CP21R7_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0925336
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0847696
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.082329
YAP1 Yes-associated protein 1 0.0781887
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0728201
ASPH aspartate beta-hydroxylase 0.0688914
HMGA2 high mobility group AT-hook 2 0.0671186
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0634881
RAB7A RAB7A, member RAS oncogene family 0.0574319
MMP12 matrix metallopeptidase 12 0.0560201
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0519959
NLGN1 neuroligin 1 0.0508352
TPM3 tropomyosin 3 0.0501746
NHSL1 NHS-like 1 0.0499359
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0496965
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0482306
PDGFC platelet derived growth factor C 0.0477774
POTEF POTE ankyrin domain family, member F 0.0464781
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.045673
JMJD1C jumonji domain containing 1C 0.0444737
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.043914
RTN4 reticulon 4 0.0418756
EGR1 early growth response 1 0.0408554
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0399354
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0378748
EHBP1 EH domain binding protein 1 0.0372453
ADIPOR2 adiponectin receptor 2 0.037206
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0369371
BCHE butyrylcholinesterase 0.0340734
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0333329
RPL3 ribosomal protein L3 0.0326411
IPO7 importin 7 0.0326036
MTAP methylthioadenosine phosphorylase 0.031517
PCDH7 protocadherin 7 0.0305385
RCOR1 REST corepressor 1 0.0299257
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0298135
RASAL2 RAS protein activator like 2 0.0296445
INTS6 integrator complex subunit 6 0.0292203
RRM2 ribonucleotide reductase M2 0.0287612
ANKRD17 ankyrin repeat domain 17 0.0268135
CCN2 cellular communication network factor 2 0.0263339
DST dystonin 0.0257802
MARCHF4 membrane associated ring-CH-type finger 4 0.0249076
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0248849
NEBL nebulette 0.0247276
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0246658
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0244706
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0243186
HSPA8 heat shock 70kDa protein 8 0.0242941
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0240271
VMP1 vacuole membrane protein 1 0.023985
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0239427
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0236881
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0234576
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0232953
MAP1B microtubule-associated protein 1B 0.0227807
DPYD dihydropyrimidine dehydrogenase 0.0227225
NAV3 neuron navigator 3 0.0225743
EDARADD EDAR-associated death domain 0.0220935
CMIP c-Maf inducing protein 0.021951
BRD2 bromodomain containing 2 0.0213089
ENO1 enolase 1, (alpha) 0.0211049
MSRB3 methionine sulfoxide reductase B3 0.0210332
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.0209728
VCL vinculin 0.0207635
SETX senataxin 0.0206842
RIMS2 regulating synaptic membrane exocytosis 2 0.0205258
DIAPH1 diaphanous-related formin 1 0.0203403
FAT1 FAT atypical cadherin 1 0.0203302
EEF2 eukaryotic translation elongation factor 2 0.0200347
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.019868
NABP1 nucleic acid binding protein 1 0.0198591
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0197966
TAS2R14 taste receptor, type 2, member 14 0.0196987
CLTC clathrin, heavy chain (Hc) 0.0194542
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0193784
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0191504
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0190019
SPATS2 spermatogenesis associated, serine-rich 2 0.0189687
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0189531
PHF14 PHD finger protein 14 0.018923
ERBIN erbb2 interacting protein 0.0188275
ZFAND3 zinc finger, AN1-type domain 3 0.0186919
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0186156
ASXL2 additional sex combs like transcriptional regulator 2 0.0185289
CCNL1 cyclin L1 0.0184544
NPC1 Niemann-Pick disease, type C1 0.0181625
PRKCE protein kinase C, epsilon 0.0179658
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0179271
ANKRD12 ankyrin repeat domain 12 0.0179145
KCMF1 potassium channel modulatory factor 1 0.0177433
FNDC3B fibronectin type III domain containing 3B 0.0176992
ZNF804A zinc finger protein 804A 0.0176817
RANBP17 RAN binding protein 17 0.0176794
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0176051
UHMK1 U2AF homology motif (UHM) kinase 1 0.0175537
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0175362
PKM pyruvate kinase, muscle 0.0173352
