COMT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description catechol-O-methyltransferase|Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 1312)
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Genes

339 genes differentially expressed following the COMT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NUTM2B NUT family member 2B 3.12759
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 3.12759
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.12759
GADL1 glutamate decarboxylase-like 1 3.12759
THRSP thyroid hormone responsive 3.12759
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.12759
FMOD fibromodulin 3.12759
KLK7 kallikrein-related peptidase 7 3.12759
ZNF843 zinc finger protein 843 3.12759
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.12759
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 3.12759
FAM186A family with sequence similarity 186, member A 3.12759
FAM163A family with sequence similarity 163, member A 3.12759
MYL5 myosin, light chain 5, regulatory 3.12759
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.12759
PLGLB1 plasminogen-like B1 3.12759
LDB3 LIM domain binding 3 3.12759
AQP4 aquaporin 4 3.12759
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.12759
CYGB cytoglobin 3.12759
TLE6 transducin-like enhancer of split 6 3.12759
HEPHL1 hephaestin-like 1 3.12759
FGF9 fibroblast growth factor 9 3.12759
LPA lipoprotein, Lp(a) 3.12759
ESPNL espin-like 3.12759
CELA3B chymotrypsin-like elastase family, member 3B 3.06122
CFHR3 complement factor H-related 3 3.06122
TMEM176A transmembrane protein 176A 3.06122
COL19A1 collagen, type XIX, alpha 1 3.06122
NAPSA napsin A aspartic peptidase 3.06122
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.06122
NOTO notochord homeobox 3.06122
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 3.06122
CDH5 cadherin 5, type 2 (vascular endothelium) 3.06122
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.06122
GPR55 G protein-coupled receptor 55 3.06122
WEE2 WEE1 homolog 2 (S. pombe) 3.06122
HGD homogentisate 1,2-dioxygenase 3.06122
TNIP3 TNFAIP3 interacting protein 3 3.06122
PSCA prostate stem cell antigen 3.06122
WNT8B wingless-type MMTV integration site family, member 8B 3.06122
MMP28 matrix metallopeptidase 28 3.06122
KLHDC8B kelch domain containing 8B 3.06122
MYO1G myosin IG 3.06122
CPLX4 complexin 4 3.06122
TMC2 transmembrane channel-like 2 3.06122
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.06122
TNS4 tensin 4 3.06122
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.06122
LRRC10B leucine rich repeat containing 10B 3.06122
NOD2 nucleotide-binding oligomerization domain containing 2 3.06122
GSTM5 glutathione S-transferase mu 5 3.06122
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 3.06122
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.06122
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.06122
PAX7 paired box 7 3.06122
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.06122
MYOM3 myomesin 3 3.06122
FOXR1 forkhead box R1 3.06122
SPATA31G1 SPATA31 subfamily G member 1 3.06122
STING1 stimulator of interferon response cGAMP interactor 1 3.06122
GOLGA6L7 golgin A6 family like 7 3.06122
C3AR1 complement component 3a receptor 1 3.06122
CXCL13 chemokine (C-X-C motif) ligand 13 3.06122
MGAT4D MGAT4 family, member D 3.06122
HOXC13 homeobox C13 3.06122
RD3 retinal degeneration 3 3.06122
SMPX small muscle protein, X-linked 3.06122
WDR64 WD repeat domain 64 3.06122
TMEM40 transmembrane protein 40 3.06122
MSANTD5 Myb/SANT DNA binding domain containing 5 3.06122
CIROP ciliated left-right organizer metallopeptidase 3.06122
CIMIP4 ciliary microtubule inner protein 4 3.06122
IRF2-DT IRF2 divergent transcript 3.06122
LOC124906010 uncharacterized LOC124906010 3.06122
CD8B2 CD8b2 molecule 3.06122
CTXND1 cortexin domain containing 1 3.06122
H4C14 H4 clustered histone 14 3.06122
AKAIN1 A-kinase anchor inhibitor 1 3.06122
MAJIN membrane anchored junction protein 3.06122
DIPK1C divergent protein kinase domain 1C 3.06122
TAFA3 TAFA chemokine like family member 3 3.06122
DOK2 docking protein 2, 56kDa 3.06122
SPATA25 spermatogenesis associated 25 3.06122
RNF113B ring finger protein 113B 3.06122
