| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | clock circadian regulator|The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 9575) |
| External Link | https://ncbi.nlm.nih.gov/gene/9575 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the CLOCK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.018736 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.0127272 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0127183 |
| SYT1 | synaptotagmin I | 0.0127072 |
| CFD | complement factor D (adipsin) | 0.0126561 |
| TXLNA | taxilin alpha | 0.0118972 |
| COQ8A | coenzyme Q8A | 0.0106204 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0100578 |
| FAM171A1 | family with sequence similarity 171, member A1 | 0.0094995 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | 0.00902278 |
| TXNIP | thioredoxin interacting protein | 0.00889902 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.00858037 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00844534 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.00822022 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.00821827 |
| INSR | insulin receptor | 0.00820894 |
| ZNF721 | zinc finger protein 721 | 0.00820172 |
| NFIB | nuclear factor I/B | 0.00804431 |
| ACKR3 | atypical chemokine receptor 3 | 0.00799952 |
| PFKL | phosphofructokinase, liver | 0.00798491 |
| MT1G | metallothionein 1G | 0.00795042 |
| TUBB6 | tubulin, beta 6 class V | 0.00783699 |
| REG1A | regenerating islet-derived 1 alpha | 0.00757971 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 0.00755951 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00749625 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0074667 |
| BRCA1 | breast cancer 1, early onset | 0.00744047 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00736143 |
| FKBP5 | FK506 binding protein 5 | 0.0073039 |
| RPS27L | ribosomal protein S27-like | 0.0072555 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00715466 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.00703604 |
| ADIRF | adipogenesis regulatory factor | 0.00700772 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.00700091 |
| JPT2 | Jupiter microtubule associated homolog 2 | 0.00699052 |
| INA | internexin neuronal intermediate filament protein, alpha | 0.00692704 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00686254 |
| ADCY1 | adenylate cyclase 1 (brain) | 0.00682655 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.00680032 |
| PCDH9 | protocadherin 9 | 0.00671891 |
| ZNF160 | zinc finger protein 160 | 0.00671097 |
| NNMT | nicotinamide N-methyltransferase | 0.00667457 |
| C9ORF3 | chromosome 9 open reading frame 3 | 0.00666558 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00664215 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.006589 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | 0.00647068 |
| PROM1 | prominin 1 | 0.00640692 |
| HSPA2 | heat shock 70kDa protein 2 | 0.00638298 |
| HELLS | helicase, lymphoid-specific | 0.00638022 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00631261 |
| MT1H | metallothionein 1H | 0.00628937 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.00623148 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0062156 |
| SYBU | syntabulin (syntaxin-interacting) | 0.00620802 |
| DEFB1 | defensin, beta 1 | 0.00616055 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00615688 |
| ASS1 | argininosuccinate synthase 1 | 0.00615405 |
| PTK2 | protein tyrosine kinase 2 | 0.00613574 |
| AXL | AXL receptor tyrosine kinase | 0.00604207 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00596481 |
| PLIN2 | perilipin 2 | 0.00590033 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00588496 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0058656 |
| MT1F | metallothionein 1F | 0.00584676 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.00583223 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00579171 |
| RBM26 | RNA binding motif protein 26 | 0.00578834 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.00576371 |
| SHCBP1 | SHC SH2-domain binding protein 1 | 0.00576197 |
| PNN | pinin, desmosome associated protein | 0.00574024 |
| CTBP2 | C-terminal binding protein 2 | 0.00573733 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.00565535 |
| KLF6 | Kruppel-like factor 6 | 0.00562578 |
| CNN1 | calponin 1, basic, smooth muscle | 0.00562482 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00561737 |
| RELN | reelin | 0.0056121 |
| MT1E | metallothionein 1E | 0.00560283 |
| MT1X | metallothionein 1X | 0.0055901 |
| BRD8 | bromodomain containing 8 | 0.00557004 |
| GOLGA8A | golgin A8 family, member A | 0.00556737 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0055499 |
| RAB13 | RAB13, member RAS oncogene family | 0.0055334 |
