COG2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description component of oligomeric golgi complex 2|This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 22796)
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Genes

359 genes differentially expressed following the COG2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.01352
OR10A4 olfactory receptor, family 10, subfamily A, member 4 3.01352
SH2D6 SH2 domain containing 6 3.01352
LRRC56 leucine rich repeat containing 56 3.01352
PAX6 paired box 6 3.01352
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 3.01352
BMP8B bone morphogenetic protein 8b 3.01352
FAM90A1 family with sequence similarity 90, member A1 3.01352
FAM156B family with sequence similarity 156, member B 3.01352
ASB10 ankyrin repeat and SOCS box containing 10 3.01352
C19ORF67 chromosome 19 open reading frame 67 3.01352
SIRPB1 signal-regulatory protein beta 1 3.01352
PGBDF plakoglobin binding and degradation factor 3.01352
PRODH2 proline dehydrogenase (oxidase) 2 3.01352
TAS2R3 taste receptor, type 2, member 3 3.01352
HNF4A hepatocyte nuclear factor 4, alpha 3.01352
UPK3A uroplakin 3A 3.01352
PARP3 poly (ADP-ribose) polymerase family, member 3 3.01352
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.01352
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.01352
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.01352
FBXL8 F-box and leucine-rich repeat protein 8 3.01352
DUXA double homeobox A 3.01352
BTC betacellulin 3.01352
NUGGC nuclear GTPase, germinal center associated 3.01352
GPR26 G protein-coupled receptor 26 3.01352
LYNX1 Ly6/neurotoxin 1 3.01352
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.01352
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.01352
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.01352
CNTN2 contactin 2 (axonal) 3.01352
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.01352
OR9K2 olfactory receptor, family 9, subfamily K, member 2 3.01352
MMRN1 multimerin 1 3.01352
MAGEC3 melanoma antigen family C3 3.01352
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.01352
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.01352
OIT3 oncoprotein induced transcript 3 3.01352
HMX3 H6 family homeobox 3 3.01352
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.01352
SP7 Sp7 transcription factor 3.01352
LY6G6F lymphocyte antigen 6 complex, locus G6F 3.01352
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.01352
LCN12 lipocalin 12 3.01352
CELA1 chymotrypsin-like elastase family, member 1 3.01352
S100A1 S100 calcium binding protein A1 3.01352
OXT oxytocin/neurophysin I prepropeptide 3.01352
TAS2R10 taste receptor, type 2, member 10 3.01352
ADH6 alcohol dehydrogenase 6 (class V) 3.01352
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.01352
IFITM10 interferon induced transmembrane protein 10 3.01352
PVRIG poliovirus receptor related immunoglobulin domain containing 3.01352
LOC124901449 uncharacterized LOC124901449 3.01352
DEFB108B defensin, beta 108B 3.01352
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.01352
PTH1R parathyroid hormone 1 receptor 3.01352
GBP4 guanylate binding protein 4 3.01352
AVPR1A arginine vasopressin receptor 1A 3.01352
PROP1 PROP paired-like homeobox 1 3.01352
CD300LF CD300 molecule-like family member f 3.01352
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.01352
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 3.01352
DNAAF1 dynein, axonemal, assembly factor 1 3.01352
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.01352
H1-6 H1.6 linker histone, cluster member 3.01352
H3-5 H3.5 histone 3.01352
EPCIP exosomal polycystin 1 interacting protein 3.01352
DAAM2-AS1 DAAM2 antisense RNA 1 3.01352
CIMIP3 ciliary microtubule inner protein 3 3.01352
CIMAP1D CIMAP1 family member D 3.01352
H4C14 H4 clustered histone 14 3.01352
SMIM43 small integral membrane protein 43 3.01352
EZHIP EZH inhibitory protein 3.01352
ACP4 acid phosphatase 4 3.01352
CLEC20A C-type lectin domain containing 20A 3.01352
MAJIN membrane anchored junction protein 3.01352
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.01352
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.01352
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.01352
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.01352
MIA melanoma inhibitory activity 3.01352
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.01352
TLR1 toll-like receptor 1 3.01352
HPR haptoglobin-related protein 3.01352
