CP21R7_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.355759
VIM vimentin 0.136951
VCL vinculin 0.1207
RPL23 ribosomal protein L23 0.0964318
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0863463
EXT1 exostosin glycosyltransferase 1 0.0850387
PTMA prothymosin, alpha 0.0844169
AKAP12 A kinase (PRKA) anchor protein 12 0.0831629
ACTG1 actin gamma 1 0.0813558
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.073941
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0701525
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0657293
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0623167
FTL ferritin, light polypeptide 0.0596869
RPLP1 ribosomal protein, large, P1 0.0595672
EEF2 eukaryotic translation elongation factor 2 0.0581853
LSAMP limbic system-associated membrane protein 0.0576614
TPT1 tumor protein, translationally-controlled 1 0.0534994
RPL19 ribosomal protein L19 0.0534493
RPS6 ribosomal protein S6 0.0532413
ZSWIM6 zinc finger, SWIM-type containing 6 0.0510672
EIF1 eukaryotic translation initiation factor 1 0.0509205
TLE4 transducin-like enhancer of split 4 0.050713
RPL35A ribosomal protein L35a 0.0506636
EGR1 early growth response 1 0.0494876
RPL34 ribosomal protein L34 0.0494029
IER3 immediate early response 3 0.0492456
TMSB10 thymosin beta 10 0.0464232
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0457681
RPS3 ribosomal protein S3 0.0452583
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0440807
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0434482
PTPRK protein tyrosine phosphatase, receptor type, K 0.0432124
PKM pyruvate kinase, muscle 0.0430447
COL3A1 collagen, type III, alpha 1 0.0429524
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0421235
LMNA lamin A/C 0.0415146
TPM4 tropomyosin 4 0.0411927
SIK2 salt-inducible kinase 2 0.0403339
RAB7A RAB7A, member RAS oncogene family 0.0395956
PACS1 phosphofurin acidic cluster sorting protein 1 0.0395901
RACK1 receptor for activated C kinase 1 0.0383552
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0376065
NAP1L1 nucleosome assembly protein 1-like 1 0.0370464
KLF6 Kruppel-like factor 6 0.0367659
KPNB1 karyopherin (importin) beta 1 0.0363254
COL4A5 collagen, type IV, alpha 5 0.0361866
TIMP3 TIMP metallopeptidase inhibitor 3 0.0361246
VMP1 vacuole membrane protein 1 0.0359461
B2M beta-2-microglobulin 0.0357816
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0356967
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0351528
MSI2 musashi RNA-binding protein 2 0.0336337
GLCCI1 glucocorticoid induced 1 0.033582
COL1A1 collagen, type I, alpha 1 0.033201
RNF213 ring finger protein 213 0.0330449
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0330239
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0321543
SLIT2 slit homolog 2 (Drosophila) 0.0316609
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0316419
MYO6 myosin VI 0.0306825
RPS24 ribosomal protein S24 0.0302822
ZBTB20 zinc finger and BTB domain containing 20 0.0300145
RPS27A ribosomal protein S27a 0.0298122
RPS19 ribosomal protein S19 0.0297166
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0296346
TPM1 tropomyosin 1 (alpha) 0.0295272
RPL31 ribosomal protein L31 0.0295171
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0287932
THSD4 thrombospondin, type I, domain containing 4 0.0287758
GNAS GNAS complex locus 0.0284944
FAM107B family with sequence similarity 107, member B 0.0281764
RPL32 ribosomal protein L32 0.027992
LOC112694756 uncharaterized LOC112694756 0.0279166
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0279164
CALD1 caldesmon 1 0.0275784
RPLP0 ribosomal protein, large, P0 0.0273415
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0272841
RPS27 ribosomal protein S27 0.0272462
RPL36 ribosomal protein L36 0.0270866
FTH1 ferritin, heavy polypeptide 1 0.0270502
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.026944
RPL26 ribosomal protein L26 0.0267398
TPI1 triosephosphate isomerase 1 0.0264353
PLPP1 phospholipid phosphatase 1 0.0263826
CTNND1 catenin (cadherin-associated protein), delta 1 0.026377
FERMT2 fermitin family member 2 0.0262713
DNM3 dynamin 3 0.0261627
RIGI RNA sensor RIG-I 0.0261451
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0259697
EIF4A1 eukaryotic translation initiation factor 4A1 0.0257807
RPS14 ribosomal protein S14 0.0255873
POTEF POTE ankyrin domain family, member F 0.0255102
LOC102724023 ES1 protein homolog, mitochondrial 0.0254875
NALF1 NALCN channel auxiliary factor 1 0.0254668
LPP LIM domain containing preferred translocation partner in lipoma 0.0254225
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0253743
NPAS2 neuronal PAS domain protein 2 0.025306
PDE10A phosphodiesterase 10A 0.0252295
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0251962

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0801755
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0733456
ITPRID2 ITPR interacting domain containing 2 -0.0570164
LPIN1 lipin 1 -0.0475602
