8 keratin associated protein 9-8 2.6418
C1ORF95 chromosome 1 open reading frame 95 2.637
FBXL18 F-box and leucine-rich repeat protein 18 2.62387
MRPL44 mitochondrial ribosomal protein L44 2.61961
LHFPL1 lipoma HMGIC fusion partner-like 1 2.61892
FAM65C family with sequence similarity 65, member C 2.61659
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 2.61193
UBASH3A ubiquitin associated and SH3 domain containing A 2.60577
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.60114
RRP36 ribosomal RNA processing 36 homolog (S. cerevisiae) 2.58955
USF1 upstream transcription factor 1 2.58729
PGLS 6-phosphogluconolactonase 2.58607
COL6A6 collagen, type VI, alpha 6 2.57507
ADAT2 adenosine deaminase, tRNA-specific 2 2.57242
GOLGA7B golgin A7 family, member B 2.56876
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.56673
SRPX sushi-repeat containing protein, X-linked 2.56053
DEFB135 defensin, beta 135 2.55893
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.55514
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 2.55333
KIAA1683 KIAA1683 2.55081
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.53974
EIF3L eukaryotic translation initiation factor 3, subunit L 2.51234
KRTAP9-9 keratin associated protein 9-9 2.51208
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 2.50821
GSC goosecoid homeobox 2.50092
TEAD2 TEA domain family member 2 2.49911
ZC3H4 zinc finger CCCH-type containing 4 2.49026
CRX cone-rod homeobox 2.48686
RDH8 retinol dehydrogenase 8 (all-trans) 2.48683
PIANP PILR alpha associated neural protein 2.4853
TMEM260 transmembrane protein 260 2.45397
SEC14L4 SEC14-like 4 (S. cerevisiae) 2.45266
RIF1 replication timing regulatory factor 1 2.44358
ORAI2 ORAI calcium release-activated calcium modulator 2 2.44037
MARK2 MAP/microtubule affinity-regulating kinase 2 2.4338
TCL1A T-cell leukemia/lymphoma 1A 2.41847
PMM2 phosphomannomutase 2 2.41086
IVD isovaleryl-CoA dehydrogenase 2.41058
HHLA2 HERV-H LTR-associating 2 2.40596
GMEB1 glucocorticoid modulatory element binding protein 1 2.40341
TMEM174 transmembrane protein 174 2.40255
LYPD4 LY6/PLAUR domain containing 4 2.39688
PSD2 pleckstrin and Sec7 domain containing 2 2.39425
ZFP3 ZFP3 zinc finger protein 2.3921
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.38837
OR6A2 olfactory receptor, family 6, subfamily A, member 2 2.38672
TAPT1 transmembrane anterior posterior transformation 1 2.37617
CIZ1 CDKN1A interacting zinc finger protein 1 2.35699
TMEM262 transmembrane protein 262 2.35112
THOP1 thimet oligopeptidase 1 2.34592
FBXL8 F-box and leucine-rich repeat protein 8 2.34318
POR P450 (cytochrome) oxidoreductase 2.32639
TARBP1 TAR (HIV-1) RNA binding protein 1 2.32541
USF2 upstream transcription factor 2, c-fos interacting 2.32536
PITRM1 pitrilysin metallopeptidase 1 2.32272
KRTDAP keratinocyte differentiation-associated protein 2.31124
TAC3 tachykinin 3 2.30823
FIGLA folliculogenesis specific basic helix-loop-helix 2.30297
KRTAP1-1 keratin associated protein 1-1 2.30289
SCGB1D2 secretoglobin, family 1D, member 2 2.2992
MORF4L1 mortality factor 4 like 1 2.29797
FSTL5 follistatin-like 5 2.29458
RRAD Ras-related associated with diabetes 2.28428
CALHM3 calcium homeostasis modulator 3 2.28416
USP18 ubiquitin specific peptidase 18 2.25519
YIPF7 Yip1 domain family, member 7 2.25454
CCER2 coiled-coil glutamate-rich protein 2 2.25392
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 2.25046
OR6V1 olfactory receptor, family 6, subfamily V, member 1 2.24728
