COPS3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description COP9 signalosome subunit 3|The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 8533)
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Genes

358 genes differentially expressed following the COPS3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM176A transmembrane protein 176A 3.00017
TUBB8 tubulin, beta 8 class VIII 3.00017
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.00017
CIITA class II, major histocompatibility complex, transactivator 3.00017
TAS2R1 taste receptor, type 2, member 1 3.00017
TAS2R8 taste receptor, type 2, member 8 3.00017
GYPE glycophorin E (MNS blood group) 3.00017
MFAP5 microfibrillar associated protein 5 3.00017
GPR20 G protein-coupled receptor 20 3.00017
ALPK2 alpha-kinase 2 3.00017
BIRC7 baculoviral IAP repeat containing 7 3.00017
FOLR2 folate receptor 2 (fetal) 3.00017
MEI1 meiosis inhibitor 1 3.00017
GFAP glial fibrillary acidic protein 3.00017
NXPH3 neurexophilin 3 3.00017
MUC6 mucin 6, oligomeric mucus/gel-forming 3.00017
PRSS41 protease, serine, 41 3.00017
PCDHB9 protocadherin beta 9 3.00017
DDN dendrin 3.00017
NOD2 nucleotide-binding oligomerization domain containing 2 3.00017
NRAP nebulin-related anchoring protein 3.00017
DSG4 desmoglein 4 3.00017
DSG3 desmoglein 3 3.00017
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 3.00017
ADAMTSL5 ADAMTS-like 5 3.00017
GADL1 glutamate decarboxylase-like 1 3.00017
NMUR2 neuromedin U receptor 2 3.00017
RTP1 receptor (chemosensory) transporter protein 1 3.00017
KIAA1755 KIAA1755 3.00017
STAP1 signal transducing adaptor family member 1 3.00017
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 3.00017
PCDHGA12 protocadherin gamma subfamily A, 12 3.00017
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.00017
GRM6 glutamate receptor, metabotropic 6 3.00017
NPR3 natriuretic peptide receptor 3 3.00017
ABRA actin binding Rho activating protein 3.00017
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 3.00017
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.00017
ASGR2 asialoglycoprotein receptor 2 3.00017
BSX brain-specific homeobox 3.00017
GNAT3 guanine nucleotide binding protein, alpha transducing 3 3.00017
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.00017
TTLL8 tubulin tyrosine ligase-like family member 8 3.00017
CRIP1 cysteine-rich protein 1 (intestinal) 3.00017
YY2 YY2 transcription factor 3.00017
AVP arginine vasopressin 3.00017
PRDM16 PR domain containing 16 3.00017
STARD6 StAR-related lipid transfer (START) domain containing 6 3.00017
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.00017
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.00017
NANOS3 nanos homolog 3 (Drosophila) 3.00017
CATSPERT catsper channel auxiliary subunit tau 3.00017
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.00017
ADRB1 adrenoceptor beta 1 3.00017
GC group-specific component (vitamin D binding protein) 3.00017
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.00017
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.00017
SELL selectin L 3.00017
F5 coagulation factor V (proaccelerin, labile factor) 3.00017
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.00017
OR7D2 olfactory receptor, family 7, subfamily D, member 2 3.00017
PARVG parvin, gamma 3.00017
FMO2 flavin containing monooxygenase 2 (non-functional) 3.00017
SRGN serglycin 3.00017
SPI1 Spi-1 proto-oncogene 3.00017
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.00017
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 3.00017
SPMIP3 sperm microtubule inner protein 3 3.00017
CFAP206 cilia and flagella associated protein 206 3.00017
MYOCOS myocilin opposite strand 3.00017
TMEM275 transmembrane protein 275 3.00017
DEFB108B defensin, beta 108B 3.00017
SPATS1 spermatogenesis associated, serine-rich 1 3.00017
BEND4 BEN domain containing 4 3.00017
GPR35 G protein-coupled receptor 35 3.00017
NPIPB8 nuclear pore complex interacting protein family, member B8 3.00017
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.00017
PCDHA2 protocadherin alpha 2 3.00017
CAPN14 calpain 14 3.00017
LIPJ lipase, family member J 3.00017
LOX lysyl oxidase 3.00017
UPK3B uroplakin 3B 3.00017
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.00017
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.00017
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 3.00017
LIPH lipase, member H 3.00017
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.00017
