CLN8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)|This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2055)
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Genes

324 genes differentially expressed following the CLN8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RAB41 RAB41, member RAS oncogene family 2.61648
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.61648
CELF3 CUGBP, Elav-like family member 3 2.61648
CELF6 CUGBP, Elav-like family member 6 2.61648
NANOS2 nanos homolog 2 (Drosophila) 2.61648
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.61648
PDIA2 protein disulfide isomerase family A, member 2 2.61648
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.61648
EYS eyes shut homolog (Drosophila) 2.61648
AMTN amelotin 2.61648
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.61648
METRNL meteorin, glial cell differentiation regulator-like 2.61648
IGFL2 IGF-like family member 2 2.61648
ACTL10 actin-like 10 2.61648
ACTL8 actin-like 8 2.61648
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.61648
FAM3D family with sequence similarity 3, member D 2.61648
TMPRSS11A transmembrane protease, serine 11A 2.61648
C19ORF73 chromosome 19 open reading frame 73 2.61648
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.61648
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.61648
SLC26A9 solute carrier family 26 (anion exchanger), member 9 2.61648
CST9L cystatin 9-like 2.61648
PAX2 paired box 2 2.61648
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase 2.61648
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.61648
TCEAL7 transcription elongation factor A (SII)-like 7 2.61648
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.61648
IL18R1 interleukin 18 receptor 1 2.61648
PRSS21 protease, serine, 21 (testisin) 2.61648
FAM81B family with sequence similarity 81, member B 2.61648
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.61648
RBP4 retinol binding protein 4, plasma 2.61648
SLIT1 slit homolog 1 (Drosophila) 2.61648
APOA1 apolipoprotein A-I 2.61648
CD226 CD226 molecule 2.61648
SPHK1 sphingosine kinase 1 2.61648
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.61648
SSTR5 somatostatin receptor 5 2.61648
ASPA aspartoacylase 2.61648
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.61648
GFI1 growth factor independent 1 transcription repressor 2.61648
RFPL3 ret finger protein-like 3 2.61648
BSX brain-specific homeobox 2.61648
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.61648
RIMBP3C RIMS binding protein 3C 2.61648
TREML1 triggering receptor expressed on myeloid cells-like 1 2.61648
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.61648
YEATS4 YEATS domain containing 4 2.61648
FOXD1 forkhead box D1 2.61648
ACKR5 atypical chemokine receptor 5 2.61648
CCN5 cellular communication network factor 5 2.61648
STYXL2 serine/threonine/tyrosine interacting like 2 2.61648
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.61648
GBP1 guanylate binding protein 1, interferon-inducible 2.61648
C3AR1 complement component 3a receptor 1 2.61648
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.61648
HTRA4 HtrA serine peptidase 4 2.61648
SPRR2B small proline-rich protein 2B 2.61648
FMOD fibromodulin 2.61648
PKD2L1 polycystic kidney disease 2-like 1 2.61648
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 2.61648
CCDC187 coiled-coil domain containing 187 2.61648
SPMIP10 sperm microtubule inner protein 10 2.61648
ERLN endoregulin 2.61648
ANKRD42-DT ANKRD42 divergent transcript 2.61648
CIMAP1D CIMAP1 family member D 2.61648
SMIM45 small integral membrane protein 45 2.61648
CTXND1 cortexin domain containing 1 2.61648
H3-7 H3.7 histone (putative) 2.61648
TMEM225B transmembrane protein 225B 2.61648
CBY2 chibby family member 2 2.61648
CHCT1 CHD1 helical C-terminal domain containing 1 2.61648
C20ORF202 chromosome 20 open reading frame 202 2.61648
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.61648
BDKRB2 bradykinin receptor B2 2.61648