RUNX1 runt-related transcription factor 1 0.0172822
BIRC3 baculoviral IAP repeat containing 3 0.0172743

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.134499
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110302
TMSB10 thymosin beta 10 -0.0899473
FTL ferritin, light polypeptide -0.0654624
PTMA prothymosin, alpha -0.0632257
MYL12B myosin, light chain 12B, regulatory -0.0630427
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0617496
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0527104
AREG amphiregulin -0.047989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0444818
KDM3A lysine (K)-specific demethylase 3A -0.0432432
RPLP1 ribosomal protein, large, P1 -0.0431083
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0417801
H1-0 H1.0 linker histone -0.0417305
HSPB1 heat shock 27kDa protein 1 -0.0410782
RPL8 ribosomal protein L8 -0.0384114
CNRIP1 cannabinoid receptor interacting protein 1 -0.0376645
RPS24 ribosomal protein S24 -0.037576
TPT1 tumor protein, translationally-controlled 1 -0.0363337
CXADR coxsackie virus and adenovirus receptor -0.0355989
AHNAK AHNAK nucleoprotein -0.0354038
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0353996
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.034248
YBX3 Y box binding protein 3 -0.0342451
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.034177
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.033595
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0330158
EIF1 eukaryotic translation initiation factor 1 -0.0322035
RPS19 ribosomal protein S19 -0.0315106
CLDN1 claudin 1 -0.0314776
GNAS GNAS complex locus -0.0309937
RPL35A ribosomal protein L35a -0.0307841
RPL34 ribosomal protein L34 -0.0302594
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0295751
RPL36 ribosomal protein L36 -0.0286776
RPL38 ribosomal protein L38 -0.0277089
RSL1D1 ribosomal L1 domain containing 1 -0.0274255
RPS27A ribosomal protein S27a -0.0270782
RPL19 ribosomal protein L19 -0.0267032
RPS8 ribosomal protein S8 -0.0265276
SYT1 synaptotagmin I -0.0263849
EDN1 endothelin 1 -0.0262997
RPS6 ribosomal protein S6 -0.0260342
ZBTB20 zinc finger and BTB domain containing 20 -0.0256056
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.025514
NAP1L1 nucleosome assembly protein 1-like 1 -0.0252174
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0251195
RPL27A ribosomal protein L27a -0.0248884
SLC38A1 solute carrier family 38, member 1 -0.0248484
KPNB1 karyopherin (importin) beta 1 -0.0245857
RAD21 RAD21 homolog (S. pombe) -0.0243415
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0240947
FUS FUS RNA binding protein -0.0239965
RPLP0 ribosomal protein, large, P0 -0.0239544
WDR45B WD repeat domain 45B -0.0236677
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0236459
RACK1 receptor for activated C kinase 1 -0.0231127
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.022848
RAB1A RAB1A, member RAS oncogene family -0.0225632
RPS3 ribosomal protein S3 -0.0225444
S100A6 S100 calcium binding protein A6 -0.0224243
HMGB1 high mobility group box 1 -0.0224124
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0222603
RPL12 ribosomal protein L12 -0.022247
KIF5B kinesin family member 5B -0.022067
GCG glucagon -0.0218735
CAVIN1 caveolae associated protein 1 -0.0217711
PDK4 pyruvate dehydrogenase kinase, isozyme 4 -0.0217493
RPL31 ribosomal protein L31 -0.0217343
PCNP PEST proteolytic signal containing nuclear protein -0.0217075
LMAN1 lectin, mannose-binding, 1 -0.0215737
NCOR1 nuclear receptor corepressor 1 -0.0213373
RPS21 ribosomal protein S21 -0.0212167
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0211209
RPL28 ribosomal protein L28 -0.0209482
RBM39 RNA binding motif protein 39 -0.0208002
RPL32 ribosomal protein L32 -0.0206659
SEPTIN7 septin 7 -0.0205534
BRWD3 bromodomain and WD repeat domain containing 3 -0.0204851
MARCHF6 membrane associated ring-CH-type finger 6 -0.0203031
CCNI cyclin I -0.0201851
RPL23 ribosomal protein L23 -0.0200799
NPR2 natriuretic peptide receptor 2 -0.0199545
TRA2A transformer 2 alpha homolog (Drosophila) -0.0196113
RPS16 ribosomal protein S16 -0.0195823
RPLP2 ribosomal protein, large, P2 -0.0193741
PGK1 phosphoglycerate kinase 1 -0.0193276
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0192728
LMO7 LIM domain 7 -0.01925
OXR1 oxidation resistance 1 -0.0191439
BIRC6 baculoviral IAP repeat containing 6 -0.0191292
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.019004
CCND1 cyclin D1 -0.0189082
RPS5 ribosomal protein S5 -0.0188019
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.018682
PEG10 paternally expressed 10 -0.0186801
KLF6 Kruppel-like factor 6 -0.0186409
LARS1 leucyl-tRNA synthetase 1 -0.0184966
NPEPPS aminopeptidase puromycin sensitive -0.0183525
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0182845