CP21R7_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the CP21R7_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.158739
AKAP12 A kinase (PRKA) anchor protein 12 0.147678
MT2A metallothionein 2A 0.135104
TMSB10 thymosin beta 10 0.131251
PODXL podocalyxin-like 0.124623
PLAT plasminogen activator, tissue 0.0890116
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0873913
CDH13 cadherin 13 0.0758768
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0668812
ASPH aspartate beta-hydroxylase 0.0664107
CSTB cystatin B (stefin B) 0.0610711
EGFR epidermal growth factor receptor 0.0572183
NAV1 neuron navigator 1 0.0529378
EFNA5 ephrin-A5 0.0525498
COL5A1 collagen, type V, alpha 1 0.0496264
AHNAK AHNAK nucleoprotein 0.0495366
CANX calnexin 0.0455371
ERRFI1 ERBB receptor feedback inhibitor 1 0.0435177
LDHA lactate dehydrogenase A 0.0433652
LOC112694756 uncharaterized LOC112694756 0.0425403
IGFBP3 insulin-like growth factor binding protein 3 0.0415306
ENO1 enolase 1, (alpha) 0.0412851
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.040223
CD44 CD44 molecule (Indian blood group) 0.0398061
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.039404
SLC39A11 solute carrier family 39, member 11 0.0387375
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0386222
LMNA lamin A/C 0.0373666
PKM pyruvate kinase, muscle 0.0365235
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0360414
CALR calreticulin 0.0355114
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0352624
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0347161
TPM4 tropomyosin 4 0.0328192
APP amyloid beta (A4) precursor protein 0.0328183
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0322024
TMSB4X thymosin beta 4, X-linked 0.0317233
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.031362
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0311917
AHNAK2 AHNAK nucleoprotein 2 0.0309791
MACF1 microtubule-actin crosslinking factor 1 0.0308049
MAP1B microtubule-associated protein 1B 0.030789
CCND1 cyclin D1 0.0306518
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.030366
DGKG diacylglycerol kinase, gamma 90kDa 0.0302787
S100A10 S100 calcium binding protein A10 0.0299979
HLA-B major histocompatibility complex, class I, B 0.0298652
PRRC2C proline-rich coiled-coil 2C 0.0296075
DSPP dentin sialophosphoprotein 0.0291782
PBX3 pre-B-cell leukemia homeobox 3 0.0289798
S100A6 S100 calcium binding protein A6 0.0289135
NT5E 5'-nucleotidase, ecto (CD73) 0.0284471
FRMD4A FERM domain containing 4A 0.027416
MYH9 myosin, heavy chain 9, non-muscle 0.027347
NAV2 neuron navigator 2 0.0267152
FN1 fibronectin 1 0.0266234
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0264852
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0259753
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0258563
FLNB filamin B, beta 0.0256144
STC1 stanniocalcin 1 0.0255403
ACTG1 actin gamma 1 0.0251859
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0249688
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0249446
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0248594
FSTL1 follistatin-like 1 0.0248309
BACE2 beta-site APP-cleaving enzyme 2 0.0246738
PRSS23 protease, serine, 23 0.024462
HDAC9 histone deacetylase 9 0.0244577
COL3A1 collagen, type III, alpha 1 0.0243113
THBS2 thrombospondin 2 0.0242503
POTEF POTE ankyrin domain family, member F 0.0240097
TPM3 tropomyosin 3 0.0239907
DOCK5 dedicator of cytokinesis 5 0.0239378
MKI67 marker of proliferation Ki-67 0.0236217
PTMA prothymosin, alpha 0.0233765
ALCAM activated leukocyte cell adhesion molecule 0.0230172
CAPN2 calpain 2, (m/II) large subunit 0.0228201
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0225037
GOLGB1 golgin B1 0.0223616
PLXNA2 plexin A2 0.0221377
RRBP1 ribosome binding protein 1 0.0219146
CENPF centromere protein F, 350/400kDa 0.0217847
FLNA filamin A, alpha 0.0212934
CD59 CD59 molecule, complement regulatory protein 0.0212359
PRELID2 PRELI domain containing 2 0.0212132
TUBB4B tubulin, beta 4B class IVb 0.0211752
SDCCAG8 serologically defined colon cancer antigen 8 0.0210847
RPL26 ribosomal protein L26 0.0210796
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0210368
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0207841
FBXL7 F-box and leucine-rich repeat protein 7 0.0205721
SEC61G Sec61 gamma subunit 0.020434
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0200473
MPRIP myosin phosphatase Rho interacting protein 0.019863
TBCA tubulin folding cofactor A 0.0197401
TPT1 tumor protein, translationally-controlled 1 0.0197211
CYTH3 cytohesin 3 0.0195932
RPL23 ribosomal protein L23 0.0194903
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0194282

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.262928
FBN1 fibrillin 1 -0.0857248
COL8A1 collagen, type VIII, alpha 1 -0.066457
