COPS5 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description COP9 signalosome subunit 5|The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10987)
External Link http://www.ncbi.nlm.nih.gov/gene/10987
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132 interacting proteins for hub protein COPS5 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
AKAP2 A kinase (PRKA) anchor protein 2
AMOT angiomotin
AMOTL1 angiomotin like 1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATRN attractin
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BTBD2 BTB (POZ) domain containing 2
C12ORF10 chromosome 12 open reading frame 10
CARD11 caspase recruitment domain family, member 11
CCNDBP1 cyclin D-type binding-protein 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
COPS2 COP9 signalosome subunit 2
COPS3 COP9 signalosome subunit 3
COPS4 COP9 signalosome subunit 4
COPS6 COP9 signalosome subunit 6
COPS7A COP9 signalosome subunit 7A
COPS7B COP9 signalosome subunit 7B
COPS8 COP9 signalosome subunit 8
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
DAPK1 death-associated protein kinase 1
DCAF11 DDB1 and CUL4 associated factor 11
DCAF4 DDB1 and CUL4 associated factor 4
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DOCK7 dedicator of cytokinesis 7
DYNLL1 dynein, light chain, LC8-type 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERCC8 excision repair cross-complementation group 8
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBL fibrillarin
FBXO11 F-box protein 11
FBXO17 F-box protein 17
FBXO22 F-box protein 22
FBXO46 F-box protein 46
FLOT1 flotillin 1
GFER growth factor, augmenter of liver regeneration
GFI1B growth factor independent 1B transcription repressor
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPS1 G protein pathway suppressor 1
HAND2 heart and neural crest derivatives expressed 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNF4A hepatocyte nuclear factor 4, alpha
HNF4G hepatocyte nuclear factor 4, gamma
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
INADL InaD-like (Drosophila)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLHL13 kelch-like family member 13
KLHL15 kelch-like family member 15
KLHL18 kelch-like family member 18
KLHL22 kelch-like family member 22
KLHL24 kelch-like family member 24
KLHL42 kelch-like family member 42
KLHL9 kelch-like family member 9
LIN7C lin-7 homolog C (C. elegans)
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
LRR1 leucine rich repeat protein 1
LRRC14 leucine rich repeat containing 14
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MEF2D myocyte enhancer factor 2D
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MPDZ multiple PDZ domain protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
NCKIPSD NCK interacting protein with SH3 domain
NCOA1 nuclear receptor coactivator 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NOD1 nucleotide-binding oligomerization domain containing 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PLAC8 placenta-specific 8
PPARG peroxisome proliferator-activated receptor gamma
PPOX protoporphyrinogen oxidase
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBX1 ring-box 1, E3 ubiquitin protein ligase
RNF139 ring finger protein 139
RORA RAR-related orphan receptor A
S100A7 S100 calcium binding protein A7
SAP130 Sin3A-associated protein, 130kDa
SHISA5 shisa family member 5
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SREBF2 sterol regulatory element binding transcription factor 2
STOML2 stomatin (EPB72)-like 2
TMOD1 tropomodulin 1
TOR1AIP2 torsin A interacting protein 2
TP53 tumor protein p53
TRAF2 TNF receptor-associated factor 2
TXN thioredoxin
UBE2H ubiquitin-conjugating enzyme E2H
UBE2I ubiquitin-conjugating enzyme E2I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPRBP Vpr (HIV-1) binding protein
VTN vitronectin
WDR6 WD repeat domain 6
WNK1 WNK lysine deficient protein kinase 1
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta