CLPB Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description ClpB homolog, mitochondrial AAA ATPase chaperonin|This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] (NCBI Entrez Gene Database, 81570)
External Link http://www.ncbi.nlm.nih.gov/gene/81570
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Genes

412 interacting proteins for hub protein CLPB from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ACO1 aconitase 1, soluble
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTL6A actin-like 6A
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ACVRL1 activin A receptor type II-like 1
ADIPOQ adiponectin, C1Q and collagen domain containing
AES amino-terminal enhancer of split
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
ALAS1 5'-aminolevulinate synthase 1
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
ANO1 anoctamin 1, calcium activated chloride channel
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ATG2A autophagy related 2A
ATG3 autophagy related 3
ATM ATM serine/threonine kinase
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATR ATR serine/threonine kinase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIN2 bridging integrator 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTS1 bladder tumor susceptibility 1
BYSL bystin-like
C4A complement component 4A (Rodgers blood group)
CA1 carbonic anhydrase I
CA6 carbonic anhydrase VI
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCDC115 coiled-coil domain containing 115
CCR4 chemokine (C-C motif) receptor 4
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD1A CD1a molecule
CD226 CD226 molecule
CD3EAP CD3e molecule, epsilon associated protein
CD40LG CD40 ligand
CDC20 cell division cycle 20
CDC34 cell division cycle 34
CDC37 cell division cycle 37
CDC73 cell division cycle 73
CEP135 centrosomal protein 135kDa
CFDP1 craniofacial development protein 1
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4
CHD1 chromodomain helicase DNA binding protein 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHRD chordin
CIAPIN1 cytokine induced apoptosis inhibitor 1
CIRH1A cirrhosis, autosomal recessive 1A (cirhin)
CLPS colipase, pancreatic
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNOT1 CCR4-NOT transcription complex, subunit 1
COG6 component of oligomeric golgi complex 6
COG7 component of oligomeric golgi complex 7
COG8 component of oligomeric golgi complex 8
COL4A1 collagen, type IV, alpha 1
COPS6 COP9 signalosome subunit 6
COQ9 coenzyme Q9
CRNKL1 crooked neck pre-mRNA splicing factor 1
CST6 cystatin E/M
CTH cystathionine gamma-lyase
CWC22 CWC22 spliceosome-associated protein
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae)
CYLD cylindromatosis (turban tumor syndrome)
CYTH1 cytohesin 1
DCTN2 dynactin 2 (p50)
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DIAPH3 diaphanous-related formin 3
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DKC1 dyskeratosis congenita 1, dyskerin
DMAP1 DNA methyltransferase 1 associated protein 1
DMTF1 cyclin D binding myb-like transcription factor 1
DNA2 DNA replication helicase/nuclease 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPH3 diphthamide biosynthesis 3
DSN1 DSN1, MIS12 kinetochore complex component
DUT deoxyuridine triphosphatase
EAF1 ELL associated factor 1
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
ECM1 extracellular matrix protein 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDC3 enhancer of mRNA decapping 3
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF3B eukaryotic translation initiation factor 3, subunit B
ELP2 elongator acetyltransferase complex subunit 2
ENG endoglin
EPC1 enhancer of polycomb homolog 1 (Drosophila)
EPHA3 EPH receptor A3
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC10 exosome component 10
EXOSC6 exosome component 6
EXOSC7 exosome component 7
EXOSC8 exosome component 8
EXOSC9 exosome component 9
FAR1 fatty acyl CoA reductase 1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FPR3 formyl peptide receptor 3
FRS2 fibroblast growth factor receptor substrate 2
FURIN furin (paired basic amino acid cleaving enzyme)
GAR1 GAR1 ribonucleoprotein
GAS1 growth arrest-specific 1
GAS5 growth arrest-specific 5 (non-protein coding)
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GFM1 G elongation factor, mitochondrial 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLG1 golgi glycoprotein 1
GLI2 GLI family zinc finger 2
GLUD1 glutamate dehydrogenase 1
