CP21R7_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description CP21R7 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the CP21R7_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.187477
MUC6 mucin 6, oligomeric mucus/gel-forming 0.083247
VEGFA vascular endothelial growth factor A 0.0683604
FTH1 ferritin, heavy polypeptide 1 0.0680064
EZR ezrin 0.0577227
LDHA lactate dehydrogenase A 0.0554169
TXNIP thioredoxin interacting protein 0.0548875
RPS6 ribosomal protein S6 0.0547597
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0499574
RPS19 ribosomal protein S19 0.0471898
FTL ferritin, light polypeptide 0.0469175
ESYT2 extended synaptotagmin-like protein 2 0.0468474
MT2A metallothionein 2A 0.0466327
LMO7 LIM domain 7 0.0461594
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0427765
EEF2 eukaryotic translation elongation factor 2 0.0417385
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0408033
GOLGA4 golgin A4 0.0400321
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0393206
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0389611
DSPP dentin sialophosphoprotein 0.0373886
NDRG1 N-myc downstream regulated 1 0.0362641
POTEF POTE ankyrin domain family, member F 0.0350837
ENO1 enolase 1, (alpha) 0.0346675
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0346127
RNF145 ring finger protein 145 0.0343691
PKM pyruvate kinase, muscle 0.0338856
LOC112694756 uncharaterized LOC112694756 0.0333666
KTN1 kinectin 1 (kinesin receptor) 0.0327535
ANXA1 annexin A1 0.0297643
AKAP9 A kinase (PRKA) anchor protein 9 0.0290034
FAM13A family with sequence similarity 13, member A 0.0277953
RPL3 ribosomal protein L3 0.0275351
AFF1 AF4/FMR2 family, member 1 0.026923
TTC3 tetratricopeptide repeat domain 3 0.0268872
TMSB10 thymosin beta 10 0.0266394
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0259504
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0243461
FAT1 FAT atypical cadherin 1 0.0242415
TMF1 TATA element modulatory factor 1 0.0241605
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0239852
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0236523
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0233369
LMNA lamin A/C 0.0231604
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0229261
KRT8 keratin 8, type II 0.0227872
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0225235
RPL18 ribosomal protein L18 0.0225137
HSPA8 heat shock 70kDa protein 8 0.0222093
MT1X metallothionein 1X 0.0218993
EIF1 eukaryotic translation initiation factor 1 0.0217457
TMC5 transmembrane channel-like 5 0.0217355
RPL36 ribosomal protein L36 0.0214762
CALR calreticulin 0.0209721
RPS4X ribosomal protein S4, X-linked 0.0206136
WDR45B WD repeat domain 45B 0.0205728
LOC102724023 ES1 protein homolog, mitochondrial 0.020468
PCBP2 poly(rC) binding protein 2 0.0201612
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0200544
PER2 period circadian clock 2 0.0199935
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0198594
KIF5B kinesin family member 5B 0.0193481
COPA coatomer protein complex, subunit alpha 0.0189212
RPS27 ribosomal protein S27 0.0188427
ZFP36 ZFP36 ring finger protein 0.0186677
RPL21 ribosomal protein L21 0.0182424
UGCG UDP-glucose ceramide glucosyltransferase 0.0181322
BRD4 bromodomain containing 4 0.0181199
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0181169
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0180438
KMT2E lysine (K)-specific methyltransferase 2E 0.0178528
APLP2 amyloid beta (A4) precursor-like protein 2 0.0177993
RAB6A RAB6A, member RAS oncogene family 0.0177386
SRRM1 serine/arginine repetitive matrix 1 0.0177271
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0176809
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0176092
UBA6 ubiquitin-like modifier activating enzyme 6 0.017295
DNM2 dynamin 2 0.0172335
ZFP36L1 ZFP36 ring finger protein-like 1 0.0170974
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0168803
HMGA1 high mobility group AT-hook 1 0.0167113
IQGAP1 IQ motif containing GTPase activating protein 1 0.016665
TPM3 tropomyosin 3 0.0165786
SLK STE20-like kinase 0.0165307
ZNF292 zinc finger protein 292 0.016493
ITGB4 integrin, beta 4 0.0164572
MATR3 matrin 3 0.0164432
SRP54 signal recognition particle 54kDa 0.0164036
HYOU1 hypoxia up-regulated 1 0.0162784
DDIT4 DNA-damage-inducible transcript 4 0.0162182
KDM5B lysine (K)-specific demethylase 5B 0.0161254
SOX9 SRY (sex determining region Y)-box 9 0.0160957
CLCN3 chloride channel, voltage-sensitive 3 0.0158855
YBX1 Y box binding protein 1 0.0157484
TSC22D1 TSC22 domain family, member 1 0.0156209
SON SON DNA binding protein 0.0155325
UNC13B unc-13 homolog B (C. elegans) 0.0155249
LMAN1 lectin, mannose-binding, 1 0.0155028
TSC22D2 TSC22 domain family, member 2 0.0154516
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0154418

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.191479
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.152024