TLR7 toll-like receptor 7 3.06122
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.06122
CD79A CD79a molecule, immunoglobulin-associated alpha 3.06122
MAGEB3 melanoma antigen family B3 3.06122
ARL5C ADP-ribosylation factor-like 5C 3.06122
DMP1 dentin matrix acidic phosphoprotein 1 3.06122
DTHD1 death domain containing 1 3.06122
IL12RB1 interleukin 12 receptor, beta 1 3.06122
LBHD1 LBH domain containing 1 3.06122
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 3.06122
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.06122
GPR37L1 G protein-coupled receptor 37 like 1 3.06122
OR51M1 olfactory receptor, family 51, subfamily M, member 1 3.06122
TBX10 T-box 10 3.06122
NDP Norrie disease (pseudoglioma) 3.06122
TOX2 TOX high mobility group box family member 2 3.06122
LRRC70 leucine rich repeat containing 70 3.06122
SAMD11 sterile alpha motif domain containing 11 3.06122
C7 complement component 7 3.06122
C7ORF57 chromosome 7 open reading frame 57 3.06122
NPFF neuropeptide FF-amide peptide precursor 3.06122
FAM3D family with sequence similarity 3, member D 3.06122
HIC1 hypermethylated in cancer 1 3.06122
GOLGA6A golgin A6 family, member A 3.06122
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.06122
ENDOU endonuclease, polyU-specific 3.06122
FOXE3 forkhead box E3 3.06122
LMOD3 leiomodin 3 (fetal) 3.06122
PLA2G4E phospholipase A2, group IVE 3.06122
CLEC18C C-type lectin domain family 18, member C 3.06122
VWA7 von Willebrand factor A domain containing 7 3.06122
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.06122
GPR50 G protein-coupled receptor 50 3.06122
HSPB2 heat shock 27kDa protein 2 3.06122
OCM oncomodulin 3.06122
PRND prion protein 2 (dublet) 3.06122
NTSR2 neurotensin receptor 2 3.06122
ABHD1 abhydrolase domain containing 1 3.06122
TF transferrin 3.06122
TMIGD2 transmembrane and immunoglobulin domain containing 2 3.06122
ANKRD33 ankyrin repeat domain 33 3.06122
IFNL4 interferon, lambda 4 (gene/pseudogene) 3.06122
KCNK3 potassium channel, two pore domain subfamily K, member 3 3.06122
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.06122
ANKRD63 ankyrin repeat domain 63 3.06122
TPSB2 tryptase beta 2 (gene/pseudogene) 3.06122
CXCR6 chemokine (C-X-C motif) receptor 6 3.06122
BTNL2 butyrophilin-like 2 3.06122
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.06122
C16ORF78 chromosome 16 open reading frame 78 3.06122
DQX1 DEAQ box RNA-dependent ATPase 1 3.06122
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.06122
EBLN1 endogenous Bornavirus-like nucleoprotein 1 3.06122
FIBIN fin bud initiation factor homolog (zebrafish) 3.06122
CTAGE15 CTAGE family, member 15 3.06122
CGB2 chorionic gonadotropin, beta polypeptide 2 3.06122
EDN1 endothelin 1 3.06122
CNTF ciliary neurotrophic factor 3.06122
BRD7 bromodomain containing 7 3.06122
ZNF132 zinc finger protein 132 3.06122
LPAR5 lysophosphatidic acid receptor 5 3.06122
PRDM1 PR domain containing 1, with ZNF domain 3.06122
LDLRAD1 low density lipoprotein receptor class A domain containing 1 3.06122
ANGPTL5 angiopoietin-like 5 3.06122
GPR17 G protein-coupled receptor 17 3.06122
RAB7B RAB7B, member RAS oncogene family 3.06122
FOXG1 forkhead box G1 3.06122
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.06122
MYADML2 myeloid-associated differentiation marker-like 2 3.06122
CLUL1 clusterin-like 1 (retinal) 3.06122
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.06122
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.06122
ERVV-1 endogenous retrovirus group V, member 1 3.06122
ADAM18 ADAM metallopeptidase domain 18 3.06122
HOXB1 homeobox B1 3.06122
WAS Wiskott-Aldrich syndrome 3.06122
CLEC18B C-type lectin domain family 18, member B 3.06122
GOLGA8K golgin A8 family, member K 3.06122
GOLGA8R golgin A8 family, member R 3.06122
ADAM29 ADAM metallopeptidase domain 29 3.06122
RGPD5 RANBP2-like and GRIP domain containing 5 3.06122
PRRX1 paired related homeobox 1 3.06122
ROM1 retinal outer segment membrane protein 1 3.06122
POTEF POTE ankyrin domain family, member F 3.06122
VTCN1 V-set domain containing T cell activation inhibitor 1 3.06122
GH1 growth hormone 1 3.06122
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.06122
