| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | catechol-O-methyltransferase|Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 1312) |
| External Link | https://ncbi.nlm.nih.gov/gene/1312 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the COMT gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SSBP2 | single-stranded DNA binding protein 2 | 0.0209805 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0164143 |
| LTF | lactotransferrin | 0.0159254 |
| S100A9 | S100 calcium binding protein A9 | 0.0128724 |
| S100A8 | S100 calcium binding protein A8 | 0.012201 |
| KRT17 | keratin 17, type I | 0.0121199 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.0115326 |
| LCN2 | lipocalin 2 | 0.0115153 |
| ANXA1 | annexin A1 | 0.0110808 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0104888 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0104858 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0100607 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00982047 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00974923 |
| ATF3 | activating transcription factor 3 | 0.00951056 |
| S100P | S100 calcium binding protein P | 0.00946832 |
| KRT23 | keratin 23, type I | 0.00938171 |
| PDGFC | platelet derived growth factor C | 0.00930374 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.0092014 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00909878 |
| KRT14 | keratin 14, type I | 0.00909566 |
| STC2 | stanniocalcin 2 | 0.0089785 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.00888073 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.00876518 |
| TPD52L1 | tumor protein D52-like 1 | 0.00873818 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00861925 |
| KYNU | kynureninase | 0.00855961 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00852651 |
| MAGEA3 | melanoma antigen family A3 | 0.00851134 |
| WT1 | Wilms tumor 1 | 0.0082498 |
| PEG10 | paternally expressed 10 | 0.00821418 |
| PLAUR | plasminogen activator, urokinase receptor | 0.00804999 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.00804246 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0080389 |
| DLK1 | delta-like 1 homolog (Drosophila) | 0.00796497 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00786805 |
| CD69 | CD69 molecule | 0.0078623 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00782125 |
| MUC16 | mucin 16, cell surface associated | 0.00759427 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00755687 |
| NDP | Norrie disease (pseudoglioma) | 0.00754889 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00745122 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 | 0.00735231 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.00729569 |
| MMP7 | matrix metallopeptidase 7 | 0.00725331 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00723479 |
| CD59 | CD59 molecule, complement regulatory protein | 0.00721848 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00710102 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.00706433 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00704333 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00702737 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.00701233 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00699169 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00695754 |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.00691488 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.0069089 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00689319 |
| LAPTM4B | lysosomal protein transmembrane 4 beta | 0.00684874 |
| S100A12 | S100 calcium binding protein A12 | 0.00684621 |
| CFB | complement factor B | 0.00681343 |
| IQCG | IQ motif containing G | 0.00679728 |
| PERP | PERP, TP53 apoptosis effector | 0.0067653 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00675717 |
| RRAGD | Ras-related GTP binding D | 0.00674757 |
| SGMS1 | sphingomyelin synthase 1 | 0.00673774 |
| CRISP3 | cysteine-rich secretory protein 3 | 0.00672341 |
| AUTS2 | autism susceptibility candidate 2 | 0.00669978 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.00668472 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.00666527 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00666493 |
| PLXNC1 | plexin C1 | 0.00664243 |
| FOSL2 | FOS-like antigen 2 | 0.00662239 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.0066182 |
| FGG | fibrinogen gamma chain | 0.00661792 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00660227 |
| PDLIM1 | PDZ and LIM domain 1 | 0.00658978 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00657819 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.00652468 |