MAG myelin associated glycoprotein 3.01352
DSG1 desmoglein 1 3.01352
PTPRH protein tyrosine phosphatase, receptor type, H 3.01352
PCDHA3 protocadherin alpha 3 3.01352
FOXD2 forkhead box D2 3.01352
CDKN2A cyclin-dependent kinase inhibitor 2A 3.01352
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 3.01352
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.01352
SAG S-antigen; retina and pineal gland (arrestin) 3.01352
FOXC1 forkhead box C1 3.01352
WNT16 wingless-type MMTV integration site family, member 16 3.01352
BHLHE41 basic helix-loop-helix family, member e41 3.01352
C15ORF62 chromosome 15 open reading frame 62 3.01352
CNTN6 contactin 6 3.01352
LTF lactotransferrin 3.01352
ACE2 angiotensin I converting enzyme 2 3.01352
TAS1R3 taste receptor, type 1, member 3 3.01352
PGA5 pepsinogen 5, group I (pepsinogen A) 3.01352
LOC390937 Ets2 repressor factor-like 3.01352
DGCR6 DiGeorge syndrome critical region gene 6 3.01352
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.01352
BCO1 beta-carotene oxygenase 1 3.01352
A3GALT2 alpha 1,3-galactosyltransferase 2 3.01352
PCDHGB1 protocadherin gamma subfamily B, 1 3.01352
VWA7 von Willebrand factor A domain containing 7 3.01352
MORC1 MORC family CW-type zinc finger 1 3.01352
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.01352
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.01352
CER1 cerberus 1, DAN family BMP antagonist 3.01352
CATIP ciliogenesis associated TTC17 interacting protein 3.01352
ANKRD62 ankyrin repeat domain 62 3.01352
IL12A interleukin 12A 3.01352
ECM1 extracellular matrix protein 1 3.01352
BTNL3 butyrophilin-like 3 3.01352
IGF2 insulin-like growth factor 2 3.01352
VWA3B von Willebrand factor A domain containing 3B 3.01352
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.01352
PCDHGA4 protocadherin gamma subfamily A, 4 3.01352
OR5H14 olfactory receptor, family 5, subfamily H, member 14 3.01352
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.01352
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.01352
GOLGA6C golgin A6 family, member C 3.01352
C9ORF64 chromosome 9 open reading frame 64 3.01352
BTNL9 butyrophilin-like 9 3.01352
BTNL8 butyrophilin-like 8 3.01352
CPA5 carboxypeptidase A5 3.01352
FATE1 fetal and adult testis expressed 1 3.01352
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 3.01352
ZNF541 zinc finger protein 541 3.01352
CERS3 ceramide synthase 3 3.01352
SOWAHA sosondowah ankyrin repeat domain family member A 3.01352
KCNK2 potassium channel, two pore domain subfamily K, member 2 3.01352
DRD2 dopamine receptor D2 3.01352
ASTL astacin-like metallo-endopeptidase (M12 family) 3.01352
SPATA9 spermatogenesis associated 9 3.01352
HEPACAM hepatic and glial cell adhesion molecule 3.01352
GCM1 glial cells missing homolog 1 (Drosophila) 3.01352
ITPKA inositol-trisphosphate 3-kinase A 3.01352
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.01352
PRAP1 proline-rich acidic protein 1 3.01352
IL20 interleukin 20 3.01352
SP140L SP140 nuclear body protein-like 3.01352
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.01352
EOMES eomesodermin 3.01352
CLCA1 chloride channel accessory 1 3.01352
BHLHA15 basic helix-loop-helix family, member a15 3.01352
PHACTR3 phosphatase and actin regulator 3 3.01352
TGM7 transglutaminase 7 3.01352
ITGA8 integrin, alpha 8 3.01352
PADI1 peptidyl arginine deiminase, type I 3.01352
HMGB4 high mobility group box 4 3.01352
CLCA2 chloride channel accessory 2 3.01352
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.01352
GSTA1 glutathione S-transferase alpha 1 3.01352
NKX6-3 NK6 homeobox 3 3.01352
TF transferrin 3.01352
MT1A metallothionein 1A 3.01352
C1ORF105 chromosome 1 open reading frame 105 3.01352
PXT1 peroxisomal, testis specific 1 3.01352
PSORS1C2 psoriasis susceptibility 1 candidate 2 3.01352
DEFB134 defensin, beta 134 3.01352
PATE2 prostate and testis expressed 2 3.01352
POU4F1 POU class 4 homeobox 1 3.01352
PRR35 proline rich 35 3.01352
RERGL RERG/RAS-like 3.01352
TNS3 tensin 3 2.98038
CDHR4 cadherin-related family member 4 2.93575
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.93575
OLFML1 olfactomedin-like 1 2.93575
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 2.93575
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 2.93575
ADRA2B adrenoceptor alpha 2B 2.93575
UXT ubiquitously-expressed, prefoldin-like chaperone 2.88061
ELP5 elongator acetyltransferase complex subunit 5 2.83082
MED17 mediator complex subunit 17 2.77126
RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.76328
TES testin LIM domain protein 2.72953
NUCLEOLIN nucleolin multifunctional protein 2.67532
NDRG2 NDRG family member 2 2.66919
KY kyphoscoliosis peptidase 2.64391
EDF1 endothelial differentiation-related factor 1 2.61896
GARIN5A golgi associated RAB2 interactor 5A 2.57681
ZIC2 Zic family member 2 2.53008
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) 2.52922
PTMA prothymosin, alpha 2.50813
CKMT1B creatine kinase, mitochondrial 1B 2.50591
MSI1 musashi RNA-binding protein 1 2.50284
NMD3 NMD3 ribosome export adaptor 2.50284
ARPC5L actin related protein 2/3 complex, subunit 5-like 2.50284
RAB36 RAB36, member RAS oncogene family 2.49019
MT1E metallothionein 1E 2.46436
PKLR pyruvate kinase, liver and RBC 2.42923
CSF1R colony stimulating factor 1 receptor 2.42923
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.42807
TJAP1 tight junction associated protein 1 (peripheral) 2.42075
ZNF879 zinc finger protein 879 2.41569
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.41429
ARMC12 armadillo repeat containing 12 2.41429
SEPTIN8 septin 8 2.38621
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 2.37715
ETNPPL ethanolamine-phosphate phospho-lyase 2.35627
QTRT1 queuine tRNA-ribosyltransferase 1 2.34117
COPS2 COP9 signalosome subunit 2 2.33787
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.33787
SCN8A sodium channel, voltage gated, type VIII alpha subunit 2.33525
COPB1 coatomer protein complex, subunit beta 1 2.28031
DCTN5 dynactin 5 (p25) 2.26245
MANEAL mannosidase, endo-alpha-like 2.26025
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.2578
LSM11 LSM11, U7 small nuclear RNA associated 2.23559
KIAA0753 KIAA0753 2.23489
REEP3 receptor accessory protein 3 2.20097
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.19329
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 2.17047
AFAP1 actin filament associated protein 1 2.16711
STK32C serine/threonine kinase 32C 2.14278
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.11223
TXN thioredoxin 2.11055
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 2.11055
PPP1R12C protein phosphatase 1, regulatory subunit 12C 2.11055
C17ORF100 chromosome 17 open reading frame 100 2.103
CMSS1 cms1 ribosomal small subunit homolog (yeast) 2.103
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.103
ARG1 arginase 1 2.103
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.103
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 2.103
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.103
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.103
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.103
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.103
ACOX2 acyl-CoA oxidase 2, branched chain 2.103
HSPA14 heat shock 70kDa protein 14 2.07246
FANCC Fanconi anemia, complementation group C 2.07246
RHOT1 ras homolog family member T1 2.06977
IFT27 intraflagellar transport 27 2.06206
PDPN podoplanin 2.06139
TEF thyrotrophic embryonic factor 2.03723
AFG3L2 AFG3-like AAA ATPase 2 2.01246
SDF2L1 stromal cell-derived factor 2-like 1 2.00903
ZNF518A zinc finger protein 518A 2.00647
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 2.00591
FBXO48 F-box protein 48 2.00591

decreased expression

Symbol Name Standardized Value
C4ORF36 chromosome 4 open reading frame 36 -3.01352
MTMR4 myotubularin related protein 4 -3.01352
SIGLEC10 sialic acid binding Ig-like lectin 10 -3.01352
SCN3B sodium channel, voltage gated, type III beta subunit -3.01352
ZNF671 zinc finger protein 671 -3.01352
GSG1 germ cell associated 1 -3.01352
MEI4 meiosis-specific 4 homolog (S. cerevisiae) -3.01352
INTS14 integrator complex subunit 14 -3.01352
SLC49A3 solute carrier family 49 member 3 -3.01352
WWC2 WW and C2 domain containing 2 -3.01352
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.93575
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -2.93575
ZNF503 zinc finger protein 503 -2.93575
DAND5 DAN domain family member 5, BMP antagonist -2.93575
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.93575
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.93575
SLC44A4 solute carrier family 44, member 4 -2.93575
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -2.93575
SHE Src homology 2 domain containing E -2.93575
C2ORF78 chromosome 2 open reading frame 78 -2.93575
GPR20 G protein-coupled receptor 20 -2.93575
SLC25A41 solute carrier family 25, member 41 -2.93575