PDCD1LG2 programmed cell death 1 ligand 2 3.06122
IBSP integrin-binding sialoprotein 3.06122
DUOXA1 dual oxidase maturation factor 1 3.06122
RGS8 regulator of G-protein signaling 8 3.06122
NKX6-1 NK6 homeobox 1 3.06122
LEUTX leucine twenty homeobox 3.06122
CSF1R colony stimulating factor 1 receptor 3.06122
SLC39A9 solute carrier family 39, member 9 2.913
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.8048
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 2.78499
H4C9 H4 clustered histone 9 2.72956
ARHGAP40 Rho GTPase activating protein 40 2.72029
MICALL2 MICAL-like 2 2.70866
MAD2L1BP MAD2L1 binding protein 2.66557
P3H3 prolyl 3-hydroxylase 3 2.6634
CREB5 cAMP responsive element binding protein 5 2.64666
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.63291
SNRPG small nuclear ribonucleoprotein polypeptide G 2.62079
ORC4 origin recognition complex, subunit 4 2.56006
SAT1 spermidine/spermine N1-acetyltransferase 1 2.53466
BCAR1 breast cancer anti-estrogen resistance 1 2.52172
S100A2 S100 calcium binding protein A2 2.52172
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.52172
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 2.46835
LYPLA1 lysophospholipase I 2.39402
CDK16 cyclin-dependent kinase 16 2.39353
HPCAL4 hippocalcin like 4 2.35307
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.34039
TMEM47 transmembrane protein 47 2.33683
SMC2 structural maintenance of chromosomes 2 2.32405
RYR3 ryanodine receptor 3 2.31707
CMSS1 cms1 ribosomal small subunit homolog (yeast) 2.31268
RGPD3 RANBP2-like and GRIP domain containing 3 2.31193
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.29505
ZNF493 zinc finger protein 493 2.29413
WDR18 WD repeat domain 18 2.29413
DUSP9 dual specificity phosphatase 9 2.28874
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.28874
BCL7A B-cell CLL/lymphoma 7A 2.26112
C19ORF44 chromosome 19 open reading frame 44 2.25478
MORC4 MORC family CW-type zinc finger 4 2.25478
GRM6 glutamate receptor, metabotropic 6 2.25478
MVB12B multivesicular body subunit 12B 2.24727
FAM20A family with sequence similarity 20, member A 2.24687
ECSIT ECSIT signalling integrator 2.22678
ARMC6 armadillo repeat containing 6 2.20414
CHRAC1 chromatin accessibility complex 1 2.20414
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.20414
USP32 ubiquitin specific peptidase 32 2.19051
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 2.18944
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 2.17582
TMEM132B transmembrane protein 132B 2.16691
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.15273
FMO3 flavin containing monooxygenase 3 2.15273
DCAF6 DDB1 and CUL4 associated factor 6 2.14999
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.13975
NBPF1 neuroblastoma breakpoint family, member 1 2.13975
ZYG11B zyg-11 family member B, cell cycle regulator 2.1121
NMU neuromedin U 2.10014
HAX1 HCLS1 associated protein X-1 2.08784
ANKRD9 ankyrin repeat domain 9 2.07431
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 2.06775
TTF2 transcription termination factor, RNA polymerase II 2.06087
ZNF79 zinc finger protein 79 2.0542
PUS10 pseudouridylate synthase 10 2.04758
SLC38A12 solute carrier family 38 member 12 2.04315
DEPDC4 DEP domain containing 4 2.04315
ZMYM1 zinc finger, MYM-type 1 2.03982
HEMK1 HemK methyltransferase family member 1 2.03218
BBLN bublin coiled coil protein 2.01817

decreased expression

Symbol Name Standardized Value
RBP2 retinol binding protein 2, cellular -3.12759
SYBU syntabulin (syntaxin-interacting) -3.12759
HLA-DMB major histocompatibility complex, class II, DM beta -3.12759
NT5E 5'-nucleotidase, ecto (CD73) -3.12759
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.06122
BHLHE40 basic helix-loop-helix family, member e40 -3.06122
TTLL1 tubulin tyrosine ligase-like family member 1 -3.06122
CSNK2A3 casein kinase 2, alpha 3 polypeptide -3.06122
SPACDR sperm acrosome developmental regulator -3.06122
CLCNKB chloride channel, voltage-sensitive Kb -3.06122
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -3.06122
APOB apolipoprotein B -3.06122
SHCBP1L SHC SH2-domain binding protein 1-like -3.06122
NPSR1 neuropeptide S receptor 1 -3.06122
