CLPX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description caseinolytic mitochondrial matrix peptidase chaperone subunit| (NCBI Entrez Gene Database, 10845)
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Genes

316 genes differentially expressed following the CLPX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLDN14 claudin 14 3.58088
CEP295NL CEP295 N-terminal like 3.58088
AQP7 aquaporin 7 3.58088
FAM177B family with sequence similarity 177, member B 3.58088
FAM9B family with sequence similarity 9, member B 3.58088
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.58088
FLI1 Fli-1 proto-oncogene, ETS transcription factor 3.58088
CHIT1 chitinase 1 (chitotriosidase) 3.58088
ZC3H12D zinc finger CCCH-type containing 12D 3.58088
EDN2 endothelin 2 3.58088
FNDC8 fibronectin type III domain containing 8 3.58088
ADAMTSL5 ADAMTS-like 5 3.58088
MEIKIN meiotic kinetochore factor 3.58088
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.58088
PRRX1 paired related homeobox 1 3.58088
ICAM2 intercellular adhesion molecule 2 3.58088
GATA6 GATA binding protein 6 3.58088
CPO carboxypeptidase O 3.58088
NCKAP1L NCK-associated protein 1-like 3.58088
ADAMTSL2 ADAMTS-like 2 3.58088
RBM20 RNA binding motif protein 20 3.58088
NYX nyctalopin 3.58088
C22ORF31 chromosome 22 open reading frame 31 3.58088
IL9R interleukin 9 receptor 3.58088
ATP13A4 ATPase type 13A4 3.58088
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.58088
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.58088
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.58088
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.58088
ZSWIM2 zinc finger, SWIM-type containing 2 3.58088
C20ORF204 chromosome 20 open reading frame 204 3.58088
SMIM31 small integral membrane protein 31 3.58088
CRH corticotropin releasing hormone 3.39461
UMODL1 uromodulin-like 1 3.39461
DOK7 docking protein 7 3.39461
EDAR ectodysplasin A receptor 3.39461
PTPRH protein tyrosine phosphatase, receptor type, H 3.39461
TSC22D2 TSC22 domain family, member 2 3.39461
DTHD1 death domain containing 1 3.39461
ZNF436 zinc finger protein 436 3.39461
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.39461
TRIM49 tripartite motif containing 49 3.39461
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.39461
ROPN1B rhophilin associated tail protein 1B 3.39461
PITX1 paired-like homeodomain 1 3.39461
MEIG1 meiosis/spermiogenesis associated 1 3.39461
TWIST1 twist family bHLH transcription factor 1 3.39461
DHRS9 dehydrogenase/reductase (SDR family) member 9 3.39461
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.39461
PRSS21 protease, serine, 21 (testisin) 3.39461
STAP1 signal transducing adaptor family member 1 3.39461
MTTP microsomal triglyceride transfer protein 3.39461
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.39461
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.39461
SP9 Sp9 transcription factor 3.39461
BHMT2 betaine--homocysteine S-methyltransferase 2 3.39461
NPIPA3 nuclear pore complex interacting protein family, member A3 3.39461
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.39461
GIMAP4 GTPase, IMAP family member 4 3.39461
TM4SF20 transmembrane 4 L six family member 20 3.39461
OOSP1 oocyte secreted protein 1, pseudogene 3.39461
RAX retina and anterior neural fold homeobox 3.39461
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 3.39461
ADGRG1 adhesion G protein-coupled receptor G1 3.39461
CX3CL1 chemokine (C-X3-C motif) ligand 1 3.39461
INSRR insulin receptor-related receptor 3.39461
ENTHD1 ENTH domain containing 1 3.39461
KNG1 kininogen 1 3.39461
SRL sarcalumenin 3.39461
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 3.39461
KLRF2 killer cell lectin-like receptor subfamily F, member 2 3.39461
MAP3K7CL MAP3K7 C-terminal like 3.39461
WNT9B wingless-type MMTV integration site family, member 9B 3.39461
C8ORF48 chromosome 8 open reading frame 48 3.39461
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.39461