DLX1 distal-less homeobox 1 2.24627
CTXN3 cortexin 3 2.24159
ORM1 orosomucoid 1 2.23802
HDAC6 histone deacetylase 6 2.236
ACP2 acid phosphatase 2, lysosomal 2.23158
DPP7 dipeptidyl-peptidase 7 2.23114
H1-1 H1.1 linker histone, cluster member 2.22201
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 2.22176
ZNF76 zinc finger protein 76 2.21626
FMO1 flavin containing monooxygenase 1 2.21602
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.21287
RPIA ribose 5-phosphate isomerase A 2.20908
CTC1 CTS telomere maintenance complex component 1 2.20881
TADA1 transcriptional adaptor 1 2.2082
HSPA14 heat shock 70kDa protein 14 2.20377
RHPN1 rhophilin, Rho GTPase binding protein 1 2.20289
MRPS17 mitochondrial ribosomal protein S17 2.1987
TUFM Tu translation elongation factor, mitochondrial 2.19703
CEP55 centrosomal protein 55kDa 2.18289
MAP10 microtubule-associated protein 10 2.18284
ASRGL1 asparaginase like 1 2.1816
ANAPC13 anaphase promoting complex subunit 13 2.16932
CTXN1 cortexin 1 2.1639
NPVF neuropeptide VF precursor 2.15717
CTSW cathepsin W 2.15457
EIF5B eukaryotic translation initiation factor 5B 2.14461
DLK1 delta-like 1 homolog (Drosophila) 2.13215
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2.13099
WAPL WAPL cohesin release factor 2.12885
CAPN11 calpain 11 2.12487
RNF208 ring finger protein 208 2.1186
PRCC papillary renal cell carcinoma (translocation-associated) 2.11806
H3C1 H3 clustered histone 1 2.11575
FGL1 fibrinogen-like 1 2.10748
SNX3 sorting nexin 3 2.10525
CD276 CD276 molecule 2.10316
IL37 interleukin 37 2.10278
MRPS9 mitochondrial ribosomal protein S9 2.10266
RBM33 RNA binding motif protein 33 2.09903
CARMIL2 capping protein regulator and myosin 1 linker 2 2.09663
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.09109
NLRP1 NLR family, pyrin domain containing 1 2.08972
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.08542
DUSP8 dual specificity phosphatase 8 2.08054
FOXA3 forkhead box A3 2.08049
STARD7 StAR-related lipid transfer (START) domain containing 7 2.08002
FEV FEV (ETS oncogene family) 2.07919
KCTD17 potassium channel tetramerization domain containing 17 2.07874
DNTT DNA nucleotidylexotransferase 2.07861
SPINDOC spindlin interactor and repressor of chromatin binding 2.07683
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 2.07662
GPR19 G protein-coupled receptor 19 2.0738
OR2H2 olfactory receptor, family 2, subfamily H, member 2 2.07082
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 2.0658
SMIM14 small integral membrane protein 14 2.06408
PNISR PNN-interacting serine/arginine-rich protein 2.06079
MRPL19 mitochondrial ribosomal protein L19 2.05721
CARD9 caspase recruitment domain family, member 9 2.05652
SULF2 sulfatase 2 2.05449
AOC3 amine oxidase, copper containing 3 2.04706
GLMN glomulin, FKBP associated protein 2.04003
FKBPL FK506 binding protein like 2.03841
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.03599
RBP4 retinol binding protein 4, plasma 2.03305
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.02911
PEX6 peroxisomal biogenesis factor 6 2.02872
RPA4 replication protein A4, 30kDa 2.02584
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 2.02535
HIKESHI heat shock protein nuclear import factor hikeshi 2.02017
TADA2B transcriptional adaptor 2B 2.01966
GFM2 G elongation factor, mitochondrial 2 2.01606
CLK3 CDC-like kinase 3 2.01491
TEX11 testis expressed 11 2.00805
HLA-B major histocompatibility complex, class I, B 2.00323
C18ORF21 chromosome 18 open reading frame 21 2.00231