| IL32 | interleukin 32 | 0.00652448 |
| TMEM45A | transmembrane protein 45A | 0.00651344 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00645375 |
| PRAME | preferentially expressed antigen in melanoma | 0.00645287 |
| DAPK1 | death-associated protein kinase 1 | 0.00645214 |
| RIN2 | Ras and Rab interactor 2 | 0.00641176 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00641003 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00639074 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.00632924 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00629741 |
| VNN1 | vanin 1 | 0.00628162 |
| TFRC | transferrin receptor | 0.00626325 |
| TUFT1 | tuftelin 1 | 0.00624399 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.00623492 |
| PSEN1 | presenilin 1 | 0.00622053 |
| PRKCI | protein kinase C, iota | 0.00619993 |
| IFRD1 | interferon-related developmental regulator 1 | 0.00619209 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0061762 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00613654 |
| APOC1 | apolipoprotein C-I | 0.00611927 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00609968 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00609348 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00607781 |
| RNF167 | ring finger protein 167 | 0.00606631 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.00606308 |
| MOSPD1 | motile sperm domain containing 1 | 0.00605626 |
| ITGAV | integrin, alpha V | 0.00605117 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.00603794 |
| ALB | albumin | 0.00602626 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.00601823 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.006009 |
| SIK1 | salt-inducible kinase 1 | 0.00600675 |
| RGCC | regulator of cell cycle | 0.00600466 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.00598149 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00597613 |
| CD52 | CD52 molecule | 0.00596462 |
| SPRR3 | small proline-rich protein 3 | 0.00596114 |
| TARP | TCR gamma alternate reading frame protein | 0.00595616 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00594112 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.00593563 |
| KRT18 | keratin 18, type I | 0.0059273 |
| LY96 | lymphocyte antigen 96 | 0.00591687 |
| BTG3 | BTG family, member 3 | 0.00591217 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00591152 |
| CD9 | CD9 molecule | 0.00590545 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00590142 |
| GPR137B | G protein-coupled receptor 137B | 0.00589109 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00588951 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.00588228 |
| TASP1 | taspase, threonine aspartase, 1 | 0.00588119 |
| CITED1 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | 0.00586721 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | 0.00584954 |
| TVP23B | trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) | 0.00583483 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00580277 |
| HIST1H2BK | histone cluster 1, H2bk | 0.00578761 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | 0.00578024 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.00577957 |
| DEPTOR | DEP domain containing MTOR-interacting protein | 0.00577025 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.00574984 |
| RTP4 | receptor (chemosensory) transporter protein 4 | 0.00574526 |
| KRT7 | keratin 7, type II | 0.00574109 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00573287 |
| HBD | hemoglobin, delta | 0.00571479 |
| GPATCH2 | G patch domain containing 2 | 0.00570214 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | 0.00569794 |
| GRAMD2B | GRAM domain containing 2B | 0.00566851 |
| RAB9A | RAB9A, member RAS oncogene family | 0.00566672 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.00566596 |
| MB | myoglobin | 0.00564569 |
| CKM | creatine kinase, muscle | 0.00564513 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0056417 |
| NOTCH2 | notch 2 | 0.00563009 |
| GLIPR1 | GLI pathogenesis-related 1 | 0.0056281 |
| DUSP2 | dual specificity phosphatase 2 | 0.00562727 |
| ABLIM1 | actin binding LIM protein 1 | 0.00561207 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00560498 |
| G6PD | glucose-6-phosphate dehydrogenase | 0.00560311 |
| KLHL41 | kelch-like family member 41 | 0.00559489 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.00558739 |
| RIT1 | Ras-like without CAAX 1 | 0.00558558 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00557436 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.00555409 |