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.39461
CIITA class II, major histocompatibility complex, transactivator 3.39461
MUSK muscle, skeletal, receptor tyrosine kinase 3.39461
ZG16B zymogen granule protein 16B 3.39461
OLFM4 olfactomedin 4 3.39461
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.39461
TMEM235 transmembrane protein 235 3.39461
PAX6 paired box 6 3.39461
FPR1 formyl peptide receptor 1 3.39461
AADACL4 arylacetamide deacetylase-like 4 3.39461
CES5A carboxylesterase 5A 3.39461
ROPN1 rhophilin associated tail protein 1 3.39461
GSTM5 glutathione S-transferase mu 5 3.39461
TBX5 T-box 5 3.39461
FAM90A11 family with sequence similarity 90 member A11 3.39461
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.39461
H2BW2 H2B.W histone 2 3.39461
TEX19 testis expressed 19 3.39461
GARIN4 golgi associated RAB2 interactor family member 4 3.39461
CCL15 chemokine (C-C motif) ligand 15 3.39461
H1-8 H1.8 linker histone 3.39461
ODAPH odontogenesis associated phosphoprotein 3.39461
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.39461
TERB1 telomere repeat binding bouquet formation protein 1 3.39461
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.39461
CPA2 carboxypeptidase A2 (pancreatic) 3.39461
JAML junction adhesion molecule like 3.39461
CTAGE9 CTAGE family, member 9 3.39461
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.39461
EFCAB9 EF-hand calcium binding domain 9 3.39461
AMIGO1 adhesion molecule with Ig-like domain 1 3.39461
LCT lactase 3.39461
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.39461
LY6L lymphocyte antigen 6 family member L 3.39461
TTLL9 tubulin tyrosine ligase-like family member 9 3.39461
SLC36A3 solute carrier family 36, member 3 3.39461
LY6S lymphocyte antigen 6 family member S 3.39461
WNT10B wingless-type MMTV integration site family, member 10B 3.39461
NOTCH2NLB notch 2 N-terminal like B 3.39461
GAS2L2 growth arrest-specific 2 like 2 3.39461
H4C15 H4 clustered histone 15 3.39461
MOBP myelin-associated oligodendrocyte basic protein 3.39461
SH2D1B SH2 domain containing 1B 3.39461
HAND2 heart and neural crest derivatives expressed 2 3.39461
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.39461
LY9 lymphocyte antigen 9 3.39461
DLX3 distal-less homeobox 3 3.39461
CRHBP corticotropin releasing hormone binding protein 3.39461
H3C3 H3 clustered histone 3 3.39461
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.39461
SIGLEC11 sialic acid binding Ig-like lectin 11 3.39461
TG thyroglobulin 3.39461
HAMP hepcidin antimicrobial peptide 3.39461
ASCL1 achaete-scute family bHLH transcription factor 1 3.39461
GIPC3 GIPC PDZ domain containing family, member 3 3.39461
TRPM1 transient receptor potential cation channel, subfamily M, member 1 3.39461
ASCL5 achaete-scute family bHLH transcription factor 5 3.39461
LRRC31 leucine rich repeat containing 31 3.39461
GBP4 guanylate binding protein 4 3.39461
IFNK interferon, kappa 3.39461
GBP6 guanylate binding protein family, member 6 3.39461
GBP1 guanylate binding protein 1, interferon-inducible 3.39461
ANGPTL3 angiopoietin-like 3 3.39461
TMEM213 transmembrane protein 213 3.39461
UNC93A unc-93 homolog A (C. elegans) 3.39461
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.39461
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.39461
FOXG1 forkhead box G1 3.39461
CD80 CD80 molecule 3.39461
DEFB108B defensin, beta 108B 3.39461
ZSCAN4 zinc finger and SCAN domain containing 4 3.39461
CCDC187 coiled-coil domain containing 187 3.39461
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.39461
MORC1 MORC family CW-type zinc finger 1 3.39461
SKAP1 src kinase associated phosphoprotein 1 3.39461
CLPS colipase, pancreatic 3.39461
ANKRD62 ankyrin repeat domain 62 3.39461
STMND1 stathmin domain containing 1 3.39461
CCN3 cellular communication network factor 3 3.39461
AGR2 anterior gradient 2 3.39461
CORO6 coronin 6 3.28814
C17ORF78 chromosome 17 open reading frame 78 3.28814