| BTG3 | BTG family, member 3 | 0.0055301 |
| SNRNP70 | small nuclear ribonucleoprotein 70kDa (U1) | 0.00551864 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00551825 |
| PHF20 | PHD finger protein 20 | 0.00551458 |
| MT1M | metallothionein 1M | 0.00547664 |
| UBAP2 | ubiquitin associated protein 2 | 0.00547463 |
| CCNA2 | cyclin A2 | 0.00546414 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | 0.00545639 |
| CDC42SE1 | CDC42 small effector 1 | 0.00544974 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00544335 |
| HAL | histidine ammonia-lyase | 0.00543716 |
| GPX2 | glutathione peroxidase 2 | 0.00541427 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.00540989 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.00540351 |
| FERMT2 | fermitin family member 2 | 0.00538973 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00537914 |
| TBC1D15 | TBC1 domain family, member 15 | 0.00537549 |
| STK10 | serine/threonine kinase 10 | 0.00537373 |
| NPTX2 | neuronal pentraxin II | 0.00536941 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | 0.00536083 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.00535214 |
| MBD1 | methyl-CpG binding domain protein 1 | 0.00535135 |
| FAM111A | family with sequence similarity 111, member A | 0.00533715 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00528921 |
| MECOM | MDS1 and EVI1 complex locus | 0.0052838 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00527908 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | 0.00527038 |
| HAUS2 | HAUS augmin-like complex, subunit 2 | 0.00526744 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.00525929 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | 0.00525638 |
| PLCB4 | phospholipase C, beta 4 | 0.00525061 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00521376 |
| CXADR | coxsackie virus and adenovirus receptor | 0.00520689 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.00520158 |
| RND3 | Rho family GTPase 3 | 0.00518448 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.00518408 |
| NVL | nuclear VCP-like | 0.00515984 |
| CNPY3 | canopy FGF signaling regulator 3 | 0.00514705 |
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.00514018 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00513631 |
| REG3A | regenerating islet-derived 3 alpha | 0.00512141 |
| OPHN1 | oligophrenin 1 | 0.00511744 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00509933 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.0050918 |
| CLU | clusterin | 0.00506425 |
| TPM2 | tropomyosin 2 (beta) | 0.00504339 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.00503025 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | 0.00502384 |
| NAV2 | neuron navigator 2 | 0.00502207 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 | 0.005019 |
| KCTD14 | potassium channel tetramerization domain containing 14 | 0.00501007 |
| NOP56 | NOP56 ribonucleoprotein | 0.00500809 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.00499431 |
| CCL21 | chemokine (C-C motif) ligand 21 | 0.00498288 |
| PLIN1 | perilipin 1 | 0.00498229 |
| JAK2 | Janus kinase 2 | 0.00496524 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.00496407 |
| DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila) | 0.00496076 |
| ORC6 | origin recognition complex, subunit 6 | 0.00495719 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00495162 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.0049506 |
| PRR11 | proline rich 11 | 0.0049441 |
| BMP4 | bone morphogenetic protein 4 | 0.00492328 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.00491262 |
| CROCCP2 | ciliary rootlet coiled-coil, rootletin pseudogene 2 | 0.00490057 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.00489259 |
| NRXN3 | neurexin 3 | 0.00487501 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.00487241 |
| MCM2 | minichromosome maintenance complex component 2 | 0.00487087 |
| RBBP4 | retinoblastoma binding protein 4 | 0.00486986 |
| IL1R1 | interleukin 1 receptor, type I | 0.00485802 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.00484599 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00482686 |
| AOC3 | amine oxidase, copper containing 3 | 0.0047934 |
| RCAN1 | regulator of calcineurin 1 | 0.00478387 |
| RANBP6 | RAN binding protein 6 | 0.00478346 |
| SCML2 | sex comb on midleg-like 2 (Drosophila) | 0.00478225 |
| SRSF10 | serine/arginine-rich splicing factor 10 | 0.00477988 |
| DST | dystonin | 0.00477193 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 0.00477047 |
| BBX | bobby sox homolog (Drosophila) | 0.00476872 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.00476094 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 0.0047425 |