DPH6 diphthamine biosynthesis 6 -0.0337574
FNDC3B fibronectin type III domain containing 3B -0.028381
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.028162
PHF21A PHD finger protein 21A -0.0253467
NAMPT nicotinamide phosphoribosyltransferase -0.02533
RPTOR regulatory associated protein of MTOR, complex 1 -0.0249957
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0248838
ANO6 anoctamin 6 -0.023497
MARCHF7 membrane associated ring-CH-type finger 7 -0.0232187
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0224714
CLTC clathrin, heavy chain (Hc) -0.0222417
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0221938
RPS2 ribosomal protein S2 -0.0218432
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0217595
ZC3H11A zinc finger CCCH-type containing 11A -0.0217335
PLCB4 phospholipase C, beta 4 -0.0210864
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0209865
FAM13A family with sequence similarity 13, member A -0.0202001
PCTP phosphatidylcholine transfer protein -0.0195157
RTN4 reticulon 4 -0.0193442
DSCAM Down syndrome cell adhesion molecule -0.0193439
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0192425
PTEN phosphatase and tensin homolog -0.0188272
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0185469
ANK2 ankyrin 2, neuronal -0.0185019
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0184391
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0183081
CDK19 cyclin-dependent kinase 19 -0.0177347
NKTR natural killer cell triggering receptor -0.0174676
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -0.0174026
XPO1 exportin 1 -0.0169953
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0169199
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0168371
MBTD1 mbt domain containing 1 -0.016802
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0167716
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0164699
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0164558
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0162877
ADAR adenosine deaminase, RNA-specific -0.0159422
DST dystonin -0.0158315
PCBP2 poly(rC) binding protein 2 -0.0158015
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0157531
NBAS neuroblastoma amplified sequence -0.0157196
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0156256
RNF150 ring finger protein 150 -0.0156164
INSIG2 insulin induced gene 2 -0.0155592
TRIM33 tripartite motif containing 33 -0.0155206
GPC5 glypican 5 -0.0154571
RBMX RNA binding motif protein, X-linked -0.0154445
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0152342
PAPOLA poly(A) polymerase alpha -0.0151971
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0151393
INTU inturned planar cell polarity protein -0.0150722
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0149993
SCAF11 SR-related CTD-associated factor 11 -0.0149845
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0149083
CEP95 centrosomal protein 95kDa -0.0148572
PIBF1 progesterone immunomodulatory binding factor 1 -0.0147523
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0147427
PRTG protogenin -0.0147202
CSNK1A1 casein kinase 1, alpha 1 -0.0147044
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0146528
RBM20 RNA binding motif protein 20 -0.0146289
RO60 Ro60, Y RNA binding protein -0.0145762
TCERG1 transcription elongation regulator 1 -0.01453
ADGRG6 adhesion G protein-coupled receptor G6 -0.0145219
EPAS1 endothelial PAS domain protein 1 -0.014391
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0143181
PPME1 protein phosphatase methylesterase 1 -0.0143103
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0142615
ZNF148 zinc finger protein 148 -0.0142615
CHD1L chromodomain helicase DNA binding protein 1-like -0.0141943
SOS1 son of sevenless homolog 1 (Drosophila) -0.0141777
ZNF451 zinc finger protein 451 -0.0141643
ARRDC3 arrestin domain containing 3 -0.0141556
H1-4 H1.4 linker histone, cluster member -0.0141026
PUM2 pumilio RNA-binding family member 2 -0.0140549
GIGYF2 GRB10 interacting GYF protein 2 -0.0140296
HAND2 heart and neural crest derivatives expressed 2 -0.0138761
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0138313
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0138298
ZC3H15 zinc finger CCCH-type containing 15 -0.0137329
RARS1 arginyl-tRNA synthetase 1 -0.0137165
PAWR PRKC, apoptosis, WT1, regulator -0.0136962
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0135581
CEP170 centrosomal protein 170kDa -0.0135024
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.013499
TNRC6A trinucleotide repeat containing 6A -0.0134773
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -0.0134728
CRYBG3 beta-gamma crystallin domain containing 3 -0.0134383
HMGA2 high mobility group AT-hook 2 -0.0134328
PFKP phosphofructokinase, platelet -0.013399
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0133595
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0133258
FKBP1A FK506 binding protein 1A, 12kDa -0.0132681
GSK3B glycogen synthase kinase 3 beta -0.0132447