FGFBP1 fibroblast growth factor binding protein 1 2.61648
ABHD15 abhydrolase domain containing 15 2.61648
CDKN2A cyclin-dependent kinase inhibitor 2A 2.61648
S100P S100 calcium binding protein P 2.61648
CCR8 chemokine (C-C motif) receptor 8 2.61648
TLR8 toll-like receptor 8 2.61648
SIM2 single-minded family bHLH transcription factor 2 2.61648
LOC124901872 uncharacterized LOC124901872 2.61648
CD48 CD48 molecule 2.61648
PTGDR2 prostaglandin D2 receptor 2 2.61648
FRK fyn-related Src family tyrosine kinase 2.61648
GPR132 G protein-coupled receptor 132 2.61648
LY6K lymphocyte antigen 6 complex, locus K 2.61648
CARM1 coactivator-associated arginine methyltransferase 1 2.61648
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.61648
OR7D2 olfactory receptor, family 7, subfamily D, member 2 2.61648
C4ORF50 chromosome 4 open reading frame 50 2.61648
MROH5 maestro heat-like repeat family member 5 2.61648
RNF183 ring finger protein 183 2.61648
CSF3 colony stimulating factor 3 (granulocyte) 2.61648
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.61648
LRRC72 leucine rich repeat containing 72 2.61648
GDA guanine deaminase 2.61648
NLRP6 NLR family, pyrin domain containing 6 2.61648
ANKRD20A1 ankyrin repeat domain 20 family, member A1 2.61648
APLNR apelin receptor 2.61648
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.61648
MYF6 myogenic factor 6 (herculin) 2.61648
VAX2 ventral anterior homeobox 2 2.61648
GSTA2 glutathione S-transferase alpha 2 2.61648
CLEC7A C-type lectin domain family 7, member A 2.61648
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2.61648
TBPL2 TATA box binding protein like 2 2.61648
ESAM endothelial cell adhesion molecule 2.61648
KRT15 keratin 15, type I 2.61648
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 2.61648
ZMYND12 zinc finger, MYND-type containing 12 2.61648
ZNF674 zinc finger protein 674 2.61648
DMTN dematin actin binding protein 2.61648
GPR62 G protein-coupled receptor 62 2.61648
GTF3A general transcription factor IIIA 2.61648
LHX5 LIM homeobox 5 2.61648
LY96 lymphocyte antigen 96 2.61648
RGS11 regulator of G-protein signaling 11 2.61648
VSTM1 V-set and transmembrane domain containing 1 2.61648
THBD thrombomodulin 2.61648
CHI3L2 chitinase 3-like 2 2.61648
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.61648
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.61648
CYS1 cystin 1 2.61648
SH2D4B SH2 domain containing 4B 2.61648
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.61648
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 2.61648
SIRPG signal-regulatory protein gamma 2.61648
SAMD5 sterile alpha motif domain containing 5 2.61648
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.61648
CHIT1 chitinase 1 (chitotriosidase) 2.61648
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.61648
GCOM1 GRINL1A complex locus 1 2.61648
CTAGE9 CTAGE family, member 9 2.61648
CXCR3 chemokine (C-X-C motif) receptor 3 2.61648
RESP18 regulated endocrine-specific protein 18 2.61648
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.61648
C5AR2 complement component 5a receptor 2 2.61648
GLT6D1 glycosyltransferase 6 domain containing 1 2.61648
APOL5 apolipoprotein L, 5 2.61648
HEPN1 hepatocellular carcinoma, down-regulated 1 2.61648
APOL1 apolipoprotein L, 1 2.61648
PHOX2A paired-like homeobox 2a 2.61648
SYTL4 synaptotagmin-like 4 2.61648
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.61648
TGM5 transglutaminase 5 2.61648
GRAP2 GRB2-related adaptor protein 2 2.61648
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.61648
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.61648
A1CF APOBEC1 complementation factor 2.61648
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.61648
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.61648
APOL6 apolipoprotein L, 6 2.61648
WNT2 wingless-type MMTV integration site family member 2 2.61648
BCL2L15 BCL2-like 15 2.61648
CSDC2 cold shock domain containing C2, RNA binding 2.61648
