CLOCK Gene Set

Dataset ChEA Transcription Factor Targets
Category genomics
Type transcription factor
Description clock circadian regulator|The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 9575)
External Link http://www.ncbi.nlm.nih.gov/gene/9575
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Genes

405 target genes of the CLOCK transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD6 abhydrolase domain containing 6
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ACOT1 acyl-CoA thioesterase 1
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTB actin, beta
ACTC1 actin, alpha, cardiac muscle 1
ACTN1 actinin, alpha 1
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
ADAMTSL4 ADAMTS-like 4
ADIPOR2 adiponectin receptor 2
AK2 adenylate kinase 2
AK3 adenylate kinase 3
AKAP1 A kinase (PRKA) anchor protein 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAS1 5'-aminolevulinate synthase 1
AMD1 adenosylmethionine decarboxylase 1
ANGPTL2 angiopoietin-like 2
ANGPTL4 angiopoietin-like 4
ANKRD46 ankyrin repeat domain 46
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA2 annexin A2
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
AQR aquarius intron-binding spliceosomal factor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARSA arylsulfatase A
ATF4 activating transcription factor 4
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AUTS2 autism susceptibility candidate 2
AVPR1A arginine vasopressin receptor 1A
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BICD2 bicaudal D homolog 2 (Drosophila)
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRI3 brain protein I3
BSN bassoon presynaptic cytomatrix protein
BTF3L4 basic transcription factor 3-like 4
C1QTNF1 C1q and tumor necrosis factor related protein 1
CALD1 caldesmon 1
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALR calreticulin
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC12 coiled-coil domain containing 12
CCDC28B coiled-coil domain containing 28B
CCNG2 cyclin G2
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD82 CD82 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP350 centrosomal protein 350kDa
CES3 carboxylesterase 3
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHD6 chromodomain helicase DNA binding protein 6
CHKA choline kinase alpha
CIRBP cold inducible RNA binding protein
CKB creatine kinase, brain
CLDN5 claudin 5
CLIP1 CAP-GLY domain containing linker protein 1
CLOCK clock circadian regulator
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CLU clusterin
COL13A1 collagen, type XIII, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A3 collagen, type V, alpha 3
COL6A1 collagen, type VI, alpha 1
COMT catechol-O-methyltransferase
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CSNK1A1 casein kinase 1, alpha 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5B cytochrome b5 type B (outer mitochondrial membrane)
CYB5R3 cytochrome b5 reductase 3
CYGB cytoglobin
CYS1 cystin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAB2IP DAB2 interacting protein
DALRD3 DALR anticodon binding domain containing 3
DAPK1 death-associated protein kinase 1
DAZAP2 DAZ associated protein 2
DBP D site of albumin promoter (albumin D-box) binding protein
DCTN2 dynactin 2 (p50)
DDIT4 DNA-damage-inducible transcript 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIO2 deiodinase, iodothyronine, type II
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPEP1 dipeptidase 1 (renal)
DPP7 dipeptidyl-peptidase 7
DUSP1 dual specificity phosphatase 1
DUSP19 dual specificity phosphatase 19
DYNLL1 dynein, light chain, LC8-type 1
EDF1 endothelial differentiation-related factor 1
EEF2 eukaryotic translation elongation factor 2
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
ELAVL1 ELAV like RNA binding protein 1
ELN elastin
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETF1 eukaryotic translation termination factor 1
F11R F11 receptor
FABP7 fatty acid binding protein 7, brain
FBXO21 F-box protein 21
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF1 fibroblast growth factor 1 (acidic)
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FLCN folliculin
FMO1 flavin containing monooxygenase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOS FBJ murine osteosarcoma viral oncogene homolog
FSCN1 fascin actin-bundling protein 1
FUBP1 far upstream element (FUSE) binding protein 1
FUS FUS RNA binding protein
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
GSTA3 glutathione S-transferase alpha 3
GTF2IRD1 GTF2I repeat domain containing 1
H1F0 H1 histone family, member 0
H3F3B H3 histone, family 3B (H3.3B)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES6 hes family bHLH transcription factor 6
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST3H2A histone cluster 3, H2a
HLF hepatic leukemia factor
HMGB3 high mobility group box 3
HRH1 histamine receptor H1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
INMT indolethylamine N-methyltransferase
INTS6 integrator complex subunit 6
INTS8 integrator complex subunit 8
IRF6 interferon regulatory factor 6
ITGA6 integrin, alpha 6
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
IVNS1ABP influenza virus NS1A binding protein
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRAS Kirsten rat sarcoma viral oncogene homolog
KRTCAP2 keratinocyte associated protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LASP1 LIM and SH3 protein 1
LITAF lipopolysaccharide-induced TNF factor
LMNA lamin A/C
LMO4 LIM domain only 4
LOXL1 lysyl oxidase-like 1
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAF1 MAF1 homolog (S. cerevisiae)
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MARC2 mitochondrial amidoxime reducing component 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MARK3 MAP/microtubule affinity-regulating kinase 3
