CP21R7_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.157263
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.154975
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.12427
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.11063
B2M beta-2-microglobulin 0.104725
PTMA prothymosin, alpha 0.0953384
FTL ferritin, light polypeptide 0.0928644
KRT18 keratin 18, type I 0.0814116
EIF1 eukaryotic translation initiation factor 1 0.0801401
RPS6 ribosomal protein S6 0.0785207
ENO1 enolase 1, (alpha) 0.0729717
RPL23 ribosomal protein L23 0.0676679
PKM pyruvate kinase, muscle 0.0675593
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0673147
RPL35A ribosomal protein L35a 0.0656632
S100A6 S100 calcium binding protein A6 0.0647852
RPS3 ribosomal protein S3 0.0623133
RPS19 ribosomal protein S19 0.0597135
ANXA1 annexin A1 0.0594793
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0590426
EMP1 epithelial membrane protein 1 0.0564457
TMC5 transmembrane channel-like 5 0.0545092
RPLP1 ribosomal protein, large, P1 0.053541
LOC112694756 uncharaterized LOC112694756 0.0534429
FTH1 ferritin, heavy polypeptide 1 0.0534054
PGK1 phosphoglycerate kinase 1 0.0516503
RPS8 ribosomal protein S8 0.0505214
S100P S100 calcium binding protein P 0.0476321
POTEF POTE ankyrin domain family, member F 0.0475671
GARS1 glycyl-tRNA synthetase 1 0.0466492
GOLGA4 golgin A4 0.0461853
IFI27 interferon, alpha-inducible protein 27 0.0455033
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0449267
PDIA6 protein disulfide isomerase family A, member 6 0.0443656
S100A9 S100 calcium binding protein A9 0.0436805
SLC38A1 solute carrier family 38, member 1 0.0430948
TPT1 tumor protein, translationally-controlled 1 0.0429192
RPL26 ribosomal protein L26 0.0428348
RPS12 ribosomal protein S12 0.0418579
CALR calreticulin 0.0402116
HLA-A major histocompatibility complex, class I, A 0.040086
LIMA1 LIM domain and actin binding 1 0.0387337
KRT8 keratin 8, type II 0.0381551
RPS25 ribosomal protein S25 0.0378673
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0377255
RPL12 ribosomal protein L12 0.0375342
IFITM3 interferon induced transmembrane protein 3 0.0373271
AGR2 anterior gradient 2 0.0354855
RPS16 ribosomal protein S16 0.0353464
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0352738
RPL19 ribosomal protein L19 0.0349931
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0347143
S100A10 S100 calcium binding protein A10 0.0346832
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.034576
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0345202
EZR ezrin 0.0339333
S100A11 S100 calcium binding protein A11 0.0335851
LOC102724023 ES1 protein homolog, mitochondrial 0.0334433
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0333646
RPS17 ribosomal protein S17 0.0333286
TPM4 tropomyosin 4 0.0327384
DSTN destrin (actin depolymerizing factor) 0.032692
LDHA lactate dehydrogenase A 0.0320812
AGR3 anterior gradient 3 0.0319831
PDIA3 protein disulfide isomerase family A, member 3 0.0311581
RPS4X ribosomal protein S4, X-linked 0.0311062
RPL18 ribosomal protein L18 0.0310252
RPL37A ribosomal protein L37a 0.0301309
LCN2 lipocalin 2 0.0300762
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0299661
RPL7 ribosomal protein L7 0.0295368
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0287091
SET SET nuclear proto-oncogene 0.0284605
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0284355
IFI6 interferon, alpha-inducible protein 6 0.0284321
AKAP9 A kinase (PRKA) anchor protein 9 0.0280833
KRT19 keratin 19, type I 0.0276674
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.027444
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.027376
GSTP1 glutathione S-transferase pi 1 0.0272107
SEPTIN9 septin 9 0.0271644
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0269716
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0267919
CLDN7 claudin 7 0.0264084
RPL35 ribosomal protein L35 0.0261049
KTN1 kinectin 1 (kinesin receptor) 0.0259804
RPS27 ribosomal protein S27 0.0257905
RPL7A ribosomal protein L7a 0.0257732
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0257097
RPL36A ribosomal protein L36a 0.0257084
RPL34 ribosomal protein L34 0.025463
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0253875
NDUFA4 NDUFA4, mitochondrial complex associated 0.0252567
RPS14 ribosomal protein S14 0.025054
HMGA1 high mobility group AT-hook 1 0.0248739
MYL12B myosin, light chain 12B, regulatory 0.0247681
HYOU1 hypoxia up-regulated 1 0.0246729
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0243645
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0241858
RPL8 ribosomal protein L8 0.0239045

decreased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 -0.236467
GMDS GDP-mannose 4,6-dehydratase -0.127922
NPSR1 neuropeptide S receptor 1 -0.117161
