CP-690334-01-4380 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the CP-690334-01-4380 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACACB acetyl-CoA carboxylase beta
ADARB1 adenosine deaminase, RNA-specific, B1
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ALOXE3 arachidonate lipoxygenase 3
APC2 adenomatosis polyposis coli 2
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
CCL5 chemokine (C-C motif) ligand 5
CD177 CD177 molecule
CD53 CD53 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDHR2 cadherin-related family member 2
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCA1 chloride channel accessory 1
CNTN1 contactin 1
CTIF CBP80/20-dependent translation initiation factor
CXCR1 chemokine (C-X-C motif) receptor 1
DDO D-aspartate oxidase
DOCK6 dedicator of cytokinesis 6
DSC3 desmocollin 3
EBF2 early B-cell factor 2
EMC3 ER membrane protein complex subunit 3
FAM46C family with sequence similarity 46, member C
FAM49A family with sequence similarity 49, member A
FBXL7 F-box and leucine-rich repeat protein 7
FGF2 fibroblast growth factor 2 (basic)
FRMD1 FERM domain containing 1
FRZB frizzled-related protein
GLS glutaminase
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H3H histone cluster 1, H3h
HIST1H3J histone cluster 1, H3j
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFT54 intraflagellar transport 54
INSIG1 insulin induced gene 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAK male germ cell-associated kinase
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP2 microtubule-associated protein 2
MIER2 mesoderm induction early response 1, family member 2
MST1 macrophage stimulating 1
MVD mevalonate (diphospho) decarboxylase
MXD4 MAX dimerization protein 4
N4BP2L2 NEDD4 binding protein 2-like 2
NPFF neuropeptide FF-amide peptide precursor
NUP54 nucleoporin 54kDa
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAX8 paired box 8
PCDH9 protocadherin 9
PCLO piccolo presynaptic cytomatrix protein
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHF20L1 PHD finger protein 20-like 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRKCI protein kinase C, iota
PVT1 Pvt1 oncogene (non-protein coding)
RAI2 retinoic acid induced 2
RFPL3 ret finger protein-like 3
RGL1 ral guanine nucleotide dissociation stimulator-like 1
SAPCD1 suppressor APC domain containing 1
SARM1 sterile alpha and TIR motif containing 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRT4 sirtuin 4
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC39A9 solute carrier family 39, member 9
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMOX spermine oxidase
SOX21 SRY (sex determining region Y)-box 21
SOX30 SRY (sex determining region Y)-box 30
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TP63 tumor protein p63
TRIM36 tripartite motif containing 36
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
XAF1 XIAP associated factor 1
YPEL1 yippee-like 1 (Drosophila)
ZBTB17 zinc finger and BTB domain containing 17
ZCCHC24 zinc finger, CCHC domain containing 24
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF10 zinc finger protein 10
ZNF264 zinc finger protein 264
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
A4GALT alpha 1,4-galactosyltransferase
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ACKR3 atypical chemokine receptor 3
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
AKAP12 A kinase (PRKA) anchor protein 12
APLP1 amyloid beta (A4) precursor-like protein 1
ARID5A AT rich interactive domain 5A (MRF1-like)
ARMC4 armadillo repeat containing 4
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C17ORF80 chromosome 17 open reading frame 80
C1ORF106 chromosome 1 open reading frame 106
CALML5 calmodulin-like 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBX2 chromobox homolog 2
CDH18 cadherin 18, type 2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLDN1 claudin 1
CNTFR ciliary neurotrophic factor receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAAM2 dishevelled associated activator of morphogenesis 2
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DEPDC5 DEP domain containing 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPY19L1P1 DPY19L1 pseudogene 1
FAM212B family with sequence similarity 212, member B
FLJ11710 uncharacterized protein FLJ11710
FOSL1 FOS-like antigen 1
FRK fyn-related Src family tyrosine kinase
GAS2 growth arrest-specific 2
GATA4 GATA binding protein 4
GJA1 gap junction protein, alpha 1, 43kDa
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GTF2IRD1 GTF2I repeat domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC7 histone deacetylase 7
HIST1H1E histone cluster 1, H1e
HOXC4 homeobox C4
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFI27 interferon, alpha-inducible protein 27
IL17RB interleukin 17 receptor B
IL4R interleukin 4 receptor
IQCC IQ motif containing C
ITPKB inositol-trisphosphate 3-kinase B
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0125 KIAA0125
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT24 keratin 24, type I
LGALS9 lectin, galactoside-binding, soluble, 9
LIF leukemia inhibitory factor
LRRC49 leucine rich repeat containing 49
LRRTM2 leucine rich repeat transmembrane neuronal 2
LY6D lymphocyte antigen 6 complex, locus D
NPTX1 neuronal pentraxin I
NT5E 5'-nucleotidase, ecto (CD73)
OCLM oculomedin
OPLAH 5-oxoprolinase (ATP-hydrolysing)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCDH17 protocadherin 17
PCDHA6 protocadherin alpha 6
PDE12 phosphodiesterase 12
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
POPDC3 popeye domain containing 3
POU3F2 POU class 3 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PRAMEF11 PRAME family member 11
PRODH proline dehydrogenase (oxidase) 1
PSCA prostate stem cell antigen
PTPRE protein tyrosine phosphatase, receptor type, E
RFXAP regulatory factor X-associated protein
RGS20 regulator of G-protein signaling 20
RIBC2 RIB43A domain with coiled-coils 2
RND1 Rho family GTPase 1
RNF208 ring finger protein 208
RPL13P5 ribosomal protein L13 pseudogene 5
RUSC2 RUN and SH3 domain containing 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOAT2 sterol O-acyltransferase 2
SYCP2 synaptonemal complex protein 2
TCP10 t-complex 10
TH tyrosine hydroxylase
THBS3 thrombospondin 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRAIP TRAF interacting protein
TRIM68 tripartite motif containing 68
WDR76 WD repeat domain 76
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF41 zinc finger protein 41
ZNF532 zinc finger protein 532
ZNF750 zinc finger protein 750