CLDN5 claudin 5 3.00017
IRF4 interferon regulatory factor 4 3.00017
TEX101 testis expressed 101 3.00017
OR2L5 olfactory receptor, family 2, subfamily L, member 5 3.00017
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.00017
ZIC4 Zic family member 4 3.00017
CXCL11 chemokine (C-X-C motif) ligand 11 3.00017
MSX2 msh homeobox 2 3.00017
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.00017
HPR haptoglobin-related protein 3.00017
THPO thrombopoietin 3.00017
DAO D-amino-acid oxidase 3.00017
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.00017
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 3.00017
WNT7B wingless-type MMTV integration site family, member 7B 3.00017
ZNF132 zinc finger protein 132 3.00017
FNDC1 fibronectin type III domain containing 1 3.00017
EBF2 early B-cell factor 2 3.00017
PCDHGB1 protocadherin gamma subfamily B, 1 3.00017
VAX2 ventral anterior homeobox 2 3.00017
SVOP SV2 related protein homolog (rat) 3.00017
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.00017
CPO carboxypeptidase O 3.00017
TBX1 T-box 1 3.00017
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.00017
MAGEB17 melanoma antigen family B17 3.00017
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.00017
ITGA11 integrin, alpha 11 3.00017
MAT1A methionine adenosyltransferase I, alpha 3.00017
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.00017
NUTM2A NUT family member 2A 3.00017
ZFP92 ZFP92 zinc finger protein 3.00017
SMKR1 small lysine-rich protein 1 3.00017
SIAH3 siah E3 ubiquitin protein ligase family member 3 3.00017
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.00017
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.00017
GPR119 G protein-coupled receptor 119 3.00017
TDRD10 tudor domain containing 10 3.00017
TMEM207 transmembrane protein 207 3.00017
TBC1D10C TBC1 domain family, member 10C 3.00017
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.00017
DHH desert hedgehog 3.00017
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.00017
CNGB3 cyclic nucleotide gated channel beta 3 3.00017
GRK7 G protein-coupled receptor kinase 7 3.00017
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.00017
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.00017
POF1B premature ovarian failure, 1B 3.00017
ERICH4 glutamate-rich 4 3.00017
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 3.00017
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.00017
LKAAEAR1 LKAAEAR motif containing 1 3.00017
APOL1 apolipoprotein L, 1 3.00017
SH2D1B SH2 domain containing 1B 3.00017
RHAG Rh-associated glycoprotein 3.00017
ITPKA inositol-trisphosphate 3-kinase A 3.00017
HHLA2 HERV-H LTR-associating 2 3.00017
NYX nyctalopin 3.00017
LDLRAD1 low density lipoprotein receptor class A domain containing 1 3.00017
CLCNKA chloride channel, voltage-sensitive Ka 3.00017
ADRA1A adrenoceptor alpha 1A 3.00017
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.00017
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.00017
CPLX2 complexin 2 3.00017
SSX3 synovial sarcoma, X breakpoint 3 3.00017
AHSG alpha-2-HS-glycoprotein 3.00017
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 3.00017
ASCL1 achaete-scute family bHLH transcription factor 1 3.00017
FGF16 fibroblast growth factor 16 3.00017
RNF224 ring finger protein 224 3.00017
EPO erythropoietin 3.00017
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.00017
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.00017
GPR62 G protein-coupled receptor 62 3.00017
ZIM2 zinc finger, imprinted 2 3.00017
HAND2 heart and neural crest derivatives expressed 2 3.00017
PGR progesterone receptor 3.00017
SFN stratifin 3.00017
NPAS4 neuronal PAS domain protein 4 3.00017
BCL2L10 BCL2-like 10 (apoptosis facilitator) 3.00017
GTF3A general transcription factor IIIA 2.97855
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 2.96627
PTX3 pentraxin 3, long 2.96627
SPATA32 spermatogenesis associated 32 2.96627
CSRNP1 cysteine-serine-rich nuclear protein 1 2.95524
FTH1 ferritin, heavy polypeptide 1 2.94902
ESYT2 extended synaptotagmin-like protein 2 2.94396
PCDHGB6 protocadherin gamma subfamily B, 6 2.91859
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 2.85576
MFN1 mitofusin 1 2.72208
ZBTB8A zinc finger and BTB domain containing 8A 2.67778
HES6 hes family bHLH transcription factor 6 2.67639
RNF121 ring finger protein 121 2.59272
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.50531