BRME1 break repair meiotic recombinase recruitment factor 1 -3.06122
STYXL2 serine/threonine/tyrosine interacting like 2 -3.06122
FAM107A family with sequence similarity 107, member A -3.06122
ASIC4 acid sensing (proton gated) ion channel family member 4 -3.06122
TACSTD2 tumor-associated calcium signal transducer 2 -3.06122
TUBA3E tubulin, alpha 3e -3.06122
NKX3-1 NK3 homeobox 1 -3.06122
TBX22 T-box 22 -3.06122
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -3.06122
SIRPB2 signal-regulatory protein beta 2 -3.06122
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -3.06122
CDHR4 cadherin-related family member 4 -3.06122
CCNI2 cyclin I family, member 2 -3.06122
EXTL1 exostosin-like glycosyltransferase 1 -3.06122
CCNA1 cyclin A1 -3.06122
ILDR2 immunoglobulin-like domain containing receptor 2 -3.06122
THBD thrombomodulin -3.06122
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -3.06122
PLCL2 phospholipase C-like 2 -2.90633
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -2.84686
EFNA3 ephrin-A3 -2.82641
PARP9 poly (ADP-ribose) polymerase family, member 9 -2.79036
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -2.79036
CCDC74B coiled-coil domain containing 74B -2.78221
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.77987
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.77763
ELAC1 elaC ribonuclease Z 1 -2.77082
TAGLN2 transgelin 2 -2.59133
FRS3 fibroblast growth factor receptor substrate 3 -2.58103
SLA Src-like-adaptor -2.54781
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.52041
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.52041
RLIM ring finger protein, LIM domain interacting -2.46232
LRRC9 leucine rich repeat containing 9 -2.45695
AGBL5 ATP/GTP binding protein-like 5 -2.42521
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 -2.41954
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.39928
PHETA2 PH domain containing endocytic trafficking adaptor 2 -2.36213
TMEM11 transmembrane protein 11 -2.34732
RTL4 retrotransposon Gag like 4 -2.34516
MTIF2 mitochondrial translational initiation factor 2 -2.33278
SKA3 spindle and kinetochore associated complex subunit 3 -2.31707
COQ9 coenzyme Q9 -2.28874
SERF2 small EDRK-rich factor 2 -2.28458
TNMD tenomodulin -2.28299
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -2.28299
ANKRD36B ankyrin repeat domain 36B -2.28299
NOS3 nitric oxide synthase 3 (endothelial cell) -2.2636
IL11RA interleukin 11 receptor, alpha -2.2636
GDPGP1 GDP-D-glucose phosphorylase 1 -2.25478
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.24304
SEPTIN1 septin 1 -2.22678
TM6SF1 transmembrane 6 superfamily member 1 -2.22678
RBM46 RNA binding motif protein 46 -2.22678
CLNK cytokine-dependent hematopoietic cell linker -2.22678
FBXO43 F-box protein 43 -2.22678
CD36 CD36 molecule (thrombospondin receptor) -2.22678
ZBBX zinc finger, B-box domain containing -2.22678
NEFL neurofilament, light polypeptide -2.22176
DTX3 deltex 3, E3 ubiquitin ligase -2.21973
ACIN1 apoptotic chromatin condensation inducer 1 -2.19804
TAS2R30 taste receptor, type 2, member 30 -2.1962
BEST4 bestrophin 4 -2.19537
MTERF1 mitochondrial transcription termination factor 1 -2.19381
LIMS2 LIM and senescent cell antigen-like domains 2 -2.19381
ITGB4 integrin, beta 4 -2.19381
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1) -2.18444
PPOX protoporphyrinogen oxidase -2.18164
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -2.15273
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.15116
TADA2B transcriptional adaptor 2B -2.13535
NCLN nicalin -2.1121
RGS7 regulator of G-protein signaling 7 -2.1121
VWCE von Willebrand factor C and EGF domains -2.11182
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3 -2.07755
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -2.07501
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -2.07431
PIGS phosphatidylinositol glycan anchor biosynthesis, class S -2.0542
ZNF177 zinc finger protein 177 -2.0542
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -2.04085
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.03982
ZNF771 zinc finger protein 771 -2.02051
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) -2.01817