COT Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description mitogen-activated protein kinase kinase kinase 8|This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] (NCBI Entrez Gene Database, 1326)
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Genes

100 substrates of the kinase COT from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MTX3 metaxin 3
PACS1 phosphofurin acidic cluster sorting protein 1
STRIP1 striatin interacting protein 1
LASP1 LIM and SH3 protein 1
LIMA1 LIM domain and actin binding 1
ZDHHC5 zinc finger, DHHC-type containing 5
MBLAC1 metallo-beta-lactamase domain containing 1
JUNB jun B proto-oncogene
MADD MAP-kinase activating death domain
ELL elongation factor RNA polymerase II
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
SAP30L SAP30-like
CHGA chromogranin A
KMT2A lysine (K)-specific methyltransferase 2A
U2SURP U2 snRNP-associated SURP domain containing
PTK2 protein tyrosine kinase 2
LARP4 La ribonucleoprotein domain family, member 4
NES nestin
SPP1 secreted phosphoprotein 1
TGFBR1 transforming growth factor, beta receptor 1
TDRKH tudor and KH domain containing
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
EML4 echinoderm microtubule associated protein like 4
EIF5B eukaryotic translation initiation factor 5B
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
C18ORF25 chromosome 18 open reading frame 25
CENPC centromere protein C
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
MIS18BP1 MIS18 binding protein 1
MYO18A myosin XVIIIA
ZBTB21 zinc finger and BTB domain containing 21
BLM Bloom syndrome, RecQ helicase-like
GTF2I general transcription factor IIi
CEP164 centrosomal protein 164kDa
BCCIP BRCA2 and CDKN1A interacting protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
GPATCH8 G patch domain containing 8
STXBP4 syntaxin binding protein 4
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
SEC23IP SEC23 interacting protein
RCOR1 REST corepressor 1
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
GJA1 gap junction protein, alpha 1, 43kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ZRANB2 zinc finger, RAN-binding domain containing 2
TRIO trio Rho guanine nucleotide exchange factor
NARS asparaginyl-tRNA synthetase
PEX1 peroxisomal biogenesis factor 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
ILF3 interleukin enhancer binding factor 3, 90kDa
BMS1 BMS1 ribosome biogenesis factor
WWC2 WW and C2 domain containing 2
ODF2 outer dense fiber of sperm tails 2
CBX3 chromobox homolog 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
ATAD2 ATPase family, AAA domain containing 2
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
GPBP1 GC-rich promoter binding protein 1
SAP30BP SAP30 binding protein
WAPAL wings apart-like homolog (Drosophila)
COPS3 COP9 signalosome subunit 3
UBE2R2 ubiquitin-conjugating enzyme E2R 2
CDC34 cell division cycle 34
RSRC2 arginine/serine-rich coiled-coil 2
MEIS2 Meis homeobox 2
RIN1 Ras and Rab interactor 1
RIF1 replication timing regulatory factor 1
USP16 ubiquitin specific peptidase 16
FXR2 fragile X mental retardation, autosomal homolog 2
PPIG peptidylprolyl isomerase G (cyclophilin G)
RBM20 RNA binding motif protein 20
MAP7 microtubule-associated protein 7
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
STXBP5L syntaxin binding protein 5-like
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP6R3 protein phosphatase 6, regulatory subunit 3
JAM3 junctional adhesion molecule 3
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
BRAP BRCA1 associated protein
RCN1 reticulocalbin 1, EF-hand calcium binding domain
ANK2 ankyrin 2, neuronal
MYO9B myosin IXB
HIRIP3 HIRA interacting protein 3
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
ERCC6L excision repair cross-complementation group 6-like
FOXO3 forkhead box O3
EIF3D eukaryotic translation initiation factor 3, subunit D
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
ARMCX3 armadillo repeat containing, X-linked 3
NOP58 NOP58 ribonucleoprotein
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
CEP170 centrosomal protein 170kDa
PARP1 poly (ADP-ribose) polymerase 1
FAN1 FANCD2/FANCI-associated nuclease 1
SPN sialophorin