NEFM neurofilament, medium polypeptide 2.49803
FBF1 Fas (TNFRSF6) binding factor 1 2.48122
IL4I1 interleukin 4 induced 1 2.48065
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.48065
ATP10B ATPase, class V, type 10B 2.48065
YME1L1 YME1-like 1 ATPase 2.4737
GAMT guanidinoacetate N-methyltransferase 2.47133
GRPR gastrin-releasing peptide receptor 2.46939
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2.46433
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2.42787
AOC3 amine oxidase, copper containing 3 2.42756
MPRIP myosin phosphatase Rho interacting protein 2.41529
TTC23L tetratricopeptide repeat domain 23-like 2.41393
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 2.40814
MBLAC1 metallo-beta-lactamase domain containing 1 2.36807
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.36807
DOCK7 dedicator of cytokinesis 7 2.35823
L3MBTL1 l(3)mbt-like 1 (Drosophila) 2.34904
ANTXR2 anthrax toxin receptor 2 2.33674
YY1 YY1 transcription factor 2.32939
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.26283
VRK3 vaccinia related kinase 3 2.23035
ZYX zyxin 2.20687
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 2.19962
MRRF mitochondrial ribosome recycling factor 2.19411
ZNF879 zinc finger protein 879 2.19411
L1CAM L1 cell adhesion molecule 2.19411
CDK2 cyclin-dependent kinase 2 2.1919
GFER growth factor, augmenter of liver regeneration 2.17213
C2ORF69 chromosome 2 open reading frame 69 2.17062
COL6A1 collagen, type VI, alpha 1 2.17062
KDM4C lysine (K)-specific demethylase 4C 2.16459
ERI3 ERI1 exoribonuclease family member 3 2.13975
PDCD6IP programmed cell death 6 interacting protein 2.13749
MOAP1 modulator of apoptosis 1 2.13685
CGNL1 cingulin-like 1 2.1092
CEP70 centrosomal protein 70kDa 2.10601
GLT8D2 glycosyltransferase 8 domain containing 2 2.09315
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.08897
BEND6 BEN domain containing 6 2.08871
RWDD4 RWD domain containing 4 2.0791
MCPH1 microcephalin 1 2.07726
MTMR12 myotubularin related protein 12 2.06783
CDK6 cyclin-dependent kinase 6 2.06711
MATR3 matrin 3 2.0583
GAS1 growth arrest-specific 1 2.05712
GAGE10 G antigen 10 2.05712
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 2.05498
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.05498
PDPN podoplanin 2.05446
FICD FIC domain containing 2.0358
TUB tubby bipartite transcription factor 2.0358
FADS6 fatty acid desaturase 6 2.02573
ADAM21 ADAM metallopeptidase domain 21 2.02573
CBR3 carbonyl reductase 3 2.02573
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.02573
LIME1 Lck interacting transmembrane adaptor 1 2.02573
GLIS1 GLIS family zinc finger 1 2.02573
ATG4A autophagy related 4A, cysteine peptidase 2.02573
FAM78A family with sequence similarity 78, member A 2.02573
CHD5 chromodomain helicase DNA binding protein 5 2.02573
ACAD10 acyl-CoA dehydrogenase family, member 10 2.02469
FUS FUS RNA binding protein 2.00024

decreased expression

Symbol Name Standardized Value
KLK8 kallikrein-related peptidase 8 -3.00017
ELF4 E74-like factor 4 (ets domain transcription factor) -3.00017
CA7 carbonic anhydrase VII -3.00017
RANBP1 RAN binding protein 1 -3.00017
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -3.00017
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -3.00017
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -3.00017
IFT122 intraflagellar transport 122 -3.00017
C19ORF84 chromosome 19 open reading frame 84 -3.00017
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -3.00017
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -3.00017
HEYL hes-related family bHLH transcription factor with YRPW motif-like -3.00017
FAM86B2 family with sequence similarity 86, member B2 -3.00017
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -3.00017
RUNDC1 RUN domain containing 1 -3.00017
HLA-DOA major histocompatibility complex, class II, DO alpha -3.00017
ACBD4 acyl-CoA binding domain containing 4 -2.99679
TRIL TLR4 interactor with leucine-rich repeats -2.96627
SRL sarcalumenin -2.96627
FAM228A family with sequence similarity 228, member A -2.96627
OR51M1 olfactory receptor, family 51, subfamily M, member 1 -2.96627
RP1L1 retinitis pigmentosa 1-like 1 -2.96627
FAM194C family with sequence similarity 149 member C -2.96627
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.96627
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -2.96627
ABHD15 abhydrolase domain containing 15 -2.96627
CD19 CD19 molecule -2.96627