SP2 Sp2 transcription factor 3.2593
C11ORF86 chromosome 11 open reading frame 86 3.23438
VN1R1 vomeronasal 1 receptor 1 3.13284
C1ORF141 chromosome 1 open reading frame 141 3.01743
MEGF8 multiple EGF-like-domains 8 2.94099
IGSF8 immunoglobulin superfamily, member 8 2.9192
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 2.89056
NECAB2 N-terminal EF-hand calcium binding protein 2 2.76445
RIPK4 receptor-interacting serine-threonine kinase 4 2.72398
ATG3 autophagy related 3 2.70362
ARHGAP23 Rho GTPase activating protein 23 2.62693
WASF1 WAS protein family, member 1 2.56288
VEGFA vascular endothelial growth factor A 2.55989
TUBGCP5 tubulin, gamma complex associated protein 5 2.55935
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 2.55849
OTUD4 OTU deubiquitinase 4 2.55849
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 2.55849
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.47816
DNAI1 dynein, axonemal, intermediate chain 1 2.41773
FRMD4B FERM domain containing 4B 2.41773
TRAF3IP2 TRAF3 interacting protein 2 2.40564
ERAP1 endoplasmic reticulum aminopeptidase 1 2.40334
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 2.39128
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 2.36648
LOX lysyl oxidase 2.36648
FAM186A family with sequence similarity 186, member A 2.36648
PAGE4 P antigen family, member 4 (prostate associated) 2.35069
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.35069
COL17A1 collagen, type XVII, alpha 1 2.35069
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.34981
ALMS1 Alstrom syndrome protein 1 2.34851
LACTB lactamase, beta 2.34851
FANCI Fanconi anemia, complementation group I 2.28933
CCDC39 coiled-coil domain containing 39 2.27394
CTRL chymotrypsin-like 2.27313
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 2.27313
PKD1L1 polycystic kidney disease 1 like 1 2.27313
ADAM17 ADAM metallopeptidase domain 17 2.24475
CSK c-src tyrosine kinase 2.24475
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 2.24287
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.24287
DEPTOR DEP domain containing MTOR-interacting protein 2.24287
TRABD2A TraB domain containing 2A 2.18843
TMEM86B transmembrane protein 86B 2.18843
TRHR thyrotropin-releasing hormone receptor 2.18843
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 2.17331
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2.16874
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 2.16874
PFKL phosphofructokinase, liver 2.16768
AASDH aminoadipate-semialdehyde dehydrogenase 2.16612
RNF169 ring finger protein 169 2.16413
NCALD neurocalcin delta 2.12012
H3C4 H3 clustered histone 4 2.11587
SEC14L6 SEC14-like 6 (S. cerevisiae) 2.11587
LOC124904942 uncharacterized LOC124904942 2.11463
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.0922
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.0922
RALY RALY heterogeneous nuclear ribonucleoprotein 2.0922
FASTKD1 FAST kinase domains 1 2.09183
GARIN2 golgi associated RAB2 interactor family member 2 2.07284
SENP5 SUMO1/sentrin specific peptidase 5 2.06815
MFSD12 major facilitator superfamily domain containing 12 2.06765
ATP7A ATPase, Cu++ transporting, alpha polypeptide 2.06686
SPINK5 serine peptidase inhibitor, Kazal type 5 2.04082
ZNF852 zinc finger protein 852 2.04057
ZNF800 zinc finger protein 800 2.03861
FANCD2OS FANCD2 opposite strand 2.01717
WAC WW domain containing adaptor with coiled-coil 2.00326

decreased expression

Symbol Name Standardized Value
NSG2 neuronal vesicle trafficking associated 2 -3.58088
HAPLN1 hyaluronan and proteoglycan link protein 1 -3.58088
CATSPER4 cation channel, sperm associated 4 -3.58088
UBQLNL ubiquilin-like -3.39461
DYDC1 DPY30 domain containing 1 -3.39461
RAB40A RAB40A, member RAS oncogene family -3.39461
SOST sclerostin -3.39461
TMEM217 transmembrane protein 217 -3.39461
TBC1D28 TBC1 domain family, member 28 -3.39461
LAMP5 lysosomal-associated membrane protein family, member 5 -3.39461
