| Dataset | Pathway Commons Protein-Protein Interactions |
| Category | physical interactions |
| Type | interacting protein |
| Description | collagen, type IV, alpha 3 (Goodpasture antigen)|Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 1285) |
| External Link | http://www.ncbi.nlm.nih.gov/gene/1285 |
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37 interacting proteins for COL4A3 from the Pathway Commons Protein-Protein Interactions dataset.
| Symbol | Name |
|---|---|
| ANTXR2 | anthrax toxin receptor 2 |
| APP | amyloid beta (A4) precursor protein |
| CAMK2B | calcium/calmodulin-dependent protein kinase II beta |
| CD93 | CD93 molecule |
| COL4A3BP | collagen, type IV, alpha 3 (Goodpasture antigen) binding protein |
| COLGALT1 | collagen beta(1-O)galactosyltransferase 1 |
| COLGALT2 | collagen beta(1-O)galactosyltransferase 2 |
| CRTAP | cartilage associated protein |
| DCN | decorin |
| FBLN1 | fibulin 1 |
| FBLN2 | fibulin 2 |
| FN1 | fibronectin 1 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| HABP2 | hyaluronan binding protein 2 |
| HSPG2 | heparan sulfate proteoglycan 2 |
| ITGAV | integrin, alpha V |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| KLK6 | kallikrein-related peptidase 6 |
| MATN2 | matrilin 2 |
| MFAP2 | microfibrillar-associated protein 2 |
| MMP9 | matrix metallopeptidase 9 |
| NID1 | nidogen 1 |
| OSM | oncostatin M |
| P3H1 | prolyl 3-hydroxylase 1 |
| P3H2 | prolyl 3-hydroxylase 2 |
| P3H3 | prolyl 3-hydroxylase 3 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) |
| PTK2 | protein tyrosine kinase 2 |
| SAA1 | serum amyloid A1 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
| TGFBI | transforming growth factor, beta-induced, 68kDa |
| UBC | ubiquitin C |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) |
| VHL | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