| TNIK | TRAF2 and NCK interacting kinase | 0.00555377 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.00553804 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00553512 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00551774 |
| IL1B | interleukin 1, beta | 0.00551423 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00551351 |
| DCT | dopachrome tautomerase | 0.00550883 |
| TTN | titin | 0.00549833 |
| IFI44 | interferon-induced protein 44 | 0.00549448 |
| MYBPC1 | myosin binding protein C, slow type | 0.00549397 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.00548836 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.00547122 |
| MYO1C | myosin IC | 0.00546645 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.00544948 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0054483 |
| PRSS23 | protease, serine, 23 | 0.00544687 |
| IFI44L | interferon-induced protein 44-like | 0.00543527 |
| VLDLR | very low density lipoprotein receptor | 0.00542783 |
| WDR41 | WD repeat domain 41 | 0.00542153 |
| TPM4 | tropomyosin 4 | 0.00541691 |
| CSTA | cystatin A (stefin A) | 0.00541185 |
| JUNB | jun B proto-oncogene | 0.00540427 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.00538266 |
| SLC16A4 | solute carrier family 16, member 4 | 0.00536633 |
| KRT5 | keratin 5, type II | 0.00536143 |
| DUSP11 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 0.00536 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00535974 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.00535391 |
| IRF2 | interferon regulatory factor 2 | 0.00534193 |
| PIP | prolactin-induced protein | 0.00533933 |
| FOXG1 | forkhead box G1 | 0.00533509 |
| ORM1 | orosomucoid 1 | 0.00533372 |
| PON2 | paraoxonase 2 | 0.00532616 |
| ZNF331 | zinc finger protein 331 | 0.00531972 |
| GSDME | gasdermin E | 0.00530482 |
| MEIS2 | Meis homeobox 2 | 0.00529514 |
| GLS | glutaminase | 0.00529026 |
| S100A4 | S100 calcium binding protein A4 | 0.00528943 |
| CPB1 | carboxypeptidase B1 (tissue) | 0.00528235 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00526714 |
| SMAD3 | SMAD family member 3 | 0.00526538 |
| RNF19B | ring finger protein 19B | 0.00525409 |
| GNLY | granulysin | 0.00524019 |
| AFP | alpha-fetoprotein | 0.00522576 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.00522574 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00522004 |
| PANK2 | pantothenate kinase 2 | 0.00521846 |
| COL6A3 | collagen, type VI, alpha 3 | 0.00521295 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.00521235 |
| KRT13 | keratin 13, type I | 0.00521223 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.00519876 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0051921 |
| CCDC6 | coiled-coil domain containing 6 | 0.00518507 |
| DSP | desmoplakin | 0.00518473 |
| KLHL24 | kelch-like family member 24 | 0.00517555 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | 0.00516381 |
| STK26 | serine/threonine protein kinase 26 | 0.00514573 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.00514139 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00514122 |
| S100A11 | S100 calcium binding protein A11 | 0.00512852 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00511743 |
| TFEC | transcription factor EC | 0.00511473 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00510926 |
| BCL2A1 | BCL2-related protein A1 | 0.005104 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.00509616 |
| SORT1 | sortilin 1 | 0.00509274 |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.00508506 |
| IL1RN | interleukin 1 receptor antagonist | 0.00507824 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0050721 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.00506976 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.0050492 |
| RBKS | ribokinase | 0.00504581 |
| VNN2 | vanin 2 | 0.00502914 |
| YME1L1 | YME1-like 1 ATPase | 0.00502856 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00502812 |
| VEGFA | vascular endothelial growth factor A | 0.00501088 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00500803 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.00500119 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00499924 |
| SLC38A6 | solute carrier family 38, member 6 | 0.00499836 |
| NFE2 | nuclear factor, erythroid 2 | 0.00499538 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00499261 |
| GATA6 | GATA binding protein 6 | 0.00498726 |
| FGB | fibrinogen beta chain | 0.004969 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00496827 |
| MMP19 | matrix metallopeptidase 19 | 0.00496592 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | 0.00496408 |