| AUP1 | ancient ubiquitous protein 1 | 0.00473928 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | 0.00473887 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | 0.00473669 |
| CEPT1 | choline/ethanolamine phosphotransferase 1 | 0.00472167 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00472158 |
| TNC | tenascin C | 0.00470536 |
| CNNM3 | cyclin and CBS domain divalent metal cation transport mediator 3 | 0.00470462 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00470267 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.00467792 |
| MFSD11 | major facilitator superfamily domain containing 11 | 0.00467015 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00466714 |
| NOTCH2NL | notch 2 N-terminal like | 0.00466091 |
| DCLRE1C | DNA cross-link repair 1C | 0.00466026 |
| OGA | O-GlcNAcase | 0.00465597 |
| MID1 | midline 1 | 0.00465587 |
| CYP1A2 | cytochrome P450, family 1, subfamily A, polypeptide 2 | 0.00465528 |
| BATF | basic leucine zipper transcription factor, ATF-like | 0.0046346 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.00462605 |
| DEK | DEK proto-oncogene | 0.00462321 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 | 0.00462183 |
| TRIOBP | TRIO and F-actin binding protein | 0.004614 |
| RBM39 | RNA binding motif protein 39 | 0.00461145 |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 | 0.00459309 |
| VSNL1 | visinin-like 1 | 0.00457266 |
| EPCAM | epithelial cell adhesion molecule | 0.00457183 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.00455985 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00455899 |
| C14ORF132 | chromosome 14 open reading frame 132 | 0.00453961 |
| FBXW12 | F-box and WD repeat domain containing 12 | 0.00453903 |
| DUSP1 | dual specificity phosphatase 1 | 0.00453874 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00453315 |
| PUM3 | pumilio RNA binding family member 3 | 0.00453237 |
| ATF3 | activating transcription factor 3 | 0.00452123 |
| ELOVL2 | ELOVL fatty acid elongase 2 | 0.00450383 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00450119 |
| FHL1 | four and a half LIM domains 1 | 0.0044963 |
| POLR1B | polymerase (RNA) I polypeptide B, 128kDa | 0.00448517 |
| MT2A | metallothionein 2A | 0.00448265 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.00447097 |
| MYRF | myelin regulatory factor | 0.00447001 |
| LOXL2 | lysyl oxidase-like 2 | 0.004467 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | 0.00446275 |
| NUP214 | nucleoporin 214kDa | 0.00446251 |
| RNASET2 | ribonuclease T2 | 0.00445911 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.00445398 |
| CCND1 | cyclin D1 | 0.00444044 |
| MYO5C | myosin VC | 0.00442206 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.00441755 |
| NCAPG | non-SMC condensin I complex, subunit G | 0.00438943 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.00438796 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.00438658 |
| BHMT | betaine--homocysteine S-methyltransferase | 0.00437709 |
| SOD1 | superoxide dismutase 1, soluble | 0.00436453 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0043621 |
| DENND4C | DENN/MADD domain containing 4C | 0.00434653 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.00434547 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.00434247 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.00433102 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.0043122 |
| CAV2 | caveolin 2 | 0.00431146 |
| PDLIM4 | PDZ and LIM domain 4 | 0.00429819 |
| BRD2 | bromodomain containing 2 | 0.00428694 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00428381 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.00428373 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.00427962 |
| HOXB7 | homeobox B7 | 0.00427839 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00425904 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0042508 |
| PRB4 | proline-rich protein BstNI subfamily 4 | 0.00424366 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 0.00423502 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.00422814 |
| PRR4 | proline rich 4 (lacrimal) | 0.00422576 |
| HMOX1 | heme oxygenase 1 | 0.00422523 |
| OLFM1 | olfactomedin 1 | 0.00421149 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | 0.00421109 |
| CD4 | CD4 molecule | 0.00420846 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00419941 |
| UBQLN4 | ubiquilin 4 | 0.00419848 |
| THOC1 | THO complex 1 | 0.00419409 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.00418762 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.0041712 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00416179 |
| NUDC | nudC nuclear distribution protein | 0.00416148 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 0.00415962 |
