CP21R7_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CLU clusterin 0.126515
MEF2A myocyte enhancer factor 2A 0.101843
FN1 fibronectin 1 0.0890814
NDRG1 N-myc downstream regulated 1 0.0843207
STC1 stanniocalcin 1 0.0801961
LDHA lactate dehydrogenase A 0.077731
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0754374
KRT17 keratin 17, type I 0.0750897
GOLGA4 golgin A4 0.0738597
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0733515
NAMPT nicotinamide phosphoribosyltransferase 0.0679873
MYOF myoferlin 0.0664096
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0648922
EMP1 epithelial membrane protein 1 0.0645243
ENO1 enolase 1, (alpha) 0.063297
CAV1 caveolin 1, caveolae protein, 22kDa 0.0630467
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0596967
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0510928
CUL4B cullin 4B 0.0500863
YBX3 Y box binding protein 3 0.0499526
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0494322
TXNIP thioredoxin interacting protein 0.0487736
TMSB4X thymosin beta 4, X-linked 0.0483208
MT2A metallothionein 2A 0.0478718
MBNL2 muscleblind-like splicing regulator 2 0.0476737
ARRDC3 arrestin domain containing 3 0.0468756
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.04686
SULF1 sulfatase 1 0.0455104
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0446283
NRG1 neuregulin 1 0.0439558
MSN moesin 0.0436339
ZNF292 zinc finger protein 292 0.0434626
EZR ezrin 0.0421125
CD44 CD44 molecule (Indian blood group) 0.0419388
ANXA2 annexin A2 0.0416396
H1-0 H1.0 linker histone 0.0415983
RICTOR RPTOR independent companion of MTOR, complex 2 0.0413598
TGM2 transglutaminase 2 0.0410326
ANKRD33B ankyrin repeat domain 33B 0.0409027
KMT2E lysine (K)-specific methyltransferase 2E 0.0406201
DSCAM Down syndrome cell adhesion molecule 0.0394996
WASF2 WAS protein family, member 2 0.0392648
BHLHE40 basic helix-loop-helix family, member e40 0.0387453
SERINC3 serine incorporator 3 0.038408
ITGA6 integrin, alpha 6 0.0382643
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0378094
LOC112694756 uncharaterized LOC112694756 0.0376264
PDLIM1 PDZ and LIM domain 1 0.0376205
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0374149
CSNK1E casein kinase 1, epsilon 0.036867
FLNB filamin B, beta 0.036861
FOXP1 forkhead box P1 0.036682
RPS4X ribosomal protein S4, X-linked 0.0360953
PGK1 phosphoglycerate kinase 1 0.0360493
TAGLN2 transgelin 2 0.0357649
RIN2 Ras and Rab interactor 2 0.0356425
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0344262
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0342541
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0339169
FOXO1 forkhead box O1 0.0332826
CEMIP cell migration inducing protein, hyaluronan binding 0.0331153
IFITM1 interferon induced transmembrane protein 1 0.0328557
HLA-E major histocompatibility complex, class I, E 0.0328185
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0318507
IFI16 interferon, gamma-inducible protein 16 0.031841
S100A4 S100 calcium binding protein A4 0.0318349
LIFR leukemia inhibitory factor receptor alpha 0.0312207
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0309177
DOK5 docking protein 5 0.0303959
DPYSL2 dihydropyrimidinase-like 2 0.030283
NEK7 NIMA-related kinase 7 0.0300902
ITCH itchy E3 ubiquitin protein ligase 0.0300399
TPM3 tropomyosin 3 0.0298816
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0298791
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0292281
MCL1 myeloid cell leukemia 1 0.0290103
KIAA1217 KIAA1217 0.0288898
AKAP9 A kinase (PRKA) anchor protein 9 0.0286871
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.028544
LNPEP leucyl/cystinyl aminopeptidase 0.0284853
FNBP1 formin binding protein 1 0.0283796
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0283239
ACTN4 actinin, alpha 4 0.0281425
EHF ets homologous factor 0.0277688
OPTN optineurin 0.0277371
ERAP2 endoplasmic reticulum aminopeptidase 2 0.0274691
KIAA0040 KIAA0040 0.0270808
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0270745
BCL10 B-cell CLL/lymphoma 10 0.0269881
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0267607
CSNK1A1 casein kinase 1, alpha 1 0.0267519
GARS1 glycyl-tRNA synthetase 1 0.0267424
KRT14 keratin 14, type I 0.0267112
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0266498
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0265806
LAMP2 lysosomal-associated membrane protein 2 0.0264743
OGA O-GlcNAcase 0.0262406
EHBP1L1 EH domain binding protein 1-like 1 0.0261813
RAD21 RAD21 homolog (S. pombe) 0.025964
KTN1 kinectin 1 (kinesin receptor) 0.0254965

decreased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 -0.101126
TIMP3 TIMP metallopeptidase inhibitor 3 -0.100635
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0879511
INTS6 integrator complex subunit 6 -0.0837342
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0833453
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0760041
TPT1 tumor protein, translationally-controlled 1 -0.0710373
PTMA prothymosin, alpha -0.0689276
SLC35F3 solute carrier family 35, member F3 -0.0630588
HMGA2 high mobility group AT-hook 2 -0.0622308
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0610682
NAV2 neuron navigator 2 -0.0589952
ANO1 anoctamin 1, calcium activated chloride channel -0.0566476
ALCAM activated leukocyte cell adhesion molecule -0.0537231
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0497745
PDLIM5 PDZ and LIM domain 5 -0.0491367
HLA-B major histocompatibility complex, class I, B -0.0483215
BCAR3 breast cancer anti-estrogen resistance 3 -0.04753
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.047253
HDAC9 histone deacetylase 9 -0.0464855
SULF2 sulfatase 2 -0.0455647
PDE4D phosphodiesterase 4D, cAMP-specific -0.044536
CDK6 cyclin-dependent kinase 6 -0.0444179
RPL37A ribosomal protein L37a -0.0442671
IFI6 interferon, alpha-inducible protein 6 -0.0436183
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0428165
RPL11 ribosomal protein L11 -0.0419336
RAD51B RAD51 paralog B -0.0415318
RPS25 ribosomal protein S25 -0.0407917
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0407222
TNS3 tensin 3 -0.0398084
RPS8 ribosomal protein S8 -0.0391458
SP100 SP100 nuclear antigen -0.0391194
ZC3H12C zinc finger CCCH-type containing 12C -0.0382706
NRIP1 nuclear receptor interacting protein 1 -0.0379188
RIGI RNA sensor RIG-I -0.0373611
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0373306
PSD3 pleckstrin and Sec7 domain containing 3 -0.0371609
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0370424
ZMYND8 zinc finger, MYND-type containing 8 -0.0369304
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0368581
RPL35A ribosomal protein L35a -0.0367529
DPYD dihydropyrimidine dehydrogenase -0.0367184
EGFR epidermal growth factor receptor -0.0363196
GRB10 growth factor receptor-bound protein 10 -0.0351781
THSD4 thrombospondin, type I, domain containing 4 -0.0347373
PCDH9 protocadherin 9 -0.0344722
AKAP12 A kinase (PRKA) anchor protein 12 -0.0343516
MTAP methylthioadenosine phosphorylase -0.0335827
SQSTM1 sequestosome 1 -0.0332334
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0325969
FTL ferritin, light polypeptide -0.0322844
RPL31 ribosomal protein L31 -0.0321474
RPS3 ribosomal protein S3 -0.0316353
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0315779
CTBP2 C-terminal binding protein 2 -0.0313153
RPS12 ribosomal protein S12 -0.030961
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0308624
CNTNAP3 contactin associated protein-like 3 -0.0307792
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0307506
ACTG1 actin gamma 1 -0.030367
RPS29 ribosomal protein S29 -0.0299363
CDK13 cyclin-dependent kinase 13 -0.0291328
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0290269
RPL9 ribosomal protein L9 -0.0289364
IFI44 interferon-induced protein 44 -0.0288624
SMYD3 SET and MYND domain containing 3 -0.0288145
RPS24 ribosomal protein S24 -0.0283687
MPRIP myosin phosphatase Rho interacting protein -0.0283511
RPLP1 ribosomal protein, large, P1 -0.0283111
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0278496
COL4A5 collagen, type IV, alpha 5 -0.0277814
RPS27 ribosomal protein S27 -0.0276905
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0276045
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0274961
RCOR1 REST corepressor 1 -0.0272866
TRA2A transformer 2 alpha homolog (Drosophila) -0.0272551
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0270218
RPL34 ribosomal protein L34 -0.0267719
RABGAP1L RAB GTPase activating protein 1-like -0.0267137
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0264969
NT5C2 5'-nucleotidase, cytosolic II -0.0263044
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0262353
S100A11 S100 calcium binding protein A11 -0.026206
DENND1A DENN/MADD domain containing 1A -0.0262018
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0258261
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0258178
SPIRE1 spire-type actin nucleation factor 1 -0.0252684
PTK2 protein tyrosine kinase 2 -0.0252093
RPLP2 ribosomal protein, large, P2 -0.0251886
RPL36 ribosomal protein L36 -0.0249414
RUNX1 runt-related transcription factor 1 -0.0248897
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0247755
RPL7A ribosomal protein L7a -0.0243825
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0240641
LAMC2 laminin, gamma 2 -0.0238514
SSH2 slingshot protein phosphatase 2 -0.0237432
USP53 ubiquitin specific peptidase 53 -0.0234801
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0233996
LRP1B low density lipoprotein receptor-related protein 1B -0.0232721