| MOCOS | molybdenum cofactor sulfurase | 0.00494829 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0049458 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.0160796 |
| BMP4 | bone morphogenetic protein 4 | -0.0132432 |
| RGS5 | regulator of G-protein signaling 5 | -0.0124686 |
| BEX1 | brain expressed, X-linked 1 | -0.0105934 |
| PLN | phospholamban | -0.00991149 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00987066 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.00978021 |
| METTL7A | methyltransferase like 7A | -0.00960903 |
| MT1E | metallothionein 1E | -0.00960441 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00954431 |
| PLK1 | polo-like kinase 1 | -0.00922743 |
| EMP2 | epithelial membrane protein 2 | -0.00906594 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | -0.00901499 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.00897376 |
| GNAS | GNAS complex locus | -0.00895029 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | -0.00891415 |
| MFAP4 | microfibrillar-associated protein 4 | -0.00873152 |
| ANXA6 | annexin A6 | -0.00845275 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.0084524 |
| DPT | dermatopontin | -0.00802999 |
| ACKR3 | atypical chemokine receptor 3 | -0.00796519 |
| ASPN | asporin | -0.00794235 |
| FASN | fatty acid synthase | -0.00787357 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0078467 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00769022 |
| COL11A1 | collagen, type XI, alpha 1 | -0.00762712 |
| FBLN2 | fibulin 2 | -0.0076142 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.00754047 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.00753794 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.00752691 |
| ADIRF | adipogenesis regulatory factor | -0.00740693 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | -0.00738102 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.00734687 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00726842 |
| SPARCL1 | SPARC-like 1 (hevin) | -0.0072527 |
| OLFML3 | olfactomedin-like 3 | -0.00718389 |
| TXNIP | thioredoxin interacting protein | -0.00716588 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00716327 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00714632 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.00712878 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00710994 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.00707533 |
| STMN2 | stathmin 2 | -0.0069543 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | -0.00689459 |
| TMEM176B | transmembrane protein 176B | -0.00686925 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00679329 |
| ZNF423 | zinc finger protein 423 | -0.00678657 |
| STK39 | serine threonine kinase 39 | -0.00677428 |
| XPO7 | exportin 7 | -0.00674402 |
| IFRD2 | interferon-related developmental regulator 2 | -0.00673571 |
| MEOX2 | mesenchyme homeobox 2 | -0.00673007 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00672351 |
| AOC3 | amine oxidase, copper containing 3 | -0.00672107 |
| MFAP2 | microfibrillar-associated protein 2 | -0.0066812 |
| FCGBP | Fc fragment of IgG binding protein | -0.00665361 |
| MSX1 | msh homeobox 1 | -0.00659085 |
| PRDX2 | peroxiredoxin 2 | -0.0065896 |
| MFAP5 | microfibrillar associated protein 5 | -0.00653409 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00652207 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00651942 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.00648404 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.00647791 |
| CCNB1 | cyclin B1 | -0.00646118 |
| OLFM1 | olfactomedin 1 | -0.00645495 |
| WASHC4 | WASH complex subunit 4 | -0.00643462 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.00642641 |
| FRZB | frizzled-related protein | -0.00642547 |
| C7 | complement component 7 | -0.00639344 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | -0.00634005 |
| CHRDL1 | chordin-like 1 | -0.00632547 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00630211 |
| CALCA | calcitonin-related polypeptide alpha | -0.0062742 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.00627294 |
| COLEC12 | collectin sub-family member 12 | -0.00617633 |
| HELLS | helicase, lymphoid-specific | -0.00613825 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00608317 |
| COL9A3 | collagen, type IX, alpha 3 | -0.00603566 |
| CD93 | CD93 molecule | -0.00601207 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.00599987 |
| SNRNP25 | small nuclear ribonucleoprotein 25kDa (U11/U12) | -0.00598548 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -0.00597747 |
| PLIN2 | perilipin 2 | -0.00594063 |
| APOD | apolipoprotein D | -0.00591437 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00588755 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | -0.00588364 |
