CP-863187-7508 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the CP-863187-7508 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACBD4 acyl-CoA binding domain containing 4
AFF1 AF4/FMR2 family, member 1
AIM2 absent in melanoma 2
AK2 adenylate kinase 2
AKAP17A A kinase (PRKA) anchor protein 17A
ANKEF1 ankyrin repeat and EF-hand domain containing 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APC adenomatous polyposis coli
ARHGAP4 Rho GTPase activating protein 4
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARTN artemin
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BMP1 bone morphogenetic protein 1
BRCA2 breast cancer 2, early onset
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C22ORF46 chromosome 22 open reading frame 46
C5 complement component 5
CALHM2 calcium homeostasis modulator 2
CCDC93 coiled-coil domain containing 93
CDYL chromodomain protein, Y-like
CHKB choline kinase beta
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLCN7 chloride channel, voltage-sensitive 7
CLDN3 claudin 3
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEPDC5 DEP domain containing 5
DIAPH2 diaphanous-related formin 2
EHD2 EH-domain containing 2
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
GADD45G growth arrest and DNA-damage-inducible, gamma
GAS6 growth arrest-specific 6
GJB3 gap junction protein, beta 3, 31kDa
GLRX3 glutaredoxin 3
GLS2 glutaminase 2 (liver, mitochondrial)
GRB10 growth factor receptor-bound protein 10
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXC4 homeobox C4
IGL immunoglobulin lambda locus
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
LARP6 La ribonucleoprotein domain family, member 6
LOC730101 uncharacterized LOC730101
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCM3AP minichromosome maintenance complex component 3 associated protein
MED16 mediator complex subunit 16
MID2 midline 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MSMB microseminoprotein, beta-
NNT nicotinamide nucleotide transhydrogenase
NPFFR1 neuropeptide FF receptor 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUP62CL nucleoporin 62kDa C-terminal like
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4A phosphodiesterase 4A, cAMP-specific
PEX1 peroxisomal biogenesis factor 1
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCG1 phospholipase C, gamma 1
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
POMT2 protein-O-mannosyltransferase 2
PSPH phosphoserine phosphatase
PTTG3P pituitary tumor-transforming 3, pseudogene
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RPL10L ribosomal protein L10-like
RPS28 ribosomal protein S28
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SETD4 SET domain containing 4
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG6 SMG6 nonsense mediated mRNA decay factor
SOCS5 suppressor of cytokine signaling 5
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STAT5B signal transducer and activator of transcription 5B
STMN1 stathmin 1
TADA2A transcriptional adaptor 2A
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TCTN2 tectonic family member 2
THBS3 thrombospondin 3
TMC6 transmembrane channel-like 6
TMEM19 transmembrane protein 19
TMPRSS4 transmembrane protease, serine 4
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPD52 tumor protein D52
TRAIP TRAF interacting protein
TRIM3 tripartite motif containing 3
USB1 U6 snRNA biogenesis 1
WAS Wiskott-Aldrich syndrome
XPO7 exportin 7
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF79 zinc finger protein 79
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADCY7 adenylate cyclase 7
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARSB arylsulfatase B
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD5 ATPase family, AAA domain containing 5
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BBC3 BCL2 binding component 3
BCORL1 BCL6 corepressor-like 1
BIRC7 baculoviral IAP repeat containing 7
BST1 bone marrow stromal cell antigen 1
CALCB calcitonin-related polypeptide beta
CAMK1 calcium/calmodulin-dependent protein kinase I
CD79B CD79b molecule, immunoglobulin-associated beta
CDH10 cadherin 10, type 2 (T2-cadherin)
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CEL carboxyl ester lipase
CHRM3 cholinergic receptor, muscarinic 3
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CNGB3 cyclic nucleotide gated channel beta 3
CRLF1 cytokine receptor-like factor 1
CXORF21 chromosome X open reading frame 21
DAGLA diacylglycerol lipase, alpha
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFNA3 ephrin-A3
EFNB3 ephrin-B3
EML4 echinoderm microtubule associated protein like 4
EPN1 epsin 1
EXD3 exonuclease 3'-5' domain containing 3
FAM114A2 family with sequence similarity 114, member A2
FAM188A family with sequence similarity 188, member A
FBXL2 F-box and leucine-rich repeat protein 2
FBXL8 F-box and leucine-rich repeat protein 8
FBXO31 F-box protein 31
FER fer (fps/fes related) tyrosine kinase
GAN gigaxonin
GEMIN8 gem (nuclear organelle) associated protein 8
GFI1 growth factor independent 1 transcription repressor
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HIST1H2BJ histone cluster 1, H2bj
IL15RA interleukin 15 receptor, alpha
IQSEC2 IQ motif and Sec7 domain 2
IRF1 interferon regulatory factor 1
IRF6 interferon regulatory factor 6
ITPKA inositol-trisphosphate 3-kinase A
JAM3 junctional adhesion molecule 3
JMJD4 jumonji domain containing 4
KANK3 KN motif and ankyrin repeat domains 3
KPTN kaptin (actin binding protein)
KREMEN2 kringle containing transmembrane protein 2
KRT75 keratin 75, type II
LPAR3 lysophosphatidic acid receptor 3
MAL mal, T-cell differentiation protein
MXRA8 matrix-remodelling associated 8
NHEJ1 nonhomologous end-joining factor 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PCDHGA9 protocadherin gamma subfamily A, 9
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR14L proline rich 14-like
PRR4 proline rich 4 (lacrimal)
PYHIN1 pyrin and HIN domain family, member 1
RAB35 RAB35, member RAS oncogene family
RAB36 RAB36, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RANBP17 RAN binding protein 17
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF43 ring finger protein 43
S100A9 S100 calcium binding protein A9
SAMHD1 SAM domain and HD domain 1
SCARA3 scavenger receptor class A, member 3
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLN sarcolipin
SPEG SPEG complex locus
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TDRD1 tudor domain containing 1
THRAP3 thyroid hormone receptor associated protein 3
TUBA3C tubulin, alpha 3c
VAX2 ventral anterior homeobox 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VIPR1 vasoactive intestinal peptide receptor 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFHX2 zinc finger homeobox 2
ZIC4 Zic family member 4
ZNF358 zinc finger protein 358
ZNF365 zinc finger protein 365
ZNF471 zinc finger protein 471
Funding