LRRC66 leucine rich repeat containing 66 -2.96627
CNTFR ciliary neurotrophic factor receptor -2.96627
OR2A25 olfactory receptor, family 2, subfamily A, member 25 -2.96627
DNAI2 dynein, axonemal, intermediate chain 2 -2.96627
ZNF469 zinc finger protein 469 -2.96627
AMBP alpha-1-microglobulin/bikunin precursor -2.96627
SH2D6 SH2 domain containing 6 -2.96627
MMRN2 multimerin 2 -2.96627
LPA lipoprotein, Lp(a) -2.96627
DYNLL1 dynein, light chain, LC8-type 1 -2.96627
C3ORF49 chromosome 3 open reading frame 49 -2.96627
SIM1 single-minded family bHLH transcription factor 1 -2.96627
ACOX2 acyl-CoA oxidase 2, branched chain -2.96627
GIPC3 GIPC PDZ domain containing family, member 3 -2.96627
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 -2.96627
RELN reelin -2.96627
C19ORF67 chromosome 19 open reading frame 67 -2.96627
AMH anti-Mullerian hormone -2.96627
FAM209B family with sequence similarity 209, member B -2.96627
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.96627
KCTD11 potassium channel tetramerization domain containing 11 -2.96627
ZNF416 zinc finger protein 416 -2.96627
HLA-DMB major histocompatibility complex, class II, DM beta -2.96627
KXD1 KxDL motif containing 1 -2.93336
COMMD5 COMM domain containing 5 -2.91494
COPS3 COP9 signalosome subunit 3 -2.89816
MLEC malectin -2.79333
XKR7 XK, Kell blood group complex subunit-related family, member 7 -2.76913
FN3K fructosamine 3 kinase -2.73547
PSD4 pleckstrin and Sec7 domain containing 4 -2.69527
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.69527
HSPA1A heat shock 70kDa protein 1A -2.69262
LGALS3 lectin, galactoside-binding, soluble, 3 -2.68459
MAP2K3 mitogen-activated protein kinase kinase 3 -2.68443
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -2.68443
PODXL2 podocalyxin-like 2 -2.67955
SLC7A6OS solute carrier family 7, member 6 opposite strand -2.63231
PRXL2B peroxiredoxin like 2B -2.62661
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -2.61611
STUM stum, mechanosensory transduction mediator homolog -2.59592
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.51836
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -2.47978
BORCS8 BLOC-1 related complex subunit 8 -2.46266
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -2.46037
PTCH1 patched 1 -2.42376
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.38106
ZNF619 zinc finger protein 619 -2.36807
INTS9 integrator complex subunit 9 -2.31284
FGF12 fibroblast growth factor 12 -2.31199
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.29129
MTF2 metal response element binding transcription factor 2 -2.29129
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 -2.25311
C5ORF63 chromosome 5 open reading frame 63 -2.23724
MASTL microtubule associated serine/threonine kinase-like -2.23197
GMEB2 glucocorticoid modulatory element binding protein 2 -2.22966
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -2.22379
ARID5A AT rich interactive domain 5A (MRF1-like) -2.21139
PLXDC1 plexin domain containing 1 -2.21139
BBOF1 basal body orientation factor 1 -2.21139
CDH18 cadherin 18, type 2 -2.21139
CATSPERQ catsper channel auxiliary subunit theta -2.20294
PEPD peptidase D -2.20294
MINK1 misshapen-like kinase 1 -2.20294
COG1 component of oligomeric golgi complex 1 -2.19411
GOPC golgi-associated PDZ and coiled-coil motif containing -2.17069
SYPL2 synaptophysin-like 2 -2.16011
TAFA1 TAFA chemokine like family member 1 -2.15328
WDR81 WD repeat domain 81 -2.13975
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.13975
KDM6B lysine (K)-specific demethylase 6B -2.13975
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like -2.13463
TMEM231 transmembrane protein 231 -2.13463
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.09315
DHFR dihydrofolate reductase -2.09047
GPATCH4 G patch domain containing 4 -2.08871
TEX261 testis expressed 261 -2.08096
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) -2.07288
ZNF660 zinc finger protein 660 -2.0583
IFI27 interferon, alpha-inducible protein 27 -2.05712
CCNP cyclin P -2.05498
MTFR1 mitochondrial fission regulator 1 -2.05498
EID2B EP300 interacting inhibitor of differentiation 2B -2.0358
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 -2.0358
MAP3K21 mitogen-activated protein kinase kinase kinase 21 -2.0358
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 -2.0358
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) -2.03165
CHRM3 cholinergic receptor, muscarinic 3 -2.02469