| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | CP21R7 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the CP21R7_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.105527 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0492426 |
| CD44 | CD44 molecule (Indian blood group) | 0.0456205 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0404933 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0389543 |
| PKM | pyruvate kinase, muscle | 0.0362852 |
| ENO1 | enolase 1, (alpha) | 0.0345567 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0310874 |
| MSN | moesin | 0.0305728 |
| FN1 | fibronectin 1 | 0.0303454 |
| SMAD3 | SMAD family member 3 | 0.0281678 |
| MAP1B | microtubule-associated protein 1B | 0.0276144 |
| FAT1 | FAT atypical cadherin 1 | 0.0266999 |
| RPL3 | ribosomal protein L3 | 0.0265318 |
| POTEF | POTE ankyrin domain family, member F | 0.0256275 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0255115 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0246475 |
| ECE1 | endothelin converting enzyme 1 | 0.022962 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0227207 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0223505 |
| FOSL1 | FOS-like antigen 1 | 0.0216797 |
| LDHA | lactate dehydrogenase A | 0.0210616 |
| ARRDC3 | arrestin domain containing 3 | 0.0207523 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0203125 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0200958 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0198816 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0196399 |
| ANXA5 | annexin A5 | 0.0194498 |
| AXL | AXL receptor tyrosine kinase | 0.0191555 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0188264 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0187036 |
| MYADM | myeloid-associated differentiation marker | 0.0177599 |
| CENPF | centromere protein F, 350/400kDa | 0.017373 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0170595 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0169316 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0168368 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0168094 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0154758 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0154483 |
| BRD2 | bromodomain containing 2 | 0.014793 |
| VEGFC | vascular endothelial growth factor C | 0.0145176 |
| TPM3 | tropomyosin 3 | 0.0142903 |
| DSPP | dentin sialophosphoprotein | 0.014248 |
| ANGPTL4 | angiopoietin-like 4 | 0.0141832 |
| MX2 | MX dynamin-like GTPase 2 | 0.0141009 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.014096 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0140642 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.014009 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0136793 |
| NOTCH2 | notch 2 | 0.0136421 |
| LAMB1 | laminin, beta 1 | 0.0136143 |
| EGR1 | early growth response 1 | 0.0136141 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0135872 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0130599 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.012905 |
| FAM107B | family with sequence similarity 107, member B | 0.0128502 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0126772 |
| MKI67 | marker of proliferation Ki-67 | 0.0126698 |
| SON | SON DNA binding protein | 0.012496 |
| HMGA1 | high mobility group AT-hook 1 | 0.0121994 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0121736 |
| RPS18 | ribosomal protein S18 | 0.0120182 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0119638 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0119212 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0118589 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0116794 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0115715 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0114386 |
| STC1 | stanniocalcin 1 | 0.011244 |
| AMOTL1 | angiomotin like 1 | 0.0111606 |
| TBC1D5 | TBC1 domain family, member 5 | 0.011112 |
| B2M | beta-2-microglobulin | 0.0109525 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0109457 |
| HYOU1 | hypoxia up-regulated 1 | 0.0109314 |
| PLSCR1 | phospholipid scramblase 1 | 0.0108154 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.0107273 |
| NRP1 | neuropilin 1 | 0.0106007 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0106004 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0104901 |
| MX1 | MX dynamin-like GTPase 1 | 0.0104651 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0103815 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0103704 |
| RNF145 | ring finger protein 145 | 0.0102354 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0102203 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0102061 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0101976 |
| MCL1 | myeloid cell leukemia 1 | 0.0101644 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0101105 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0101039 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.00992962 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00986969 |
| RPS4X | ribosomal protein S4, X-linked | 0.00979058 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.00973637 |
| JAK2 | Janus kinase 2 | 0.00959635 |
| EZR | ezrin | 0.00953988 |
| SVIL | supervillin | 0.00945305 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.00917593 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0091063 |
| MLF1 | myeloid leukemia factor 1 | 0.00892376 |
| HAS2 | hyaluronan synthase 2 | 0.00886983 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.385489 |
| COL1A1 | collagen, type I, alpha 1 | -0.23386 |
| COL1A2 | collagen, type I, alpha 2 | -0.122893 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.120017 |
| IER3 | immediate early response 3 | -0.108143 |
| CDH13 | cadherin 13 | -0.107774 |
| VIM | vimentin | -0.106755 |
| NDRG1 | N-myc downstream regulated 1 | -0.103514 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0961112 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0955971 |
| FBN1 | fibrillin 1 | -0.0839372 |
| TMSB10 | thymosin beta 10 | -0.0784714 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.075945 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0734076 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0640627 |
| CANX | calnexin | -0.0624803 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0596342 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0594601 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0590623 |
| AHNAK | AHNAK nucleoprotein | -0.0581096 |
| CAVIN1 | caveolae associated protein 1 | -0.0578905 |
| LOX | lysyl oxidase | -0.0567276 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0538955 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0525574 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0523157 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0515819 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0509789 |
| CADM1 | cell adhesion molecule 1 | -0.0508982 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0502923 |
| CALR | calreticulin | -0.0495562 |
| PTMA | prothymosin, alpha | -0.0491676 |
| TPM4 | tropomyosin 4 | -0.0488476 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0486232 |
| RAB1A | RAB1A, member RAS oncogene family | -0.048302 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0467452 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0458866 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0451392 |
| FTL | ferritin, light polypeptide | -0.0451149 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0450539 |
| UBC | ubiquitin C | -0.0444855 |
| RPS8 | ribosomal protein S8 | -0.0443584 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0443248 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0442259 |
| RPL35A | ribosomal protein L35a | -0.0432614 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0413444 |
| COL3A1 | collagen, type III, alpha 1 | -0.0412611 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.041219 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0410888 |
| COL5A1 | collagen, type V, alpha 1 | -0.0409748 |
| ACTG1 | actin gamma 1 | -0.0405518 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0389696 |
| PDE10A | phosphodiesterase 10A | -0.0381076 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0380942 |
| MTDH | metadherin | -0.0374545 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0364249 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0351435 |
| RRBP1 | ribosome binding protein 1 | -0.0348597 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0348052 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0343165 |
| TMSB4X | thymosin beta 4, X-linked | -0.0334121 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0332203 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0330713 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0328268 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0322244 |
| RPS6 | ribosomal protein S6 | -0.0319467 |
| GNAS | GNAS complex locus | -0.031651 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0314603 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0311984 |
| RPL8 | ribosomal protein L8 | -0.0310762 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0309522 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0306496 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0298878 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0290399 |
| HDLBP | high density lipoprotein binding protein | -0.02846 |
| MAP4 | microtubule-associated protein 4 | -0.0283789 |
| MT1X | metallothionein 1X | -0.0282476 |
| ANXA2 | annexin A2 | -0.0281554 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.028137 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0275309 |
| OXR1 | oxidation resistance 1 | -0.0274197 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0274165 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0273352 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0266229 |
| QKI | QKI, KH domain containing, RNA binding | -0.0263847 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0263697 |
| CALU | calumenin | -0.0261143 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0258864 |
| S100A6 | S100 calcium binding protein A6 | -0.0257931 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0257263 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0256211 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0254124 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0252678 |
| ADM | adrenomedullin | -0.0252588 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0251564 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0250731 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0250205 |
| GOLGA4 | golgin A4 | -0.0247758 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0246777 |
| CALD1 | caldesmon 1 | -0.0245921 |
| RPS24 | ribosomal protein S24 | -0.024591 |
