CLOCK Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description clock circadian regulator|The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 9575)
External Link http://www.ncbi.nlm.nih.gov/gene/9575
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99 interacting proteins for CLOCK from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
BRCA1 breast cancer 1, early onset
BRD7 bromodomain containing 7
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C4ORF27 chromosome 4 open reading frame 27
CABIN1 calcineurin binding protein 1
CDK5 cyclin-dependent kinase 5
CHRAC1 chromatin accessibility complex 1
CKAP5 cytoskeleton associated protein 5
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTBP1 C-terminal binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DEC1 deleted in esophageal cancer 1
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1
EP300 E1A binding protein p300
ESRRA estrogen-related receptor alpha
GSK3B glycogen synthase kinase 3 beta
GTF2I general transcription factor IIi
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H3A histone cluster 2, H3a
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
INO80E INO80 complex subunit E
KAT2B K(lysine) acetyltransferase 2B
MBD2 methyl-CpG binding domain protein 2
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTA3 metastasis associated 1 family, member 3
NAV3 neuron navigator 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFIA nuclear factor I/A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NGEF neuronal guanine nucleotide exchange factor
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRF1 nuclear respiratory factor 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PKNOX1 PBX/knotted 1 homeobox 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRDM16 PR domain containing 16
RAD50 RAD50 homolog (S. cerevisiae)
RAN RAN, member RAS oncogene family
RARA retinoic acid receptor, alpha
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
SAP130 Sin3A-associated protein, 130kDa
SIN3B SIN3 transcription regulator family member B
SIRT1 sirtuin 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SOGA3 SOGA family member 3
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFCP2 transcription factor CP2
TFCP2L1 transcription factor CP2-like 1
THYN1 thymocyte nuclear protein 1
TIMELESS timeless circadian clock
TOPBP1 topoisomerase (DNA) II binding protein 1
TTF2 transcription termination factor, RNA polymerase II
UBC ubiquitin C
UBP1 upstream binding protein 1 (LBP-1a)
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USF2 upstream transcription factor 2, c-fos interacting
VRK1 vaccinia related kinase 1
WIZ widely interspaced zinc finger motifs
YEATS2 YEATS domain containing 2
ZBTB7A zinc finger and BTB domain containing 7A
ZBTB7B zinc finger and BTB domain containing 7B
ZHX3 zinc fingers and homeoboxes 3
ZNF335 zinc finger protein 335
ZNF462 zinc finger protein 462
ZZZ3 zinc finger, ZZ-type containing 3