VCL vinculin -0.129243
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.10908
NALF1 NALCN channel auxiliary factor 1 -0.0989595
GMDS GDP-mannose 4,6-dehydratase -0.0985007
MYO1E myosin IE -0.0753246
GPHN gephyrin -0.074379
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0711495
CEMIP cell migration inducing protein, hyaluronan binding -0.0708981
TPT1 tumor protein, translationally-controlled 1 -0.0705431
ALCAM activated leukocyte cell adhesion molecule -0.0701389
ANTXR2 anthrax toxin receptor 2 -0.0686432
SMYD3 SET and MYND domain containing 3 -0.0601352
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0596966
PDE4D phosphodiesterase 4D, cAMP-specific -0.0583199
AHNAK AHNAK nucleoprotein -0.0581351
FHIT fragile histidine triad -0.0565599
PIGR polymeric immunoglobulin receptor -0.056289
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0562448
ONECUT3 one cut homeobox 3 -0.0552873
LPP LIM domain containing preferred translocation partner in lipoma -0.0535967
ANXA2 annexin A2 -0.0506908
PATJ PATJ crumbs cell polarity complex component -0.0485487
PDLIM5 PDZ and LIM domain 5 -0.0478904
SLC35F3 solute carrier family 35, member F3 -0.0473163
CCSER1 coiled-coil serine-rich protein 1 -0.0466213
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0446521
PTPRB protein tyrosine phosphatase, receptor type, B -0.0445276
POF1B premature ovarian failure, 1B -0.0435822
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.04099
PRELID2 PRELI domain containing 2 -0.0398061
EXT1 exostosin glycosyltransferase 1 -0.0393646
FLNB filamin B, beta -0.0391725
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.038766
TAS2R14 taste receptor, type 2, member 14 -0.038732
NRXN3 neurexin 3 -0.0386641
RPS24 ribosomal protein S24 -0.0384891
MECOM MDS1 and EVI1 complex locus -0.0380731
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0380103
DIAPH2 diaphanous-related formin 2 -0.0376715
RAB10 RAB10, member RAS oncogene family -0.0371151
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0363879
RAD51B RAD51 paralog B -0.0355727
MAML3 mastermind-like 3 (Drosophila) -0.0355189
MAML2 mastermind-like 2 (Drosophila) -0.0351515
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0340873
GREB1L growth regulation by estrogen in breast cancer-like -0.0339491
LAMA4 laminin, alpha 4 -0.0337724
PARD3 par-3 family cell polarity regulator -0.0329767
MBNL1 muscleblind-like splicing regulator 1 -0.0328239
EXOC4 exocyst complex component 4 -0.0327049
SAMD5 sterile alpha motif domain containing 5 -0.0325339
MYO1D myosin ID -0.0323691
NFIA nuclear factor I/A -0.0323085
CUX1 cut-like homeobox 1 -0.03202
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0318265
ANKRD17 ankyrin repeat domain 17 -0.0315785
TRIM2 tripartite motif containing 2 -0.0314892
IER3 immediate early response 3 -0.0302654
PTPRK protein tyrosine phosphatase, receptor type, K -0.0299537
KLF5 Kruppel-like factor 5 (intestinal) -0.0299341
ZBTB20 zinc finger and BTB domain containing 20 -0.0298936
PALLD palladin, cytoskeletal associated protein -0.0298837
MACF1 microtubule-actin crosslinking factor 1 -0.029853
ANKRD10 ankyrin repeat domain 10 -0.0295825
DENND1A DENN/MADD domain containing 1A -0.0294591
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0294582
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0291112
MBD5 methyl-CpG binding domain protein 5 -0.0288772
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0288548
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.02874
PKP2 plakophilin 2 -0.0282551
FRMD5 FERM domain containing 5 -0.0281791
MYH14 myosin, heavy chain 14, non-muscle -0.0278552
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.027843
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0277133
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0276013
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.027486
ETV6 ets variant 6 -0.0273186
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0266623
SAMD4A sterile alpha motif domain containing 4A -0.026661
TBC1D5 TBC1 domain family, member 5 -0.0264533
AHCYL2 adenosylhomocysteinase-like 2 -0.0261728
ARHGAP26 Rho GTPase activating protein 26 -0.026169
EPCAM epithelial cell adhesion molecule -0.0261674
EHBP1 EH domain binding protein 1 -0.0259984
OSBPL10 oxysterol binding protein-like 10 -0.0259249
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.025533
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.025138
MSI2 musashi RNA-binding protein 2 -0.0250916
DLG1 discs, large homolog 1 (Drosophila) -0.0250785
MTAP methylthioadenosine phosphorylase -0.0247794
ACTN4 actinin, alpha 4 -0.0247085
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0246785
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0246782
FOXP1 forkhead box P1 -0.0246671
USP53 ubiquitin specific peptidase 53 -0.0246171
PSD3 pleckstrin and Sec7 domain containing 3 -0.0241895
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.024187