| ETNPPL | ethanolamine-phosphate phospho-lyase | 0.00415707 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.0204634 |
| HOPX | HOP homeobox | -0.0183193 |
| LTF | lactotransferrin | -0.0160918 |
| EGR2 | early growth response 2 | -0.0129065 |
| CDC20 | cell division cycle 20 | -0.0120543 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.010535 |
| FABP7 | fatty acid binding protein 7, brain | -0.0104926 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.010381 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.0100375 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00997649 |
| PLBD1 | phospholipase B domain containing 1 | -0.00965167 |
| HNMT | histamine N-methyltransferase | -0.00952255 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | -0.00951695 |
| LUM | lumican | -0.00951522 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00949326 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0094399 |
| IL32 | interleukin 32 | -0.00935256 |
| GSTA4 | glutathione S-transferase alpha 4 | -0.0092864 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | -0.00925523 |
| RTN2 | reticulon 2 | -0.00918599 |
| GSTT1 | glutathione S-transferase theta 1 | -0.00911057 |
| NES | nestin | -0.00894828 |
| RGCC | regulator of cell cycle | -0.00885007 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.008777 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00874548 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.00871617 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00847079 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.008409 |
| CA2 | carbonic anhydrase II | -0.00829983 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00823797 |
| SMYD3 | SET and MYND domain containing 3 | -0.00818321 |
| CLCA2 | chloride channel accessory 2 | -0.00814019 |
| BEX4 | brain expressed, X-linked 4 | -0.00813145 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00811475 |
| HBD | hemoglobin, delta | -0.00805496 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00803709 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.007926 |
| COL3A1 | collagen, type III, alpha 1 | -0.00787937 |
| MAP7 | microtubule-associated protein 7 | -0.00774101 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00773763 |
| SFRP4 | secreted frizzled-related protein 4 | -0.00772272 |
| ANOS1 | anosmin 1 | -0.00770586 |
| TTN | titin | -0.00770227 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00769067 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00761069 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.00758294 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00743435 |
| FOLR1 | folate receptor 1 (adult) | -0.00735775 |
| MB | myoglobin | -0.00732723 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00727843 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00724989 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00723603 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.00720935 |
| DENND1B | DENN/MADD domain containing 1B | -0.0071915 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | -0.00714897 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00713415 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.00709113 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | -0.00701578 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00697936 |
| CLC | Charcot-Leyden crystal galectin | -0.00696312 |
| MPO | myeloperoxidase | -0.00695532 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.00694898 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | -0.00694514 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00693038 |
| PEG3 | paternally expressed 3 | -0.00691144 |
| MALL | mal, T-cell differentiation protein-like | -0.00688097 |
| TARP | TCR gamma alternate reading frame protein | -0.00686026 |
| LDB2 | LIM domain binding 2 | -0.00673363 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.006649 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00663452 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | -0.00663203 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.00662308 |
| CLIC3 | chloride intracellular channel 3 | -0.00661164 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.0065984 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00658441 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.00654402 |
| NRBF2 | nuclear receptor binding factor 2 | -0.00649267 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.00646847 |
| MSMO1 | methylsterol monooxygenase 1 | -0.00644837 |
| LAMP3 | lysosomal-associated membrane protein 3 | -0.00638188 |
| MFAP2 | microfibrillar-associated protein 2 | -0.00637946 |
| S100A12 | S100 calcium binding protein A12 | -0.00636899 |
| PRDX2 | peroxiredoxin 2 | -0.00634048 |
