CP-690334-01-4383 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the CP-690334-01-4383 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADAM22 ADAM metallopeptidase domain 22
AHNAK2 AHNAK nucleoprotein 2
APOL3 apolipoprotein L, 3
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C10ORF10 chromosome 10 open reading frame 10
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CDH8 cadherin 8, type 2
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA1 chloride channel accessory 1
CNN3 calponin 3, acidic
CTNS cystinosin, lysosomal cystine transporter
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
EHD2 EH-domain containing 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FMO5 flavin containing monooxygenase 5
FRMD1 FERM domain containing 1
FRZB frizzled-related protein
FXYD5 FXYD domain containing ion transport regulator 5
GFER growth factor, augmenter of liver regeneration
GJA4 gap junction protein, alpha 4, 37kDa
GK glycerol kinase
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
HFE hemochromatosis
HRG histidine-rich glycoprotein
HSF1 heat shock transcription factor 1
ICOSLG inducible T-cell co-stimulator ligand
IFI6 interferon, alpha-inducible protein 6
IGLJ3 immunoglobulin lambda joining 3
INSR insulin receptor
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIAA1024 KIAA1024
KLHL1 kelch-like family member 1
KLK13 kallikrein-related peptidase 13
KRT75 keratin 75, type II
LAT2 linker for activation of T cells family, member 2
LEPR leptin receptor
LOXL3 lysyl oxidase-like 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MATN1 matrilin 1, cartilage matrix protein
MCAM melanoma cell adhesion molecule
MOB3B MOB kinase activator 3B
MST1 macrophage stimulating 1
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYT1 myelin transcription factor 1
NEFM neurofilament, medium polypeptide
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPY4R neuropeptide Y receptor Y4
NXF2 nuclear RNA export factor 2
OR1E1 olfactory receptor, family 1, subfamily E, member 1
PAPPA2 pappalysin 2
PAX8 paired box 8
PCDHB6 protocadherin beta 6
PCDHGA8 protocadherin gamma subfamily A, 8
PDE4C phosphodiesterase 4C, cAMP-specific
PDLIM3 PDZ and LIM domain 3
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHF20L1 PHD finger protein 20-like 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAC4 placenta-specific 4
PLCD1 phospholipase C, delta 1
PRAMEF10 PRAME family member 10
PRSS53 protease, serine, 53
RB1 retinoblastoma 1
SARM1 sterile alpha and TIR motif containing 1
SCG2 secretogranin II
SEC14L4 SEC14-like 4 (S. cerevisiae)
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPN sialophorin
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STARD8 StAR-related lipid transfer (START) domain containing 8
SYNDIG1 synapse differentiation inducing 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TGFA transforming growth factor, alpha
THSD4 thrombospondin, type I, domain containing 4
TRIM36 tripartite motif containing 36
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TSC2 tuberous sclerosis 2
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VCAN versican
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WNT6 wingless-type MMTV integration site family, member 6
ZNF446 zinc finger protein 446
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACTL8 actin-like 8
ADCY7 adenylate cyclase 7
ADM adrenomedullin
ALOX15 arachidonate 15-lipoxygenase
ARID5A AT rich interactive domain 5A (MRF1-like)
ARR3 arrestin 3, retinal (X-arrestin)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BHLHE41 basic helix-loop-helix family, member e41
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C11ORF63 chromosome 11 open reading frame 63
CCDC69 coiled-coil domain containing 69
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIC capicua transcriptional repressor
CRBN cereblon
CSF1R colony stimulating factor 1 receptor
CTSF cathepsin F
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DAAM2 dishevelled associated activator of morphogenesis 2
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEPDC5 DEP domain containing 5
DNASE1L2 deoxyribonuclease I-like 2
DRD1 dopamine receptor D1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELP6 elongator acetyltransferase complex subunit 6
ERCC2 excision repair cross-complementation group 2
EXOC6B exocyst complex component 6B
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ22184
FLT4 fms-related tyrosine kinase 4
FMOD fibromodulin
GAS2 growth arrest-specific 2
GATA4 GATA binding protein 4
GFI1 growth factor independent 1 transcription repressor
GPR157 G protein-coupled receptor 157
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSTP1 glutathione S-transferase pi 1
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDAC7 histone deacetylase 7
HIST1H2AK histone cluster 1, H2ak
HMOX1 heme oxygenase 1
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IFNA14 interferon, alpha 14
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL17RA interleukin 17 receptor A
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
KIAA1324 KIAA1324
KIF13A kinesin family member 13A
KIFC3 kinesin family member C3
KRT83 keratin 83, type II
LGALS9 lectin, galactoside-binding, soluble, 9
LMTK1 lemur tail kinase 1
LOC390998 ribosomal protein L10 pseudogene
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MAPK10 mitogen-activated protein kinase 10
NDE1 nudE neurodevelopment protein 1
NIPSNAP3B nipsnap homolog 3B (C. elegans)
OCLM oculomedin
OSMR oncostatin M receptor
PADI3 peptidyl arginine deiminase, type III
PARD6B par-6 family cell polarity regulator beta
PCDHB8 protocadherin beta 8
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PHEX phosphate regulating endopeptidase homolog, X-linked
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHS1 pleckstrin homology domain containing, family S member 1
POM121 POM121 transmembrane nucleoporin
POU3F2 POU class 3 homeobox 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS2 regulator of G-protein signaling 2
RHBDD3 rhomboid domain containing 3
RHBG Rh family, B glycoprotein (gene/pseudogene)
RND1 Rho family GTPase 1
RNF126P1 ring finger protein 126 pseudogene 1
S100A7 S100 calcium binding protein A7
SAYSD1 SAYSVFN motif domain containing 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
TLR2 toll-like receptor 2
TM6SF1 transmembrane 6 superfamily member 1
TPSG1 tryptase gamma 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
USP27X ubiquitin specific peptidase 27, X-linked
VGF VGF nerve growth factor inducible
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF204P zinc finger protein 204, pseudogene
ZNF37BP zinc finger protein 37B, pseudogene
ZNF480 zinc finger protein 480
ZNF639 zinc finger protein 639