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.93575
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.93575
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -2.93575
TWIST1 twist family bHLH transcription factor 1 -2.93575
RHOV ras homolog family member V -2.93575
SCG2 secretogranin II -2.93575
POTEJ POTE ankyrin domain family, member J -2.93575
CSTA cystatin A (stefin A) -2.93575
ANKRD53 ankyrin repeat domain 53 -2.93575
REP15 RAB15 effector protein -2.93575
EGR2 early growth response 2 -2.93575
EFCC1 EF-hand and coiled-coil domain containing 1 -2.93575
TRHDE thyrotropin-releasing hormone degrading enzyme -2.93575
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.93575
TRHR thyrotropin-releasing hormone receptor -2.93575
ARHGAP40 Rho GTPase activating protein 40 -2.93575
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -2.93575
HLA-DMB major histocompatibility complex, class II, DM beta -2.93575
OTOA otoancorin -2.93575
PRB2 proline-rich protein BstNI subfamily 2 -2.93575
PIWIL3 piwi-like RNA-mediated gene silencing 3 -2.93575
DVL2 dishevelled segment polarity protein 2 -2.84934
SZT2 seizure threshold 2 homolog (mouse) -2.84934
CDH4 cadherin 4, type 1, R-cadherin (retinal) -2.80867
UNC5CL unc-5 homolog C (C. elegans)-like -2.7965
GPHA2 glycoprotein hormone alpha 2 -2.76328
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -2.72584
RECQL4 RecQ protein-like 4 -2.72584
INHBA inhibin, beta A -2.62603
CIC capicua transcriptional repressor -2.62558
LIN9 lin-9 DREAM MuvB core complex component -2.62159
EWSR1 EWS RNA-binding protein 1 -2.61832
THAP10 THAP domain containing 10 -2.61517
COG2 component of oligomeric golgi complex 2 -2.60219
RUNX2 runt-related transcription factor 2 -2.55389
CAPN11 calpain 11 -2.46436
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -2.46436
TAFA1 TAFA chemokine like family member 1 -2.46436
INHA inhibin, alpha -2.46436
NUTM1 NUT midline carcinoma, family member 1 -2.46436
CCKBR cholecystokinin B receptor -2.42923
RAB6B RAB6B, member RAS oncogene family -2.41569
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -2.41429
CA8 carbonic anhydrase VIII -2.41429
ATG101 autophagy related 101 -2.40269
CCDC43 coiled-coil domain containing 43 -2.38621
NTN4 netrin 4 -2.35701
ZNF106 zinc finger protein 106 -2.3451
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.34073
DUSP2 dual specificity phosphatase 2 -2.34073
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.3096
ZNF570 zinc finger protein 570 -2.28833
ZNF317 zinc finger protein 317 -2.26343
FAM3B family with sequence similarity 3, member B -2.23559
GPR78 G protein-coupled receptor 78 -2.23559
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -2.23559
NOP56 NOP56 ribonucleoprotein -2.23362
CDH24 cadherin 24, type 2 -2.22638
ZC3H11A zinc finger CCCH-type containing 11A -2.19543
PRRC2B proline-rich coiled-coil 2B -2.18829
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.18829
STX8 syntaxin 8 -2.16639
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.1657
ICE1 interactor of little elongation complex ELL subunit 1 -2.15011
AFAP1L2 actin filament associated protein 1-like 2 -2.14913
ZEB1 zinc finger E-box binding homeobox 1 -2.14029
SNX6 sorting nexin 6 -2.14029
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.14029
UNC5A unc-5 homolog A (C. elegans) -2.14029
SMOC1 SPARC related modular calcium binding 1 -2.14029
NLRP2 NLR family, pyrin domain containing 2 -2.14029
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -2.103
MLF1 myeloid leukemia factor 1 -2.09638
TUBG2 tubulin, gamma 2 -2.09638
DPH5 diphthamide biosynthesis 5 -2.09638
ZCCHC10 zinc finger, CCHC domain containing 10 -2.08826
METAP1D methionyl aminopeptidase type 1D (mitochondrial) -2.0669
PIGBOS1 PIGB opposite strand 1 -2.0669
USP4 ubiquitin specific peptidase 4 (proto-oncogene) -2.05724
SEC24B SEC24 family member B -2.05585
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -2.05573
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.05573
RPUSD4 RNA pseudouridylate synthase domain containing 4 -2.05257
PPP4R2 protein phosphatase 4, regulatory subunit 2 -2.04113
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.03723
PRICKLE2 prickle homolog 2 (Drosophila) -2.01828
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.0132
TRRAP transformation/transcription domain-associated protein -2.00591
TULP2 tubby like protein 2 -2.00591
STAMBP STAM binding protein -2.00311
EXOC1 exocyst complex component 1 -2.00311