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.61648
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.61648
AOC1 amine oxidase, copper containing 1 2.61648
CLEC1A C-type lectin domain family 1, member A 2.61648
GGN gametogenetin 2.61648
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.61648
LAMB3 laminin, beta 3 2.61648
ADAM18 ADAM metallopeptidase domain 18 2.61648
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.61648
PF4V1 platelet factor 4 variant 1 2.61648
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 2.61648
TMPRSS13 transmembrane protease, serine 13 2.61648
PTGES3 prostaglandin E synthase 3 (cytosolic) 2.58306
CFAP54 cilia and flagella associated 54 2.58306
TNC tenascin C 2.58306
TMEM209 transmembrane protein 209 2.50877
PIAS4 protein inhibitor of activated STAT, 4 2.50164
RANBP1 RAN binding protein 1 2.49817
RELN reelin 2.49236
SLC12A9 solute carrier family 12, member 9 2.47839
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.44657
RPL35A ribosomal protein L35a 2.44657
IK IK cytokine, down-regulator of HLA II 2.42155
KIAA1549 KIAA1549 2.42155
UST uronyl-2-sulfotransferase 2.41906
CXADR coxsackie virus and adenovirus receptor 2.4075
PARVG parvin, gamma 2.40646
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.40646
ANKRD61 ankyrin repeat domain 61 2.40646
SMIM15 small integral membrane protein 15 2.4051
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase 2.356
C1GALT1C1 C1GALT1-specific chaperone 1 2.34049
F10 coagulation factor X 2.33102
BTBD19 BTB (POZ) domain containing 19 2.33102
TJP1 tight junction protein 1 2.31289
SLC30A8 solute carrier family 30 (zinc transporter), member 8 2.30551
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 2.30366
DTX3 deltex 3, E3 ubiquitin ligase 2.2949
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 2.2726
ACSS2 acyl-CoA synthetase short-chain family member 2 2.26945
UBXN10 UBX domain protein 10 2.25877
NOP10 NOP10 ribonucleoprotein 2.25869
MST1 macrophage stimulating 1 2.25714
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 2.25569
DDR2 discoidin domain receptor tyrosine kinase 2 2.25093
COA6 cytochrome c oxidase assembly factor 6 2.24332
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.24242
PRR7 proline rich 7 (synaptic) 2.24184
EML3 echinoderm microtubule associated protein like 3 2.24088
POLR1F RNA polymerase I subunit F 2.23918
BTD biotinidase 2.22187
FLRT2 fibronectin leucine rich transmembrane protein 2 2.21482
HILPDA hypoxia inducible lipid droplet-associated 2.19917
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 2.16746
HLA-C major histocompatibility complex, class I, C 2.1652
AMY2B amylase, alpha 2B (pancreatic) 2.14529
RWDD4 RWD domain containing 4 2.14529
SAMD4B sterile alpha motif domain containing 4B 2.13446
SCD5 stearoyl-CoA desaturase 5 2.11218
TPBG trophoblast glycoprotein 2.10211
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2.09627
KYAT3 kynurenine aminotransferase 3 2.09522
PHF10 PHD finger protein 10 2.05895
INHBA inhibin, beta A 2.05131
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 2.03916
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 2.03326
ARMC7 armadillo repeat containing 7 2.02698
ZIC1 Zic family member 1 2.02068
ACBD7 acyl-CoA binding domain containing 7 2.01787
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.00813
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 2.00813
MFN2 mitofusin 2 2.00813
ATL3 atlastin GTPase 3 2.00181
MTG2 mitochondrial ribosome-associated GTPase 2 2.00126

decreased expression

Symbol Name Standardized Value
SYNJ1 synaptojanin 1 -2.61648
H4C12 H4 clustered histone 12 -2.61648
ULK2 unc-51 like autophagy activating kinase 2 -2.61648
C1ORF116 chromosome 1 open reading frame 116 -2.61648
PANO1 proapoptotic nucleolar protein 1 -2.61648
ARG1 arginase 1 -2.61648
APLF aprataxin and PNKP like factor -2.61648
REM2 RAS (RAD and GEM)-like GTP binding 2 -2.61648
ZNF449 zinc finger protein 449 -2.61648
RILPL2 Rab interacting lysosomal protein-like 2 -2.61648
GPC3 glypican 3 -2.61648
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.61648
DOCK5 dedicator of cytokinesis 5 -2.61648
NXPH4 neurexophilin 4 -2.58306
PTX3 pentraxin 3, long -2.58306
SELENOK selenoprotein K -2.58306
VTCN1 V-set domain containing T cell activation inhibitor 1 -2.58306
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) -2.58306
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -2.58306
MAGEA4 melanoma antigen family A4 -2.58306
TMEM215 transmembrane protein 215 -2.58306
MUC1 mucin 1, cell surface associated -2.58306
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -2.58306
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.58306
SHISA7 shisa family member 7 -2.58306
HES2 hes family bHLH transcription factor 2 -2.58306
SLC49A3 solute carrier family 49 member 3 -2.58306
NPSR1 neuropeptide S receptor 1 -2.58306
SHOX short stature homeobox -2.58306
FAIM2 Fas apoptotic inhibitory molecule 2 -2.58306
NDRG1 N-myc downstream regulated 1 -2.58306
CDH10 cadherin 10, type 2 (T2-cadherin) -2.58306
LOC107986837 uncharacterized LOC107986837 -2.58306
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 -2.58306
WNK4 WNK lysine deficient protein kinase 4 -2.58306
TEX11 testis expressed 11 -2.58306
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.58306
NT5C1B 5'-nucleotidase, cytosolic IB -2.58306
GLOD5 glyoxalase domain containing 5 -2.58306
LHCGR luteinizing hormone/choriogonadotropin receptor -2.58306
UPK3B uroplakin 3B -2.58306
IL19 interleukin 19 -2.58306
NPPA natriuretic peptide A -2.58306
UBQLNL ubiquilin-like -2.58306
TASP1 taspase, threonine aspartase, 1 -2.58306
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.58306
KLHL26 kelch-like family member 26 -2.56629
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.49817
TNNC1 troponin C type 1 (slow) -2.44657
JUNB jun B proto-oncogene -2.44657
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -2.41906
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.41906
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -2.41906
OSBPL10 oxysterol binding protein-like 10 -2.41839
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -2.38919
CDKL4 cyclin-dependent kinase-like 4 -2.36668
PLK3 polo-like kinase 3 -2.34629
RAVER2 ribonucleoprotein, PTB-binding 2 -2.34629
CABIN1 calcineurin binding protein 1 -2.34397
ZNF583 zinc finger protein 583 -2.34251
MORN1 MORN repeat containing 1 -2.33975
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -2.33407
RPS21 ribosomal protein S21 -2.31289
STBD1 starch binding domain 1 -2.28765
GNG3 guanine nucleotide binding protein (G protein), gamma 3 -2.28765
COL5A2 collagen, type V, alpha 2 -2.2743
TMEM171 transmembrane protein 171 -2.26945
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -2.25877
FEM1B fem-1 homolog b (C. elegans) -2.25877
MSTO1 misato 1, mitochondrial distribution and morphology regulator -2.22384
PLAUR plasminogen activator, urokinase receptor -2.2198
ENTREP2 endosomal transmembrane epsin interactor 2 -2.19917
NUTM1 NUT midline carcinoma, family member 1 -2.1442
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.09981
LAYN layilin -2.08131
CFAP96 cilia and flagella associated protein 96 -2.08131
FLNA filamin A, alpha -2.08131
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.0787
RNF157 ring finger protein 157 -2.07869
CISD3 CDGSH iron sulfur domain 3 -2.06541
SLC67A1 solute carrier family 67 member 1 -2.05895
TMC2 transmembrane channel-like 2 -2.05895
CNST consortin, connexin sorting protein -2.05895
USP54 ubiquitin specific peptidase 54 -2.05131
FGF14 fibroblast growth factor 14 -2.03326
ARHGAP31 Rho GTPase activating protein 31 -2.02698
ZSCAN21 zinc finger and SCAN domain containing 21 -2.02698
SDHAF4 succinate dehydrogenase complex assembly factor 4 -2.02261
CD200 CD200 molecule -2.00813
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.00813
LYG2 lysozyme G-like 2 -2.00813
NMT2 N-myristoyltransferase 2 -2.00813