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0501526
SOD2 superoxide dismutase 2, mitochondrial -0.0500348
UBC ubiquitin C -0.043511
COL1A2 collagen, type I, alpha 2 -0.041619
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0387297
FNDC3B fibronectin type III domain containing 3B -0.0359231
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0327855
HILPDA hypoxia inducible lipid droplet-associated -0.0315846
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.029425
DPYSL3 dihydropyrimidinase-like 3 -0.0282161
CYLD cylindromatosis (turban tumor syndrome) -0.0280796
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0276876
NT5C2 5'-nucleotidase, cytosolic II -0.0274963
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.027487
ADM adrenomedullin -0.0267708
SETD5 SET domain containing 5 -0.0264421
WTAP Wilms tumor 1 associated protein -0.0262719
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0260471
NDRG1 N-myc downstream regulated 1 -0.0258865
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0253089
FTH1 ferritin, heavy polypeptide 1 -0.0251183
SBF2 SET binding factor 2 -0.0241896
PICALM phosphatidylinositol binding clathrin assembly protein -0.0240631
ADAM17 ADAM metallopeptidase domain 17 -0.023739
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0235288
ADAM9 ADAM metallopeptidase domain 9 -0.0233568
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.021934
MBNL2 muscleblind-like splicing regulator 2 -0.0219196
KMT2E lysine (K)-specific methyltransferase 2E -0.0217099
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0216565
GPBP1 GC-rich promoter binding protein 1 -0.0215719
MEIS2 Meis homeobox 2 -0.021304
AUTS2 autism susceptibility candidate 2 -0.0211083
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.021073
CD109 CD109 molecule -0.0210077
FRMD5 FERM domain containing 5 -0.0206165
HIP1 huntingtin interacting protein 1 -0.0204731
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0199006
COPA coatomer protein complex, subunit alpha -0.0198994
TNIP1 TNFAIP3 interacting protein 1 -0.0198365
SPAG9 sperm associated antigen 9 -0.0196303
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.019558
WDFY1 WD repeat and FYVE domain containing 1 -0.0194191
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0191064
GPC6 glypican 6 -0.019096
DENND5A DENN/MADD domain containing 5A -0.019013
NAMPT nicotinamide phosphoribosyltransferase -0.0186249
IRF1 interferon regulatory factor 1 -0.0186024
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0182077
IER3 immediate early response 3 -0.0181034
XPO1 exportin 1 -0.0179938
QKI QKI, KH domain containing, RNA binding -0.0178575
SSBP2 single-stranded DNA binding protein 2 -0.0178212
PCGF5 polycomb group ring finger 5 -0.0177969
OGA O-GlcNAcase -0.0177596
ESYT2 extended synaptotagmin-like protein 2 -0.0177138
TSC22D2 TSC22 domain family, member 2 -0.0174617
DDIT4 DNA-damage-inducible transcript 4 -0.0172695
KIF13A kinesin family member 13A -0.0170118
ZNF207 zinc finger protein 207 -0.0166775
ABI1 abl-interactor 1 -0.0166435
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0166362
WARS1 tryptophanyl-tRNA synthetase 1 -0.0163055
SKIC3 SKI3 subunit of superkiller complex -0.016226
KCTD9 potassium channel tetramerization domain containing 9 -0.0159908
HELZ helicase with zinc finger -0.0159894
KDM6A lysine (K)-specific demethylase 6A -0.0158711
GOLGA4 golgin A4 -0.0154386
RNMT RNA (guanine-7-) methyltransferase -0.0153814
RTN4 reticulon 4 -0.0152982
SDK1 sidekick cell adhesion molecule 1 -0.0151785
INSIG2 insulin induced gene 2 -0.0150248
TPM1 tropomyosin 1 (alpha) -0.0150236
JAZF1 JAZF zinc finger 1 -0.0148739
BBX bobby sox homolog (Drosophila) -0.014828
ARL15 ADP-ribosylation factor-like 15 -0.014776
SSH2 slingshot protein phosphatase 2 -0.0147639
PIAS1 protein inhibitor of activated STAT, 1 -0.0147457
CAPN7 calpain 7 -0.01457
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.014528
TAPBP TAP binding protein (tapasin) -0.0145142
RNF145 ring finger protein 145 -0.014508
INSIG1 insulin induced gene 1 -0.0144697
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.014443
RREB1 ras responsive element binding protein 1 -0.0144414
CLINT1 clathrin interactor 1 -0.0143954
EPAS1 endothelial PAS domain protein 1 -0.0143732
ANKRD33B ankyrin repeat domain 33B -0.0143474
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0143183
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0142285
RNF24 ring finger protein 24 -0.0141222
PDIA3 protein disulfide isomerase family A, member 3 -0.0141042
GGNBP2 gametogenetin binding protein 2 -0.0140733
PRKD1 protein kinase D1 -0.0140012
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0138911
UGCG UDP-glucose ceramide glucosyltransferase -0.0138617
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0138587