PPP1R3G protein phosphatase 1, regulatory subunit 3G -3.39461
LPA lipoprotein, Lp(a) -3.39461
RNF183 ring finger protein 183 -3.39461
IL16 interleukin 16 -3.39461
PCDH8 protocadherin 8 -3.39461
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -3.39461
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -3.39461
VSTM1 V-set and transmembrane domain containing 1 -3.39461
LYPD5 LY6/PLAUR domain containing 5 -3.39461
HRH4 histamine receptor H4 -3.39461
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.39461
POM121C POM121 transmembrane nucleoporin C -3.39461
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 -3.39461
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.39461
CA9 carbonic anhydrase IX -3.39461
LRRN4 leucine rich repeat neuronal 4 -3.39461
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -3.2593
SORD sorbitol dehydrogenase -3.16427
XRRA1 X-ray radiation resistance associated 1 -3.0552
DRC9 dynein regulatory complex subunit 9 -3.03801
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -2.98274
KLHDC8A kelch domain containing 8A -2.92563
CENPF centromere protein F, 350/400kDa -2.88086
E2F8 E2F transcription factor 8 -2.71342
FOXL2 forkhead box L2 -2.66786
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.66714
BRCA1 breast cancer 1, early onset -2.61649
MYG1 MYG1 exonuclease -2.58783
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.55935
GGACT gamma-glutamylamine cyclotransferase -2.47816
PCDHGC3 protocadherin gamma subfamily C, 3 -2.47816
BFAR bifunctional apoptosis regulator -2.47816
CD200R1 CD200 receptor 1 -2.47816
ANKRD65 ankyrin repeat domain 65 -2.47816
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 -2.47816
TNNT2 troponin T type 2 (cardiac) -2.43384
MROH6 maestro heat-like repeat family member 6 -2.42236
EDC3 enhancer of mRNA decapping 3 -2.40334
MRPL2 mitochondrial ribosomal protein L2 -2.36962
GLOD4 glyoxalase domain containing 4 -2.36532
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1 -2.34851
UNC119B unc-119 homolog B (C. elegans) -2.33521
COL15A1 collagen, type XV, alpha 1 -2.33436
WNT3A wingless-type MMTV integration site family, member 3A -2.33436
SERINC1 serine incorporator 1 -2.32656
POU2F3 POU class 2 homeobox 3 -2.312
ANXA9 annexin A9 -2.312
MUSTN1 musculoskeletal, embryonic nuclear protein 1 -2.312
ARHGAP44 Rho GTPase activating protein 44 -2.29146
RUMY2 RUMY family member 2 -2.29146
RNF122 ring finger protein 122 -2.27511
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.27511
SNX13 sorting nexin 13 -2.26743
METTL18 methyltransferase like 18 -2.24287
FOXA3 forkhead box A3 -2.2405
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.2332
FSCN3 fascin actin-bundling protein 3, testicular -2.2332
SMTN smoothelin -2.21636
JPH1 junctophilin 1 -2.20466
CSRP1 cysteine and glycine-rich protein 1 -2.18843
MAP2K5 mitogen-activated protein kinase kinase 5 -2.18843
ATXN1 ataxin 1 -2.16874
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.16413
ZNF501 zinc finger protein 501 -2.1631
SLC44A2 solute carrier family 44 (choline transporter), member 2 -2.1631
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.15961
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -2.14991
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.12378
CFAP96 cilia and flagella associated protein 96 -2.11463
PXK PX domain containing serine/threonine kinase -2.0922
EML5 echinoderm microtubule associated protein like 5 -2.08584
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.08282
TPR translocated promoter region, nuclear basket protein -2.07284
ZNF830 zinc finger protein 830 -2.06815
RETREG2 reticulophagy regulator family member 2 -2.06815
RAB19 RAB19, member RAS oncogene family -2.06815
H2BC14 H2B clustered histone 14 -2.06765
NSUN4 NOP2/Sun domain family, member 4 -2.06538
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.04397
SAP18 Sin3A-associated protein, 18kDa -2.01465
SCRN2 secernin 2 -2.00682