| PDZK1 | PDZ domain containing 1 | -0.00633996 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.00630511 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | -0.00630462 |
| CDC25B | cell division cycle 25B | -0.00630182 |
| TGFB1 | transforming growth factor, beta 1 | -0.00624898 |
| XIC | X chromosome inactivation center | -0.00624607 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | -0.00621726 |
| DCN | decorin | -0.00617331 |
| BLVRB | biliverdin reductase B | -0.00615872 |
| PLAT | plasminogen activator, tissue | -0.00612497 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | -0.0060919 |
| MSMB | microseminoprotein, beta- | -0.00608946 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0060889 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.00604488 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | -0.00598831 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -0.00596402 |
| S100A9 | S100 calcium binding protein A9 | -0.00594201 |
| ATXN1 | ataxin 1 | -0.00590701 |
| ITGA6 | integrin, alpha 6 | -0.00590277 |
| OLFML2A | olfactomedin-like 2A | -0.0058945 |
| NUCB1 | nucleobindin 1 | -0.00587879 |
| FMOD | fibromodulin | -0.00587298 |
| TCTA | T-cell leukemia translocation altered | -0.00586416 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00581536 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00579912 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00578858 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.00578246 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -0.00575473 |
| G6PD | glucose-6-phosphate dehydrogenase | -0.00575459 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | -0.00575114 |
| C5ORF28 | chromosome 5 open reading frame 28 | -0.00575005 |
| MEX3D | mex-3 RNA binding family member D | -0.00574128 |
| TLE4 | transducin-like enhancer of split 4 | -0.00573731 |
| FMO1 | flavin containing monooxygenase 1 | -0.00572911 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.00572277 |
| NIBAN1 | niban apoptosis regulator 1 | -0.00571961 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | -0.00571002 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | -0.00570892 |
| STC2 | stanniocalcin 2 | -0.00570506 |
| ABLIM1 | actin binding LIM protein 1 | -0.00569685 |
| TNNC1 | troponin C type 1 (slow) | -0.00567895 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00565488 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | -0.00563891 |
| KRT15 | keratin 15, type I | -0.00563205 |
| CLEC11A | C-type lectin domain family 11, member A | -0.00562187 |
| PKM | pyruvate kinase, muscle | -0.00559779 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.00559255 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00558927 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.00558809 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | -0.0055838 |
| GM2A | GM2 ganglioside activator | -0.00557991 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00555385 |
| KRT6A | keratin 6A, type II | -0.00554864 |
| FAM198B | family with sequence similarity 198, member B | -0.00551594 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -0.00550897 |
| CAPG | capping protein (actin filament), gelsolin-like | -0.00550485 |
| MXRA7 | matrix-remodelling associated 7 | -0.00549496 |
| TMSB15A | thymosin beta 15a | -0.00549218 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | -0.00547216 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00546836 |
| AHSP | alpha hemoglobin stabilizing protein | -0.00546413 |
| POSTN | periostin, osteoblast specific factor | -0.00544237 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00543744 |
| GNLY | granulysin | -0.00542742 |
| ARMCX1 | armadillo repeat containing, X-linked 1 | -0.00542146 |
| DEFA4 | defensin, alpha 4, corticostatin | -0.0054081 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.00540394 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00539845 |
| PRSS8 | protease, serine, 8 | -0.00539281 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | -0.00538503 |
| TCF21 | transcription factor 21 | -0.00538421 |
| STXBP2 | syntaxin binding protein 2 | -0.00537934 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.00537614 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.00535803 |
| RPRD1A | regulation of nuclear pre-mRNA domain containing 1A | -0.0053443 |
| ST6GALNAC5 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 | -0.00527684 |
| CDA | cytidine deaminase | -0.0052586 |
| LY96 | lymphocyte antigen 96 | -0.00524473 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.00524063 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00522995 |
| TYMP | thymidine phosphorylase | -0.00522745 |
| GATA3 | GATA binding protein 3 | -0.0052201 |
| BPI | bactericidal/permeability-increasing protein | -0.0052165 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.00519717 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.00518477 |