| H1-10 | H1.10 linker histone | -0.00588282 |
| DHFR | dihydrofolate reductase | -0.00584046 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.00583503 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.00581887 |
| MAB21L2 | mab-21-like 2 (C. elegans) | -0.00581041 |
| LEFTY1 | left-right determination factor 1 | -0.00580987 |
| EPHB2 | EPH receptor B2 | -0.00580446 |
| ANGPTL2 | angiopoietin-like 2 | -0.00578237 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00577611 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00576873 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -0.00576504 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.00574156 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00572705 |
| MT1M | metallothionein 1M | -0.00570381 |
| MEN1 | multiple endocrine neoplasia I | -0.00567749 |
| GLO1 | glyoxalase I | -0.0056754 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | -0.00566799 |
| MPDZ | multiple PDZ domain protein | -0.00566758 |
| FKBP5 | FK506 binding protein 5 | -0.00566094 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.00564944 |
| MUC2 | mucin 2, oligomeric mucus/gel-forming | -0.00564835 |
| HSPB8 | heat shock 22kDa protein 8 | -0.00564728 |
| PTCH1 | patched 1 | -0.00557039 |
| SETBP1 | SET binding protein 1 | -0.00556657 |
| MCAM | melanoma cell adhesion molecule | -0.00555595 |
| MAOA | monoamine oxidase A | -0.00555453 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.00555162 |
| GPX3 | glutathione peroxidase 3 | -0.005537 |
| MMP1 | matrix metallopeptidase 1 | -0.00550511 |
| CDC20 | cell division cycle 20 | -0.00550212 |
| MMP3 | matrix metallopeptidase 3 | -0.00547882 |
| REEP1 | receptor accessory protein 1 | -0.00546875 |
| BCHE | butyrylcholinesterase | -0.00545728 |
| PRPH | peripherin | -0.00543578 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | -0.00541454 |
| RNASEH2A | ribonuclease H2, subunit A | -0.00538986 |
| FANCI | Fanconi anemia, complementation group I | -0.00538692 |
| SFTPC | surfactant protein C | -0.0053808 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | -0.00536871 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | -0.00533711 |
| HIRIP3 | HIRA interacting protein 3 | -0.00533058 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | -0.0053205 |
| PSMC3 | proteasome (prosome, macropain) 26S subunit, ATPase, 3 | -0.00531173 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00531126 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.00528115 |
| GPSM2 | G-protein signaling modulator 2 | -0.00528085 |
| JAG2 | jagged 2 | -0.00525087 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.00524569 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | -0.00522383 |
| EPHB3 | EPH receptor B3 | -0.00521925 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00520236 |
| MXRA8 | matrix-remodelling associated 8 | -0.00519339 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.00519038 |
| PFKL | phosphofructokinase, liver | -0.00518066 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00517684 |
| JUN | jun proto-oncogene | -0.00513868 |
| SLC43A3 | solute carrier family 43, member 3 | -0.00513683 |
| TMSB15A | thymosin beta 15a | -0.00512764 |
| NNMT | nicotinamide N-methyltransferase | -0.00512007 |
| EDN3 | endothelin 3 | -0.00510431 |
| SORBS3 | sorbin and SH3 domain containing 3 | -0.00509192 |
| SMTN | smoothelin | -0.00509034 |
| MDFIC | MyoD family inhibitor domain containing | -0.00507171 |
| PRC1 | protein regulator of cytokinesis 1 | -0.00504748 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00504333 |
| NFIB | nuclear factor I/B | -0.0050421 |
| UNG | uracil-DNA glycosylase | -0.00502953 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00502596 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.00501732 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -0.00501204 |
| DKK4 | dickkopf WNT signaling pathway inhibitor 4 | -0.00500046 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -0.00499258 |
| MGP | matrix Gla protein | -0.00497301 |
| NMU | neuromedin U | -0.00496459 |
| SCAND1 | SCAN domain containing 1 | -0.0049528 |
| RETREG1 | reticulophagy regulator 1 | -0.00494541 |
| LMNB1 | lamin B1 | -0.00494428 |
| KRT1 | keratin 1, type II | -0.00494104 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | -0.00491016 |
| CIT | citron rho-interacting serine/threonine kinase | -0.00489523 |
| SELENOW | selenoprotein W | -0.00487613 |
| APIP | APAF1 interacting protein | -0.00486706 |
| HRAS | Harvey rat sarcoma viral oncogene homolog | -0.00486612 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | -0.004858 |
