COPS6 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description COP9 signalosome subunit 6|The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 10980)
External Link http://www.ncbi.nlm.nih.gov/gene/10980
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Genes

129 interacting proteins for hub protein COPS6 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
BTBD1 BTB (POZ) domain containing 1
BTBD2 BTB (POZ) domain containing 2
BTBD9 BTB (POZ) domain containing 9
C1ORF174 chromosome 1 open reading frame 174
C4ORF17 chromosome 4 open reading frame 17
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC106 coiled-coil domain containing 106
CDH10 cadherin 10, type 2 (T2-cadherin)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CKS1B CDC28 protein kinase regulatory subunit 1B
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
COPS2 COP9 signalosome subunit 2
COPS3 COP9 signalosome subunit 3
COPS4 COP9 signalosome subunit 4
COPS5 COP9 signalosome subunit 5
COPS6 COP9 signalosome subunit 6
COPS7A COP9 signalosome subunit 7A
COPS7B COP9 signalosome subunit 7B
COPS8 COP9 signalosome subunit 8
COX17 COX17 cytochrome c oxidase copper chaperone
COX5A cytochrome c oxidase subunit Va
CRBN cereblon
CRELD1 cysteine-rich with EGF-like domains 1
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
DCAF11 DDB1 and CUL4 associated factor 11
DCAF4 DDB1 and CUL4 associated factor 4
DDA1 DET1 and DDB1 associated 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DIS3L2 DIS3 like 3'-5' exoribonuclease 2
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDN1 endothelin 1
EIF3E eukaryotic translation initiation factor 3, subunit E
EMD emerin
EP300 E1A binding protein p300
ERCC8 excision repair cross-complementation group 8
ERH enhancer of rudimentary homolog (Drosophila)
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
FBXO11 F-box protein 11
FBXO17 F-box protein 17
FBXO22 F-box protein 22
FBXO44 F-box protein 44
FBXO7 F-box protein 7
FBXW9 F-box and WD repeat domain containing 9
FEM1B fem-1 homolog b (C. elegans)
GPS1 G protein pathway suppressor 1
HMOX2 heme oxygenase 2
KCTD3 potassium channel tetramerization domain containing 3
KLHL13 kelch-like family member 13
KLHL15 kelch-like family member 15
KLHL18 kelch-like family member 18
KLHL20 kelch-like family member 20
KLHL22 kelch-like family member 22
KLHL24 kelch-like family member 24
KLHL42 kelch-like family member 42
KLHL8 kelch-like family member 8
KLHL9 kelch-like family member 9
LAMA4 laminin, alpha 4
LPL lipoprotein lipase
LRR1 leucine rich repeat protein 1
LRRC14 leucine rich repeat containing 14
MAP7D1 MAP7 domain containing 1
MCC mutated in colorectal cancers
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYCBP MYC binding protein
MYEOV2 myeloma overexpressed 2
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORAI2 ORAI calcium release-activated calcium modulator 2
PAEP progestagen-associated endometrial protein
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBX2 pre-B-cell leukemia homeobox 2
PDZK1IP1 PDZK1 interacting protein 1
PFKL phosphofructokinase, liver
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PMF1 polyamine-modulated factor 1
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PSAP prosaposin
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTEN phosphatase and tensin homolog
QTRT1 queuine tRNA-ribosyltransferase 1
RAB27A RAB27A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RFC5 replication factor C (activator 1) 5, 36.5kDa
ROGDI rogdi homolog (Drosophila)
RPA2 replication protein A2, 32kDa
RPL15 ribosomal protein L15
S100A10 S100 calcium binding protein A10
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SHKBP1 SH3KBP1 binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMN1 survival of motor neuron 1, telomeric
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SNRPG small nuclear ribonucleoprotein polypeptide G
STK40 serine/threonine kinase 40
STX5 syntaxin 5
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TDGF1 teratocarcinoma-derived growth factor 1
TK1 thymidine kinase 1, soluble
TOR1AIP2 torsin A interacting protein 2
TP53 tumor protein p53
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIB3 tribbles pseudokinase 3
TSG101 tumor susceptibility 101
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VIM vimentin
VPRBP Vpr (HIV-1) binding protein
WIPI2 WD repeat domain, phosphoinositide interacting 2
ZEB2 zinc finger E-box binding homeobox 2
ZNF24 zinc finger protein 24
ZYG11B zyg-11 family member B, cell cycle regulator