MARVELD1 MARVEL domain containing 1
MCL1 myeloid cell leukemia 1
MED28 mediator complex subunit 28
MEF2A myocyte enhancer factor 2A
MFSD1 major facilitator superfamily domain containing 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MGST3 microsomal glutathione S-transferase 3
MIDN midnolin
MINA MYC induced nuclear antigen
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLXIP MLX interacting protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MORF4L2 mortality factor 4 like 2
MRAP melanocortin 2 receptor accessory protein
MTDH metadherin
MTSS1 metastasis suppressor 1
MVD mevalonate (diphospho) decarboxylase
MYH9 myosin, heavy chain 9, non-muscle
MYL9 myosin, light chain 9, regulatory
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NAP1L1 nucleosome assembly protein 1-like 1
NCAM1 neural cell adhesion molecule 1
NCL nucleolin
NDEL1 nudE neurodevelopment protein 1-like 1
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NHSL1 NHS-like 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPAS2 neuronal PAS domain protein 2
NPC1 Niemann-Pick disease, type C1
NPR3 natriuretic peptide receptor 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OSBPL11 oxysterol binding protein-like 11
OSBPL9 oxysterol binding protein-like 9
PABPN1 poly(A) binding protein, nuclear 1
PARN poly(A)-specific ribonuclease
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCD6IP programmed cell death 6 interacting protein
PDHB pyruvate dehydrogenase (lipoamide) beta
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDRG1 p53 and DNA-damage regulated 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGRMC1 progesterone receptor membrane component 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLD1 phospholipase D1, phosphatidylcholine-specific
PMVK phosphomevalonate kinase
PNPLA3 patatin-like phospholipase domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPID peptidylprolyl isomerase D
PPP1R15B protein phosphatase 1, regulatory subunit 15B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
PRKCDBP protein kinase C, delta binding protein
PRPF4B pre-mRNA processing factor 4B
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTDSS2 phosphatidylserine synthase 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRS protein tyrosine phosphatase, receptor type, S
PVRL3 poliovirus receptor-related 3
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB34 RAB34, member RAS oncogene family
RASD1 RAS, dexamethasone-induced 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS2 regulator of G-protein signaling 2
RHOBTB2 Rho-related BTB domain containing 2
RORC RAR-related orphan receptor C
RPN2 ribophorin II
RRAD Ras-related associated with diabetes
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX2 runt-related transcription factor 2
S100A10 S100 calcium binding protein A10
SASH1 SAM and SH3 domain containing 1
SCARB1 scavenger receptor class B, member 1
SDC2 syndecan 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERINC1 serine incorporator 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SF1 splicing factor 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGPL1 sphingosine-1-phosphate lyase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIX3 SIX homeobox 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
SLC25A30 solute carrier family 25, member 30
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC44A2 solute carrier family 44 (choline transporter), member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMAD6 SMAD family member 6
SNRK SNF related kinase
SNTA1 syntrophin, alpha 1
SNX4 sorting nexin 4
SNX5 sorting nexin 5
SOX12 SRY (sex determining region Y)-box 12
SP3 Sp3 transcription factor
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF5 serine/arginine-rich splicing factor 5
SRSF6 serine/arginine-rich splicing factor 6
SSR1 signal sequence receptor, alpha
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST5 suppression of tumorigenicity 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK24 serine/threonine kinase 24
STMN2 stathmin 2
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
STX6 syntaxin 6
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SUMO1 small ubiquitin-like modifier 1
TARDBP TAR DNA binding protein
TARS threonyl-tRNA synthetase
TBC1D20 TBC1 domain family, member 20
TBCEL tubulin folding cofactor E-like
TCAP titin-cap
TEF thyrotrophic embryonic factor
TEX261 testis expressed 261
TFRC transferrin receptor
TGM2 transglutaminase 2
THBD thrombomodulin
THRAP3 thyroid hormone receptor associated protein 3
TIMP3 TIMP metallopeptidase inhibitor 3
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TMEM33 transmembrane protein 33
TMEM86A transmembrane protein 86A
TMSB10 thymosin beta 10
TNS2 tensin 2
TOB2 transducer of ERBB2, 2
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPD52L2 tumor protein D52-like 2
TRAK1 trafficking protein, kinesin binding 1
TRIB2 tribbles pseudokinase 2
TRUB2 TruB pseudouridine (psi) synthase family member 2
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UBAP2L ubiquitin associated protein 2-like
UBC ubiquitin C
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UBE2H ubiquitin-conjugating enzyme E2H
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USP10 ubiquitin specific peptidase 10
USP2 ubiquitin specific peptidase 2
USP3 ubiquitin specific peptidase 3
VAMP3 vesicle-associated membrane protein 3
VCL vinculin
WDR6 WD repeat domain 6
XBP1 X-box binding protein 1
XDH xanthine dehydrogenase
XPO7 exportin 7
XRN2 5'-3' exoribonuclease 2
YPEL3 yippee-like 3 (Drosophila)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFAND6 zinc finger, AN1-type domain 6
ZFP36L1 ZFP36 ring finger protein-like 1
ZFR zinc finger RNA binding protein
ZIM2 zinc finger, imprinted 2
ZMYM6 zinc finger, MYM-type 6
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase