| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | CP21R7 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the CP21R7_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.219297 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.151931 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.149602 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.139184 |
| FN1 | fibronectin 1 | 0.131526 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.106575 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0929536 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0898319 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0787889 |
| EHBP1 | EH domain binding protein 1 | 0.0764113 |
| ENO1 | enolase 1, (alpha) | 0.0678297 |
| SVIL | supervillin | 0.0531927 |
| DSPP | dentin sialophosphoprotein | 0.0472793 |
| TMSB10 | thymosin beta 10 | 0.0418862 |
| GPC6 | glypican 6 | 0.0410689 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0400934 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0389752 |
| ASPH | aspartate beta-hydroxylase | 0.0383736 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0367924 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0363594 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0359643 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0353279 |
| TF | transferrin | 0.0333622 |
| APOB | apolipoprotein B | 0.0319165 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0307928 |
| FAM107B | family with sequence similarity 107, member B | 0.0294003 |
| LDHA | lactate dehydrogenase A | 0.0288899 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0286628 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0285232 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0281101 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0275727 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0270474 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0268935 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0266894 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0266467 |
| HMGA1 | high mobility group AT-hook 1 | 0.0260241 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.025978 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0250071 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0246393 |
| PEG3 | paternally expressed 3 | 0.0245625 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.024336 |
| FOXP1 | forkhead box P1 | 0.0240619 |
| C3 | complement component 3 | 0.0239599 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0238737 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0230747 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.022998 |
| RAI14 | retinoic acid induced 14 | 0.0227737 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0219961 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0213639 |
| DSTN | destrin (actin depolymerizing factor) | 0.0212211 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0208771 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0200112 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0199093 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0197981 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.019587 |
| FAT1 | FAT atypical cadherin 1 | 0.0195367 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.019149 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0189596 |
| DIAPH1 | diaphanous-related formin 1 | 0.0189535 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0188256 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0187922 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | 0.0186953 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0186766 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0185375 |
| KIF5B | kinesin family member 5B | 0.0184318 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0178891 |
| ATXN1 | ataxin 1 | 0.0174356 |
| KYNU | kynureninase | 0.0173149 |
| PRELID2 | PRELI domain containing 2 | 0.0170677 |
| TXNIP | thioredoxin interacting protein | 0.0170317 |
| PKM | pyruvate kinase, muscle | 0.0168042 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0167261 |
| BCL2L1 | BCL2-like 1 | 0.0165869 |
| RASA2 | RAS p21 protein activator 2 | 0.016474 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0164686 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | 0.016351 |
| USP6NL | USP6 N-terminal like | 0.0161487 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0160879 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0160471 |
| GK | glycerol kinase | 0.0157805 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0157273 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0156672 |
| FILIP1L | filamin A interacting protein 1-like | 0.0156649 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0154765 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0154041 |
| FERMT1 | fermitin family member 1 | 0.0152735 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0152104 |
| IPO7 | importin 7 | 0.0151931 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0149431 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0148799 |
| CDK13 | cyclin-dependent kinase 13 | 0.014861 |
| KLF6 | Kruppel-like factor 6 | 0.0146102 |
| SIK3 | SIK family kinase 3 | 0.0145001 |
| JAG1 | jagged 1 | 0.0144523 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0142967 |
| RACK1 | receptor for activated C kinase 1 | 0.0141658 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0141303 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.014106 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0140993 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0140031 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0763203 |
| RPL37A | ribosomal protein L37a | -0.043511 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0310526 |
| RPS27A | ribosomal protein S27a | -0.0293922 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0263646 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0251708 |
| RBM39 | RNA binding motif protein 39 | -0.0242028 |
| GPC3 | glypican 3 | -0.0227047 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0226941 |
| PTCHD4 | patched domain containing 4 | -0.0224119 |
| RPL9 | ribosomal protein L9 | -0.0222556 |
| RPL31 | ribosomal protein L31 | -0.0215002 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0200795 |
| RPS12 | ribosomal protein S12 | -0.0200036 |
| APOA2 | apolipoprotein A-II | -0.0198693 |
| RPS24 | ribosomal protein S24 | -0.0197057 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0190214 |
| APOE | apolipoprotein E | -0.0189611 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0189536 |
| RRBP1 | ribosome binding protein 1 | -0.0179329 |
| IER3 | immediate early response 3 | -0.017362 |
| UBC | ubiquitin C | -0.017141 |
| TRIM26 | tripartite motif containing 26 | -0.0163743 |
| FUS | FUS RNA binding protein | -0.0163086 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0160861 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0158994 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0158667 |
| RPS6 | ribosomal protein S6 | -0.0154181 |
| GNAS | GNAS complex locus | -0.0154151 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0148177 |
| RPL23 | ribosomal protein L23 | -0.0146896 |
| RNF213 | ring finger protein 213 | -0.0146815 |
| RPS16 | ribosomal protein S16 | -0.0144109 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0143255 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0141743 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0140986 |
| RPL13A | ribosomal protein L13a | -0.014042 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0139105 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0137952 |
| RPL38 | ribosomal protein L38 | -0.0136512 |
| RPL36A | ribosomal protein L36a | -0.0136446 |
| ACYP2 | acylphosphatase 2, muscle type | -0.0130767 |
| RPL27 | ribosomal protein L27 | -0.0130498 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0128773 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0128591 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0126356 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0126225 |
| H3-3B | H3.3 histone B | -0.0124027 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0122789 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0121621 |
| RPL28 | ribosomal protein L28 | -0.011897 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0116497 |
| HLA-A | major histocompatibility complex, class I, A | -0.0115148 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0115073 |
| RPL35A | ribosomal protein L35a | -0.0114823 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0113786 |
| CALD1 | caldesmon 1 | -0.0113686 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0111477 |
| OLA1 | Obg-like ATPase 1 | -0.0110398 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.011021 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0110176 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -0.0109797 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0109506 |
| BRD2 | bromodomain containing 2 | -0.0108783 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0107994 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0107941 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0107528 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0106392 |
| MT2A | metallothionein 2A | -0.0106038 |
| CCND1 | cyclin D1 | -0.0105393 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0104321 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0104052 |
| PTMA | prothymosin, alpha | -0.0103138 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0102858 |
| TMEM245 | transmembrane protein 245 | -0.010257 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0102158 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0102008 |
| ADNP | activity-dependent neuroprotector homeobox | -0.010159 |
| RPL7A | ribosomal protein L7a | -0.0101325 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0100289 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.00997117 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.00994046 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00990191 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.00986599 |
| NDRG1 | N-myc downstream regulated 1 | -0.00975507 |
| NUP153 | nucleoporin 153kDa | -0.00966129 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.009659 |
| LAMA4 | laminin, alpha 4 | -0.00960192 |
| SRSF10 | serine/arginine-rich splicing factor 10 | -0.00954903 |
| DTNA | dystrobrevin, alpha | -0.00949173 |
| RPS21 | ribosomal protein S21 | -0.00947424 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | -0.00944621 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.00944079 |
| FGFR2 | fibroblast growth factor receptor 2 | -0.00942463 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.00940394 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00935833 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00935295 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.00921712 |
| CFB | complement factor B | -0.00918972 |
| RPS25 | ribosomal protein S25 | -0.00918622 |