| PTN | pleiotrophin | -0.00517938 |
| MEST | mesoderm specific transcript | -0.0051739 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0051708 |
| NCOA4 | nuclear receptor coactivator 4 | -0.00516496 |
| ITM2A | integral membrane protein 2A | -0.00514819 |
| TAGLN2 | transgelin 2 | -0.00514066 |
| PTHLH | parathyroid hormone-like hormone | -0.00512762 |
| C1QA | complement component 1, q subcomponent, A chain | -0.00510148 |
| SNAI2 | snail family zinc finger 2 | -0.00508996 |
| CLDN7 | claudin 7 | -0.00508807 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.00508209 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00507848 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | -0.0050747 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.00506719 |
| WDR7 | WD repeat domain 7 | -0.00505873 |
| CTSH | cathepsin H | -0.00505858 |
| S100A8 | S100 calcium binding protein A8 | -0.00505769 |
| ITGB6 | integrin, beta 6 | -0.00502103 |
| RNF19B | ring finger protein 19B | -0.00501729 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -0.00501163 |
| LIMA1 | LIM domain and actin binding 1 | -0.00497927 |
| KRT16 | keratin 16, type I | -0.00495957 |
| CLEC7A | C-type lectin domain family 7, member A | -0.00494758 |
| PHACTR2 | phosphatase and actin regulator 2 | -0.00494578 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.00494483 |
| FGL2 | fibrinogen-like 2 | -0.00493905 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.00492668 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | -0.00490539 |
| MAGED2 | melanoma antigen family D2 | -0.00490535 |
| CST7 | cystatin F (leukocystatin) | -0.00490525 |
| SIRT3 | sirtuin 3 | -0.0048933 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.00489153 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.00487597 |
| CREB1 | cAMP responsive element binding protein 1 | -0.00487527 |
| GLRX5 | glutaredoxin 5 | -0.0048736 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00487324 |
| SCPEP1 | serine carboxypeptidase 1 | -0.00486898 |
| TCF4 | transcription factor 4 | -0.00486853 |
| MYL4 | myosin, light chain 4, alkali; atrial, embryonic | -0.00486779 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.00486666 |
| LY6D | lymphocyte antigen 6 complex, locus D | -0.00485906 |
| METRN | meteorin, glial cell differentiation regulator | -0.00485534 |
| SLC44A4 | solute carrier family 44, member 4 | -0.00485506 |
| XCL1 | chemokine (C motif) ligand 1 | -0.0048415 |
| NDN | necdin, melanoma antigen (MAGE) family member | -0.00483951 |
| KLK11 | kallikrein-related peptidase 11 | -0.00482776 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00480652 |
| CCL4 | chemokine (C-C motif) ligand 4 | -0.00480449 |
| GPD1L | glycerol-3-phosphate dehydrogenase 1-like | -0.00480302 |
| HLA-C | major histocompatibility complex, class I, C | -0.0047943 |
| GSDME | gasdermin E | -0.0047817 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | -0.00475723 |
| CHKB | choline kinase beta | -0.00474738 |
| CD52 | CD52 molecule | -0.00473965 |
| EPAS1 | endothelial PAS domain protein 1 | -0.00471623 |
| APOA1 | apolipoprotein A-I | -0.00471121 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -0.00471102 |
| S100P | S100 calcium binding protein P | -0.00470723 |
| EGFL6 | EGF-like-domain, multiple 6 | -0.00470588 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00470179 |
| ACP5 | acid phosphatase 5, tartrate resistant | -0.00469834 |
| SGMS1 | sphingomyelin synthase 1 | -0.00468472 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00467158 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00465705 |
| TOX3 | TOX high mobility group box family member 3 | -0.00464833 |
| C1QB | complement component 1, q subcomponent, B chain | -0.00463671 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | -0.00462831 |
| TTYH1 | tweety family member 1 | -0.00461718 |
| TNNI1 | troponin I type 1 (skeletal, slow) | -0.00461385 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.00461294 |
| SNX7 | sorting nexin 7 | -0.00460885 |
| AFP | alpha-fetoprotein | -0.00459941 |
| GNAS | GNAS complex locus | -0.00459649 |
| OSBPL1A | oxysterol binding protein-like 1A | -0.00459243 |
| HNRNPH2 | heterogeneous nuclear ribonucleoprotein H2 (H') | -0.00458876 |
| RAB33A | RAB33A, member RAS oncogene family | -0.00458723 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 | -0.00457447 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.00456242 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.00456015 |
| WWC2 | WW and C2 domain containing 2 | -0.00454575 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.00454231 |
| RALB | v-ral simian leukemia viral oncogene homolog B | -0.00454226 |