GPR65 G protein-coupled receptor 65
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
GSG1 germ cell associated 1
H1FX H1 histone family, member X
HAT1 histone acetyltransferase 1
HEATR1 HEAT repeat containing 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HHATL hedgehog acyltransferase-like
HIRA histone cell cycle regulator
HK1 hexokinase 1
HK2 hexokinase 2
HMP19 HMP19 protein
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL2RG interleukin 2 receptor, gamma
INO80 INO80 complex subunit
INO80B INO80 complex subunit B
ISM1 isthmin 1, angiogenesis inhibitor
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAKMIP1 janus kinase and microtubule interacting protein 1
KIAA0020 KIAA0020
KIAA0368 KIAA0368
KLRC3 killer cell lectin-like receptor subfamily C, member 3
KRI1 KRI1 homolog (S. cerevisiae)
LEPROT leptin receptor overlapping transcript
LRG1 leucine-rich alpha-2-glycoprotein 1
LRP1 low density lipoprotein receptor-related protein 1
LSG1 large 60S subunit nuclear export GTPase 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSP1 lymphocyte-specific protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MATR3 matrin 3
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MDFI MyoD family inhibitor
MDH1 malate dehydrogenase 1, NAD (soluble)
MEAF6 MYST/Esa1-associated factor 6
MED14 mediator complex subunit 14
MED31 mediator complex subunit 31
MEF2A myocyte enhancer factor 2A
MGA MGA, MAX dimerization protein
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MORF4L1 mortality factor 4 like 1
MRC1 mannose receptor, C type 1
MRGBP MRG/MORF4L binding protein
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL10 mitochondrial ribosomal protein L10
MRPL17 mitochondrial ribosomal protein L17
MRPL37 mitochondrial ribosomal protein L37
MRPL50 mitochondrial ribosomal protein L50
MRPS5 mitochondrial ribosomal protein S5
MSH6 mutS homolog 6
MSI1 musashi RNA-binding protein 1
MVP major vault protein
MYO5A myosin VA (heavy chain 12, myoxin)
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NABP1 nucleic acid binding protein 1
NAP1L3 nucleosome assembly protein 1-like 3
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NCOA1 nuclear receptor coactivator 1
NDC80 NDC80 kinetochore complex component
NDNL2 necdin-like 2
NET1 neuroepithelial cell transforming 1
NFYC nuclear transcription factor Y, gamma
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMT1 N-myristoyltransferase 1
NOL6 nucleolar protein 6 (RNA-associated)
NOP14 NOP14 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOP58 NOP58 ribonucleoprotein
NR0B2 nuclear receptor subfamily 0, group B, member 2
NTSR2 neurotensin receptor 2
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1
OGG1 8-oxoguanine DNA glycosylase
OLA1 Obg-like ATPase 1
ORC1 origin recognition complex, subunit 1
ORC3 origin recognition complex, subunit 3
ORC4 origin recognition complex, subunit 4
ORC5 origin recognition complex, subunit 5
ORC6 origin recognition complex, subunit 6
OSBPL10 oxysterol binding protein-like 10
OSGEP O-sialoglycoprotein endopeptidase
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PDCD1 programmed cell death 1
PDCD11 programmed cell death 11
PDX1 pancreatic and duodenal homeobox 1
PEBP1 phosphatidylethanolamine binding protein 1
PFDN1 prefoldin subunit 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKM phosphofructokinase, muscle
PIF1 PIF1 5'-to-3' DNA helicase
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLAA phospholipase A2-activating protein
PLG plasminogen
POLH polymerase (DNA directed), eta
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POMP proteasome maturation protein
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POT1 protection of telomeres 1
PPAN peter pan homolog (Drosophila)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPT1 palmitoyl-protein thioesterase 1
PRDM1 PR domain containing 1, with ZNF domain
PROKR1 prokineticin receptor 1
PRPF3 pre-mRNA processing factor 3
PRPF31 pre-mRNA processing factor 31
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PRPF6 pre-mRNA processing factor 6
PRPF8 pre-mRNA processing factor 8
PRRC2A proline-rich coiled-coil 2A
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSPC1 paraspeckle component 1
PTBP3 polypyrimidine tract binding protein 3
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PWP1 PWP1 homolog (S. cerevisiae)
PYCARD PYD and CARD domain containing
RABIF RAB interacting factor
RAD51 RAD51 recombinase