CEMIP cell migration inducing protein, hyaluronan binding -0.0598894
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0572995
SAMD12 sterile alpha motif domain containing 12 -0.044102
RUNX1 runt-related transcription factor 1 -0.0436653
ATXN1 ataxin 1 -0.0430504
AHR aryl hydrocarbon receptor -0.0427729
AHNAK AHNAK nucleoprotein -0.0411825
PTPRK protein tyrosine phosphatase, receptor type, K -0.0410533
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0376074
INTS6 integrator complex subunit 6 -0.0370774
TRPS1 trichorhinophalangeal syndrome I -0.0360089
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0353672
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0352222
MECOM MDS1 and EVI1 complex locus -0.032945
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0324686
RAD51B RAD51 paralog B -0.0316316
POF1B premature ovarian failure, 1B -0.0306945
PRKCA protein kinase C, alpha -0.0306466
RNF213 ring finger protein 213 -0.0304544
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0299694
H1-0 H1.0 linker histone -0.0283194
TFRC transferrin receptor -0.0274464
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0270225
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0268248
DSPP dentin sialophosphoprotein -0.0266692
MTUS1 microtubule associated tumor suppressor 1 -0.0263865
ANO1 anoctamin 1, calcium activated chloride channel -0.0263082
PATJ PATJ crumbs cell polarity complex component -0.0251392
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0238736
CNKSR3 CNKSR family member 3 -0.0238066
IFRD1 interferon-related developmental regulator 1 -0.0236162
CAPN8 calpain 8 -0.0235111
SPIDR scaffolding protein involved in DNA repair -0.0233384
YAP1 Yes-associated protein 1 -0.0232834
SP100 SP100 nuclear antigen -0.0230752
EHBP1 EH domain binding protein 1 -0.02268
LPP LIM domain containing preferred translocation partner in lipoma -0.0225062
KLF5 Kruppel-like factor 5 (intestinal) -0.0222511
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0222083
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0221841
NF1 neurofibromin 1 -0.0218406
EXOC4 exocyst complex component 4 -0.0217957
TNS3 tensin 3 -0.0217479
GPHN gephyrin -0.0205704
ECT2 epithelial cell transforming 2 -0.020556
MAML2 mastermind-like 2 (Drosophila) -0.0204612
ETV6 ets variant 6 -0.0204122
PRELID2 PRELI domain containing 2 -0.0202828
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0201785
CEMIP2 cell migration inducing hyaluronidase 2 -0.0197504
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0197155
COBL cordon-bleu WH2 repeat protein -0.0194201
CTBP2 C-terminal binding protein 2 -0.0189092
ARHGAP32 Rho GTPase activating protein 32 -0.0188385
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0187261
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0186501
AXIN2 axin 2 -0.0183362
DIAPH2 diaphanous-related formin 2 -0.0183122
FOXO3 forkhead box O3 -0.0183057
KLHL29 kelch-like family member 29 -0.0182295
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0181168
ZC3H12B zinc finger CCCH-type containing 12B -0.0179998
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0179728
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.017949
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0178321
TJP1 tight junction protein 1 -0.0177774
TRAPPC9 trafficking protein particle complex 9 -0.0177292
NCOA7 nuclear receptor coactivator 7 -0.0177133
TBC1D22A TBC1 domain family, member 22A -0.0175954
MACC1 metastasis associated in colon cancer 1 -0.0173138
FNIP1 folliculin interacting protein 1 -0.0171931
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.017073
CATSPERB catsper channel auxiliary subunit beta -0.0169907
WARS1 tryptophanyl-tRNA synthetase 1 -0.0169544
MED13 mediator complex subunit 13 -0.0168691
ALCAM activated leukocyte cell adhesion molecule -0.0167252
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0165569
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0165536
ACACA acetyl-CoA carboxylase alpha -0.0162482
MTAP methylthioadenosine phosphorylase -0.0161958
TAS2R14 taste receptor, type 2, member 14 -0.0161924
XAF1 XIAP associated factor 1 -0.0160958
RTN3 reticulon 3 -0.0160867
AEBP2 AE binding protein 2 -0.0160329
DENND1A DENN/MADD domain containing 1A -0.0157092
CENPP centromere protein P -0.0156275
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0155554
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0154929
ANKRD10 ankyrin repeat domain 10 -0.0154389
VCL vinculin -0.0153475
CDK13 cyclin-dependent kinase 13 -0.0153086
FAF1 Fas (TNFRSF6) associated factor 1 -0.0152622
NUPR1 nuclear protein, transcriptional regulator, 1 -0.015185
PHF14 PHD finger protein 14 -0.0150981
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0149377
CADPS2 Ca++-dependent secretion activator 2 -0.0149263
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0149061