| CCL21 | chemokine (C-C motif) ligand 21 | -0.00485672 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | -0.00484019 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00483896 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.00483089 |
| ADAMTSL3 | ADAMTS-like 3 | -0.00482487 |
| HMP19 | HMP19 protein | -0.00477756 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | -0.00475873 |
| HOXC6 | homeobox C6 | -0.00474075 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0047391 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.004729 |
| PCP4 | Purkinje cell protein 4 | -0.00472757 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | -0.00472145 |
| PLSCR4 | phospholipid scramblase 4 | -0.00472007 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.00471721 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) | -0.00469191 |
| AXL | AXL receptor tyrosine kinase | -0.00468341 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.00466774 |
| L1CAM | L1 cell adhesion molecule | -0.0046598 |
| SLIT1 | slit homolog 1 (Drosophila) | -0.00464351 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | -0.00459744 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.00459029 |
| MZT2A | mitotic spindle organizing protein 2A | -0.00458454 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | -0.00458193 |
| RUVBL1 | RuvB-like AAA ATPase 1 | -0.00457873 |
| FST | follistatin | -0.00456117 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | -0.00456048 |
| RARRES2 | retinoic acid receptor responder (tazarotene induced) 2 | -0.00455739 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | -0.00453533 |
| KIAA0100 | KIAA0100 | -0.00452018 |
| CDCA3 | cell division cycle associated 3 | -0.00451223 |
| TLE2 | transducin-like enhancer of split 2 | -0.0045095 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.00449832 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.00449788 |
| CYP2B6 | cytochrome P450, family 2, subfamily B, polypeptide 6 | -0.00449532 |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | -0.00449326 |
| TPX2 | TPX2, microtubule-associated | -0.00449015 |
| NRN1 | neuritin 1 | -0.00448604 |
| ASRGL1 | asparaginase like 1 | -0.00448216 |
| SEPTIN8 | septin 8 | -0.00446852 |
| ILK | integrin-linked kinase | -0.00446196 |
| COMP | cartilage oligomeric matrix protein | -0.00446121 |
| MRPL23 | mitochondrial ribosomal protein L23 | -0.00446119 |
| LAMA4 | laminin, alpha 4 | -0.00445945 |
| ZNF318 | zinc finger protein 318 | -0.00444648 |
| E2F2 | E2F transcription factor 2 | -0.00444568 |
| RET | ret proto-oncogene | -0.00444139 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.00443815 |
| GSN | gelsolin | -0.00442515 |
| SCRIB | scribbled planar cell polarity protein | -0.00442045 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00441715 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | -0.00441361 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | -0.00440083 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00439704 |
| PLXNA2 | plexin A2 | -0.00438822 |
| CDCA4 | cell division cycle associated 4 | -0.00438374 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | -0.0043733 |
| EPHA3 | EPH receptor A3 | -0.00437158 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.00436642 |
| BARD1 | BRCA1 associated RING domain 1 | -0.00436627 |
| PTTG1 | pituitary tumor-transforming 1 | -0.00435868 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.00435264 |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | -0.00435228 |
| RDH14 | retinol dehydrogenase 14 (all-trans/9-cis/11-cis) | -0.00434825 |
| RELN | reelin | -0.0043426 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.0043419 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00434018 |
| HOXB6 | homeobox B6 | -0.0043395 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | -0.00433932 |
| KCND3 | potassium channel, voltage gated Shal related subfamily D, member 3 | -0.00433452 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00433276 |
| CFD | complement factor D (adipsin) | -0.00433182 |
| COL10A1 | collagen, type X, alpha 1 | -0.00432896 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00432626 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -0.00431795 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | -0.00430983 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.00430982 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00430681 |
| CCKBR | cholecystokinin B receptor | -0.00429879 |
| ZNF219 | zinc finger protein 219 | -0.00429638 |
| FMOD | fibromodulin | -0.0042878 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | -0.0042835 |