RAD54B RAD54 homolog B (S. cerevisiae)
RCL1 RNA terminal phosphate cyclase-like 1
RET ret proto-oncogene
RFC1 replication factor C (activator 1) 1, 145kDa
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RHOA ras homolog family member A
RIC1 RAB6A GEF complex partner 1
RIMS1 regulating synaptic membrane exocytosis 1
RIOK2 RIO kinase 2
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNR1 RNA, ribosomal cluster 1
RNR2 RNA, ribosomal cluster 2
RNR4 RNA, ribosomal cluster 4
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPF2 ribosome production factor 2 homolog (S. cerevisiae)
RPH3AL rabphilin 3A-like (without C2 domains)
RPL7A ribosomal protein L7a
RPL7AP7 ribosomal protein L7a pseudogene 7
RPN1 ribophorin I
RPN2 ribophorin II
RPSA ribosomal protein SA
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
RTN1 reticulon 1
RYBP RING1 and YY1 binding protein
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SART1 squamous cell carcinoma antigen recognized by T cells
SCARA3 scavenger receptor class A, member 3
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SEC13 SEC13 homolog (S. cerevisiae)
SEC24B SEC24 family member B
SETD2 SET domain containing 2
SF3B1 splicing factor 3b, subunit 1, 155kDa
SH2D3A SH2 domain containing 3A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SIN3A SIN3 transcription regulator family member A
SIRT2 sirtuin 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLTM SAFB-like, transcription modulator
SMAD1 SMAD family member 1
SMAD9 SMAD family member 9
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNF8 SNF8, ESCRT-II complex subunit
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPC small nuclear ribonucleoprotein polypeptide C
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SNW1 SNW domain containing 1
SOCS1 suppressor of cytokine signaling 1
SPP1 secreted phosphoprotein 1
SPPL3 signal peptide peptidase like 3
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SQSTM1 sequestosome 1
SRCAP Snf2-related CREBBP activator protein
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP68 signal recognition particle 68kDa
SRRM2 serine/arginine repetitive matrix 2
SRSF5 serine/arginine-rich splicing factor 5
SSBP3 single stranded DNA binding protein 3
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STIP1 stress-induced phosphoprotein 1
STK24 serine/threonine kinase 24
STOML1 stomatin (EPB72)-like 1
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae)
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TARBP1 TAR (HIV-1) RNA binding protein 1
TAZ tafazzin
TBCE tubulin folding cofactor E
TBL3 transducin (beta)-like 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TEAD2 TEA domain family member 2
TES testin LIM domain protein
TEX10 testis expressed 10
TFIP11 tuftelin interacting protein 11
THEMIS thymocyte selection associated
THOC2 THO complex 2
THRB thyroid hormone receptor, beta
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TOM1 target of myb1 (chicken)
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TRAPPC5 trafficking protein particle complex 5
TRIM21 tripartite motif containing 21
TRIM24 tripartite motif containing 24
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae)
TROVE2 TROVE domain family, member 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPS1 trichorhinophalangeal syndrome I
TRX-CAT1-3 transfer RNA-iMet (CAT) 1-3
TSPAN13 tetraspanin 13
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TTC3 tetratricopeptide repeat domain 3
TTF2 transcription termination factor, RNA polymerase II
TTK TTK protein kinase
TXN2 thioredoxin 2
TXNDC11 thioredoxin domain containing 11
TXNIP thioredoxin interacting protein
UBA1 ubiquitin-like modifier activating enzyme 1
UBA2 ubiquitin-like modifier activating enzyme 2
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBE4B ubiquitination factor E4B
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP18 ubiquitin specific peptidase 18
USP30 ubiquitin specific peptidase 30
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
UVRAG UV radiation resistance associated
VAC14 Vac14 homolog (S. cerevisiae)
VCP valosin containing protein
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
VSX2 visual system homeobox 2
VTA1 vesicle (multivesicular body) trafficking 1
VWF von Willebrand factor
WDR18 WD repeat domain 18
WDR26 WD repeat domain 26
WDR36 WD repeat domain 36
WDR43 WD repeat domain 43
XPO1 exportin 1
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1